Search clinical trials for: Phase 1 safety, tolerability and pharmacokinetics study

Total 480272 results

Tibotec Pharmaceuticals, Ireland

Completed

TMC125-C203: Phase II Randomized (Patients Are Assigned Different Treatments Based on Chance), Placebo Controlled Dose Escalating Trial of TMC125 in HIV-1 Infected Patients

HIV-1 | Anti-Retroviral Agents
Ningbo No. 1 Hospital

Completed

Nonalcoholic Fatty Liver Disease is Associated With Increased Atrial Fibrillation Risk in an Elderly Chinese Population

Atrial Fibrillation | Nonalcoholic Fatty Liver Disease | Cross-sectional Study

China
Sterna Biologicals GmbH & Co. KG

Completed

Efficacy, Pharmacokinetics, Tolerability, Safety of SB012 Intrarectally Applied in Active Ulcerative Colitis Patients (SECURE)

Colitis, Ulcerative

Germany
Sequella, Inc.
Quintiles, Inc.

Completed

Escalating Single-dose Safety, Tolerability, and Pharmacokinetics of SQ109 in Healthy Volunteers

Tuberculosis

United States
Pfizer

Completed

A Study to Determine the Effects of PF-04965842 on Midazolam PK in Healthy Volunteers

Phase 1

Belgium
Uro-1 Medical

Recruiting

Assessment of VMCore Biopsy Versus Standard of Care Biopsy

Prostate Cancer

United States
Alpha-1 Foundation

Recruiting

Alpha-1 Research Registry

Alpha 1-Antitrypsin Deficiency

United States
Mitsubishi Tanabe Pharma Corporation

Completed

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of MT-8554 in Healthy Subjects

Healthy

United Kingdom
Milton S. Hershey Medical Center
The Hollister Confidence Fund

Completed

Aevidum Curriculum/Club Evaluation

Mental Health Wellness 1

United States
Janssen Research & Development, LLC

Completed

A Study of JNJ-40346527 in Patients With Relapsed or Refractory Hodgkin Lymphoma

Relapsed or Refractory Hodgkin Lymphoma

France, Germany
Eli Lilly and Company

Not yet recruiting

A Study to Compare Tablets and Capsules of Orforglipron (LY3502970) in Healthy Participants Who Are Obese or Overweight

Healthy | Obesity | Overweight | Obese

United States
Saniona

Completed

A Study to Examine the Effect of Tesofensine and Metoprolol on the 24-hour Mean Heart Rate

Phase 1

Germany
Wakayama Medical University
Human Genome Center, Institute of Medical Science, University of Tokyo

Unknown

PhaseⅠ/Ⅱ Study of URLC10-177 and TTK-567 Peptide Vaccine Combined With CpG7909 in Patients With Esophageal Cancer

Esophageal Cancer

Japan
Harbour BioMed (Guangzhou) Co. Ltd.

Completed

A Phase I Study Evaluating the Safety, Tolerability, PK and PD in Healthy Chinese Volunteers

Healthy Chinese Volunteers

China
Dragonboat Biopharmaceutical Company Limited
Shanghai East Hospital

Unknown

A Preliminary Clinical Study on the Pharmacokinetics and Safety of CDP1 in Patients With Advanced CRC or HNSCC

Colorectal Cancer

China
TrueBinding, Inc.

Completed

Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of TB006 in Participants With Alzheimer's Disease

Alzheimer's Disease

United States
Northwest Portland Area Indian Health Board
mHealth Impact Lab

Completed

BRAVE Study: Designing and Evaluating Technologies to Promote Adolescent Mental Health (BRAVE)

Mental Health Wellness 1

United States
Columbia University
Alpha-1 Foundation

Terminated

COPD Exacerbation Blood and Urine Biomarkers Study

Chronic Obstructive Pulmonary Disease | Acute Exacerbation Copd | Alpha-1 Anti-trypsin Deficiency

United States
Jiulongpo No.1 People's Hospital

Unknown

NHFOV vs NIPPV vs nCPAP in Preterm Infants With Respiratory Distress Syndrome

Preterm Infant

China
LENZ Therapeutics, Inc
ORA, Inc.

Completed

Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia

Eye Diseases | Refractive Errors | Presbyopia

United States
Eli Lilly and Company

Recruiting

A Study to Investigate the Safety and Pharmacokinetics of Lebrikizumab in Healthy Chinese Participants

Healthy

China
Eli Lilly and Company

Completed

A Study to Compare Two Formulations of LY3209590 in Healthy Participants

Healthy

Singapore
Eli Lilly and Company

Active, not recruiting

A Study of LY3502970 in Chinese Participants With Obesity or Are Overweight With Weight-related Comorbidities

Obesity | Overweight

China
Celgene

Completed

Extension Study to Further Evaluate the Safety, Pharmacodynamics and Pharmacokinetics of Ozanimod and Active Metabolites

Healthy Volunteers

United States
Eli Lilly and Company

Recruiting

A Study of LY3876602 in Healthy Participants

Healthy

Netherlands
Merck Sharp & Dohme LLC

Active, not recruiting

Study of Doravirine/Islatravir (DOR/ISL 100 mg/0.75 mg) to Evaluate the Antiretroviral Activity, Safety, and Tolerability in Treatment-Naïve Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-020)

HIV-1 Infection

United States, Argentina, Canada, Chile, Colombia, France, Germany, Israel, Italy, Japan, South Africa, Spain, Taiwan
Eyenovia Inc.

