Clinical Trials Sponsored by National Institute of Diseases of the Chest and Hospital

Total 8703 results

National Institute of Allergy and Infectious Diseases...

Recruiting

A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With Pseudomonas Aeruginosa

Cystic Fibrosis | Bacterial Disease Carrier

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis

Tuberculous Meningitis

South Africa, Zimbabwe, India, Kenya, Malawi, Mexico, Peru, Brazil, Philippines, Tanzania, Thailand, Vietnam
National Institute of Allergy and Infectious Diseases...

Recruiting

Safety and Efficacy Study of Meningococcal Group B Vaccine rMenB+OMV NZ (Bexsero) to Prevent Gonococcal Infection

Gonococcal Infection

United States, Malawi, Thailand
National Institute of Allergy and Infectious Diseases...

Not yet recruiting

Single-Dose Study to Evaluate the PKs of Pretomanid in Subjects With Renal Impairment Compared to Subjects With Normal Renal Function

Renal Impairment | Tuberculosis

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Evaluating the Infectivity, Safety and Immunogenicity of Respiratory Syncytial Virus Vaccines, RSV 6120/∆NS1 and RSV 6120/F1/G2/∆NS1, in RSV-Seropositive Children and RSV-Seronegative Infants and Children

RSV Infection

United States
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

Dried Blood Spot Testing of CMV Detection in HCT Recipients

Cytomegalovirus Infection

United States
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

Safety and Immunogenicity of CJCV2 With and Without ALFQ

Campylobacter Infection

United States
National Institute of Allergy and Infectious Diseases...

Completed

Safety and Immunogenicity of a Single Dose of the Recombinant Live-Attenuated Respiratory Syncytial Virus (RSV) Vaccines RSV ΔNS2/Δ1313/I1314L, RSV 6120/ΔNS2/1030s, RSV 276 or Placebo, Delivered as Nose Drops to RSV-Seronegative Children 6 to 24 Months of Age

Respiratory Syncytial Virus (RSV)

United States
National Institute of Allergy and Infectious Diseases...

Completed

Phase I Norovirus Challenge Model

Gastroenteritis Norovirus

United States
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

Siplizumab in T1DM (DESIGNATE)

Type 1 Diabetes Mellitus

United States
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

Phase 1 Study of SAR440894 vs Placebo

Chikungunya Virus Infection

United States
National Institute of Allergy and Infectious Diseases...

Completed

H7N9 Vaccination With and Without AS03 and Unadjuvanted H3N2v Vaccination: Standard and Systems Biology Analyses

Influenza | Avian Influenza | H1N1 Influenza

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluation of Tofacitinib in Prevention of Photosensitivity in Lupus

Systemic Lupus Erythematosus | Cutaneous Lupus

United States
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

Clinical Trial to Evaluate the Safety and Immunogenicity of Ferritin Nanoparticles Expressing Native-like HIV-1 Envelope Trimers Followed by Boost With mRNA Lipid Nanoparticles Encoding a Native-like HIV-1 Envelope Trimer in Adults Without HIV

Hiv

United States
National Institute of Allergy and Infectious Diseases...

Completed

Pleconaril Enteroviral Sepsis Syndrome

Enterovirus Infection

United States, Canada
National Institute of Allergy and Infectious Diseases...

Completed

DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia

Staphylococcal Bacteraemia

United States, Canada
National Institute of Allergy and Infectious Diseases...

Completed

VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents (DNA)

RNA Virus Infections | Virus Diseases | Flavivirus Infections | Flaviviridae Infections | Zika Virus Infection | Zika Virus | Flaviviral Diseases

United States, Puerto Rico, Mexico, Brazil, Colombia, Costa Rica, Ecuador, Panama, Peru
National Institute of Allergy and Infectious Diseases...

Completed

An Observational Study to Assess the Prevalence and Outcomes of Primary Pulmonary Coccidioidomycosis in Persons Aged > / = 14 Years Presenting With Community Acquired Pneumonia (CAP) in Endemic Areas (SAnds-PPC)

Pneumonia | Coccidioidomycosis

United States
National Institute of Allergy and Infectious Diseases...

Completed

Influenza Challenge Study to Determine the Optimal Infection Dose and Safety of a Recombinant H3N2 (A/Texas/71/2017 (H3N2, Clade 3C3a) Influenza Strain

Influenza

United States
National Institute of Allergy and Infectious Diseases...

Terminated

Evaluation of Human Immune Responses to Influenza Virus Vaccination in Healthy Volunteers

Influenza | Influenza Immunisation

United States
National Institute of Allergy and Infectious Diseases...

Terminated

Analysis of Bone Marrow and Blood B Cell Immune Responses to Influenza Vaccination

Influenza | Influenza Immunisation

United States
National Institute of Allergy and Infectious Diseases...

Completed

Impact of CCR5 Blockade in HIV+ Kidney Transplant Recipients

HIV Infections | Kidney Diseases

United States
National Institute of Allergy and Infectious Diseases...

Completed

Acceptability, Safety, and Use of Daily Truvada Pre-Exposure Prophylaxis in Adolescents

HIV Infections

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety of and Adherence to a Vaginal Matrix Ring Containing Dapivirine and Oral Emtricitabine/Tenofovir Disoproxil Fumarate in an Adolescent and Young Adult Female Population

HIV Infections

South Africa, Uganda, Zimbabwe
National Institute of Allergy and Infectious Diseases...

