Search clinical trials for: Prophylactic whole brain radiotherapy

Total 44466 results

Instituto Nacional de Cancerologia de Mexico

Terminated

Study of Whole-brain Irradiation With Chloroquine for Brain Metastases (CLQ)

Brain Metastasis

Mexico
HCA International Limited

Terminated

Investigating the Efficacy of Hair Sparing Radiotherapy Treatment to the Whole Brain. (SPARE)

Metastatic Brain Cancer

United Kingdom
Sheba Medical Center

Unknown

Neurocognitive Function After Prophylactic Cranial Irradiation & Hippocampal Sparing in LD SCLC Patients - a Pilot Study

Carcinoma, Small Cell

Israel
University Hospital, Ghent

Terminated

Hair-sparing Whole Brain Radiotherapy

Small Cell Lung Cancer | Brain Metastases

Belgium
Cancer Institute and Hospital, Chinese Academy...

Recruiting

SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC (SHARP)

Small-cell Lung Cancer | Brain Metastases | SRS | Stereotactic Radiotherapy | Whole Brain Radiotherpay | Hippocampal-avoidance

China
Sichuan University

Recruiting

Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer

NSCLC | PD-1 Inhibitor | Leptomeningeal Metastasis | Low Dose Radiotherapy

China
Emory University
National Cancer Institute (NCI)

Not yet recruiting

Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases

Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
Fudan University

Recruiting

WBRT With Hippocampal-avoidance Technique Followed by SRT for Extensive-stage SCLC With Baseline Brain Metastases

Brain Metastases | SCLC,Extensive Stage

China
Chang Gung Memorial Hospital

Not yet recruiting

HF-SRT vs. HS-WBRT in Treating Patients With Brain Oligometastases

Brain Oligometastases

Taiwan
Xiaorong Dong

Not yet recruiting

Circulating Tumor DNA and T Cell Repertoire Predict Radiotherapeutic Outcomes in NSCLC Patients With Brain Metastasis

Carcinoma, Non-Small-Cell Lung | Brain Metastases

China
Zhejiang Cancer Hospital
Sun Yat-sen University; First Affiliated Hospital, Sun Yat-Sen University

Recruiting

PCI and Brain MRI Follow-up vs Brain MRI Follow-up Alone in Limited-stage SCLC Patients

Small Cell Lung Cancer Limited Stage

China
ImmunoChem Therapeutics, LLC
National Cancer Institute (NCI); Northwestern Medicine

Recruiting

MW151 and Whole-brain Radiotherapy in Patients With Intracranial Metastases (MW151-102)

Cognitive Dysfunction, Cognitive Disorder

United States
University Hospital Heidelberg

Recruiting

The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases? (CyberChallenge)

Brain Metastases | Nsclc

Germany
Tata Memorial Hospital

Recruiting

Observation or Upfront Cranial RT in Oncogene Mutated NSCLC With Asymptomatic BM: A Phase III RCT

Asymptomatic Brain Metastases | Driver Mutation Positive Non-small Cell Lung Cancer

India
Postgraduate Institute of Medical Education and...

Recruiting

Stereotactic Radiosurgery vs Whole Brain Radiotherapy in Breast Cancer With Brain Oligometastasis (SRSvsWBRT)

Breast Cancer | Brain Metastases, Adult | Stereotactic Radiosurgery | Whole Brain Radiotherapy

India
Chongqing University Cancer Hospital

Recruiting

Almonertinib Combined With Cerebral Radiation Treat Brain Metastases From EGFR Positive NSCLC

Non-Small Cell Lung Cancer (NSCLC)

China
Dana-Farber Cancer Institute
NH TherAguix SAS

Recruiting

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

Melanoma | Breast Cancer | Colorectal Cancer | Lung Cancer | Brain Cancer | Brain Tumor | HER2-positive Breast Cancer | Gastrointestinal Cancer | Brain Metastases | SRS | SRT | Whole Brain Radiation | Stereotactic Radiation | AGuIX | Nanoparticle | Cystic

United States
Mediterranean Institute of Oncology
University of Palermo; University of Messina

Recruiting

WHOle Brain Irradiation or STEreotactic Radiosurgery for Five or More Brain Metastases (WHOBI-STER) (WHOBI-STER)

Quality of Life | Neurocognitive Deficit | Activities of Daily Living

Italy
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Lung Small Cell Carcinoma | Recurrent Lung Small Cell Carcinoma

United States, Canada
National Taiwan University Hospital

Recruiting

Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases

Metastatic Malignant Neoplasm to Brain

Taiwan
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

Metastatic Renal Cell Carcinoma | Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Melanoma | Stage IV Lung Cancer AJCC v8 | Stage IV Renal Cell... and other conditions

United States
Chang Gung Memorial Hospital

Recruiting

Prospective Neurobehavioral Functions in Newly-diagnosed Patients With Primary CNS Lymphoma Treated With Hyperfractionated Conformal Whole-brain Radiation Therapy Plus Simultaneous Integrated Boost

Primary CNS Lymphoma | Brain Lymphoma

Taiwan
Lawrence D Recht
Sanofi

Recruiting

Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma

Glioblastoma | Malignant Glioma | Gliosarcoma | Glioblastoma With Primitive Neuronal Component | Oligodendroglial Component Present

United States
Canadian Cancer Trials Group
Alliance for Clinical Trials in Oncology; NRG Oncology

Recruiting

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Brain Metastases

Canada, United States
Chang Gung Memorial Hospital

Recruiting

Neurocognitive Impact and Dose-Effect Relationship of Hippocampal Avoidance During Whole Brain Radiotherapy Plus Simultaneous Integrated Boost - A Prospective Follow-up Study

