Search clinical trials for: Synthetic Lethality

Total 1325 results

National Institute of Allergy and Infectious Diseases...

Completed

A Phase I Multicenter, Randomized, Double-Blind Trial to Evaluate the Safety and Immunogenicity of Recombinant Vaccinia Virus Expressing the Envelope Glycoproteins of Human Immunodeficiency Virus

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
Biocine

Completed

A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of 100 mcg of Env 2-3 in MF59

HIV Infections | HIV Seronegativity

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Phase I Randomized Trial to Evaluate the Safety and Immunogenicity of Vaccinia-HIV Envelope Recombinant Vaccine (HIVAC-1e) in Combination With Soluble Recombinant Envelope Vaccine (VaxSyn)

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
Immuno-US

Completed

A Phase I Multicenter Clinical Trial to Evaluate the Safety and Immunogenicity of Immuno-AG Recombinant HIV gp160 in Asymptomatic HIV Seropositive Individuals

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Study of Megestrol Acetate Alone or in Combination With Testosterone Enanthate Drug in the Treatment of HIV-Associated Weight Loss

HIV Infections | HIV Wasting Syndrome

United States
National Institute of Allergy and Infectious Diseases...

Completed

Effect of an Intrauterine Contraceptive Device (IUD) in HIV Infected Women

HIV Infections

United States, Puerto Rico
National Institute of Allergy and Infectious Diseases...

Completed

Active Immunization of HIV-1 Infected, Pregnant Women With CD4 Lymphocyte Counts >= 400/mm3: A Phase I Study of Safety and Immunogenicity of MN rgp120/HIV-1 Vaccine (NOTE: Some Patients Receive Placebo)

HIV Infections | Pregnancy

United States
National Institute of Allergy and Infectious Diseases...

Withdrawn

Active Immunization of HIV-Infected Pregnant Women: A Phase I Study of Safety and Immunogenicity of a rgp120/HIV-1 Vaccine (NOTE: Some Patients Receive Placebo)

HIV Infections | Pregnancy | HIV Seronegativity
National Institute of Allergy and Infectious Diseases...

Completed

Anti-HIV Activity and Safety of 3 Different Doses of Mifepristone in HIV Infected People

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Randomized Phase I Safety and Immunogenicity Trial of Live Recombinant Canarypox ALVAC-HIV vCP205 Delivered by Alternate Mucosal Routes in HIV-1 Uninfected Adult Volunteers

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
Bristol-Myers Squibb; Immuno-US

Completed

A Phase I/II Double-Blind Controlled Trial to Determine the Safety and Immunogenicity of HIV-1 MN rgp160 Immuno AG Vaccine Therapy in HIV-Infected Individuals With Greater Than or Equal to 500/mm3 CD4+ T Cells and 200-400/mm3 CD4+ T Cells

HIV Infections

United States
Fundació Institut de Recerca de l'Hospital de la...
Bayer

Completed

A Study to Compare the Menstrual Bleeding Profile Among Jaydess® and Copper Intrauterine Device (IUD) Users. COLIBRI STUDY (Copper and Levonorgestrel IUD Barcelona Research Initiative). (COLIBRI)

Contraception

Spain
National Institute of Allergy and Infectious Diseases...

Completed

A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial to Evaluate the Safety and Immunogenicity of the Therion Recombinant Vaccinia-HIV-1 IIIB ENV/GAG/POL Vaccine (TCB-3B) and MN RGP 120/HIV-1 In Alum.

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Active Immunization of HIV-1 Infected, Pregnant Women With CD4 Lymphocyte Counts >= 400/mm3: A Phase I Study of Safety and Immunogenicity of VaxSyn Recombinant gp160 (NOTE: Some Patients Receive Placebo)

HIV Infections | Pregnancy | HIV Seronegativity

United States
National Institute of Allergy and Infectious Diseases...
Lederle-Praxis Biologicals

Completed

A Double-Blind Placebo-Controlled Trial of the Safety and Immunogenicity of a Seven Valent Pneumococcal Conjugate Vaccine in Presumed HIV-Infected Infants

HIV Infections | Pneumococcal Infections

United States, Puerto Rico
National Institute of Allergy and Infectious Diseases...

