Search clinical trials for: Impaired Hepatic Function

Total 27998 results

H. Lundbeck A/S

Completed

Pharmacokinetic Properties of Idalopirdine (Lu AE58054) in Subjects With and Without Impaired Kidney Function

Alzheimer Disease

Germany
Odense University Hospital

Unknown

Haemodynamic Changes During Anaesthesia in the Prone Position, Evaluated Using Transoesophageal Ultrasound

Obesity | Anaesthesia | Spinal Surgery | Changes in Left and Right Ventricle Dimension | Changes in Bloodflow Across Cardiac Valves | Changes in Dimensions of Inferior Caval Dimension and Hepatic Venous Bloodflow | Changes i Myocardial Velocities | Changes in Diastolic Function

Denmark
Otsuka Pharmaceutical Development & Commercialization...

Completed

Trial Evaluating OPC-34712 in Subjects With Normal Renal Function and Renally Impaired Subjects

Schizophrenia | Psychiatric Disorders

United States
Imperial College London

Completed

Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate

Hepatic Encephalopathy | Cirrhosis | Minimal Hepatic Encephalopathy

United Kingdom
Assistance Publique - Hôpitaux de Paris
Agence Regionale de Sante d'Ile de France

Unknown

Assessment of Teleconsulting in Nursing Homes (EVLINE)

Functionally-Impaired Elderly

France
Universitätsklinikum Hamburg-Eppendorf

Unknown

Non-invasive Blood Pressure and Cardiac Output Measurement by Using Applanation Tonometry

Atrial Fibrillation | Aortic Valve Stenosis | Left Ventricular Failure | Left Ventricular Impaired Function

Germany
Novartis Pharmaceuticals

Completed

Multiple Dose Pharmacokinetics of LCZ696 and Its Metabolites in Subjects With Severe Renal Impairment vs. Matched Healthy Subjects With Normal Renal Function

Pharmacokinetics | Healthy Volunteer | Renal Impaired

Russian Federation, Germany, Serbia
Medical University of Vienna

Unknown

Effect of Vardenafil on Erectile Dysfunction and Portal Hemodynamics in Patients With Liver Cirrhosis

Erectile Dysfunction | Cirrhosis

Austria
Merck Sharp & Dohme LLC

Completed

Pharmacokinetics of Anacetrapib (MK0859) in Subjects With Impaired Renal Function (MK-0859-038)

Dyslipidemia
Baylor Research Institute

Unknown

Assessment of Renal Function in Cirrhotic Patients

Liver Failure | Renal Failure

United States
Novartis Pharmaceuticals

Completed

Safety & Effectiveness on Vascular Structure and Function of ACZ885 in Atherosclerosis and Either T2DM or IGT Patients

Diabetes Mellitus, Type 2 | Atherosclerosis | Prediabetic State

Germany, Israel, United States, Canada, United Kingdom
Unilever R&D
Aspect Clinical

Completed

Effects of Dietary Ingredients on Vascular Function

Vascular Diseases | Impaired Glucose Tolerance

United Kingdom
Imperial College London
University of London; Royal College of Physicians; Paddington Charitable Estates...

Completed

Brain Imaging in Patients With Chronic Liver Disease and Functional Impairment.

Hepatic Encephalopathy | Cirrhosis

United Kingdom
University of Michigan Rogel Cancer Center

Completed

A Study of Changes in Hepatic Function During Radiation Therapy Using Hepatobiliary Single Photon Emission Tomography (SPECT)

Hepatocellular Carcinoma

United States
Eisai Inc.

Completed

A Pharmacokinetic and Safety Study of E7080 in Subjects With Mild (10 mg), Moderate (10 mg), and Severe Hepatic Impairment (5 mg) and Normal Hepatic Function (10 mg)

Hepatic Impairment | Hepatic Function

United States
Medical University Innsbruck

Terminated

Profile of Soluble and Cellular Biomarkers and of Functional Imaging During Antiangiogenic Therapies in Cancer Patients

Colorectal Cancer | Non-small Cell Lung Cancer | Renal Cell Cancer | Hepatocellular Cancer

Austria
US Department of Veterans Affairs

Completed

Enhancing Fitness in Older Pre-diabetic Veterans

Obesity | Diabetes | Impaired Glucose Tolerance

United States
Assistance Publique - Hôpitaux de Paris

Completed

ACute and Chronic Effects of Saxagliptin (ACCES)

Impaired Glucose Tolerance

France
Biotronik SE & Co. KG

Completed

Influence of Home Monitoring on the Clinical Status of Heart Failure Patients With an Impaired Left Ventricular Function (IN-TIME)

Ventricular Fibrillation | Ventricular Tachycardia | Congestive Heart Failure

Denmark, Germany, Israel, Australia, Austria, Czech Republic, Latvia
Rehabilitation Hospital of Indiana
Eli Lilly and Company

Terminated

Feasibility Study of Duloxetine in the Treatment of Depression in Patients With Traumatic Brain Injury (Duloxetine)

Depression | Traumatic Brain Injury

United States
University of Sao Paulo General Hospital

Completed

Effects of THW and rhTSH in Glomerular Filtration Rate During RIT

Other Impaired Renal Function Disorder

Brazil
First Affiliated Hospital of Chongqing Medical...

Unknown

Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy

Depressive Symptoms | Impaired Cognition | Electroconvulsive Therapy

China
Exelixis

Completed

Study to Assess the Pharmacokinetics of Cabozantinib (XL184) in Hepatic Impaired Adult Subjects

Healthy | Hepatic Impairment

United States
Exelixis

Completed

A Single-Dose Study to Assess the Pharmacokinetics of Cabozantinib (XL184) Capsules in Subjects With Impaired Renal Function

Healthy | Renal Impairment

United States
University of Liverpool
Imperial College London; Royal Liverpool University Hospital; University of Surrey and other collaborators

Unknown

The Effect of Exercise Intervention on Insulin Resistance in Non-alcoholic Fatty Liver Disease (NAFLD)

Non Alcoholic Fatty Liver Disease

United Kingdom
Repros Therapeutics Inc.

