Search clinical trials for: Mechanisms

Total 96219 results

Seoul National University

Not yet recruiting

Thoracic Sympathetic Ganglion Block With Botulinum Toxin Type A

Complex Regional Pain Syndromes
Shanghai Jiaolian Drug Research and Development...
Shanghai Pharmaceuticals Holding Co., Ltd

Not yet recruiting

A Clinical Study of B007 in the Treatment of Primary Membranous Nephropathy.

Primary Membranous Nephropathy

China
Zaparackas and Knepper LTD
Northwestern University Feinberg School of Medicine

Not yet recruiting

RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β

Alzheimer Disease | Mild Cognitive Impairment | Cognitive Decline

United States
GlaxoSmithKline
iTeos Therapeutics

Recruiting

A Study of Belrestotug Plus Dostarlimab Compared With Placebo Plus Pembrolizumab in Previously Untreated Participants With Programmed Death Ligand 1 (PD-L1) High Non-small-cell Lung Cancer (NSCLC)

Lung Cancer, Non-Small Cell

Argentina, Belgium, Brazil, Canada, Finland, Germany, Italy, Japan, Mexico, Panama, Spain, Taiwan, Turkey, Poland, Netherlands, Korea, Republic of, France, Greece, Bulgaria, Croatia, Czechia, Estonia, Hong Kong, Hungary, India, Philippines, Portuga... and more
Chinese PLA General Hospital

Recruiting

A Phase ll Trial of the Combination of Zanubrutinib, Rituximab and Venetoclax in Patients With Previously Untreated Follicular Lymphoma (ZARAV)

Ann Arbor Stage II Follicular Lymphoma | Ann Arbor Stage III Follicular Lymphoma | Ann Arbor Stage IV Follicular Lymphoma | Grade 1 Follicular Lymphoma | Grade 2 Follicular Lymphoma | Grade 3a Follicular Lymphoma

China
Boston Children's Hospital

Not yet recruiting

Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine

Post Operative Pain | Spinal Fusion

United States
Azienda Usl di Bologna

Recruiting

Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock (EVSS)

Septic Shock | Renal Function Replacement

Italy
Zhiyong Huang
Hubei Cancer Hospital; Wuhan Union Hospital, China; Renmin Hospital of Wuhan... and other collaborators

Recruiting

Palliative Hepatectomy Combined With Targeted Therapy and Immunotherapy for Advanced Hepatocellular Carcinoma

Advanced Hepatocellular Carcinoma

China
Soligenix

Not yet recruiting

Confirmatory Phase 3 Study of Topical HyBryte™ vs. Placebo for the Treatment of CTCL (FLASH2)

Mycosis Fungoides | Cutaneous T Cell Lymphoma | CTCL | CTCL/ Mycosis Fungoides
University of Chicago

Not yet recruiting

Effects of Drugs on Stress Memories (ETS)

Stress | THC

United States
The First Affiliated Hospital with Nanjing Medical...
Jiangsu Hengrui Pharmaceuticals Co.,Ltd

Not yet recruiting

To Evaluate the Efficacy of Adebrelimab Combined With Chemotherapy After HIFU Induction Neoadjuvant Therapy HR+/HER2- Breast Cancer

Breast Cancer | HR+/HER2- Breast Cancer
Merck Sharp & Dohme LLC

Not yet recruiting

Substudy 06C: A Study of Sacituzumab Tirumotecan (MK-2870) With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

Esophageal Cancer | Esophageal Neoplasms | Gastroesophageal Adenocarcinoma | Gastroesophageal Junction
AstraZeneca

Not yet recruiting

A Study to Investigate Efficacy and Safety of PT027 Compared With PT007 in Symptomatic Chinese Adults With Asthma (BAIYUN)

Asthma

China
Navy General Hospital, Beijing

Not yet recruiting

VA Conditioning Regimen Allo-HSCT for Elderly Higher-risk MDS

Higher-risk Myelodysplastic Syndromes

China
Liverpool Heart and Chest Hospital NHS Foundation...

