Search clinical trials for: Unfolded protein response

Total 34714 results

Kanto CML Study Group
Epidemiological and Clinical Research Information Network

Completed

A Study of Complete Molecular Response for Chronic Myeloid Leukemia in Chronic Phase Patients, Treated With Dasatinib (CMR-CML)

Chronic Myeloid Leukemia

Japan
Mayo Clinic
rEVO Biologics

Terminated

Response of Recombinant Antithrombin in Heparin Resistant Patients Undergoing Cardiac Surgery

Thrombophilia Due to Acquired Antithrombin III Deficiency

United States
University of Cologne

Completed

Moxifloxacin in the Prevention of Bacteremia After High-dose Chemotherapy and Transplantation of Peripheral Stem Cells (MoxiProph)

Multiple Myeloma | Hodgkin Disease | Bacteremia | Non-Hodgkin Lymphoma

Germany
Aga Khan University
London School of Hygiene and Tropical Medicine; Emory University; World Health... and other collaborators

Completed

Simplified Antibiotic Therapy for Sepsis in Young Infants (SATT)

Sepsis | Infection | Neonatal Sepsis

Pakistan
University of Pisa
Eastman Dental Insitute and Hospital

Completed

Acute Phase Response & Periodontal Treatment (PERIOSYST-1)

Periodontal Diseases
Liverpool Heart and Chest Hospital NHS Foundation...

Completed

How Effective Are Antithrombotic Therapies in Primary Percutaneous Coronary Intervention (HEAT-PPCI)

Acute ST Elevation Myocardial Infarction

United Kingdom
M.D. Anderson Cancer Center
United States Department of Defense

Completed

Inflammatory Response and Tissue Fibrosis/ Lymphatico-venous Bypass

Melanoma | Sarcoma | Breast Cancer | Malignant Female Reproductive System Neoplasm | Genitourinary Cancer

United States
Assistance Publique - Hôpitaux de Paris

Terminated

Predictive Biomarkers of Response to Sunitinib in the Treatment of Poorly-differentiated NEURO-Endocrine Tumors (NET)

Pancreatic Neoplasms | Neuroendocrine Tumors | Advanced Disease | Sunitinib

France
Ono Pharmaceutical Co. Ltd

Completed

Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan

Systemic Inflammatory Response Syndrome | Acute Lung Injury

Japan
Nestlé

Completed

Gut Microbiota and Proteins Intake

Healthy

Switzerland
Prothya Biosolutions

Completed

Treatment of Deficient Subclass or Anti-polysaccharide Antibody Response (Subklasse)

Infections | IgG Deficiency

Netherlands
Pfizer

Completed

A Retrospective Real World Analysis Of Sutent In Patients With Metastatic Renal Cell Carcinoma In Community And Academic Centers To Assess The Impact Of Dose Variation On Duration Of Response And Overall Survival

Metastatic Renal Cell Carcinoma
Duke University
Bristol-Myers Squibb

Terminated

Phase II Study Evaluating The Safety And Response To Neoadjuvant Dasatinib In Early Stage Non-Small Cell Lung Cancer (TOP0706)

Carcinoma, Non-Small-Cell Lung

United States
Clinica Universidad de Navarra, Universidad de...
University of Navarrra Hospital (Clinica Universitaria)

Unknown

Concentration of Antimicrobials in Catheter-lock Solutions (CONAN)

Catheter-Related Infections | Bacteremia.

Spain
KU Leuven
Research Foundation Flanders; National Institute for Health and Disability...

Completed

Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care (ERNIE2)

Pneumonia | Sepsis | Abscess | Cellulitis | Meningitis | Osteomyelitis | Complicated Urinary Tract Infection | Bacteraemia | Gastro-enteritis With Dehydration | Viral Respiratory Infection Complicated With Hypoxia

Belgium
PENTA Foundation
Chiesi Farmaceutici S.p.A.