Completed

ACTIV-5 / Big Effect Trial (BET-C) for the Treatment of COVID-19

COVID-19

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Pharmacokinetics of PC-1005 Administered Rectally to HIV-1 Seronegative Adults

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

Evaluating the Safety and Efficacy of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women

HIV Infections

Zimbabwe, South Africa, Botswana, Kenya, Malawi, Uganda, Swaziland
National Institute of Allergy and Infectious Diseases...

Completed

Suppression Of Bacterial Vaginosis (BV) [SUBVert]

Bacterial Vaginosis

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Pharmacokinetics, Safety, and Tolerability of Doravirine (MK-1439) and Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (MK-1439A) in HIV-1-Infected Children and Adolescents

HIV Infections

United States, South Africa, Thailand
National Institute of Allergy and Infectious Diseases...

Completed

Dual bNAb Treatment in Children

HIV Infection

Botswana
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Pharmacokinetics of VRC01, VRC01LS, and VRC07-523LS, Potent Anti-HIV Neutralizing Monoclonal Antibodies, in HIV-1-Exposed Infants

HIV Infections

United States, Puerto Rico, Zimbabwe, South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Immunogenicity of the AIDSVAX B/E Vaccine and the MVA/HIV62B Vaccine in Healthy, HIV-1-Uninfected Adults Who Previously Received MVA/HIV62B in DNA/MVA or MVA/MVA Regimens in HVTN 205

HIV Infections

United States, Peru
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Immunogenicity of an HIV-1 gp41 MPER-656 Liposome Vaccine in Healthy, HIV-uninfected Adult Participants

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluation of the Safety and Immunogenicity of the Live Attenuated Zika Vaccine rZIKV/D4Δ30-713 in Flavivirus-naïve Adults

Zika Virus

United States
National Institute of Allergy and Infectious Diseases...

Completed

Pharmacokinetic and Safety Study of a 90 Day Intravaginal Ring Containing Tenofovir

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Adaptive COVID-19 Treatment Trial 3 (ACTT-3)

COVID-19

United States, Japan, Mexico, Singapore, Korea, Republic of
National Institute of Allergy and Infectious Diseases...

Completed

Adaptive COVID-19 Treatment Trial (ACTT)

COVID-19

United States, Denmark, Japan, Mexico, Spain, Korea, Republic of, Germany, Greece, Singapore, United Kingdom
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Pharmacokinetics of VRC07-523LS in the Sera and Mucosae of Healthy, HIV-Uninfected Adult Participants (VRC07-523LS)

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Infectivity, Safety, and Immunogenicity of a Single Dose of a Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccine (D46/NS2/N/ΔM2-2-HindIII) in RSV-Seronegative Infants 6 to 24 Months of Age

Respiratory Syncytial Virus Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating HIV-1 Neutralization Antibody Breadth in Response to HIV gp120 Protein Vaccine in HIV-uninfected Adults With Quiescent Systemic Lupus Erythematosus

HIV Infections | Systemic Lupus Erythematosus

United States
National Institute of Allergy and Infectious Diseases...

Completed

Safety and Immunogenicity of Intranasal BPZE1 Vaccination in Healthy Adults

Pertussis | Pertussis Immunisation

United States
National Institute of Allergy and Infectious Diseases...

Completed

Experimental Human Infection With Neisseria Gonorrhoeae (LptA Trial)

Gonococcal Infection

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Pharmacokinetics of High-Dose Rifapentine When Given as a Single Dose or in Divided Doses to Healthy Adults

Tuberculosis

United States
National Institute of Allergy and Infectious Diseases...

Completed

Safety and Pharmacokinetics of Raltegravir in HIV-1-Exposed Newborn Infants at Risk of Acquiring HIV-1 Infection

HIV Infections

United States, Thailand, Puerto Rico, Brazil, South Africa
National Institute of Allergy and Infectious Diseases...

Completed

A Study of Trimetrexate in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Not Previously Treated for PCP

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Phase I Safety and Immunogenicity Trial of Live Recombinant Canarypox ALVAC-HIV (vCP205) in HIV-1 Uninfected Adult Volunteers

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides

HIV Infections | Pneumonia, Pneumocystis Carinii

United States, Tanzania
National Institute of Allergy and Infectious Diseases...

Completed

A Phase II, Double-Blind Trial of Recombinant Human Nerve Growth Factor for Treatment of HIV-Associated Sensory Neuropathy

HIV Infections | Peripheral Nervous System Disease

United States
National Institute of Allergy and Infectious Diseases...

Completed

The Safety and Effectiveness of Injections of Human Recombinant Interferon-gamma in Patients With AIDS Who Have Taken Zidovudine

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Phase I, Multicenter, Randomized, Double-Blind, Placebo-Controlled HIV-1 Vaccine Trial to Evaluate the Safety and Immunogenicity of rgp120/HIV-1MN (Genentech) in Combination With QS21 Adjuvant and/or Alum in Healthy Adults.

HIV Infections

United States

Clinical Trials Sponsored by National Institute of Diseases of the Chest and Hospital

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