Search clinical trials for: pharmacodynamics,

Total 2240 results

University Hospital, Toulouse

Recruiting

ASPirin in Immune thRombocytopenia Patients With Cardiovascular disEase (ASPIRE)

Purpura, Thrombocytopenic

France
GlaxoSmithKline

Active, not recruiting

Study of Subcutaneous (SC) Belimumab in Pediatric Participants With Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus

Mexico, Netherlands, United States, Germany, Spain, Argentina, Japan
UNC Lineberger Comprehensive Cancer Center
University of North Carolina, Chapel Hill

Completed

Tacrolimus in Allogeneic Hematopoietic Stem Cell Transplant (HCT)

Acute GVHD

United States
Collegium Medicum w Bydgoszczy

Completed

Effectiveness of Lower Maintenance Dose of Ticagrelor Early After Myocardial Infarction (ELECTRA) Pilot Study

Myocardial Infarction

Poland
Icahn School of Medicine at Mount Sinai
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Enrolling by invitation

Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD

ADHD | Attention Deficit Hyperactivity Disorder

United States
Orient Europharma Co., Ltd.

Completed

Pharmacokinetic and Pharmacodynamic Study of Glufast Tablets 10mg(Mitiglinide)

Type 2 Diabetes Mellitus | Liver Dysfunction

Taiwan
GlaxoSmithKline
Biomedical Advanced Research and Development Authority

Terminated

Effects of GSK2798745 on Alveolar Barrier Disruption in a Segmental Lipopolysaccharide (LPS) Challenge Model

Healthy Volunteers

Germany
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Effects Of Eplerenone On Serum Aldesterone And Plasma Renin Activity

Healthy Volunteers

United States
GlaxoSmithKline

Terminated

Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK3117391 in Subjects With Rheumatoid Arthritis

Arthritis, Rheumatoid

Poland, Romania
GlaxoSmithKline

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK3389404 in Chronic Hepatitis B (CHB) Subjects

Hepatitis B

Singapore, China, Hong Kong, Japan, Korea, Republic of, Philippines
Intas Pharmaceuticals, Ltd.
Lambda Therapeutic Research Ltd.

Completed

Comparative, Pharmacokinetic and Pharmacodynamic Study of Subcutaneous Injections of INTP5 of Intas Pharmaceuticals Ltd., India Against Neulasta of Amgen Inc., USA in Healthy, Adult Human Subjects.

Pharmacokinetic Bioequivalence Study in Human Healthy Volunteers

India
Intas Pharmaceuticals, Ltd.
Lambda Therapeutic Research Ltd.

Completed

Comparative Immunogenicity Study of Multiple Doses of Proposed Pegfilgrastim Biosimilar, INTP5 of Intas Pharmaceuticals Ltd., India Against Neulasta of Amgen Inc., USA in Healthy, Adult Human Subjects.

Healthy Volunteers | Immunogenicity

India
Genexine, Inc.

Completed

Clinical Trial of GX-I7 in Healthy Volunteers

Healthy

Korea, Republic of
Johns Hopkins Bloomberg School of Public Health
Johns Hopkins University; University of Pittsburgh; University of Minnesota; National... and other collaborators

Completed

Broccoli Sprout Intervention in Qidong, P.R. China

Environmental Carcinogenesis

China
GlaxoSmithKline

Completed

Repeat Doses Of A New Medication (GW642444) In Asthmatic Patients

Pulmonary Disease, Chronic Obstructive

Germany, Sweden, New Zealand, Russian Federation, United Kingdom
Eisai Inc.

Completed

Study to Assess the Safety, Tolerability, Pharmacokinetics of E2027 in Healthy Adult and Elderly Subjects, and the Pharmacodynamics in Healthy Adult Subjects

Healthy Participants

United States
Astellas Pharma Europe B.V.

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASP6294 Administered Intravenously or Subcutaneously in Healthy Young Male and Female Subjects

Healthy Subjects | Pharmacokinetics of ASP6294

United Kingdom
GlaxoSmithKline

Completed

Study to Assess GW642444 in Asthma Patients

Pulmonary Disease, Chronic Obstructive

Australia, New Zealand
Sutep Jaruratanasirikul
Prince of Songkla University

Completed

The Pharmacodynamics of Meropenem in Patient With Ventilator-associated Pneumonia

Ventilator-Associated Pneumonia

Thailand
Asan Medical Center
Seoul National University Hospital

Completed

Early Clinical Evaluation of the Pharmacokinetics and Mechanism Based Pharmacodynamics of Haloperidol Using Positron Emission Tomography in Healthy Volunteers

Healthy

Korea, Republic of
Azidus Brasil

Completed

Pharmacokinetics and Pharmacodynamics of the Interferon Beta-1a Produced by Laboratorio Quimico Farmaceutico Bergamo Compared to Interferon Beta-1a (Rebif - Merck Serono) in Healthy Subjects

Healthy

Brazil
Yale University
National Institute on Drug Abuse (NIDA); Merck Sharp & Dohme LLC

Completed

Buprenorphine/Raltegravir Pharmacokinetic Interaction Study

HIV Infections | HIV Infection

United States
Eisai Co., Ltd.

Completed

Pharmacodynamic and Pharmacokinetic Study of E3710 Following Oral Administration to Healthy, Male, Japanese Subjects

Gastroesophageal Reflux Disease

United States
Johnson & Johnson Pharmaceutical Research & Development...
Eisai Inc.