Brain Metastasis | Brain Metastases

Taiwan
Chang Gung Memorial Hospital

Recruiting

A Prospective Study of the Impact of Hippocampal Avoidance During Whole Brain Radiotherapy on Neurocognitive Function Decline

Brain Metastasis | Brain Metastases

Taiwan
University Hospital, Grenoble
NH TherAguix SAS

Active, not recruiting

Radiotherapy of Multiple Brain Metastases Using AGuIX® (NANORAD2)

Radiotherapy | Brain Metastases, Adult

France
M.D. Anderson Cancer Center

Active, not recruiting

Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer

Metastatic Malignant Neoplasm in the Brain | Stage IV Non-Small Cell Lung Cancer AJCC v7

United States
M.D. Anderson Cancer Center

Active, not recruiting

Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium

Bladder Cancer

United States
BioMimetix JV, LLC
National Cancer Institute (NCI); Duke Cancer Institute

Terminated

A Trial for Treatment of Cancer Patients With Multiple Brain Metastases Undergoing Whole-Brain Radiotherapy

Multiple Brain Metastases

United States
National Cancer Institute (NCI)

Active, not recruiting

Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
National Cancer Institute (NCI)

Active, not recruiting

Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

Metastatic Malignant Neoplasm in the Brain

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Metastatic Lung Neuroendocrine Neoplasm | Metastatic Malignant Neoplasm in the Brain | Metastatic Lung Small Cell Carcinoma

United States
National Cancer Centre, Singapore
Singapore General Hospital; Singhealth Duke-NUS Oncology Academic Clinical...

Active, not recruiting

Phase 2 Trial in Multiple Brain Metastases Outcomes With HA-SIB-WBRT

Brain Metastases

Singapore
Sidney Kimmel Cancer Center at Thomas Jefferson...
Bristol-Myers Squibb

Completed

Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma

Recurrent Melanoma | Stage IV Melanoma | Tumors Metastatic to Brain

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases

Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm

United States
H. Lee Moffitt Cancer Center and Research Institute
Pfizer

Active, not recruiting

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

Leptomeningeal Metastases | Leptomeningeal Disease

United States
NRG Oncology
National Cancer Institute (NCI); Radiation Therapy Oncology Group

Active, not recruiting

Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Treating Patients With Limited Stage or Extensive Stage Small Cell Lung Cancer

Extensive Stage Small Cell Lung Carcinoma | Limited Stage Small Cell Lung Carcinoma

United States, Canada
New Mexico Cancer Care Alliance

Completed

Whole Brain Radiation Using IMRT for Patients With Brain Metastases

Neoplasm Metastasis | Central Nervous System Metastases

United States
Juergen Debus
Heidelberg University

Completed

Whole Brain Radiation Therapy Alone vs. Radiosurgery for SCLC Patients With 1-10 Brain Metastases (ENCEPHALON)

SCLC | Brain Metastases

Germany
University Hospital Heidelberg

Suspended

Supportive Care With or Without Repeated Whole Brain Radiotherapy in Patients With Recurrent Brain Metastases (RECARE)

Brain Metastases

Germany
National Cancer Institute (NCI)
NRG Oncology

Completed

Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer

Recurrent Breast Carcinoma | Invasive Breast Carcinoma | Metastatic Malignant Neoplasm in the Brain | Stage IV Breast Cancer AJCC v6 and v7 | HER2-Positive Breast Carcinoma

United States, Korea, Republic of, Canada
British Columbia Cancer Agency

Active, not recruiting

Volumetric Modulated Arc Therapy (VMAT) for Brain Metastases

Brain Metastases

Canada
M.D. Anderson Cancer Center

Completed

Randomized Trial Comparing Radiosurgery With vs Without Whole Brain Radiotherapy

Brain Cancer

United States
International Extranodal Lymphoma Study Group (IELSG)

Active, not recruiting

New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement

Diffuse Large B-cell Lymphoma

Netherlands, United Kingdom, Italy, Czechia
University of Maryland, Baltimore

Terminated

Phase II Trial of Low-Dose Whole Brain Radiotherapy With Concurrent Temozolomide and Adjuvant Temozolomide in Patients With Newly-Diagnosed Glioblastoma Multiforme (GCC 1224)

Histologically Proven Diagnosis of Glioblastoma or Gliosarcoma (WHO Grade IV)

United States
Washington University School of Medicine
Varian Medical Systems

Completed

Simulation-Free Hippocampal-Avoidance Whole Brain Radiotherapy Using Diagnostic MRI-Based and Cone Beam Computed Tomography-Guided On-Table Adaptive Planning in a Novel Ring Gantry Radiotherapy Device

Intracranial Metastatic Disease From Any Solid Malignancy

United States
Juergen Debus
Heidelberg University

Completed

Stereotactic Radiotherapy of the Resection Cavity of Brain Metastases vs. Post-operative Whole-brain Radiotherapy (ESTRON)

Brain Metastases, Adult

Germany
Juergen Debus
Heidelberg University

Completed

Cyberknife Radiosurgery for Patients With Brain Metastases Diagnosed With Either SPACE or MPRAGE Sequence (CYBER-SPACE)

Adult Solid Tumor | Brain Metastases

Germany
The George Institute

Completed

Controlled evaLuation of Angiotensin Receptor Blockers for COVID-19 respIraTorY Disease (CLARITY)

COVID-19 | Coronavirus Disease 2019

Australia, India

Search clinical trials for: Prophylactic whole brain radiotherapy

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