Completed

Efficacy, Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days With Clinical or Confirmed Late-onset Sepsis (NeoMero-1)

Sepsis

Italy
McMaster University

Completed

Influence of Reduced Daily Step Count and Anabolic Interventions on Muscle Protein Metabolism in Older Persons

Older Adults | Muscle Protein Synthetic Response to Protein | Reduced Physical Activity

Canada
Bayer

Completed

BAY43-9006 Phase II Study for Renal Cell Carcinoma

Carcinoma, Renal Cell

Japan
Sheba Medical Center

Unknown

Ex Vivo Laboratory Assays Application for Therapy Tailoring in Patients With Severe Bleeding Disorders

Severe Hemophilia

Israel
University of Zurich

Terminated

Single-center Investigator Initiated Pilot Study Investigating the Tumor Response of Squamous Cell Carcinoma Lesions in Patients Under Lapatinib Treatment

Squamous Cell Carcinoma

Switzerland
Università degli Studi di Brescia

Completed

Intermittent Imatinib Treatment in Chronic Myeloid Leukemia and Philadelphia Chromosome (Ph+CML) Patients Who Achieved a Complete Cytogenetic Response (CCgR) on Standard Imatinib Therapy (INTERIM0407)

Chronic Myeloid Leukemia

Italy
Maastricht University Medical Center

Completed

Impact of Fat Co-ingestion With Protein on the Post-prandial Anabolic Response in Elderly Men (Pro-Fat)

Sarcopenia

Netherlands
Radboud University Medical Center
UMC Utrecht; Prothya Biosolutions

Completed

In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia - VECTOR II (VECTORII)

Sepsis | Inflammation | Endotoxemia | Innate Immune Response

Netherlands
University of Aarhus

Completed

Effects of Free Fatty Acids and 3-hydroxybutyrate on Protein, Glucose, Lipid Metabolism and Intracellular Signals.

Systemic Inflammatory Response Syndrome

Denmark
Ablon Skin Institute Research Center
Irish Response t/a Lifes2good

Completed

Viviscal Extra-Strength Formulation To Promote Hair Growth And Decrease Shedding In Women With Thinning Hair

Hair Thinning
International Centre for Diarrhoeal Disease Research...
Johns Hopkins Bloomberg School of Public Health; Bangabandhu Sheikh Mujib Medical...

Completed

Neonatal Sepsis, Evaluation, Bangladesh

Sepsis

Bangladesh
Shenyang Northern Hospital

Completed

BivaliRudin in Acute Myocardial Infarction vs Glycoprotein IIb/IIIa and Heparin :a Randomised Controlled Trial. (BRIGHT)

Percutaneous Coronary Intervention | Acute Myocardial Infarction

China
VaxInnate Corporation
University of Colorado, Denver

Completed

Study to Investigate the Immune Response to Two Doses of VAX102 Healthy Adults

Influenza

United States
Eleos, Inc.

Withdrawn

Aezea® (Cenersen) and Chemotherapy for AML Subjects ≥ 55 Years of Age With No Response to Frontline Induction Course

Acute Myelogenous Leukemia
Johns Hopkins Bloomberg School of Public Health
Dhaka Shishu Hospital

Completed

Simplified Antibiotic Regimens for Outpatient Treatment of Suspected Sepsis in Neonates and Young Infants in Bangladesh

Sepsis

Bangladesh
University of Arkansas

Withdrawn

A Single Agent Study to Evaluate the Overall Response Rate, Safety and Tolerability of Orally Administered Vemurafenib

Multiple Myeloma

United States
Heidelberg University

Unknown

Molecular Determinants for Therapy Response on Renal Cell Carcinoma (MORE)

Renal Cell Carcinoma

Germany
Aarhus University Hospital
University of Aarhus

Completed

Dose-response Effect of Whey Protein Consumed as Pre-meal on Postprandial Lipaemia in Subjects With Metabolic Syndrome

Metabolic Syndrome

Denmark
Soroka University Medical Center

Unknown

Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery

Post Cardiac Surgery Systemic Inflammatory Response
Hvidovre University Hospital
University of Copenhagen; Københavns Kommune

Completed

The Effect of Protein and Resistance Training on Muscle Mass in Acutely Ill Old Medical Patients

Systemic Inflammatory Response Syndrome

Denmark
Australasian Leukaemia and Lymphoma Group
Merck Sharp & Dohme LLC; Novartis Pharmaceuticals

