Search clinical trials for: phase I/II

Total 18536 results

Aeonvital Biomedicine

Not yet recruiting

A Phase I Study on ReT01 ACT for the Treatment of Advanced Solid Tumors

Advanced Solid Tumor
Beijing Dongfang Biotech Co., Ltd.

Not yet recruiting

A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin

Type2 Diabetes Mellitus

China
CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.

Not yet recruiting

Phase 3 Study of TG103 Injection Monotherapy in Treatment of Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus
Aummune Ltd.

Recruiting

Study of AM003 in Patients With Locally Advanced and Metastatic Solid Tumors

Solid Tumor

Israel
BrodenBio Co., Ltd.

Recruiting

A Phase 1 Study of BB102 in Participants With Advanced Solid Tumors

Advanced Solid Tumor

China
Shanxi Province Cancer Hospital

Not yet recruiting

A Single-arm, Single-center, Open-label Phase II Study of Zanubrutinib Combined With R-CHOP/R-DHAP in Newly Diagnosed Mantle CellLymphoma Patients (Z+RCHOP/RDHAP)

Mantle Cell Lymphoma

China
Nanjing Immunophage Biotech Co., Ltd
Zhejiang Hospital

Recruiting

Phase 1 Study for IPG11406 in Health Volunteer

Inflammatory Bowel Diseases

China
Shanghai Pulmonary Hospital, Shanghai, China

Recruiting

Neoadjuvant Therapy With Toripalimab and JS004 Combined With Etoposide and Platinum Chemotherapy for Limited-stage Small Cell Lung Cancer : A Phase 2 Trial

Limited Stage Small Cell Lung Cancer

China
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

Randomized, Open, Controlled, Multicenter Phase III Clinical Study of Fluzoparib in Combination With Apatinib Versus Investigator-Selected Chemotherapy for HRD-Positive/HER2-negative Advanced Breast Cancer

Breast Cancer

China
UTC Therapeutics Inc.
Peking University Cancer Hospital & Institute

Recruiting

Phase 1 Study of UCMYM802 Injection in Mesothelin-positive Advanced Malignant Solid Tumors

Colorectal Cancer | Pancreatic Cancer | Rectal Cancer | Malignant Mesothelioma | Bile Duct Cancer | Breast Cancer Female | Ovary Cancer

China
Central Hospital, Nancy, France
Institut National de la Santé Et de la Recherche Médicale, France; University... and other collaborators

Not yet recruiting

Impact on Quality of Life of Symptoms Routine E-monitoring Among Dialysis Patients. (F-SWIFT)

End Stage Renal Disease

France
The First Affiliated Hospital with Nanjing Medical...
Anhui Provincial Cancer Hospital; Affiliated Hospital of Jiangnan University; The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School and other collaborators

Recruiting

The Dosing Regimen of Pyrotinib in HER2-positive Advanced First-line Breast Cancer: a Phase II Clinical Study

Breast Cancer

China
Beijing Dongfang Biotech Co., Ltd.

Not yet recruiting

A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Placebo in T2DM Patients

Type 2 Diabetes Mellitus

China
Iambic Therapeutics, Inc

Recruiting

A Phase 1/1b Study of IAM1363 in HER2 Cancers

HER2 Mutation-Related Tumors

United States
University of North Carolina, Chapel Hill
National Institute of Mental Health (NIMH)

Not yet recruiting

Causal Role of Top-Down Theta Oscillations in Prioritization

Epilepsy | Working Memory

United States
Guangzhou Lupeng Pharmaceutical Company LTD.

