Search clinical trials for: HER2 mutation

Total 5910 results

Provitro GmbH
Charite University, Berlin, Germany; AstraZeneca

Completed

Pathomolecular Analysis of Rare EGFR Mutations in Advanced NSCLC

Mutations in Exons 18 to 21

Germany
Taipei Medical University WanFang Hospital

Unknown

Mutational Profiling in Colorectal Tumors to Determine Its Role in the Diagnosis, Prognostic Significance and Their Impact in Clinical Management

Colorectal Cancer

Taiwan
Illumina, Inc.

Completed

Detection of Factor V Leiden G1691A and Factor II (Prothrombin) G20210A Point Mutations in DNA

Detection and Genotyping of Factor V and Factor II Point Mutations
Vejle Hospital

Completed

Temsirolimus and Irinotecan for Treatment Resistant Patients With Metastatic Colorectal Cancer and KRAS Mutations (TIRASMUS)

Metastatic Colorectal Cancer

Denmark
SCRI Development Innovations, LLC
GlaxoSmithKline

Completed

Weekly Topotecan in Patients Treated for Metastatic Colorectal Cancer

Colon Cancer

United States
Penwest Pharmaceuticals Co.

Terminated

Safety and Efficacy Study of A0001 in Patients With the A3243G Mitochondrial DNA Point Mutation

Neuromuscular Disease

United Kingdom
Bristol-Myers Squibb

Completed

A Study of Prevalence of the I50L Mutation When ATV Treated Patients Fail the Regimen

HIV Infections

United States
Bristol-Myers Squibb

Completed

Effect of the Atazanavir (ATV) 150L Mutation on Subsequent Treatment Response in HIV Infected Subjects

HIV Infection

United States, Argentina, Brazil, Guatemala, Mexico, Peru, South Africa
Hillel Yaffe Medical Center
Weizmann Institute of Science

Unknown

Functional Role of RUNX1 Mutations in the Etiology of Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia

Israel
Peking Union Medical College

Suspended

The Chinese Mutation Hotspot of ENaC Causing Liddle's Syndrome and the Association of ENaC Variations and Hypertension

Hypertension

China
Gynecologic Oncology Group
National Cancer Institute (NCI)

Unknown

Studying Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers

Breast Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United States
RostaQuo S.p.A.

Unknown

Antihypertensive Effect of Rostafuroxin Compared With Losartan in Hypertensive Patients Bearing Specified Gene Mutations

Essential Hypertension

Ireland, Italy, Poland
AstraZeneca

Completed

Epidemiological Study to Evaluate the Prevalence of Epidermal Growth Factor Receptor (EGFR) Mutation Status in Patients With Newly Diagnosed Locally Advanced or Metastatic Non Small Cell Lung Cancer (NSCLC) (Spanish REASON)

Non Small Cell Lung Cancer

Spain
Samsung Medical Center

Unknown

Iressa for EGFR Mutation Negative Non-small Cell Lung Cancer (NSCLC)

Nonsmall Cell Lung Cancer

Korea, Republic of
Assistance Publique - Hôpitaux de Paris

Unknown

Efficacy of Nilotinib in First or Second Line Treatment of Primary Melanomas Stage III Unresectable Melanomas. (NILOMEL)

Stage IV Melanoma | Stage III Melanoma | Amplification | Malignant Skin Melanoma T0

France
Peking University
Novartis

Completed

Trial of Imatinib (Gleevec®) in Selected Patients With Metastatic Melanoma

Metastatic Melanoma

China
Medical University of Graz

Completed

Study to Test Genetic Alterations Among Different Dermoscopic Types of Melanocytic Nevi.

Nevi

Austria
Mayo Clinic
GlaxoSmithKline

Completed

Phase I Study of GW572016 With Topotecan to Treat Advanced Solid Malignancies

Advanced Solid Malignancies

United States
Assistance Publique - Hôpitaux de Paris

Completed

Study of Factors of Genetic Susceptibility Associated to Severe Caries Phenotype (Cariogene)

Dental Caries

France
China Medical University Hospital

Unknown

Inherited Myokymia: A Clinical and Genetic Study of a Family

A Study of Clinical and Genetic Mutations in a Family of Neuromyotonia, so Called Isaac's Syndrome

Taiwan
Rambam Health Care Campus

Unknown

Safety and Clinical Effectiveness of 2 Lower Dose Combined PDE5i's vs. Single Maximal Dose PDE5i

Impotence

Israel
Memorial Sloan Kettering Cancer Center
New York University; Hadassah Medical Organization; New York Presbyterian Hospital and other collaborators

Completed

Awareness and Attitudes Regarding Prenatal and Preimplantation Genetic Diagnosis for Inherited Breast/Ovarian Cancer Risk

Breast Cancer | Ovarian Cancer

United States
Gustave Roussy, Cancer Campus, Grand Paris

Unknown

Sorafenib and Temozolomide in Treating Patients With Stage III or Stage IV Melanoma

Melanoma (Skin)

