Search clinical trials for: Immune failure

Total 71123 results

Elizabeth C. Verna
ITB-Med LLC

Not yet recruiting

SIPLIZUMAB in AILD and LT (SET-SAIL)

Autoimmune Liver Disease | Primary Sclerosing Cholangitis | Autoimmune Hepatitis | Cirrhosis, Liver | Liver Transplant Disorder | End Stage Liver DIsease

United States
University of Dundee
Juvenile Diabetes Research Foundation; Lexicon Pharmaceuticals

Not yet recruiting

Sotagliflozin in Patients With Heart Failure Symptoms and Type 1 Diabetes (SOPHIST)

Heart Failure | Type 1 Diabetes
Jinghui Wang

Recruiting

A Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy.

Lung Cancer

China
Tianjin Medical University Cancer Institute and...

Recruiting

Nimotuzumab Combined With ICIs for the Treatment of Advanced Liver Cancer After First Line Treatment Failure

HCC

China
University of Edinburgh

Recruiting

Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition (CHIEFTain)

Myocarditis | Hypertrophic Cardiomyopathy | Cardiac Sarcoidosis | Heart Failure With Preserved Ejection Fraction | Hypertensive Heart Disease | Arrhythmogenic Right Ventricular Cardiomyopathy 1 | Tako Tsubo Cardiomyopathy

United Kingdom
Universitätsklinikum Hamburg-Eppendorf

Recruiting

Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study, 2nd Wave (CLIMATE-II)

Depressive Disorder | Myocardial Infarction | Heart Failure | Stroke | Coronary Disease | Diabetes Mellitus, Type 2 | Renal Insufficiency | Diabetes Mellitus, Type 1 | Schizophrenia | Pulmonary Disease, Chronic Obstructive | Peripheral Nervous System Diseases | Anxiety Disorders | Ischemic Attack, Transient | Arrhythmias... and other conditions

Germany
University of Zurich
Swiss HIV Cohort Study

Recruiting

Cabotegravir Plus Rilpivirine Long-acting Regimen in the Swiss HIV Cohort Study:Uptake, Outcome, and Risk Factors for Treatment Failures

HIV Infections

Switzerland
Sidney Kimmel Comprehensive Cancer Center at Johns...
Janssen Research & Development, LLC

Not yet recruiting

Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies

Lymphoma | Multiple Myeloma | Hodgkin Lymphoma | Myelofibrosis | Non Hodgkin Lymphoma | Chronic Myeloid Leukemia | Hematologic Malignancy | Aplastic Anemia | Myelodysplastic Syndromes (MDS) | Acute Myeloid Leukemia (AML) | Bone Marrow Transplant Rejection | Acute Lymphoblastic Leukemia (ALL), Adult
Cairo University

Not yet recruiting

Composite Repair Using Silane Coupling Agent

Hypersensitivity | Tooth Discoloration | Dental Restoration Failure of Marginal Integrity | Tooth Fracture
Yehua Shen

Not yet recruiting

HAIC Combined With PD-L1 Plus Regorafenib in the Treatment of Advanced Hepatocellular Carcinoma After Immunotherapy Failure

HCC - Hepatocellular Carcinoma
Tourmaline Bio, Inc.

Recruiting

A Study to Evaluate TOUR006 in Patients With Chronic Kidney Disease and Elevated Hs-CRP (TRANQUILITY)

Chronic Kidney Diseases | Chronic Renal Insufficiency | Chronic Kidney Insufficiency | C-Reactive Protein | Chronic Renal Diseases | Kidney Insufficiency, Chronic | hsCRP | High Sensitivity C-Reactive Protein | Hs-CRP

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Combination Immunotherapy of Adebrelimab With Apatinib and Tegafur for Immune Rechallenge Therapy in Esophageal Squamous Cell Carcinoma

Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma

China
European Institute of Oncology

Recruiting

Total Body Irradiation Treatments for Patients Treated at European Institute of Oncology

Lymphoma | Leukemia | Aplastic Anemia | Leukemia, Acute | Leukemia, Chronic

Italy
Istituto Auxologico Italiano

Not yet recruiting

Chemoreflex Sensitivity in HFpEF (CHEMO-HFpEF)

Heart Failure With Preserved Ejection Fraction

Italy
Aristotle University Of Thessaloniki
University Hospital of Crete; University Hospital of Patras; Pulmonary Clinic... and other collaborators

Recruiting

BenRalizumab Effect on Airway Remodeling in Severe asTHma (BREATH)

Airway Remodeling | Asthma; Eosinophilic

Greece
University of Bern
University of Zurich; University of Bristol; ETH Zurich; University of KwaZulu

Recruiting

HIV-1 Subtype-specific Drug Resistance in Patients Failing Dolutegravir (DTG) Based Regimen (DTG-Resist)

