- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03008122
Phase I, Randomized, Double-blinded, Placebo-Controlled Dose De-escalation Study to Evaluate Safety and Immunogenicity of Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) in Adults in a Flavivirus Endemic Area
Phase I, Randomized, Double-blinded, Placebo-Controlled Dose De-escalation Study to Evaluate the Safety and Immunogenicity of Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) Administered by the Intramuscular Route in Adult Subjects Who Reside in a Flavivirus Endemic Area
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Phase 1
Contacts and Locations
Study Locations
-
-
-
Ponce, Puerto Rico, 00716
- Ponce School of Medicine CAIMED Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Must be a male or non-pregnant, non-breastfeeding female between the age of 21 and 49 years, inclusive at the time of screening and enrollment.
- Must be willing and able to read, sign and date the informed consent document before study related procedures are performed.
- Must be willing and able to comply with study requirements and available for follow-up visits for the entire study.
- Must have a means to be contacted by telephone.
- Must have a body mass index (BMI) > /= 18.1 and < 35.0 kg/m2.
Must have acceptable* screening laboratory findings within 28 days before enrollment.
Acceptable clinical laboratory parameters include:
- Hemoglobin: women: > /= 11.5 g/dL; men > /= 13.5 g/dL
- Hemotocrit: women: > /= 34.5%; men > /= 40.5%
- White blood cell count: > /= 3.500 cells/mm3 but < /= 10,800 cells/mm3
- Platelets: > /= 150,000 but < /= 450,000 per mm3
- Urine dipstick (clean urine sample): protein < 1+, glucose negative
- Serum creatinine < /= 1 x institutional upper limit of normal (ULN)
- Blood urea nitrogen (BUN) < 25
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 1.25 x institutional ULN
- Total bilirubin < 1.25 x institutional ULN
- Note: If laboratory screening tests are out of acceptable range, repeat of screening tests is permitted once, provided there is an alternative explanation for the out of range value.
Must be in good health based on the investigator's clinical judgment when considering findings from past medical history, medication use, vital signs, and an abbreviated physical examination.
Note 1: Good health is defined by the absence of any medical condition described in the exclusion criteria in a subject with a normal abbreviated physical exam and vital signs. If the subject has a preexisting condition not listed in exclusion criteria, it cannot meet any of the following criteria: 1) first diagnosed in last 3 months; 2) worsening in terms of clinical outcome in last 6 months; or 3) involves need for medication that may pose a risk to subject's safety or impede assessment of adverse events or immunogenicity if they participate in study.
Note 2: An abbreviated physical exam differs from a complete exam in that it does not include a genitourinary and rectal exam.
Note 3: Vital signs must be normal by protocol toxicity grading scale or determined to be normal-variant by investigator. In the event of an abnormal heart rate or blood pressure due to physiological variation or activity, the subject may rest for 10 minutes in a quiet room, and then blood pressure and/or heart rate may be re-measured. Repeated vital signs may be used to determine eligibility.
Women of childbearing potential* must have a negative serum pregnancy test at screening and a negative urine pregnancy test immediately prior to each vaccination.
Note: All female subjects are considered of childbearing potential unless postmenopausal or surgically sterilized and > /= 3 months have passed since sterilization procedure. Postmenopausal is defined as amenorrhea for > /= 12 months without an alternative medical cause. Permanent female sterilization procedures include tubal ligation, bilateral salpingectomy, hysterectomy, bilateral oophorectomy, or successful Essure placement.
Women of childbearing potential must use an acceptable method of contraception* from one month (30 days) prior to the first vaccination until the end of the study.
*Acceptable methods of contraception include the following:
- Use highly effective contraceptive methods, defined by < 1% failure rate per year independent of user adherence, including long-acting reversible contraception (LARC): progestin-releasing subdermal implants and intrauterine devices (IUD), OR
- Use effective contraceptive methods, defined by 5-9% failure rate with typical use and < 1% failure rate with consistent and correct use, including: prescription oral contraceptives, contraceptive injections, combined pill, progestin-only pill, hormone-releasing transdermal patch or vaginal ring, and depot medroxyprogesterone acetate injection (Depo-Provera), OR
- Male sex partners must have had a vasectomy > /= 3 months prior to first vaccination, OR
- Practice abstinence defined as refraining from heterosexual intercourse from 30 days before first vaccination until the end of the study.
- Female subjects must agree to not donate eggs (ova, oocytes) from the start of screening period until the end of the study.
