Search clinical trials for: Dose escalation clinical study

Total 165787 results

National Institute of Allergy and Infectious Diseases...

Recruiting

A Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral Reservoirs in People Living With HIV and on Suppressive Antiretroviral Therapy

HIV-1

United States
University of California, San Diego
University of Minnesota; Rady Children's Hospital, San Diego; Middlemore Hospital... and other collaborators

Recruiting

A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures (NEOLEV3)

Hypoxic-Ischemic Encephalopathy | Neonatal Encephalopathy | Neonatal Seizure | Seizure Newborn

United States, New Zealand
Aurigene Discovery Technologies Limited

Recruiting

First in Human, Dose Escalation, Dose Expansion Study of AUR105 (SURYA-1)

Hodgkin Lymphoma | Solid Tumor, Adult | Non-hodgkin Lymphoma

India
IlDong Pharmaceutical Co Ltd
Parexel; YUNOVIA CO.,LTD.

Recruiting

Safety, Tolerability, and Pharmacokinetics of ID119031166M With the Exploration of Pharmacodynamic Effects

Healthy Participants

United States
SynAct Pharma Aps
NBCD A/S

Recruiting

A Dose-range Study of the Safety and Efficacy of Treatment in Adult Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate (RESOLVE)

Rheumatoid Arthritis

Moldova, Republic of
National Institute of Allergy and Infectious Diseases...
NeoImmune Tech

Not yet recruiting

A Single-arm, Dose-escalation Trial of Long-acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia

Idiopathic CD4 Lymphopenia

United States
AIM Vaccine Co., Ltd.
Ningbo Rongan Biological Pharmaceutical Co. Ltd.; LiveRNA Therapeutics Inc.

Not yet recruiting

Clinical Study of SARS-CoV-2 Variant mRNA Vaccine in Healthy Participants

SARS-CoV-2
Melinta Therapeutics, LLC

Recruiting

Study to Evaluate the Safety and Tolerability of Single-Dose Intravenous (IV) Oritavancin

Acute Bacterial Skin and Skin Structure Infection

United States, Spain, Greece, Portugal, Bulgaria, Latvia, Romania, Lithuania, Poland
Hanmi Pharmaceutical Company Limited

Recruiting

Dose Escalation and Expansion Study of HM97662 in Advanced or Metastatic Solid Tumors

Advanced or Metastatic Solid Tumors

Korea, Republic of, Australia
ImmVira Pharma Co. Ltd

Recruiting

A Study of T3011 Administered Via Intravenously in Patients With Advanced Solid Tumors.

Lymphoma | Lung Cancer | Advanced Solid Tumor | Liver Cancer | Mesothelioma of Pleura

China
RayzeBio, Inc.

Recruiting

Study of RYZ101 in Combination With SoC in Subjects With SSTR+ ES-SCLC

SCLC,Extensive Stage

United States, Puerto Rico
University of Zurich

Recruiting

Dose Escalation for SBRT of Recurrent VT Ventricular Tachyarrhythmia - a Single Center, Phase II Clinical Trial (DEFT STAR)

Ventricular Tachycardia

Switzerland
AtoGen Co. Ltd
ATOGEN AUSTRALIA PTY LTD

Recruiting

Safety, Tolerability, and Acceptability Study of Intravaginal Administration of LABTHERA-001 Capsules in Healthy Women

Bacterial Infections | Vaginal Disease | Vaginitis | Infection, Bacterial | Bacterial Vaginosis

Australia
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Study of a Single Dose of Pretomanid Added to an Optimized Background Regimen in Children With Rifampicin-Resistant Tuberculosis

Tuberculosis | Rifampicin Resistant Tuberculosis

Brazil, India, South Africa, Tanzania, Thailand
Allarity Therapeutics
Amarex Clinical Research

Recruiting

Study to Determine the Maximum Tolerated Dose (MTD) of PARPi 2X-121 Monotherapy and the MTD of Dovitinib in Combination With 2X-121 in Patients With Advanced Solid Tumors

Advanced Solid Tumors

United States
Sinew Pharma Inc.