Unknown

Pegylated Interferon Alfa-2b and Nilotinib for Augmentation of Complete Molecular Response in Chronic Myeloid Leukaemia (PInNACLe)

Chronic Myeloid Leukaemia

Australia
Mayo Clinic
National Cancer Institute (NCI)

Completed

Tumor Response to Pemetrexed Disodium in Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Enrolled in Clinical Trial MCCRC-RC0524

Lung Cancer

United States
University of Erlangen-Nürnberg Medical School
German Research Foundation; University Hospital, Essen; Wuerzburg University... and other collaborators

Unknown

Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination (B-cell therapy)

Acute Myeloid Leukemia | Multiple Myeloma | Acute Lymphoblastic Leukemia | Chronic Myeloid Leukemia | Myelodysplastic Syndrome | Aplastic Anemia | Non Hodgkin's Lymphoma | Hodgkin's Disease

Germany
Boehringer Ingelheim

Completed

A Dose Response Study of Dabigatran Etexilate(BIBR 1048) in Pharmacodynamics and Safety in Patients With Non-valvular Atrial Fibrillation in Comparison to Warfarin

Atrial Fibrillation

Japan
Fondazione Michelangelo

Terminated

Modulation of Response to Hormonal Therapy With Lapatinib and/or Metformin in Patients With Metastatic Breast Cancer

Metastatic Breast Cancer

Italy
National Institute of Allergy and Infectious Diseases...

Terminated

Detoxified J5 Core Glycolipid/ Group B Meningococcal Outer Membrane Protein Vaccine for Gram-negative Bacterial Sepsis Administered With and Without Synthetic CPG Oligodeoxynucleotide 7909 Adjuvant

Bacterial Sepsis

United States
Centre Hospitalier Universitaire de Saint Etienne

Terminated

Serum CA9 Level as Biological Marker of the Treatment Response in Metastatic Renal Cell Cancer (CA9CRM)

Metastatic Renal Cell Carcinoma | Metastatic Kidney Cancer

France
Hospices Civils de Lyon

Completed

Treatment of Myeloma in Patients <= 65 Years Old With Response >= 50% After HSC Autotransplant by Allogenic Transplant Genoidentical or Phenoidentical After Reduced Intensity Conditioning (IFM 2005-03)

Myeloma

France
Seoul St. Mary's Hospital
Novartis

Unknown

Efficacy of Nilotinib Versus Imatinib in Ph+ CML in Early CP Who Have a Suboptimal Molecular Response to Imatinib (RE-NICE)

Chronic Myeloid Leukemia

Korea, Republic of
Seoul St. Mary's Hospital
Ministry of Health & Welfare, Korea

Unknown

Discontinuation Study of Imatinib in Adult CP CML Patients Who Have a Complete Molecular Response to Imatinib

Chronic Myeloid Leukemia | Imatinib | Complete Molecular Response

Korea, Republic of
Hospital Universitario Dr. Jose E. Gonzalez
Novartis Pharmaceuticals

Completed

Low-dose Nilotinib and Imatinib Combination in Chronic Myeloid Leukemia Patients, With Failure, Suboptimal Response or Treatment Intolerance

Leukemia, Myeloid, Chronic, BCR-ABL Positive

Mexico
Azienda Ospedaliera San Giovanni Battista

Unknown

IMMUNOPHENOTYPE ROLE IN THE EVALUATION OF CLINICAL RESPONSE

Multiple Myeloma | Post Allografting
University of Toronto

Completed

Effect of Yellow Pea Protein and Fibre Added to a High-carb Meal on Glycemic Response and Food Intake

Obesity | Diabetes

Canada
Bristol-Myers Squibb

Terminated

Study of Dasatinib in Patients With Chronic Phase Chronic Myeloid Leukemia and a Suboptimal Response to Imatinib

Leukemia, Myeloid, Chronic

Sweden, United Kingdom, Russian Federation, France, Germany, Belgium, Portugal, Finland, Norway, Spain, Italy
Università Politecnica delle Marche
Azienda Ospedaliero, Universitaria Ospedali Riuniti

Completed

Activated Protein C and Microcirculation

Septic Shock | Severe Sepsis

Italy

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