- Subjects must provide concurrent consent at the time of enrollment and 1st vaccination to future use of stored blood samples to measure immunity to ZIKV.
Exclusion Criteria:
- Has plans to become pregnant during the course of the study, or is currently pregnant or breastfeeding.
- Plans to receive a licensed flavivirus vaccine or participate in another flavivirus vaccine trial during the study.
- Has positive serology for HIV 1/2, Hepatitis C virus, or Hepatitis B surface antigen.
- Has known or suspected congenital or acquired immunodeficiency, or recent history or current use of immunosuppressive therapy* *Anti-cancer chemotherapy or radiation therapy within the preceding 6 months, or long-term (at least 2 weeks within the previous 3 months) systemic corticosteroids therapy (at a dose of at least 0.5 mg/kg/day). Intranasal or topical prednisone (or equivalent) is allowed.
- Had organ and/or stem cell transplantation whether or not on chronic immunosuppressive therapy.
Has history of malignancy other than squamous cell or basal cell skin cancer, unless there has been surgical excision that is considered to have achieved cure*.
*Subjects with a history of skin cancer must not be vaccinated at the previous tumor site.
Has history of chronic or acute severe neurologic condition*.
*Including history of Guillain-Barre syndrome, seizure disorder or epilepsy, Bell's palsy, meningitis, or disease with any focal neurologic deficits.
Has diabetes mellitus type 1 or type 2, including cases controlled with diet alone.
*Note: history of isolated gestational diabetes is not an exclusion criterion.
- Has history of thyroidectomy, or thyroid disease requiring medication during the last 12 months.
- Has major psychiatric illness during last 12 months that in the investigator's opinion would preclude participation.
Has history of other chronic disease or condition*.
*Includes the conditions and diagnoses defined as AESI in section 9, as well as autoimmune disease, hypercholesterolemia, chronic hepatitis or cirrhosis, chronic pulmonary disease, chronic renal disease, and chronic cardiac disease including hypertension even if medically controlled
- Vital signs must be normal by protocol toxicity grading scale or determined to be normal-variant by investigator. In the event of an abnormal heart rate or blood pressure due to physiological variation or activity, the subject may rest for 10 minutes in a quiet room, and then blood pressure and/or heart rate may be re-measured. Repeated vital signs may be used to determine eligibility.
- Has current or past history of substance abuse that in the investigator's opinion would preclude participation.
- Has tattoos, scars, or other marks on both deltoid areas that would, in the opinion of the investigator, interfere with assessment of the vaccination site.
- Has a history of chronic urticaria (recurrent hives).
Has known allergy or history of anaphylaxis or other serious reaction to a vaccine or vaccine component*.
*Including aluminum hydroxide (alum) or aminoglycosides (e.g., neomycin and streptomycin).
- Had major surgery (per the investigator's judgment) in the month prior to screening or plans to have major surgery during the study.
- Received blood products or immunoglobulin in the 3 months prior to screening or planned use during the course of the study.
- Donated a unit of blood within 8 weeks before Day 1 or plans to donate blood during the course of the study.
- Received live attenuated vaccine from 30 days before Day 1 or plans to receive a live attenuated vaccine from Day 1 until 30 days after the last vaccination.
- Received killed or inactivated vaccine from 14 days before Day 1 or plans to receive a killed or inactivated vaccine from Day 1 until 14 days after the last vaccination.
- Received experimental therapeutic agents within 3 months prior to the first study vaccination or plans to receive any experimental therapeutic agents during the course of the study.
Is currently participating or plans to participate in another clinical study involving an investigational product, blood drawing, or an invasive procedure listed below.
*An invasive procedure requiring administration of anesthetics or intravenous dyes or removal of tissue would be excluded. This includes endoscopy, bronchoscopy, or administration of IV contrast.
Has an acute illness or temperature > /= 38.0ºC on Day 1 or Day 29* or within 2 days prior to vaccination.
*Subjects with fever or an acute illness on the day of vaccination or in the 2 days prior to vaccination may be re-assessed and enrolled if healthy or only minor residual symptoms remain within 2 days of Day 1 or Day 29.
Is a study site employee* or staff paid entirely or partially by the OCRR contract or subcontract for the trial, or staff who are supervised by the PI or Sub-Investigators.