Completed

A Study to Evaluate the Safety and Effectiveness of HIV-1 LAI gp120 (an HIV Vaccine) Given With or Without HIV-1 MN rgp120 (Another HIV Vaccine) to HIV-Negative Volunteers

HIV Infections | HIV Seronegativity

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial to Evaluate the Safety and Immunogenicity of a Recombinant Vaccinia-HIV-1 IIIB Env/Gag/Pol Vaccine (TBC-3B)

HIV Infections

United States
Washington University School of Medicine
Bristol-Myers Squibb

Terminated

Neoantigen-based Personalized Vaccine Combined With Immune Checkpoint Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma

Glioblastoma

United States
National Institute of Allergy and Infectious Diseases...

Completed

Phase I Safety and Immunogenicity Trial of Vaccinia-HIV Envelope Recombinant Vaccine (HIVAC-1e) in Combination With Soluble Recombinant Envelope Vaccine (gp160; VaxSyn)

HIV Infections

United States
Synthetic Biologics Inc.
Spaulding Clinical Research LLC

Completed

Pharmacokinetics, Safety, and Tolerability of SYN-020

Enteritis Caused by Radiation (Disorder)

United States
National Institute of Allergy and Infectious Diseases...

Completed

Safety and Immune Response Study of High-Dose Canarypox ALVAC-HIV Vaccine in Healthy, HIV Uninfected Adults

HIV Infections | HIV Seronegativity

United States
University of Sao Paulo General Hospital

Completed

Abdominal Wall Reconstruction With PVDF Mesh in the Setting of Active Infection

Abdominal Wall Defect | Infection | Abdominal Wall Hernia | Abdominal Wall Fistula | Abdominal Wall Infection

Brazil
AbbVie

Completed

A Study With Upadacitinib (ABT-494) in Subjects From China and Selected Countries With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs)

Rheumatoid Arthritis (RA)

Brazil, China, Korea, Republic of
Gynuity Health Projects
Bharatpur Eye Hospital; KIST Medical College and Teaching Hospital; Center for... and other collaborators

Completed

Assessing Outpatient 'Day Procedure' for Second-trimester Medical Abortion at Two Public Sector Hospitals in Nepal

Abortion in Second Trimester

Nepal
Xiaojun Chen
Zhejiang Cancer Hospital; Fudan University; Shanghai 6th People's Hospital; Shanghai...

Completed

Megestrol Acetate Plus Metformin to Megestrol Acetate in Patients With Endometrial Atypical Hyperplasia or Early Stage Endometrial Adenocarcinoma

Endometrial Adenocarcinoma | Endometrial Atypical Hyperplasia

China
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer

Quality of Life | Anorexia | Head and Neck Cancer | Cachexia

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Oxandrolone Compared With Megestrol in Preventing Weight Loss in Patients Receiving Chemotherapy for Cancer

Unspecified Adult Solid Tumor, Protocol Specific | Weight Changes

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer

Anorexia | Lung Cancer | Cachexia

United States
Ankara Training and Research Hospital

Completed

Transobturator Urethral Sling Placement With an Autologous Rectus Facia

Surgery--Complications | Stress Urinary Incontinence
Gaziosmanpasa Research and Education Hospital

Completed

Can Intrauterine Levonorgestrel Releasing Device Be a Treatment Option for Postmenstrual Spotting in Isthmocele

Pelvic Pain | Isthmocele | Post-menstrual Spotting Bleeding

Turkey
Wyeth is now a wholly owned subsidiary of Pfizer

Withdrawn

Study Evaluating the Bioequivalence of Levonorgestrel/Ethinyl Estradiol Combinations in Cycling Women

Contraception
Chiesi Farmaceutici S.p.A.

