Search clinical trials for: Interferon Sparing

Total 3285 results

Eisai Inc.
H3 Biomedicine Inc.

Terminated

Study of Intratumorally Administered Stimulator of Interferon Genes (STING) Agonist E7766 in Participants With Advanced Solid Tumors or Lymphomas - INSTAL-101

Lymphoma | Advanced Solid Tumors

United States, Spain, France, Korea, Republic of, United Kingdom
Janssen Research & Development, LLC

Terminated

A Study of JNJ-73763989, Pegylated Interferon Alpha-2a and Nucleos(t)Ide Analogs in Participants With Chronic Hepatitis B Virus Infection (PENGUIN-2)

Hepatitis B, Chronic

Taiwan, Spain, Canada, Poland, United States, Japan
Xiamen Amoytop Biotech Co., Ltd.
Peking University First Hospital

Completed

A Study of Peginterferon Alfa-2b Combined With TDF in Patients With Chronic Hepatitis B

Chronic Hepatitis B

China
Kanuni Sultan Suleyman Training and Research Hospital

Completed

Comparison of Laparoscopic Pectopexy and Laparoscopic Lateral Suspension Techniques in Uterine-preserving Apical Prolapsus Repair

Pelvic Organ Prolapse

Turkey
Hoffmann-La Roche

Completed

A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis

Relapsing Multiple Sclerosis

United States, Belgium, Czechia, Russian Federation, Serbia, Spain, Italy, Netherlands, Finland, Estonia, Brazil, France, Germany, Poland, Switzerland, Ukraine, Peru, Argentina, Lithuania, Slovakia, Portugal, Australia, Hungary, Tunisia, Bulgar... and more
Corestemchemon, Inc.

Active, not recruiting

Evaluation the Efficacy and Safety of Mutiple Lenzumestrocel (Neuronata-R® Inj.) Treatment in Patients With ALS (ALSummit)

Amyotrophic Lateral Sclerosis

Korea, Republic of
University Hospital, Brest

Active, not recruiting

Unilateral Secondary Breast Reconstruction Using a Muscle-sparing Pedicled Dorsal Flap After Breast Cancer (RMSU-LDPEM)

Patient Satisfaction

France
Indonesia University

Completed

The Effect of Oral Nanocurcumin as an Adjuvant Therapy for Anogenital Warts: Evaluation of Clinical Improvement, NFĸB, IFN-γ, and FOXP3+TReg From Lesions Tissue

Anogenital Wart

Indonesia
Massachusetts General Hospital
Novartis; Genentech, Inc.

Completed

Reducing the Residual Reservoir of HIV-1 Infected Cells in Patients Receiving Antiretroviral Therapy (ACTIVATE)

HIV Infection

United States
Craig L Slingluff, Jr
University of Virginia

Completed

Phase I/II Trial of a Long Peptide Vaccine (LPV7) Plus TLR Agonists (MEL60)

Melanoma | Metastatic Melanoma | Mucosal Melanoma

United States
Alexandria University

Completed

Gender-based Differences in the Outcome of Treatment With Aldosterone Antagonists in Patients With Heart Failure (GBDAL-HF)

Heart Failure | Heart Failure NYHA Class II | Heart Failure NYHA Class III | Heart Failure With Reduced Ejection Fraction | Heart Failure NYHA Class IV

Egypt
KBP Biosciences
Medpace, Inc.

Completed

Bioavailability of KBP-5074 Tablet vs Capsule Formulations

Bioequivalence

United States
University College, London
University College London Hospitals; Sheffield Teaching Hospitals NHS Foundation... and other collaborators

Active, not recruiting

Evaluating the Effects of Frozen Section Technology on Oncological and Functional Outcomes at Radical Prostatectomy. (NeuroSAFEPROOF)

Prostate Cancer

United Kingdom
Roswell Park Cancer Institute
AIM ImmunoTech Inc.

Suspended

Aspirin and Rintatolimod With or Without Interferon-alpha 2b in Treating Patients With Prostate Cancer Before Surgery

Prostate Adenocarcinoma | Stage I Prostate Cancer AJCC v8 | Stage II Prostate Cancer AJCC v8 | Stage IIIA Prostate Cancer AJCC v8 | Stage IIIB Prostate Cancer AJCC v8 | Stage IIC Prostate Cancer AJCC v8 | Stage III Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8 | Stage IIA Prostate Cancer... and other conditions

United States
University of Wisconsin, Madison
National Institute of Dental and Craniofacial Research (NIDCR); University...