*Including the Principal Investigator, sub-Investigators listed in Form FDA 1572 or Investigator of Record Form
- In the investigator's opinion, the subject cannot communicate reliably, is unlikely to adhere to the study requirements, or has a condition that would limit their ability to complete the study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Group 1
5 mcg ZPIV administered IM in a homologous prime-boost regimen on Day 1 and Day 29 , n=45 (2 sentinels, 43 non-sentinels) or placebo, n=5
|
Placebo
Zika Virus Purified Inactivated Vaccine with aluminum hydroxide adjuvant.
|
Experimental: Group 2
2.5 mcg ZPIV administered IM in a homologous prime-boost regimen on Day 1 and Day 29, n=35 or placebo, n=5
|
Placebo
Zika Virus Purified Inactivated Vaccine with aluminum hydroxide adjuvant.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Frequency and Severity of Solicited Local Events Post Dose 1 by Treatment Group for All Participants
Time Frame: Day 1 through Day 8
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Local Events Post Dose 2 by Treatment Group for All Participants
Time Frame: Day 29 through Day 36
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Local Events Post Dose 1 by Treatment Group for Baseline ZIKV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Local Events Post Dose 2 by Treatment Group for Baseline ZIKV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Local Events Post Dose 1 by Treatment Group for Baseline ZIKV Seronegative Participants
Time Frame: Day 1 through Day 8
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Local Events Post Dose 2 by Treatment Group for Baseline ZIKV Seronegative Participants
Time Frame: Day 29 through Day 36
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Local Events Post Dose 1 by Treatment Group for Baseline ZIKV Seropositive and DENV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Local Events Post Dose 2 by Treatment Group for Baseline ZIKV Seropositive and DENV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Local Events Post Dose 1 by Treatment Group for Baseline ZIKV Seropositive and DENV Seronegative Participants
Time Frame: Day 1 through Day 8
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Local Events Post Dose 2 by Treatment Group for Baseline ZIKV Seropositive and DENV Seronegative Participants
Time Frame: Day 29 though Day 36
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 though Day 36
|
Frequency and Severity of Solicited Local Events Post Dose 1 by Treatment Group for Baseline ZIKV Seronegative and DENV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Local Events Post Dose 2 by Treatment Group for Baseline ZIKV Seronegative and DENV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Local Events Post Dose 1 by Treatment Group for Baseline ZIKV Seronegative and DENV Seronegative Participants
Time Frame: Day 1 through Day 8
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Local Events Post Dose 2 by Treatment Group for Baseline ZIKV Seronegative and DENV Seronegative Participants
Time Frame: Day 29 through Day 36
|
The following injection site reactogenicity events were measured: pain, tenderness, pruritus, ecchymosis, erythema, and induration.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Systemic Events Post Dose 1 by Treatment Group for All Participants
Time Frame: Day 1 through Day 8
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Systemic Events Post Dose 2 by Treatment Group for All Participants
Time Frame: Day 29 through Day 36
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Systemic Events Post Dose 1 by Treatment Group for Baseline ZIKV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Systemic Events Post Dose 2 by Treatment Group for Baseline ZIKV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Systemic Events Post Dose 1 by Treatment Group for Baseline ZIKV Seronegative Participants
Time Frame: Day 1 through Day 8
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Systemic Events Post Dose 2 by Treatment Group for Baseline ZIKV Seronegative Participants
Time Frame: Day 29 through Day 36
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Systemic Events Post Dose 1 by Treatment Group for Baseline ZIKV Seropositive and DENV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Systemic Events Post Dose 2 by Treatment Group for Baseline ZIKV Seropositive and DENV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Systemic Events Post Dose 1 by Treatment Group for Baseline ZIKV Seropositive and DENV Seronegative Participants
Time Frame: Day 1 through Day 8
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Systemic Events Post Dose 2 by Treatment Group for Baseline ZIKV Seropositive and DENV Seronegative Participants
Time Frame: Day 29 through Day 36
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Systemic Events Post Dose 1 by Treatment Group for Baseline ZIKV Seronegative and DENV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Systemic Events Post Dose 2 by Treatment Group for Baseline ZIKV Seronegative and DENV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Solicited Systemic Events Post Dose 1 by Treatment Group for Baseline ZIKV Seronegative and DENV Seronegative Participants
Time Frame: Day 1 through Day 8
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 1 through Day 8
|
Frequency and Severity of Solicited Systemic Events Post Dose 2 by Treatment Group for Baseline ZIKV Seronegative and DENV Seronegative Participants
Time Frame: Day 29 through Day 36
|
The following systemic solicited events were measured: feverishness, fatigue, malaise, myalgia, arthralgia, headache, nausea, vomiting, diarrhea, abdominal pain, rash, and fever.