Recruiting

Phase Ib Study of Rocbrutinib in Combination With R-CHOP in Patients With Newly Diagnosed B-cell Non-Hodgkin Lymphoma

B-cell Non-Hodgkin Lymphoma

China
Neuracle Science Co., LTD.
Samsung Medical Center; Korea University Anam Hospital; Severance Hospital

Recruiting

A Phase 1b/2a, Study Evaluating the Safety, PK/PD and Efficacy of NS101 in Healthy Volunteers and SSNHL Patients

Sudden Sensorineural Hearing Loss | Seneorineural Deafness

Korea, Republic of
Pro-Change Behavior Systems

Recruiting

Compass for Care: A Theory-driven Mobile Solution to Promote Well-being Among Caregivers of Individuals With ADRD (Compass4Care)

Dementia | Mental Health

United States
Georgetown University
Gilead Sciences

Recruiting

A Phase II Trial of Sacituzumab Govitecan in Patients With Advanced Thymic Epithelial Tumors

Thymic Carcinoma | Thymoma

United States
Novartis Pharmaceuticals

Not yet recruiting

A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.

Breast Cancer
Advenchen Laboratories Nanjing Ltd.

Recruiting

A Phase IIII Study of AL8326 in Small Cell Lung Cancer

Small Cell Lung Carcinoma

China
National Taiwan University Hospital
Shin Kong Wu Ho-Su Memorial Hospital

Not yet recruiting

EMPAgliflozin in Heart Failure With PReserved Ejection Fraction and End Stage Renal Disease (EMPA-PRED)

Heart Failure With Preserved Ejection Fraction | End Stage Renal Disease on Dialysis
National Taiwan University Hospital
Shin Kong Wu Ho-Su Memorial Hospital

Not yet recruiting

Empagliflozin in Heart Failure With Reduced Ejection Fraction and End Stage Renal Disease (EMPA-RRED)

Heart Failure With Reduced Ejection Fraction | End Stage Renal Disease on Dialysis
Lund University Hospital

Recruiting

a Multicentre Phase III Study of Risk-based Treatment Intensification With Hyperfractionated Radiotherapy in Head and Neck Cancer Patients (ARTSCAN VI)

Head and Neck Squamous Cell Carcinoma

Sweden
Shanghai Best-Link Bioscience, LLC

Recruiting

A Phase I Study to Assess the Safety and Tolerability of BL0006 for Patients With Advanced Solid Tumours

Advanced Solid Tumor

China
Versameb AG
PPD

Not yet recruiting

A Phase 2a Study To Evaluate VMB-100 In Females With Stress Urinary Incontinence

Stress Urinary Incontinence
Ascentawits Pharmaceuticals, Ltd

Recruiting

A Phase I/II Study of AST-001 in Subjects With Advanced Solid Tumors

Pancreatic Cancer | Solid Tumor

China
Eikon Therapeutics

Recruiting

A Phase 2 Study of EIK1001 in Combination With Pembrolizumab and Chemotherapy in Patients With Stage 4 Non-Small Cell Lung Cancer

NSCLC

United States
Alzheimer's Disease Expert Lab (ADEL), Inc.
Oscotec Inc.

Recruiting

A Phase Ia/Ib, First-in-human (FIH) Study for Safety, Tolerability, Pharmacokinetics (PK), and Clinical Activity Evaluation of ADEL-Y01

Alzheimer Disease

United States
European Organisation for Research and Treatment...
Northwell Health Cancer Institute

Not yet recruiting

Adjuvant Tebentafusp in High Risk Ocular Melanoma (ATOM)

Uveal Melanoma
Sichuan Huiyu Pharmaceutical Co., Ltd

Recruiting

Phase 1/2 Study of HYP-2090PTSA in Patients With Advanced Solid Tumors Harboring KRAS Mutation

Efficacy | Tolerability | Safety

China
Beijing Union Pharmaceutical Factory Ltd
R&G Pharma Studies Co.,Ltd.

Recruiting

Phase Ⅲ Clinical Trial of Buagafuran Capsules in the Treatment of GAD (BGFN-2022-01)

Generalized Anxiety Disorder

China
Advanced Reconstructive Surgery Alliance

Recruiting

Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis: Patient Experiences and Reported Outcomes.

Pain, Chest | Diaphragmatic Paralysis | Breath Shortness

United States
GCP-Service International West GmbH
Saint-Louis Hospital, Paris, France; University of Florence; Medical University... and other collaborators

Not yet recruiting

RVU120 for Treatment of Anemia in Patients With Lower-risk Myelodysplastic Neoplasms ((MDS))

Low Risk Myelodysplastic Syndromes

Spain, Poland, Italy, Germany, France
Beijing Union Pharmaceutical Factory Ltd
R&G Pharma Studies Co.,Ltd.