Not yet recruiting

Haemostasis After Venous Access in Atrial Fibrillation Catheter Ablation: The HARNESS Trial (HARNESS)

Atrial Fibrillation | Bleeding | Femoral Vein Injury
University of California, San Francisco
Merck Sharp & Dohme LLC; Astellas Pharma Inc

Not yet recruiting

Enfortumab Vedotin and Pembrolizumab Combined With Radiotherapy in Muscle Invasive Bladder Cancer

Bladder Cancer | Muscle-Invasive Bladder Carcinoma | Stage IIIA Bladder Cancer AJCC v8 | Stage II Bladder Cancer AJCC v8

United States
Navy General Hospital, Beijing

Not yet recruiting

CHG Combined With Venetoclax and Azacytidine in Newly Diagnosed AML

Acute Myeloid Leukemia

China
Anaveon AG
Merck Sharp & Dohme LLC

Not yet recruiting

A Study Evaluating ANV600 Single Agent or in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (EXPAND-1)

Advanced Solid Tumor
Shanghai Ninth People's Hospital Affiliated to...

Recruiting

A Prospective, Randomised Controlled, Phase II Clinical Study of Tirilizumab in Combination With Albumin-bound Paclitaxel With Cisplatin for Neoadjuvant and Adjuvant Treatment of Locally Advanced Resectable Oral Squamous Cell Carcinoma (OPTimal)

Locally Advanced Head and Neck Squamous Cell Carcinoma

China
Poznan University of Medical Sciences

Not yet recruiting

Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty

Knee Osteoarthritis | Knee Arthritis | Knee Pain Chronic | Knee Disease

Poland
Tianjin Medical University Cancer Institute and...

Not yet recruiting

The Efficacy of Gemcitabine and Nab-palitaxe Combined With Cadonilimab Sequential Short-course Radiotherapy in the Treatment of Patients With Locally Advanced Pancreatic Ductal Adenocarcinoma

Locally Advanced Pancreatic Ductal Adenocarcinoma

China
Shanghai Changzheng Hospital
The First Affiliated Hospital of Nanchang University; Shanghai Zhongshan Hospital and other collaborators

Not yet recruiting

The Efficacy and Safety of Alverine in the Treatment of Portal Hypertension in Patients With Liver Cirrhosis

Hypertension, Portal
Aalborg University

Not yet recruiting

Investigation of Corticospinal Excitability Aspects of Itch and Pain

Pain | Itch
Beijing Chest Hospital, Capital Medical University

Not yet recruiting

Adebrelimab Plus Chemo and Recaticimab Perioperative Treatment for Resectable NSCLC

Non Small Cell Lung Cancer

China
Ohio State University
Patient-Centered Outcomes Research Institute; Northwestern University; Preeclampsia...

Not yet recruiting

Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL (ASPIRIN)

Preeclampsia | Gestational Hypertension | Hypertensive Disorders of Pregnancy

United States
AstraZeneca
Daiichi Sankyo Company, Limited 3-5-1 Nihonbashihoncho, Chuo-ku, Tokyo

Not yet recruiting

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer (DESTINY-BTC01)

Biliary Tract Cancer

Belgium, Canada, Brazil, Japan, Korea, Republic of, Taiwan, Germany, Austria, Netherlands
Chang Gung Memorial Hospital

Not yet recruiting

Efficacy and Safety of Hydroxychloroquine in the Treatment of Sudden Sensorineural Hearing Loss

Sudden Hearing Loss
Tang-Du Hospital

Recruiting

Study on the Therapeutic Effect of Irinotecan Liposomes in Small Cell Lung Cancer

Small Cell Lung Cancer

China
University of East Anglia
Clinical Research and Trials Unit (Norfolk & Norwich University Hospital,...

Recruiting

The Role of SGLT2i in Management of Moderate AS

Moderate Aortic Valve Stenosis

United Kingdom
Xianmin Song, MD

Recruiting

Reduced Intensity Conditioning With Thiotepa Combined With Bu/Flu/Ara-C in Allo-HSCT for Relapsed or Refractory Peripheral T-cell Lymphoma.

Peripheral T Cell Lymphoma

China
Mikko Niemi
University of Helsinki

Recruiting

KF2023#1-Trial: Influence of Statin Intake on Cellular Readouts

Pharmacodynamics

Finland
Peking University First Hospital
Peking University International Hospital; Tianjin Medical University General...