Recruiting

A Partial Randomized, Single-blind or Open-label, Dose-escalation With Multiple-dose Design Study to Evaluate the Pharmacokinetics of Acetaminophen and Its Toxic Metabolites With Panadol® and SafeTynadol® in Healthy Volunteers

Hepatitis | Pharmacology

Taiwan
Novo Nordisk A/S

Recruiting

A Research Study Looking at How a Single Dose of the Medicine Cagrilintide Behaves in Participants With Reduced Liver Function and in Healthy Participants With Normal Liver Function

Hepatic Impairment

Germany, Slovakia
International Vaccine Institute
Massachusetts General Hospital; EuBiologics Co.,Ltd

Recruiting

Dose Escalation Study to Evaluate the Safety and Immunogenicity of the Cholera Conjugate Vaccine in Healthy Adults

Cholera Vaccination Reaction

Korea, Republic of
Organon and Co
Iqvia Pty Ltd

Recruiting

A Study to Investigate Efficacy and Safety of OG-6219 BID in 3 Dose Levels Compared With Placebo in Participants Aged 18 to 49 With Moderate to Severe Endometriosis-related Pain (ELENA)

Endometriosis

Belgium, United States, Poland, Germany, France, Hungary, Czechia, Bulgaria, Italy, Latvia
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.

Not yet recruiting

IMM40H Phase I Dose Escalation and Expansion

Tumor
Acrivon Therapeutics
GOG Foundation

Recruiting

A Study of ACR-368 in Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma

Platinum-resistant Ovarian Cancer | Urothelial Carcinoma | Endometrial Adenocarcinoma

United States
BioNTech SE
Pfizer

Recruiting

A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children

COVID-19 | Severe Acute Respiratory Syndrome Coronavirus 2 | SARS-CoV-2 Virus

United States, South Africa, Brazil, Puerto Rico
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Recruiting

The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE)

Systemic Lupus Erythematosus

United States, Spain, China, Korea, Republic of, Argentina, Bulgaria, Chile, Greece, Japan, Mauritius, Mexico, Moldova, Republic of, Poland, South Africa, Australia, Colombia, Philippines, Serbia
Bayer

Recruiting

A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors

Advanced Solid Tumors

United States, Canada, Belgium, Singapore, China, Spain, United Kingdom
Selecxine

Recruiting

A Phase 1/2, Open-label, Multicenter, Dose Escalation and Expansion Study of SLC-3010 Monotherapy and in Combination

Advanced Solid Tumor

United States, Australia, Korea, Republic of
AstraZeneca

Recruiting

Zibotentan and Dapagliflozin Combination, EvAluated in Liver Cirrhosis (ZEAL Study) (ZEAL)

Liver Cirrhosis

Denmark, Spain, Germany, United States, France, Australia, China, Netherlands, Belgium, Switzerland, Austria, United Kingdom, Taiwan, Canada, Czechia
Novo Nordisk A/S

Recruiting

A Research Study to Look Into How Semaglutide, Together With a Lower Dose of Insulin Glargine, Compares to a Higher Dose of Insulin Glargine Alone in People With Type 2 Diabetes (SUSTAIN OPTIMIZE)

Obesity | Diabetes Mellitus, Type 2

United States, Spain, Portugal, Italy, Greece, Romania, Czechia, Slovakia, South Africa, Ukraine
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

A Phase Ib Study of HS-10352 Plus Fulvestrant in Patients With Advanced Breast Cancer

Breast Cancer

China
BioSight Ltd.

Recruiting

A Phase I/II Dose Escalation and Expansion Study of BST-236 Plus Venetoclax in Patients With Unfit Newly Diagnosed AML

AML, Adult

United States
Scarless Laboratories, Inc.

Recruiting

Dose Regimen Study of SLI-F06 in Healthy Volunteers

Scar | Wound Healing

United States
Pfizer
Thrombolysis In Myocardial Infarction (TIMI)

Recruiting

A Study of Ponsegromab in People With Heart Failure (GARDEN TIMI 74)

Heart Failure

United States, Canada, China, Australia, Spain, Japan, Czechia, Hungary, Germany, United Kingdom, Poland
Locus Biosciences
Parexel

Recruiting

A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial) (ELIMINATE)

Urinary Tract Infections

United States
GlaxoSmithKline
Bill and Melinda Gates Foundation; Wellcome Trust; Biomedical Advanced Research... and other collaborators

Recruiting

A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella and Typhoid Fever

Salmonella Infections

Belgium, Malawi
Zhenzhen Liu

Recruiting

Clinical Study of Camrelizumab Combined With TCb Versus TCb in Neoadjuvant Treatment of Triple-negative Breast Cancer

