Search clinical trials for: Enzyme Replacement

Total 52446 results

National Center for Research Resources (NCRR)
University of Texas

Completed

Studies in Porphyria III: Heme and Tin Mesoporphyrin in Acute Porphyrias

Porphyria

United States
Glaxo Wellcome

Completed

The Safety and Effectiveness of Zidovudine Plus Acyclovir in Patients With Early HIV Infection

HIV Infections

United States
Astra USA

Completed

The Pilot Study of Foscarnet Cream in the Treatment of Mucocutaneous Herpes Simplex Virus Infections in Immunocompromised Patients Unresponsive to Acyclovir Treatment

HIV Infections | Herpes Simplex

United States
Astra USA

Completed

An Open, Multicenter Study of Foscarnet Treatment of Acyclovir-Resistant Herpes Simplex Virus in Patients With the Acquired Immunodeficiency Syndrome and Other Immunodeficiencies

HIV Infections | Herpes Simplex

United States
Pfizer

Completed

A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis.

HIV Infections | Meningitis, Cryptococcal

United States
Pfizer

Completed

A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination With Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients

HIV Infections | Mycobacterium Avium-intracellulare Infection

United States
National Center for Research Resources (NCRR)
Tufts Medical Center

Completed

Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis

Liver Cirrhosis, Biliary
National Center for Research Resources (NCRR)
Ohio State University

Completed

Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dichlorphenamide for Periodic Paralyses and Associated Sodium Channel Disorders

Paralysis, Hyperkalemic Periodic | Paramyotonia Congenita | Hypokalemic Periodic Paralysis
Astra USA

Completed

Safety and Efficacy of Intravenous Magnesium Sulfate in Modulating Changes in Symptoms and Divalent Cation Levels Associated With Foscavir Therapy: A Phase IV Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Pilot Study

HIV Infections | Hypocalcemia | Cytomegalovirus Infections

United States
Community Research Initiative of New England

Completed

A Study to Evaluate the Effect of Cimetidine on CD4 Lymphocyte Counts in HIV Infection

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
Harvard School of Public Health (HSPH)

Completed

Allopurinol, Glucantime, or Allopurinol/Glucantime for Cutaneous Leishmaniasis in Brazil

Leishmaniasis
Janssen, LP

Completed

An Open Study of the Effect of Itraconazole Oral Solution for the Treatment of Fluconazole Refractory Oropharyngeal Candidiasis in HIV-Positive Subjects.

HIV Infections | Candidiasis, Oral

United States
Lederle Laboratories

Completed

A Randomized, Double-Blind, Placebo Controlled Study of l-Leucovorin in Combination With Trimethoprim / Sulfamethoxazole in the Therapy of Pneumocystis Carinii Pneumonia in Patients With the Acquired Immunodeficiency Syndrome

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Sandoz

Completed

A Pilot Trial Evaluating an Alternating Schedule of Recombinant Human GM-CSF and Azidothymidine in Patients With HIV Infection and Leukopenia

HIV Infections | Cytopenias

United States
Glaxo Wellcome

Completed

A Pilot Study To Evaluate the Effect of Retrovir (Zidovudine: AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Associated Dementia and Neuromuscular Diseases

HIV Infections | Neuromuscular Diseases | AIDS Dementia Complex

United States
Stanford University

Completed

A Dose-Escalating Study of Ro 31-8959 ( HIV Protease Inhibitor ) in Patients With HIV Disease.

HIV Infections

United States
Gilead Sciences

Completed

A Phase I/II Study of the Safety, Tolerance, and Pharmacokinetics of 9-(2-Phosphonylmethoxyethyl)Adenine ( PMEA; Adefovir ) in Patients With Advanced HIV Disease.

HIV Infections

United States
Sequus Pharmaceuticals

Completed

Use of Stealth Liposomal Doxorubicin HCl ( DOX-SL ) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma.

HIV Infections | Sarcoma, Kaposi

United States
Gilead Sciences

Completed

A Study of PMPA in HIV-Infected Patients

HIV Infections

United States
Lexigen Pharmaceuticals

Completed

Phase I Trial of S-1153 in Patients With HIV Infection

HIV Infections

United States
Amgen

Completed

A Study of Granulocyte Colony-Stimulating Factor Plus Recombinant Erythropoietin Plus Zidovudine in Patients With AIDS or AIDS-Related Complex

HIV Infections | Cytopenias

United States
Pfizer

Completed

A Study of Fluconazole in the Prevention of Fungal Infections in HIV-Infected Patients Living in Areas Where Fungal Infections Are Common

HIV Infections | Mycoses | Coccidioidomycosis

United States
Glaxo Wellcome

Completed

A Study to Compare Two Anti-HIV Drug Combinations That Include Amprenavir in HIV-Infected Patients Who Have Failed Anti-HIV Drug Combinations That Did Not Include Amprenavir

HIV Infections

United States
Merck Sharp & Dohme LLC

Completed

The Safety and Effectiveness of MK-639 and Zidovudine, Used Alone and Together, in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections
National Center for Research Resources (NCRR)
Penn State University