Suspended

MSC in Patients With Xerostomia Post XRT in Head and Neck Cancer

Xerostomia Following Radiotherapy

United States
Fakultas Kedokteran Universitas Indonesia

Enrolling by invitation

The Effectivity of Anti Tuberculosis Therapy in Idiopathic Uveitis With Positive IGRA

Tuberculous Uveitis

Indonesia
Genentech, Inc.
Roche Pharma AG

Completed

A Study of the Efficacy and Safety of Ocrelizumab in Patients With Relapsing-Remitting Multiple Sclerosis

Multiple Sclerosis, Relapsing-Remitting

United States, Canada, Belgium, Spain, France, Switzerland, Ukraine, Mexico, Germany, Bulgaria, United Kingdom, Romania, Czechia, Italy, Russian Federation, Serbia, Slovakia, Denmark
Ainos, Inc. (f/k/a Amarillo Biosciences Inc.
CytoPharm, Inc.

Completed

Interferon-alpha Lozenges for Prevention of Relapse in Hepatitis C

Hepatitis C, Chronic

Taiwan
Necmettin Erbakan University

Completed

Bladder Suture in Uterus-Sparing Surgery and Hysterectomy for Placenta Percreta

Bladder Injury | Sutures | Placenta Percreta

Turkey
Memorial Sloan Kettering Cancer Center

Completed

Placebo Controlled Clinical Trial of the Postoperative Opioid Sparing Effects of Intraoperative Dexmedetomidine Infusion for Thoracic Surgery

Pain

United States
Peloton Therapeutics, Inc., a subsidiary of Merck...

Active, not recruiting

A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)

VHL - Von Hippel-Lindau Syndrome | VHL Gene Mutation | VHL Syndrome | VHL Gene Inactivation | VHL-Associated Renal Cell Carcinoma | VHL-Associated Clear Cell Renal Cell Carcinoma

United States, Denmark, United Kingdom, France
Istituto Auxologico Italiano
European Society of Hypertension; Chinese Hypertension League

Completed

Optimal Blood Pressure and Cholesterol Targets for Preventing Recurrent Stroke in Hypertensives (ESH-CHL-SHOT)

Stroke | Hypertension | Transient Ischemic Attack

Russian Federation
Case Comprehensive Cancer Center

Terminated

Proton Based Cardiac Sparing Accelerated Fractionated RadioTherapy in Unresectable NSCLC

Non-Small Cell Lung Cancer

United States
Brigham and Women's Hospital

Completed

MR Antagonist and STRIATIN

Hypertension | Genetics Hypertension

United States
Castagna Antonella
Bristol-Myers Squibb; ViiV Healthcare

Completed

A Study of a Nucleoside Sparing Regimen in HIV-1 Infected Patients With Detectable Viremia (Dolatav)

HIV-1 Infection

Italy
Cairo University

Completed

Survival and Reproductive Outcomes of Malignant Ovarian Germ Cell Tumors

Fertility Issues

Egypt
Pfizer

Completed

An Extension Study for Participants Who Have Completed the Treatment Period of a Qualifying Parent Study

Dermatomyositis

United States, Spain, Hungary, Poland
Mayo Clinic
National Cancer Institute (NCI)

Completed

Study of Mucosal Sparing Adjuvant Radiotherapy After Surgical Exploration in HPV+ Head and Neck Cancer of Unknown Primaries

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Pathologic Stage I HPV-Mediated (p16-Positive)... and other conditions

United States
Craig L Slingluff, Jr
Celldex Therapeutics

Completed

Vaccination With 6MHP, With or Without Systemic CDX-1127, in Patients With Stage II-IV Melanoma (Mel-65)

Melanoma

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Imiquimod and Pembrolizumab in Treating Patients With Stage IIIB-IV Melanoma

Metastatic Melanoma | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Stage IIIC Cutaneous Melanoma AJCC v7 | Stage IIIB Cutaneous Melanoma AJCC v7

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Suspended

Nivolumab, Fluorouracil, and Interferon Alpha 2B for the Treatment of Unresectable Fibrolamellar Cancer

Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular Carcinoma AJCC v8 | Stage IIIB Hepatocellular Carcinoma AJCC v8 | Unresectable Fibrolamellar...

United States
Stingthera, Inc.
Merck Sharp & Dohme LLC

Terminated

Study of SNX281 in Subjects With Advanced Solid Tumors and Lymphoma

Advanced Solid Tumor | Advanced Lymphoma

United States
Melbourne Health
Hoffmann-La Roche; Monash University; The University of New South Wales; St Vincent... and other collaborators

Completed

Pegylated Interferon and Ribavirin in Hepatitis C Patients on Opioid Pharmacotherapy

Chronic Hepatitis C

Australia
Zealand University Hospital

Completed

Nephron Sparing Renal Surgery and Total Nephrectomy

Kidney Diseases

Denmark
National Eye Institute (NEI)
The Emmes Company, LLC

Completed

Topical Interferon Gamma-1b for Central Serous Chorioretinopathy

Macular Disease | Retinal Disease

United States
Kaohsiung Veterans General Hospital.