Participants who reported not having a symptom are listed as "None", while participants who did not complete their Memory Aid or could not remember whether they had a symptom are listed as "Not Reported".
Severity is the maximum severity reported over all solicited symptoms post dosing for each participant.
|
Day 29 through Day 36
|
Frequency and Severity of Unsolicited Adverse Events by Treatment Group for All Participants
Time Frame: Day 1 through Day 57
|
Adverse events (AEs) are defined as any untoward medical occurrence regardless of its causal relationship to study treatment.
Number of participants with an AE are summarized by MedDRA System Organ Class (SOC).
If a condition was present at screening, it was not considered an AE unless the severity worsened.
|
Day 1 through Day 57
|
Frequency and Severity of Unsolicited Adverse Events by Treatment Group for Baseline ZIKV Seropositive Participants
Time Frame: Day 1 through Day 57
|
Adverse events (AEs) are defined as any untoward medical occurrence regardless of its causal relationship to study treatment.
Number of participants with an AE are summarized by MedDRA System Organ Class (SOC).
If a condition was present at screening, it was not considered an AE unless the severity worsened.
|
Day 1 through Day 57
|
Frequency and Severity of Unsolicited Adverse Events by Treatment Group for Baseline ZIKV Seronegative Participants
Time Frame: Day 1 through Day 57
|
Adverse events (AEs) are defined as any untoward medical occurrence regardless of its causal relationship to study treatment.
Number of participants with an AE are summarized by MedDRA System Organ Class (SOC).
If a condition was present at screening, it was not considered an AE unless the severity worsened.
|
Day 1 through Day 57
|
Frequency and Severity of Unsolicited Adverse Events by Treatment Group for Baseline ZIKV Seropositive and DENV Seropositive Participants
Time Frame: Day 1 through Day 57
|
Adverse events (AEs) are defined as any untoward medical occurrence regardless of its causal relationship to study treatment.
Number of participants with an AE are summarized by MedDRA System Organ Class (SOC).
If a condition was present at screening, it was not considered an AE unless the severity worsened.
|
Day 1 through Day 57
|
Frequency and Severity of Unsolicited Adverse Events by Treatment Group for Baseline ZIKV Seropositive and DENV Seronegative Participants
Time Frame: Day 1 through Day 57
|
Adverse events (AEs) are defined as any untoward medical occurrence regardless of its causal relationship to study treatment.
Number of participants with an AE are summarized by MedDRA System Organ Class (SOC).
Each participant was counted once per SOC.
If a condition was present at screening, it was not considered an AE unless the severity worsened.
|
Day 1 through Day 57
|
Frequency and Severity of Unsolicited Adverse Events by Treatment Group for Baseline ZIKV Seronegative and DENV Seropositive Participants
Time Frame: Day 1 through Day 57
|
Adverse events (AEs) are defined as any untoward medical occurrence regardless of its causal relationship to study treatment.
Number of participants with an AE are summarized by MedDRA System Organ Class (SOC).
If a condition was present at screening, it was not considered an AE unless the severity worsened.
|
Day 1 through Day 57
|
Frequency and Severity of Unsolicited Adverse Events by Treatment Group for Baseline ZIKV Seronegative and DENV Seronegative Participants
Time Frame: Day 1 through Day 57
|
Adverse events (AEs) are defined as any untoward medical occurrence regardless of its causal relationship to study treatment.
Number of participants with an AE are summarized by MedDRA System Organ Class (SOC).
If a condition was present at screening, it was not considered an AE unless the severity worsened.
|
Day 1 through Day 57
|
Frequency and Type of Serious Adverse Events (SAE) Considered Related to Study Vaccine for All Participants
Time Frame: Day 1 through Day 750
|
SAEs included any untoward medical occurrence that resulted in death; was life threatening; was a persistent/significant disability/incapacity; required inpatient hospitalization or prolongation or a congenital anomaly/birth defect.
|
Day 1 through Day 750
|
Duration of Serious Adverse Events (SAE) Considered Related to Study Vaccine for All Participants
Time Frame: Day 1 through Day 750
|
SAEs included any untoward medical occurrence that resulted in death; was life threatening; was a persistent/significant disability/incapacity; required inpatient hospitalization or prolongation or a congenital anomaly/birth defect.