Terminated

Evaluate PK and Safety of Proellex® in Females With Various Stages of Impaired Renal Function and Healthy Females

Renal Impairment

United States
Tobira Therapeutics, Inc.

Completed

Phase 1 Study of Multiple-Dose Pharmacokinetics of Cenicriviroc in Subjects With Mild and Moderate Hepatic Impairment

Liver Insufficiency

United States
Repros Therapeutics Inc.

Completed

Evaluation of Pharmacokinetic and Safety Profile of Androxal in Male Subjects With Impaired Renal Function

Secondary Hypogonadism

United States
Maastricht University Medical Center

Completed

Egg Protein Hydrolysate and Vascular Function

Type 2 Diabetes Mellitus | Impaired Glucose Tolerance | Dietary Modification | Arterial Stiffness

Netherlands
Yonsei University

Completed

The Comparison of Desflurane and Sevoflurane on Postoperative Recovery and Hepatic Function of Biliary Atresia Patients During Kasai Operation

Biliary Atresia | Kasai Operation

Korea, Republic of
AstraZeneca

Completed

Phase 1 PK Study of Cediranib in Single and Multiple Doses in Hepatically Impaired Patients With Solid Tumours

Hepatic Impairment | Advanced Cancer

Netherlands, Denmark
Janssen Research & Development, LLC

Completed

A Pharmacokinetic Study of Abiraterone Acetate in Patients With Severe Hepatic Impairment Compared to Patients With Normal Hepatic Function

Hepatic Impairment

United States
Boehringer Ingelheim

Completed

Single Dose of BI 1744 CL in Patients With Mild and Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Liver Diseases | Healthy
Boehringer Ingelheim

Completed

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Hepatic Insufficiency
Astellas Pharma Europe B.V.
FibroGen

Completed

A Study to Investigate the Exposure and Safety and Tolerability of a Single Dose of FG-4592 in Subjects With Moderately Diminished Liver Function Compared to Those With Normal Liver Function

Hepatic Insufficiency | Healthy Subjects | PK of FG-4592

Bulgaria
Kumamoto University

Completed

Impaired Peripheral Endothelial Function and In-stent Restenosis

Coronary Artery Disease

Japan
Carl T. Hayden VA Medical Center
American Diabetes Association; Amylin Pharmaceuticals, LLC.

Completed

The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes

Type 2 Diabetes Mellitus

United States
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Investigate the Effect of Severely Diminished Liver Function on the Metabolism, Safety, and Tolerability of a Single Oral Dose of Enzalutamide in Men

Severe Hepatic Impairment | Normal Hepatic Function

Bulgaria
Damanhour University

Completed

Linezolid Pharmacokinetics In Patients With Impaired Renal Function (PPT6) (LZDPPT6)

Renal Failure | Impaired Renal Function
Hunter Holmes Mcguire Veteran Affairs Medical Center
Otsuka America Pharmaceutical

Completed

Effect of Tolvaptan on Cognitive Function in Cirrhosis

Hepatic Encephalopathy | Cirrhosis | Hyponatremia

United States
AVEO Pharmaceuticals, Inc.

Completed

A Single-Dose Study of Tivozanib in Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Impairment

United States
Neurocrine Biosciences

Completed

Safety, Tolerability, and Pharmacokinetics of a Single Dose of NBI-98854 in Subjects With Mild,Moderate, or Severe Hepatic Insufficiency

Safety, Tolerability, and PK of NBI-98854 in Hepatically Impaired Subjects

United States
Cougar Biotechnology, Inc.

Completed

A Study to Assess the Effect of Abiraterone Acetate in Male Participants With Mild or Moderate Hepatic Impairment Compared to Matched Control Participants With Normal Hepatic Function

Prostate Cancer

United States
Astellas Pharma Inc

Completed

A Pharmacokinetic Study of YM178 in Normal Subjects and Those With Mild, Moderate, and Severe Renal Impairment

Renal Impairment

United States
Chonbuk National University Hospital

Completed

Hypoglycemic Effects of Fermented Red Ginseng in Subject With Impaired Fasting Glucose or Type 2 Diabetes

Impaired Glucose or Type 2 Diabetes

Korea, Republic of
Gilead Sciences

Completed

A Phase 1 Study to Evaluate the Pharmacokinetics of GS-5816 in Subjects With Normal Hepatic Function and Moderate or Severe Hepatic Impairment

Chronic Hepatitis C

United States, Puerto Rico
Guangdong Provincial People's Hospital

Unknown

Arsenic Trioxide TACE and Intravenous Administration in Unresectable Hepatocellular Carcinoma (ACTION)

Carcinoma, Hepatocellular
University of Aarhus
Danish Cancer Society

Unknown

Functional Treatment Planning Utilizing 18-FDGal PET/CT in SBRT for Liver Metastases

Liver Metastases

Denmark
PhaseBio Pharmaceuticals Inc.

Completed

Pharmacokinetic, Safety/Tolerability Study of a Single SC Dose of PB1023 Injection in Subjects With Normal and Impaired Renal Function

Diabetes Mellitus, Type 2

United States
Newron Pharmaceuticals SPA

Completed

A Study to Assess the Effect of Hepatic Impairment on Safinamide Pharmacokinetics

Hepatic Impairment

Germany

Search clinical trials for: Impaired Hepatic Function

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