Completed

Dexmedetomidine in Thoracoscopic Surgery: Opioid-Sparing Strategy

Postoperative Pain | Opioid Use

Taiwan
Celgene

Completed

Safety Study to Evaluate Immune Response of Vaccines in Participants With Relapsing Forms of Multiple Sclerosis Who Receive Ozanimod Compared to Non-Pegylated Interferon (IFN)-β or No Disease Modifying Therapy

Multiple Sclerosis | Multiple Sclerosis, Relapsing-Remitting

United States, Germany
SPP Pharmaclon Ltd.
North-Western State Medical University named after I.I.Mechnikov

Completed

Study of Interferon-Gamma in the Complex Treatment of Patients Infected With HIV and Tuberculosis (MSPB_TB)

RNA Virus Infections | Lentivirus Infections | Tuberculosis, Pulmonary | Human Immunodeficiency Virus | HIV Coinfection | Aids/Hiv Problem

Russian Federation
Bristol-Myers Squibb

Completed

A Study to Investigate the Effects of BMS-986278 on Drospirenone and Ethinyl Estradiol Drug Levels in Healthy Female Participants

Healthy Volunteers

Canada
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

VSV-hIFNbeta-NIS With or Without Ruxolitinib Phosphate in Treating Stage IV or Recurrent Endometrial Cancer

Recurrent Endometrial Adenocarcinoma | Recurrent Endometrial Carcinoma | Recurrent Endometrial Clear Cell Adenocarcinoma | Recurrent Endometrial Endometrioid Adenocarcinoma | Recurrent Endometrial Mixed Cell Adenocarcinoma | Recurrent Endometrial Serous Adenocarcinoma | Recurrent Endometrial Undifferentiated... and other conditions

United States
Centre Cardiologique du Nord
Universita degli Studi di Genova; Campus Bio-Medico University; Henri Mondor... and other collaborators

Enrolling by invitation

Optimal Strategy for Repair of Type A Acute Aortic Dissection (TARAD)

Aortic Dissection

France
Centre Cardiologique du Nord
Universita degli Studi di Genova; Henri Mondor University Hospital; Pitié-Salpêtrière...

Enrolling by invitation

Outcomes of Type A Aortic Dissection Repair (STAAD)

Aortic Valve Insufficiency | Aortic Diseases | Ascending Aortic Dissection | Aortic Arch | Aortic Root Dissection | Aortic Root Dilatation | Type A Aortic Dissection

France
Centre Cardiologique du Nord
Universita degli Studi di Genova; Henri Mondor University Hospital; Pitié-Salpêtrière... and other collaborators

Enrolling by invitation

Repair Versus Non-repair of the Aortic Arch in Type A Aortic Dissection (TAAD) (AoArch)

Aortic Dissection | Aortic Arch | Aortic Dilatation | Aortic Dissection Rupture

France
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of Arkansas; The Emmes Company, LLC

Active, not recruiting

Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions

HIV Infection | Anal Intraepithelial Neoplasia | High-grade Squamous Intraepithelial Lesion

United States, Puerto Rico
AIM ImmunoTech Inc.
Amarex Clinical Research

Completed

Study to Evaluate the Efficacy and Safety of Ampligen in Patients With Post-COVID Conditions

Long COVID | Post COVID-19 Condition

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of California, San Francisco; University... and other collaborators

Active, not recruiting

Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions (ANCHOR)

HIV Infection | Anal Cancer | Human Papilloma Virus Infection | High-grade Squamous Intraepithelial Lesion

United States, Puerto Rico
MIPO Clinic

Completed

Role of Neutrophils and Electro-bioluminescence in the Rehabilitation (RNE)

Nonsmall-cell Lung Cancer

Kazakhstan
Sun Yat-sen University

Active, not recruiting

SBRT Followed by Neoadjuvant Immunochemotherapy in Resectable Stage II to III Non-small Cell Lung Cancer (SACTION01)

Carcinoma, Non-Small-Cell Lung

China
Centre Hospitalier Universitaire de Nice

Completed

Functional Non Specific Immunity Monitoring After Kidney Transplantation Using an Interferon Gamma Test (QuantiFERON)

Kidney Transplantation

France
Royal Devon and Exeter NHS Foundation Trust
University of Exeter

Completed

A Modified Muscle Sparing Posterior Technique (SPAIRE) in Hip Hemiarthroplasty for Displaced Intracapsular Fractures. (HemiSPAIRE)

Hip Fracture

United Kingdom

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