Completed

A Double Blind, Randomized, Controlled Study to Evaluate CHF 5633 (Synthetic Surfactant) and Poractant Alfa in Neonates With Respiratory Distress Syndrome (RDS) (POC)

Respiratory Distress Syndrome, Newborn

United States
Yale University
National Center for Research Resources (NCRR)

Completed

Health Benefits of Vitamin D and Calcium in Women With PCOS (Polycystic Ovarian Syndrome)

Vitamin D Deficiency | Polycystic Ovarian Syndrome

United States
Women and Infants Hospital of Rhode Island

Active, not recruiting

Stopping Heavy Periods Project (SHiPP)

Abnormal Uterine Bleeding | Abnormal Uterine Bleeding, Ovulatory Dysfunction | Abnormal Uterine Bleeding, Endometrial Hemostatic Dysfunction

United States
Cancer Registry of Norway
University of Oslo; The Research Council of Norway; Haukeland University Hospital

Completed

The Digital Breast Tomosynthesis Trial in Bergen (TOBE)

Breast Neoplasms

Norway
La Jolla Pharmaceutical Company

Terminated

A Study With LJPC-401 for the Treatment of Myocardial Iron Overload in Patients With Transfusion-Dependent Beta Thalassemia

Beta-Thalassemia

Australia, Thailand, United States, Greece, Italy, Lebanon, Turkey, United Kingdom
Gynuity Health Projects

Terminated

Non-surgical Alternatives to Treatment of Failed Medical Abortion

Abortion Failure

United States
Gynuity Health Projects

Terminated

Pilot Study of an Ambulatory Medical Abortion Service at 13-18 Weeks of Gestation in Colombia

Second Trimester Abortion

Colombia
Birmingham Women's NHS Foundation Trust
University of Birmingham; Medicem International CR s.r.o.

Completed

An RCT of a Synthetic Osmotic Cervical Dilator for Induction of Labour in Comparison to Dinoprostone Vaginal insErt (SOLVE)

Induction of Labor Affected Fetus / Newborn

United Kingdom
AbbVie (prior sponsor, Abbott)

Completed

Safety and Efficacy of Elagolix in Pre-Menopausal Women With Heavy Uterine Bleeding and Uterine Fibroids

Uterine Fibroids | Heavy Uterine Bleeding
AbbVie

Completed

An Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids

Uterine Fibroids | Heavy Menstrual Bleeding

United States, Canada, Puerto Rico
AbbVie

Completed

Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women (Replicate Study)

Uterine Fibroids | Heavy Menstrual Bleeding

United States, Canada
Daniel Grossman
University of California, San Diego; University of California, Davis; University... and other collaborators

Completed

Medication Abortion Via Pharmacy Dispensing

Pregnancy Related | Abortion Early

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...

Completed

Stereotactic Body Radiation With Nelfinavir for Oligometastases

Oligometastases

United States
University of Colorado, Denver
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Home-based Delivery of the Contraceptive Implant in Postpartum Guatemalan Women

Postpartum

United States, Guatemala
Myovant Sciences GmbH

Completed

SPIRIT 2: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain

Endometriosis Related Pain

United States, Poland, Australia, Brazil, Chile, Czechia, Georgia, Italy, New Zealand, Romania, Sweden
Myovant Sciences GmbH

Completed

SPIRIT 1: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain

Endometriosis Related Pain

United States, Spain, Hungary, Argentina, Belgium, Bulgaria, Canada, Czechia, Finland, Poland, Portugal, South Africa, Ukraine
UCB Biopharma SRL

Terminated

A Study to Test the Interaction of Padsevonil With Oral Contraceptives in Healthy Female Participants

Healthy Female Participants

United Kingdom
Johns Hopkins University
National Cancer Institute (NCI); Lustgarten Foundation

Completed

Cancer of the Pancreas Screening Study (CAPS 3) (CAPS 3)

Pancreatic Neoplasm | Peutz-Jeghers Syndrome

United States
Massachusetts General Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes

Exercise-related Amenorrhea

United States

Search clinical trials for: Synthetic Lethality

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