Not yet recruiting

Dexmedetomidine-Esketamine Combination for Sedation and Analgesia in ICU Patients

Delirium | Dexmedetomidine | Aged | Intensive Care Units | Esketamine | Ventilators, Mechanical

China
King's College Hospital NHS Trust
King's College London

Not yet recruiting

ESCALATion of Medical Therapy Following Multimodality Plaque Evaluation in High-risk Chronic Coronary Syndromes (ESCALATE)

Coronary Artery Disease
National Aeronautics and Space Administration (NASA)

Recruiting

Effect of Sex on Orthostatic Intolerance and Cardiovascular Response During Lunar Descent and Ascent (Lunar OI)

Healthy

United States
Clinica Especializada en el Manejo de la Diabetes...

Recruiting

Multidisciplinary Care for Lifestyle Change for Metabolic Control and Quality of Life in Prediabetes (PreCPro) (PreCPro)

PreDiabetes

Mexico
The First Affiliated Hospital with Nanjing Medical...

Recruiting

NALIRIFOX as Induction Therapy in LAPC

Pancreatic Ductal Adenocarcinoma

China
University of Aarhus

Recruiting

Strategy for Withdrawal of Pharmacological Treatment for Urinary Incontinence in Children (StayDry)

Urinary Incontinence in Children

Denmark
Second Affiliated Hospital, School of Medicine,...
Huashan Hospital; The Affiliated Nanjing Drum Tower Hospital of Nanjing University... and other collaborators

Not yet recruiting

Tract-based Artificial Intelligence (AI) Robot Guiding System in Basal Ganglion Hemorrhage Evacuation

Basal Ganglia Hemorrhage

China
Radboud University Medical Center

Not yet recruiting

Methylphenidate in KBG Syndrome: N-of-1 Series (KBGS_N_of_1)

ADHD - Combined Type | Kbg Syndrome
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

Efficacy and Safety of Dupilumab in Combination With Tofacitinib in Moderate to Severe Adult AD Patients

Atopic Dermatitis
Pfizer

Not yet recruiting

A Study to Learn How Different Forms of The Study Medicine Called Phenytoin Are Taken up Into the Blood in Healthy Adults

Healthy
Kerry Rogers

Not yet recruiting

Pirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients With CLL or SLL Resistant to Covalent BTKi

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma

United States
Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Not yet recruiting

Adebrelimab With or Without SHR-8068 in Combination With Cisplatin Plus Gemcitabine as First-line Treatment in Patients With Advanced Biliary Tract Cancer

Biliary Tract Cancer
David Ilan Sandberg

Not yet recruiting

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

Recurrent Ependymoma | Recurrent Medulloblastoma | CNS Malignancies

United States
Institut de Recherches Internationales Servier
Servier Bio-Innovation LLC

Not yet recruiting

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation (PyramIDH)

Myelodysplastic Syndromes (MDS) | Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS)
Tanta University

Not yet recruiting

Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis

Hemodialysis | ESRD | Renal Replacement Therapy | End-stage Renal Disease | Uremic Pruritus | Chronic Kidney Disease-associated Pruritus

Egypt
Swiss GO Trial Group
Tumor Profiler Center Switzerland

Not yet recruiting

OV Precision: Study Examining the Benefit of a Tumor- and Patient-specific Cancer Therapy (OVPrecision)

Fallopian Tube Neoplasms | Ovarian Neoplasm Epithelial | High-grade Serous Ovarian Carcinoma (HGSOC) | Ovarian Endometrioid Carcinoma

Switzerland
Stefano Vicari
Italian Institute of Technology (IIT)

Recruiting

Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome

Down Syndrome

Italy
M.D. Anderson Cancer Center

Not yet recruiting

A Phase I Study of Hyper-CVAD In Combination With Venetoclax In Pediatric Patients With Relapsed or Refractory Acute Leukemias That Are of the Lymphoid Lineage Including Bi-Phenotypic or Undifferentiated Leukemias

Refractory Acute Leukemia | Undifferentiated Leukemia | Relapsed Acute Leukemia | Bi-Phenotypic Leukemia

United States
University of Chile
Centro FONDAP de Gerociencia, Salud mental y Metabolismo (GERO); Center for...

Recruiting

Nicotinamide Supplementation Improves Physical Performance in Older Adults at Risk of Falls (NICE-FIT)

Frailty | Fall | Frailty Syndrome | Falls

Chile

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