Completed

A Pharmacokinetic and Safety Study of Single and Multiple Doses of Rabreprazole in Pediatric Patients With Gastroesophageal Reflux Disease (GERD) 1 to 11 Years Old, Inclusive

GERD
Abbott

Completed

A Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of ABT-436 in Healthy Adults

Healthy

United States
Novartis

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of AEB071

Healthy

Switzerland
Uppsala University
Swedish Society for Medical Research; Swedish Parkinson's Disease Foundation

Completed

Pharmacokinetics of Levodopa/Carbidopa Infusion With and Without Oral Catechol-O-methyl Transferase (COMT) Inhibitors (DuoCOMT)

Parkinson Disease

Sweden
Bristol-Myers Squibb

Recruiting

Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) (AURORA-HFpEF)

Heart Failure

United States, Spain, Canada, Italy, Poland
ZYUS Life Sciences Inc.
Novotech (Australia) Pty Limited; ZYUS Life Sciences Australia Pty Ltd

Completed

Trichomylin® Safety, Tolerability & Pharmacokinetics in Healthy Adults and First in Human Osteoarthritis Pain Evaluation (HOPE)

Healthy | Osteoarthritis

Australia
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University College, London; University... and other collaborators

Active, not recruiting

PRACTECAL-PKPD Sub Study (PRACTECAL-PKPD)

Multi-drug Resistant Tuberculosis | Pulmonary Tuberculosis | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa
GlaxoSmithKline
Nucleus Network Ltd

Completed

Safety, Tolerability and Preliminary Pharmacokinetics (PK) and Pharmacodynamics (PD) of Single and Repeat Oral Doses of GSK3008356 in Healthy and Obese Subjects

Healthy Volunteers

Australia
Pfizer

Completed

Study In Healthy Subjects To Evaluate The Changes In The Protein sAPP-Alpha In Cerebrospinal Fluid Following A Single Oral Dose Of PF-04995274

Healthy

United States
National Cancer Institute (NCI)

Completed

Indenoisoquinoline LMP400 for Advanced Solid Tumors and Lymphomas

Lymphoma | Neoplasm

United States
Astellas Pharma Europe B.V.

Completed

A Phase 1 Study to Investigate the Mechanism of Action of Ipragliflozin

Type 2 Diabetes Mellitus

Germany
Seung-Jung Park
Roche Pharma AG; AstraZeneca; KBM pharm

Completed

Comparison of Low-Dose, Standard-Dose Ticagrelor and Clopidogrel for Inhibition of Platelet Reactivity in Patients With Acute Coronary Syndromes (OPTIMA)

Acute Coronary Syndrome

Korea, Republic of
Pfizer

Completed

A First In Human Study In Healthy People To Evaluate Safety, Toleration, Pharmacokinetics and Pharmacodynamics of Single Oral Doses Of PF-06372865

Healthy

Netherlands
Wockhardt

Completed

Comparative Glucose Clamp Study of Wockhardt's Insulin Human Regular for Injection and Actrapid, in Type 1 Diabetics

Diabetes

United States
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics, Pharmacodynamics, and Safety of Glyburide in Healthy Volunteers

Healthy
Diakron Pharmaceuticals

Completed

A Healthy Volunteer Study to Evaluate for a Single Dose of 4 Different Tablets of DPOC-4088 the Absorption and Elimination From the Body and the Potential Effect on Blood Clotting

Deep Vein Thrombosis Leg

Belgium
Novartis

Completed

Single Dose Study to Assess the Safety, Tolerability, Concentration in Body and Effect of BAF312

Healthy

United States
National Cancer Institute (NCI)

Completed

Sorafenib to Treat Children and Young Adults With Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas

Plexiform Neurofibroma | Neurofibromatosis Type I

United States
Universitas Padjadjaran
Radboud University Medical Center

Completed

Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study

Pharmacokinetics | Pharmacodynamics | Tolerability | Meningitis, Tuberculous

Indonesia
Everest Medicines (China) Co.,Ltd.

Recruiting

Evaluate The Efficacy, Safety, Pharmacokinetics And Pharmacodynamics Of EVER001

Primary Membranous Nephropathy

China
Haisco Pharmaceutical Group Co., Ltd.

Completed

Relative Bioavailability and Pharmacodynamics of HSK7653 in Healthy Volunteers

Healthy

China
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI)

Completed

Safety, Tolerability, and Pharmacokinetics and Pharmacodynamics of TB31F (TB31F)

Malaria,Falciparum

Netherlands
R-Pharm
MonitorCRO

Completed

Pharmacokinetics and Pharmacodynamics of RPH-104 in Healthy Subjects

Healthy

Turkey
NeuroBo Pharmaceuticals Inc.

Completed

Pharmacokinetics and Pharmacodynamics Study of Gemcabene in Healthy Volunteers

Hypercholesterolemia
Philip Morris Products S.A.

Completed

Nicotine Pharmacokinetics and Pharmacodynamics, Safety and Tolerability of P3P

Pharmacokinetics

Switzerland
Johns Hopkins University

Completed

The Pharmacokinetics and Pharmacodynamics of Oral and Vaporized Cannabidiol

Cannabidiol Pharmacokinetics

United States
FHI 360
Oregon Health and Science University; Asociación Dominicana Pro Bienestar de...

Completed

Pharmacodynamics and Pharmacokinetics Study of Existing DMPA Contraceptive Methods

Contraception

United States, Dominican Republic

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