|
Day 1 through Day 750
|
Frequency and Type of Adverse Events of Special Interest (AESI) Considered Related to Study Vaccine for All Participants
Time Frame: Day 1 through Day 750
|
For this study Neurologic and Neuroinflammatory Disorders after the first vaccination were considered as Adverse Events of Special Interest (AESI).
|
Day 1 through Day 750
|
Duration of Adverse Events of Special Interest (AESI) Considered Related to Study Vaccine for All Participants
Time Frame: Day 1 through Day 750
|
For this study Neurologic and Neuroinflammatory Disorders after the first vaccination were considered as Adverse Events of Special Interest (AESI).
|
Day 1 through Day 750
|
Frequency of New Onset Chronic Medical Conditions for All Participants
Time Frame: Day 1 through Day 750
|
New onset chronic medical conditions (NOCMCs) were any new medical conditions reported from the first administration of study vaccine until the end of the study.
|
Day 1 through Day 750
|
Comparison of Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for All Participants
Time Frame: Day 1 through Day 8
|
The number of participants experiencing each adverse event are listed.
|
Day 1 through Day 8
|
Comparison of the Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for All Participants
Time Frame: Day 29 through Day 36
|
The number of participants experiencing each adverse event are listed.
|
Day 29 through Day 36
|
Comparison of the Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for Baseline ZIKV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The number of participants experiencing each adverse event are listed.
|
Day 1 through Day 8
|
Comparison of the Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for Baseline ZIKV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The number of participants experiencing each adverse event are listed.
|
Day 29 through Day 36
|
Comparison of the Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for Baseline ZIKV Seronegative Participants
Time Frame: Day 1 through Day 8
|
The number of participants experiencing each adverse event are listed.
|
Day 1 through Day 8
|
Comparison of the Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for Baseline ZIKV Seronegative Participants
Time Frame: Day 29 through Day 36
|
The number of participants experiencing each adverse event are listed.
|
Day 29 through Day 36
|
Comparison of the Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for Baseline ZIKV Seropositive and DENV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The number of participants experiencing each adverse event are listed.
|
Day 1 through Day 8
|
Comparison of the Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for Baseline ZIKV Seropositive and DENV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The number of participants experiencing each adverse event are listed.
|
Day 29 through Day 36
|
Comparison of the Frequency, Type, and Duration of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for Baseline ZIKV Seropositive and DENV Seronegative Participants
Time Frame: Day 1 through Day 8
|
The number of participants experiencing each adverse event and the median duration of adverse events are listed.
|
Day 1 through Day 8
|
Comparison of the Frequency, Type, and Duration of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for Baseline ZIKV Seropositive and DENV Seronegative Participants
Time Frame: Day 29 through Day 36
|
The number of participants experiencing each adverse event and the median duration of adverse events are listed.
|
Day 29 through Day 36
|
Comparison of the Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for Baseline ZIKV Seronegative and DENV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The number of participants experiencing each adverse event are listed.
|
Day 1 through Day 8
|
Comparison of the Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for Baseline ZIKV Seronegative and DENV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The number of participants experiencing each adverse event will be listed
|
Day 29 through Day 36
|
Comparison of the Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for Baseline ZIKV Seronegative and DENV Seronegative Participants
Time Frame: Day 1 through Day 8
|
The number of participants experiencing each adverse event are listed.
|
Day 1 through Day 8
|
Comparison of the Frequency and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for Baseline ZIKV Seronegative and DENV Seronegative Participants
Time Frame: Day 29 through Day 36
|
The number of participants experiencing each adverse event are listed.
|
Day 29 through Day 36
|
Comparison of the Duration and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for All Participants
Time Frame: Day 1 through Day 8
|
The median duration of adverse events are listed.
|
Day 1 through Day 8
|
Comparison of the Duration and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for All Participants
Time Frame: Day 29 through Day 36
|
The median duration of adverse events are listed.
|
Day 29 through Day 36
|
Comparison of the Duration and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for Baseline ZIKV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The median duration of adverse events are listed.
|
Day 1 through Day 8
|
Comparison of the Duration and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for Baseline ZIKV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The median duration of adverse events are listed.
|
Day 29 through Day 36
|
Comparison of the Duration and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for Baseline ZIKV Seronegative Participants
Time Frame: Day 1 through Day 8
|
The median duration of adverse events are listed.
|
Day 1 through Day 8
|
Comparison of the Duration and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for Baseline ZIKV Seronegative Participants
Time Frame: Day 29 through Day 36
|
The median duration of adverse events are listed.