Hiv

Mexico, Malawi, Argentina, Brazil, Burkina Faso, Cambodia, Cameroon, Congo, Côte D'Ivoire, Kenya, Rwanda, Tanzania, Thailand, Uganda, Zambia, Zimbabwe
Peking University People's Hospital

Not yet recruiting

Sirolimus+Abatacept+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to Calcineurin Inhibitors

Myelodysplastic Syndromes | Acute Leukemia | Severe Aplastic Anemia
Hospital Universitari Vall d'Hebron Research Institute
ERN-EuroBloodNet (European Reference Network on Rare Hematological Diseases

Recruiting

European Rare Blood Disorders Platform (ENROL) (ENROL)

Leukemia | Anemia | Iron Metabolism Disorders | Anemia, Sickle Cell | Thalassemia | Bleeding Disorder | Myeloma | Lymphoid Neoplasm | Blood Cancer | Bone Marrow Failure | Red Cell Membrane and Enzyme Abnormalities | Myeloma, Malignant

Spain
Institute of Hematology & Blood Diseases Hospital...
Juventas Cell Therapy Ltd.

Recruiting

CNCT19 for Patients With Autoimmune Hemolytic Anemia After Failure ≥3 Lines of Therapy.

Autoimmune Hemolytic Anemia | Autologous CD19 CAR-T | Failure of Three or More Lines of Therapy

China
Stichting Hemato-Oncologie voor Volwassenen Nederland
UMC Utrecht; Amsterdam University Medical Centers; The Dutch Network for Cardiovascular...

Not yet recruiting

Prevention of Anthracycline-Induced Cardiac Dysfunction With Dexrazoxane in Patients With Diffuse Large-B Cell Lymphoma (HO170DLBCL)

DLBCL - Diffuse Large B Cell Lymphoma

Netherlands
Alessandro Doria
University of Colorado, Denver; University Health Network, Toronto; University... and other collaborators

Not yet recruiting

Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease (SUGARNSALT)

Heart Failure | Diabetic Nephropathies | Kidney Failure, Chronic | Diabetes Mellitus Type 1

Canada, United States
Ruijin Hospital

Recruiting

Safety and Efficacy of LPE in Clearing DSA in Patients Who Received Allo-HSCT

Leukemia

China
Post Graduate Institute of Medical Education and...

Recruiting

A Randomized Trial of Prednisolone, Itraconazole, or Their Combination in Allergic Bronchopulmonary Aspergillosis (PICA)

Allergic Bronchopulmonary Aspergillosis

India
University of Padova
Azienda Ospedaliera di Padova

Not yet recruiting

Assessing Detection Algorithms for Insulin Pump Malfunctions in Type 1 Diabetes

Diabetes Mellitus, Type I

Italy
Artcline GmbH
ZKS Jena

Recruiting

Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy - Observational Long-term Outcome Follow up (ReActIF- LTO)

Severe Sepsis

Germany
Augusta University
Janssen Scientific Affairs, LLC

Not yet recruiting

Pilot Study Dara-CyBorD in Newly Diagnosed Multiple Myeloma Patients With Renal Failure

Multiple Myeloma | Renal Failure

United States
Steno Diabetes Center Copenhagen
Zealand University Hospital; Aarhus University Hospital; Rigshospitalet, Denmark and other collaborators

Not yet recruiting

Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes (Steno1)

Cardiovascular Diseases | Heart Failure | Type 1 Diabetes | Kidney Failure
University of Pisa

Recruiting

Tacrolimus Blood Concentration and Transplant-related Outcomes in Pediatric HSCT Recipients

Graft Vs Host Disease | Stem Cell Transplant Complications | Transplant Failure

Italy
King's College London

Recruiting

The Living With a Long-Term Condition Study (LTC)

Liver Diseases | Heart Diseases | Heart Failure | Stroke | Cerebrovascular Disorders | Epilepsy | Pain | Multiple Sclerosis | Hypertension | Obesity | Diabetes | Cancer | Arthritis | Osteoarthritis | Rheumatoid Arthritis | Parkinson Disease | Migraine | Hepatitis | Atrial Fibrillation | Asthma | Endometriosis | Dementia | Fibromyalgia | Celiac... and other conditions

United Kingdom
University of Malaya
Caring Up Pte Ltd, Malaysia; Institute of Adherence to Medication, American...

Recruiting

Efficacy of CareAide® App in Improving Adherence in Adults With Chronic Diseases (CAREAide)

Heart Failure | Quality of Life | Hypertension | Diabetes | Asthma | Chronic Disease | Adherence, Medication | Economic Burden

Malaysia
UK Kidney Association

Recruiting

National Registry of Rare Kidney Diseases (RaDaR)

Vasculitis | AL Amyloidosis | Tuberous Sclerosis | Fabry Disease | Cystinuria | Focal Segmental Glomerulosclerosis | IgA Nephropathy | Bartter Syndrome | Pure Red Cell Aplasia | Membranous Nephropathy | Atypical Hemolytic Uremic Syndrome | Autosomal Dominant Polycystic Kidney Disease | Cystinosis | Nephronophthisis | BK Nephropathy and other conditions

United Kingdom
Virginia Commonwealth University

Recruiting

The Effects of IL-1 Blockade on Inotrope Sensitivity in Patients With Heart Failure (AID-HEART) (AID-HEART)

Heart Failure

United States
Shanghai Zhongshan Hospital
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Not yet recruiting

Anlotinib and TQB2450 in Advanced Hepatocellular Carcinoma After Failure of Prior Immune Checkpoint Inhibitors (FAITH)

Hepatocellular Carcinoma

China
University of California, San Francisco
UCSF CAPS-HIV Innovative Grant; UCSF CFAR-ARI HIV Boost Award; ACC/ABC Merck...