Completed

Phase II Pilot Study of Early Cortisol Replacement to Prevent Bronchopulmonary Dysplasia

Bronchopulmonary Dysplasia
Agouron Pharmaceuticals

Unknown

Treatment With Nelfinavir or Efavirenz of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs

HIV Infections

United States
SUGEN

Completed

SU5416 in Patients With AIDS-Related Kaposi's Sarcoma Who Have Not Responded to Treatment

HIV Infections | Sarcoma, Kaposi

United States
Texas Biotechnology Corporation

Completed

Pharmacokinetics/Pharmacodynamics of Argatroban Injection in End-Stage Renal Disease Patients Undergoing Hemodialysis

Kidney Failure, Chronic | Renal Disease, End-Stage

United States
Agouron Pharmaceuticals

Completed

A Study of Viracept in AIDS Patients With Mycobacterium Avium Complex Disease (MAC)

HIV Infections | Mycobacterium Avium-Intracellulare Infection

United States
AJI Pharma USA

Unknown

Phase II/III Study of the Tolerance and Efficacy of Combined Use of Didanosine (2',3'-Dideoxyinosine; ddI) and Lentinan in HIV-Positive Patients

HIV Infections

United States
Merck Sharp & Dohme LLC

Suspended

A Study to Compare the Safety and Effectiveness of Indinavir Combined With Stavudine and Lamivudine

HIV Infections

United States
Northwestern Memorial Hospital

Unknown

Study of Allogeneic Bone Marrow and T-Cell Depleted, CD34+ Peripheral Blood Stem Cell Transplantation in Patients With Aplastic Anemia

Aplastic Anemia | Graft Versus Host Disease

United States
Hoffmann-La Roche

Completed

A Phase II Open-Label Exploratory Study of Saquinavir + Zidovudine + Lamivudine in HIV Infected Patients

HIV Infections

United States
Hoffmann-La Roche

Completed

Safety and Effectiveness of Adding Saquinavir (FORTOVASE) in Soft Gel Capsule Form to an Anti-HIV Drug Combination in HIV-Infected Patients

HIV Infections

United States, Canada, Puerto Rico
Glaxo Wellcome

Completed

A Study of 1592U89 in HIV-Infected Adults

HIV Infections

United States
Hoffmann-La Roche

Completed

A Study to Compare Two Anti-HIV Drug Combinations

HIV Infections

Canada, United States, Puerto Rico
SmithKline Beecham

Completed

Safety and Effectiveness of Topotecan HCl to Treat HIV-Infected Patients With AIDS-Related Progressive Multifocal Leukoencephalopathy (PML)

HIV Infections | Leukoencephalopathy, Progressive Multifocal

United States
Hoffmann-La Roche

Completed

A Randomized Controlled Study of the Efficacy and Safety of Maintenance Treatment With Oral Ganciclovir for Newly Diagnosed Cytomegalovirus Retinitis in People With AIDS

HIV Infections | Cytomegalovirus Retinitis

United States, Canada
Hoffmann-La Roche

Completed

A Study of Saquinavir Soft Gelatin Capsules Combined With Other Anti-HIV Drugs in HIV-1 Infected Patients

HIV Infections

United States
Glaxo Wellcome

Completed

The Effect of Teaching HIV-Infected Patients About HIV and Treatment

HIV Infections

United States
Glaxo Wellcome

Completed

A Comparison of Three Anti-HIV Drug Combinations in HIV-Infected Patients

HIV Infections

United States
Sandoz

Completed

A Pilot Study to Evaluate the Effects of Subcutaneously Administered Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor in Pediatric HIV-Infected Patients With Neutropenia Secondary to Azidothymidine

HIV Infections | Cytopenias

United States
Gilead Sciences

Completed

The Safety and Effectiveness of Zidovudine Plus Adefovir in HIV-Infected Patients

HIV Infections

United States
Agouron Pharmaceuticals

Completed

A Study of Viracept in HIV-Positive Women

HIV Infections

United States
VaxGen

Completed

Effectiveness of AIDSVAX B/E Vaccine in Intravenous Drug Users in Bangkok, Thailand

HIV Infections | HIV Seronegativity

Thailand
Dupont Merck

Completed

A Study of Indinavir Taken With or Without DMP 266

HIV Infections

Puerto Rico, United States, Canada
U.S. Bioscience
Jacobus Pharmaceutical

Completed

Randomized Phase I Study of Trimetrexate Glucuronate (TMTX) With Leucovorin (LCV) Protection Plus Dapsone Versus Trimethoprim / Sulfamethoxazole (TMP/SMX) for Treatment of Moderately Severe Episodes of Pneumocystis Carinii Pneumonia

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Glaxo Wellcome

Completed

3TC (Lamivudine; GR109714X) Open-Label Program

HIV Infections

United States
Pfizer

Completed

A Study of Fluconazole in the Treatment of Fungal Infections of the Throat in Patients With Weakened Immune Systems

HIV Infections | Candidiasis, Esophageal

United States
Astra USA

Completed

An Open Study of Foscarnet Treatment First Episode CMV-Retinitis in AIDS Patients

HIV Infections | Cytomegalovirus Retinitis

United States

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