Completed

Safety & Efficacy of Pilocarpine Eye Solutions for Temporary Improvement of Near Vision in Presbyopic Adults (VISION-1)

Presbyopia

United States
UCB Biopharma S.P.R.L.

Completed

A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil

Epilepsy

Bulgaria, Netherlands
Kitasato University
Yokohama City University Medical Center; St. Marianna University School of... and other collaborators

Unknown

Intensive Medical Treatment for Nephropathy Caused by Type 2 Diabetes With Hypertension

Hypertension | Type 2 Diabetes Mellitus

Japan
Uro-1 Medical

Not yet recruiting

Evaluation of a Soft Tissue Biopsy System for Trans-rectal and Trans-perineal Biopsy of the Prostate

Prostate Disease
Children's Hospital 1

Recruiting

Sutureless Closure for Primary Total Anomalous Pulmonary Venous Connection (TAPVC)

Total Anomalous Pulmonary Venous Connection | Pulmonary Venous Stenosis | Sutureless Closure

Vietnam
Alpha-1 Foundation

Completed

Prevalence of Alpha-1 Antitrypsin Deficiency in Chronic Obstructive Pulmonary Disease (COPD) (PFT)

Chronic Obstructive Pulmonary Disease | Alpha-1 Antitrypsin Deficiency

United States, Puerto Rico
SinoMab BioScience Ltd

Recruiting

A Phase 1 Study of Single and Multiple Intravenous Doses of SM17 in Healthy Subjects

1. Asthma

United States
Guohui Li

Recruiting

Multi-Centre, Prospective, Non-Interventional Study to Intensively Monitor the Safety of Sintilimab in Clinical Practice Among Chinese Patients

PD-1 | Immune Related Adverse Events

China
Cinnagen

Completed

A Study Of CinnoRA (Adalimumab-CinnaGen) And Adalimumab (Humira) In Healthy Subjects

Bioequivalence | Phase 1

Iran, Islamic Republic of
Eastern Mediterranean University

Not yet recruiting

The Effect of Health Education and Yoga on Menopause Symptoms and Quality of Life According to Pender's Model

Quality of Life | Health Education | Yoga | Menopause Symptoms

Cyprus
Eastern Mediterranean University

Not yet recruiting

Effect of Acupressure on Pain, Anxiety and Vital Signs in Patients With Coronary Angiography

Pain | Anxiety | Coronary Angiography | Vital Signs

Cyprus
BeiGene

Completed

A Two-Part Phase 1 Study to Investigate the Safety and Tolerability of Supratherapeutic Dose of Zanubrutinib and Effect of Zanubrutinib on Cardiac Repolarization in Healthy Subjects

Healthy Volunteers

United States
National Institute of Allergy and Infectious Diseases...

Completed

VRC 601: A Phase I, Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC HIVMAB060-00-AB (VRC01), With Broad HIV-1 Neutralizing Activity, Administered Intravenously or Subcutaneously to HIV-Infected...

HIV-1 Infection | HIV Antibodies | Neutralizing Antibody | Viral Load | Monoclonal Antibody

United States
Takeda

Terminated

A Study of TAK-994 in Adults With Narcolepsy

Narcolepsy Type 1 (NT 1)

United States, Italy, Finland, Canada, Hungary, Czechia, France, Japan, Korea, Republic of, Spain
Eli Lilly and Company

Completed

Multiple Dose Study of the Safety, Tolerability, Pharmacokinetics and Effect on Renal Potassium Clearance

Chronic Kidney Disease

Netherlands
Eli Lilly and Company

Recruiting

A Study of LY3885125 in Participants With Dyslipidemia or Non-Alcoholic Fatty Liver Disease (NAFLD)

Dyslipidemias | Non-Alcoholic Fatty Liver Disease

United States
Cairo University

Unknown

Clinical Evaluation of Pink Esthetic Score

Thin Gingiva
PurGenesis Technologies Inc.

Completed

A Study to Assess the Safety and Tolerability of PUR 0110 Rectal Enema in Normal Healthy Volunteers

Ulcerative Colitis

Germany
AstraZeneca

Completed

To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ascending Doses of Inhaled AZD7594

Pharmacokinetics | Safety | Pharmacodynamics of AZD7594

United Kingdom
Alio, Inc.

Recruiting

Alio WEAR Study: Long-term Wear of the Alio Platform

End Stage Kidney Disease

United States
UCB Biopharma SRL

Completed

A Study to Assess the Bioequivalence Between Brivaracetam Tablet and Dry Syrup in Healthy Male Japanese Study Participants

Healthy Study Participants

Japan
Astellas Pharma Europe B.V.

Completed

A Study to Assess the Safety, Tolerability and Effects of Single and Multiple Ascending Doses of ASP1707 in Healthy Male and Pre-menopausal Female Subjects, Including a Comparison of the Effects Under Fasted and Fed Conditions in Healthy Young Male Subjects

Pharmacokinetics of ASP1707 | Pharmacodynamics of ASP1707

France
Celgene

Completed

A Study to Evaluate Effects of CC-99677 on the Pharmacokinetics of an Oral Contraceptive in Healthy Female Participants

Healthy Volunteers

United States
Göteborg University

Completed

Fall Study in Gothenburg (FallsGOT) (FallsGOT)

Accidental Falls

Sweden

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