|
Day 29 through Day 36
|
Comparison of the Duration and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for Baseline ZIKV Seropositive and DENV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The median duration of adverse events are listed.
|
Day 1 through Day 8
|
Comparison of the Duration and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for Baseline ZIKV Seropositive and DENV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The median duration of adverse events are listed.
|
Day 29 through Day 36
|
Comparison of the Duration and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for Baseline ZIKV Seronegative and DENV Seropositive Participants
Time Frame: Day 1 through Day 8
|
The median duration of adverse events are listed.
|
Day 1 through Day 8
|
Comparison of the Duration and Type Duration of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for Baseline ZIKV Seronegative and DENV Seropositive Participants
Time Frame: Day 29 through Day 36
|
The median duration of adverse events are listed.
|
Day 29 through Day 36
|
Comparison of the Duration and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 1 for Baseline ZIKV Seronegative and DENV Seronegative Participants
Time Frame: Day 1 through Day 8
|
The median duration of adverse events are listed.
|
Day 1 through Day 8
|
Comparison of the Duration and Type of Vaccine-related Grade 3 Local, Systemic, or Laboratory AE, and Grade 2 or Greater Local or Systemic Reactogenicity Post Dose 2 for Baseline ZIKV Seronegative and DENV Seronegative Participants
Time Frame: Day 29 through Day 36
|
The median duration of adverse events are listed.
|
Day 29 through Day 36
|
Comparison of Study Withdrawals and Discontinuation of Study Vaccination Due to Any Reason for All Participants
Time Frame: Day 1 through Day 750
|
Comparisons of the number of participants who withdrew early and who discontinued treatment are presented.
|
Day 1 through Day 750
|
Comparison of Study Withdrawals and Discontinuation of Study Vaccination Due to Any Reason for Baseline ZIKV Seropositive Participants
Time Frame: Day 1 through Day 750
|
Comparisons of the number of participants who withdrew early and who discontinued treatment are presented.
|
Day 1 through Day 750
|
Comparison of Study Withdrawals and Discontinuation of Study Vaccination Due to Any Reason for Baseline ZIKV Seronegative Participants
Time Frame: Day 1 through Day 750
|
Comparisons of the number of participants who withdrew early and who discontinued treatment are presented.
|
Day 1 through Day 750
|
Comparison of Study Withdrawals and Discontinuation of Study Vaccination Due to Any Reason for Baseline ZIKV Seropositive and DENV Seropositive Participants
Time Frame: Day 1 through Day 750
|
Comparisons of the number of participants who withdrew early and who discontinued treatment are presented.
|
Day 1 through Day 750
|
Comparison of Study Withdrawals and Discontinuation of Study Vaccination Due to Any Reason for Baseline ZIKV Seropositive and DENV Seronegative Participants
Time Frame: Day 1 through Day 750
|
Comparisons of the number of participants who withdrew early and who discontinued treatment are presented.
|
Day 1 through Day 750
|
Comparison of Study Withdrawals and Discontinuation of Study Vaccination Due to Any Reason for Baseline ZIKV Seronegative and DENV Seropositive Participants
Time Frame: Day 1 through Day 750
|
Comparisons of the number of participants who withdrew early and who discontinued treatment are presented.
|
Day 1 through Day 750
|
Comparison of Study Withdrawals and Discontinuation of Study Vaccination Due to Any Reason for Baseline ZIKV Seronegative and DENV Seronegative Participants
Time Frame: Day 1 through Day 750
|
Comparisons of the number of participants who withdrew early and who discontinued treatment are presented.
|
Day 1 through Day 750
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Frequency of seroconversion to ZIKV measured by neutralization assay in comparison with baseline sample
Time Frame: Time Frame: Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Time Frame: Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Frequency of seroconversion to ZIKV measured by ZIKV ELISA in comparison with baseline sample
Time Frame: Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Peak GMT as measured by neutralization assay
Time Frame: Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Peak GMT as measured by ZIKV ELISA
Time Frame: Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Per Visit GMT as measured by neutralization assay
Time Frame: Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Per Visit GMT as measured by ZIKV ELISA
Time Frame: Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Days 1, 15, 29, 43, 57, 210, 388, 569, 750
|
Proportion of subjects with at least a 4-fold rise in ZIKV GMT as measured by ZIKV ELISA and neutralization assay compared with baseline overall
Time Frame: Days 29 to 57
|
Days 29 to 57
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 16-0034
- HHSN272201300021I
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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