Recruiting

Phase 3 Clinical Trial of Buagafuran Capsules in the Treatment of GAD (BGFN-2022-02)

Generalized Anxiety Disorder

China
Sun Yat-sen University

Recruiting

A Multi-center, Randomized, Double-blind, Phase II/III Clinical Trial of AK104 or Placebo in Combination With Chemotherapy as Second-line or More Lines for Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC)

Recurrent or Metastatic Nasopharyngeal Carcinoma

China
Centre Hospitalier Régional Metz-Thionville

Recruiting

Quantification of Dilutional Anemia in the Initial Phase of Sepsis Management: Preliminary Retrospective Study (QUADS)

Sepsis

France
Worg Biotherapeutics Inc.

Recruiting

Phase 2 Study to Assess Efficacy & Safety of WP1302 Prevent Relapse of MMI w/Draw in Subj. w/ Graves' dz

Graves Disease

United States
MediLink Therapeutics (Suzhou) Co., Ltd.

Recruiting

A Phase II Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of YL201 in Patients With mCRPC

Metastatic Castration-resistant Prostate Cancer (mCRPC)

China
Wu Jun

Not yet recruiting

Efficacy and Safety of Sintilimab Combined With Nab-paclitaxel and Tegio (aTS) as First-line Treatment of Unresectable Locally Advanced, Recurrent or Metastatic Adenocarcinoma of Gastric and Gastroesophageal Junction，a Phase II Clinical Study

Adenocarcinoma | Gastric Cancer | GastroEsophageal Cancer

China
General Hospital of Shenyang Military Region

Not yet recruiting

Effect of Different Frequencies of Umbilical Cord-mesenchymal Stem Cells Through Peripheral Vein in Patients With ESLD

End-Stage Liver DIsease

China
Diasome Pharmaceuticlas, Inc.

Recruiting

Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludec (OPTI-2)

Diabetes Mellitus, Type 1

United States
Ascentawits Pharmaceuticals, Ltd

Recruiting

A Phase I/II Study of AST-3424 in Subjects With Advanced Solid Tumors

Hepatocellular Carcinoma | Advanced Solid Tumors

China
Yunnan Cancer Hospital
Beijing Bethune Charitable Foundation

Recruiting

Single-arm, Single-center, Exploratory Phase II Clinical Study of Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer (ESTIMATE)

Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer

China
Innovent Biologics (Suzhou) Co. Ltd.

Not yet recruiting

A Multicenter, Phase 3 Study of IBI343 Monotherapy Versus Treatment of Investigator's Choice in Subjects With Previously Treated, Claudin (CLDN) 18.2-positive, HER2-negative, Gastric or Gastroesophageal Junction Adenocarcinoma (G-HOPE-001)

Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

China
M.D. Anderson Cancer Center
KSQ Therapeutics, Inc.

Recruiting

A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors

Melanoma | Head and Neck Neoplasms | Lung Neoplasms | Advanced Solid Tumor

United States
Regina Elena Cancer Institute
Fondazione Policlinico Universitario Agostino Gemelli IRCCS; Catholic University... and other collaborators

Recruiting

Biomarkers of Efficacy and Tolerability of Sacituzumab-Govitecan in the Treatment of Patients With Triple-negative Breast Cancer in the Metastatic Phase: Prospective Multicenter Real-world Study (BIO-PROSA)

Breast Cancer

Italy
Palvella Therapeutics, Inc.

Not yet recruiting

A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study Evaluating Safety and Efficacy of QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations (SELVA)

Microcystic Lymphatic Malformation

United States
Novartis Pharmaceuticals

Recruiting

Study of Efficacy and Safety of LCZ696/Amlodipine in Grade 1 and 2 Hypertension Patients Uncontrolled by LCZ696 Monotherapy

Hypertension

Japan
Gilgamesh Pharmaceuticals

Recruiting

A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD

Major Depressive Disorder

United Kingdom

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