Recruiting

Heart Failure Polypill at a Safety Net Hospital

HIV Infections | Heart Failure With Reduced Ejection Fraction

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure

Severe Aplastic Anemia | Single Lineage Cytopenias, T-LGL | Hypoplastic MDS

United States
Guy's and St Thomas' NHS Foundation Trust
King's College London

Recruiting

The Effect of CRT on the Frank Starling Mechanism (CRT)

Pacemaker | Heartfailure

United Kingdom
University of Alberta
Merck Canada Inc.

Not yet recruiting

Is a Third Dose of MMRV Vaccine Beneficial for the Adult Population in Alberta?

Vaccine Response Impaired | Vaccination Failure
Prime Foundation

Not yet recruiting

Comparison of the Effectiveness of Self Etch Adhesive and Fluoride Varnish in Reducing Hypersensitivity in Patients With Gingival Recession

Dentin Sensitivity

Pakistan
National Cheng-Kung University Hospital

Recruiting

Strategy Therapy on Cancer Therapy-Related Cardiac Dysfunction

Heart Failure | Lymphoma | Breast Cancer | Cardiotoxicity | Chemotherapeutic Toxicity

Taiwan
Academisch Medisch Centrum - Universiteit van Amsterdam...
Netherlands Organisation for Scientific Research

Recruiting

Effect of Nocturnal Parenteral Nutrition on Bone Turnover and Energy Metabolism (NutriSync)

Osteoporosis | Insulin Sensitivity | Intestinal Failure

Netherlands
Children's Hospital of Fudan University
Shanghai Children's Hospital; Shanghai Children's Medical Center; Xinhua Hospital... and other collaborators

Not yet recruiting

Rituximab in the First Episode of Paediatric Nephrotic Syndrome

Steroid-Sensitive Nephrotic Syndrome

China
University of Birmingham
Cancer Research UK; Genmab

Recruiting

Relapsed Follicular Lymphoma Randomised Trial Against Standard ChemoTherapy (REFRACT)

Relapsed Follicular Lymphoma | Refractory Follicular Lymphoma

United Kingdom
University of Leicester

Recruiting

Usability and Acceptability Study of the P-STEP Mobile Application

Heart Failure | Chronic Obstructive Pulmonary Disease | Asthma | Type 2 Diabetes | Coronary Heart Disease | Interstitial Lung Disease

United Kingdom
Biohope Scientific Solutions for Human Health,...

Recruiting

BIOtechnology Applied to Renal TRansplantation With IMmunobiogram (BIOTRAIM)

Kidney Transplant Failure and Rejection

Spain, Germany, Sweden, Brazil, France
Cairo University

Recruiting

Methods Decreasing Bleeding in Open Myomectomy

Myoma | Blood Loss, Surgical | Misoprostol Allergy | Oxytocin Allergy | Tranexamic Acid Allergy | Ethamsylate Allergy

Egypt
St George's, University of London
King's College Hospital NHS Trust

Recruiting

S100A8/A9 and Innate Immunity in Liver Disease

Infections | Cirrhosis, Liver | Ascites Hepatic | Immune Suppression | Liver Failure, Acute on Chronic

United Kingdom
Ohio State University

Recruiting

An Exploratory Analysis of Immune and Inflammatory Response Associated With Clozapine

Treatment-resistant Schizophrenia

United States
Aristotle University Of Thessaloniki
1st ORL Department, AHEPA Hospital, Aristotle University of Thessaloniki; Department... and other collaborators

Recruiting

Biomarkers of Response to Mepolizumab Treatment in Patients With Nasal Polyps With or Without Bronchial Asthma (CALIOPI)

Asthma | Chronic Rhinosinusitis With Nasal Polyps

Greece
NHS Greater Glasgow and Clyde
AstraZeneca

Recruiting

Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure (TARTAN-HF)

Cardiovascular Diseases | Heart Failure | Diabetes Mellitus | Type 1 Diabetes | Type 2 Diabetes

United Kingdom
Exactech

Recruiting

Vantage Mobile Bearing Total Ankle System Post Market Clinical Follow-up (Outside US)

Rheumatoid Arthritis | Arthritis of Ankle | Failure, Prosthesis

Spain, Switzerland

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