Breast Cancer | Triple Negative Breast Cancer | Camrelizumab

China
Boehringer Ingelheim

Recruiting

A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)

Solid Tumors

Spain, Japan, United Kingdom, United States
Intra-Cellular Therapies, Inc.
National Institute on Drug Abuse (NIDA)

Recruiting

A PET Study Following a Single Oral Dose of ITI-333 in Healthy Subjects

Healthy Volunteers

United States
AC Immune SA
Worldwide Clinical Trials

Recruiting

A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

Alzheimer's Disease | Prodromal Alzheimer's Disease | Amyloid Plaque | Beta-Amyloid | Alzheimer's Disease in Down Syndrome

United States, Spain, United Kingdom
Pacira Pharmaceuticals, Inc

Recruiting

Phase 1, Dose Escalation Study to Evaluate of Safety, Pharmacokinetics and Pharmacodynamics of Liposomal Bupivacaine 13.3 Administered Via a Single Intrathecal Injection to Healthy Volunteers

Healthy

United States
Esfam Biotech Pty Ltd

Not yet recruiting

A Dose Escalation Phase 1 Study Evaluating the Safety and Pharmacokinetics of an Inhaled COVID-19 Inhibitor Delcetravir in Healthy Subjects

COVID-19
AstraZeneca
Parexel

Recruiting

AZD7798 Safety, Tolerability, and Pharmacokinetics After a Single Ascending and Repeat Dose Administrations to Healthy Subjects, and Patients With Crohn's Disease

Healthy Subjects | Crohns Disease

United Kingdom
Erasmus Medical Center

Recruiting

Intraperitoneal Paclitaxel for Patients With Primary Malignant Peritoneal Mesothelioma (INTERACT MESO)

Peritoneal Malignant Mesothelioma

Netherlands
Sanofi

Recruiting

Dose Escalation and Expansion Study of SAR444200-based Regimen in Adult Participants With Advanced Solid Tumors

Neoplasm

United States, Canada, China, Korea, Republic of, Singapore
Phanes Therapeutics

Recruiting

Dose Escalation/Expansion Study of PT199 (an Anti-CD73 mAb) Administered Alone and in Combination With a PD-1 Inhibitor (the MORNINGSTAR Study)

Non Small Cell Lung Cancer | Pancreatic Ductal Adenocarcinoma

United States
Idorsia Pharmaceuticals Ltd.

Recruiting

Dose-finding Study Assessing the Efficacy, Safety, and Pharmacokinetics of Daridorexant in Subjects Aged 10 to < 18 Years With Insomnia Disorder

Insomnia

Spain, United States, Belgium, Italy, Germany, Bulgaria
Hoffmann-La Roche

Recruiting

A Study of Multiple Doses of RO7247669 in Participants With Previously Untreated Unresectable or Metastatic Melanoma

Melanoma

Brazil, Czechia, Spain, Turkey, New Zealand, Canada, Australia, Poland, Slovakia, Greece
AbbVie

Recruiting

Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD (ASCENT)

CNV | AMD | nAMD | Wet Age-related Macular Degeneration | wAMD | WetAMD

United States, Puerto Rico, Canada
Pharvaris Netherlands B.V.

Recruiting

Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema (RAPIDe-2)

Hereditary Angioedema | Hereditary Angioedema Type I | Hereditary Angioedema Type II | Hereditary Angioedema Types I and II | Hereditary Angioedema Attack | Hereditary Angioedema With C1 Esterase Inhibitor Deficiency | Hereditary Angioedema - Type 1 | Hereditary Angioedema - Type 2 | C1 Esterase Inhibitor... and other conditions

United States, Bulgaria, Czechia, Hungary, Spain, France, Germany, Poland, Canada, Israel
Eli Lilly and Company

Recruiting

A Single-Ascending and Repeated Dose Study of LY3849891 in Participants With Nonalcoholic Fatty Liver Disease

Non-Alcoholic Fatty Liver Disease

United States, Japan
Guy's and St Thomas' NHS Foundation Trust

Recruiting

InGReS: Intra-treatment Image Guided Adaptive Radiotherapy Dose-escalation Study (InGReS)

Head and Neck Cancer

United Kingdom
Emory University
National Cancer Institute (NCI)

Recruiting

Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer

Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Oropharyngeal HPV-Positive Squamous Cell Carcinoma

United States

Search clinical trials for: Dose escalation clinical study

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