France
Odense University Hospital

Completed

Clinical Assessment of Patients With High Bone Mass Due to Mutation in Lrp5

Osteopetrosis

Denmark
Istituto Clinico Humanitas

Completed

Molecular Features Predicting Response/Resistance to Trastuzumab in Metastatic Breast Cancer Patients

Breast Cancer

Italy
SCRI Development Innovations, LLC
GlaxoSmithKline

Completed

Weekly Topotecan in the Second-Line Treatment of Small Cell Lung Cancer

Lung Cancer
Assistance Publique - Hôpitaux de Paris
Novartis; Association Rhumatisme et Travail

Completed

Genetic Study of Families Affected by Paget's Disease of Bone (PAGET)

Paget's Disease of Bone

France
GlaxoSmithKline

Completed

Meta-analysis of Efficacy of Topotecan

Cervical Intraepithelial Neoplasia
AstraZeneca

Completed

First-line Treatment for Adenocarcinoma Patients With Epidermal Growth Factor Receptor (EGFR) Mutation

Pulmonary Cancer

Korea, Republic of
SCRI Development Innovations, LLC
GlaxoSmithKline; AstraZeneca; Aventis Pharmaceuticals

Completed

Oral Topotecan Versus Docetaxel in Second-Line Treatment of Non-Small Cell Lung Cancer

Lung Cancer

United States
Marywood University

Completed

Does Sildenafil Increase Exercise Performance in Air Pollution?

Pulmonary Hypertension | Air Pollution | Exercise Performance | Pulmonary Artery Pressure

United States
University Hospital, Tours

Completed

ABCB4 Gene Mutations in Intrahepatic Cholestasis of Pregnancy and Controls

Intrahepatic Cholestasis of Pregnancy

France
Hadassah Medical Organization

Unknown

Thymidine Kinase 1 in Risk Assessment for Hereditary Breast /Ovarian Cancer

Breast Cancer | Ovarian Cancer

Israel
Chinese PLA General Hospital

Unknown

A Chinese Randomized Crossover Study of Erlotinib Versus Docetaxel/Cisplatin in Previously Untreated Stage IIIB/IV Lung Adenocarcinoma With EGFR Mutations

Neoplasms, Lung | Carcinoma, Non-Small Cell Lung | Drug Therapy | Genes, EGFR

China
AstraZeneca

Completed

A Study on the Long Term Survivals in an Expand Access Program (EAP) of Iressa

Non-small Cell Lung Cancer

China
AstraZeneca
Laboratorio Progenetica

Completed

Epidemiologic Study of KRAS Mutation in Brazilian Patients With Advanced or Metastatic Non Small Cell Lung Cancer

Non Small Cell Lung Cancer

Brazil
University of Arizona
National Cancer Institute (NCI)

Completed

Fenretinide in Preventing Ovarian Cancer in Participants Who Are at High Risk for Developing Ovarian Cancer and Planning to Undergo Surgery to Remove the Ovaries

Ovarian Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United States
National Taiwan University Hospital

Withdrawn

Efficacy of Type-5 Phosphodiesterase Inhibitors in Primary and Secondary Pulmonary Hypertension

Primary and Secondary Pulmonary Hypertension

Taiwan
Samsung Medical Center

Unknown

Genome Wide SNP Array-based Approach to Detect Micro-cytogenetic Lesions and KIT Mutation to Improve Treatment Outcomes in Patients With Core-binding Factor Positive Acute Myeloid Leukemia

Myeloid Leukemia

Korea, Republic of
University of New Mexico

Completed

Study of Adjuvant Topotecan and Cisplatin With Concurrent Radiation Therapy for Advanced Cervical Cancer

Cervical Cancer

United States
New York Presbyterian Hospital
Women At Risk

Unknown

Women At Risk: The High Risk Breast Cancer Program (WAR)

Breast Cancer

United States
Institut du Cancer de Montpellier - Val d'Aurelle

Unknown

Biological Factors in Predicting Response to Treatment in Patients With Esophageal Cancer or Rectal Cancer

Colorectal Cancer | Esophageal Cancer

France
Women's College Hospital
BioResponse

Unknown

The Potential for Oral Diindolylmethane (DIM) Supplementation to Increase the Production of the BRCA1 Protein in BRCA1 Mutation Carriers

Breast Cancer

Canada
National Taiwan University Hospital

Unknown

Detection of EGFR Mutation in Malignant Pleural Effusion of Lung Cancer Patients and Cancer Cell Lines Establishment (EGFR)

NSCLC

Taiwan
National Taiwan University Hospital

Completed

Correlation of Genetic Polymorphism and Livedo Vasculitis

Livedo Vasculitis | Livedoid Vasculitis | Livedoid Vasculopathy | Genetic Pleomorphism | Leiden Mutation

Taiwan
Yonsei University

Unknown

Sorafenib and Erlotinib in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Has Not Responded to Chemotherapy

Lung Cancer

Korea, Republic of
Massachusetts General Hospital

Completed

Study of Sildenafil in Advanced Heart Failure.

Congestive Heart Failure
Memorial Sloan Kettering Cancer Center
American Cancer Society, Inc.

Completed

Adherence to Intensive Surveillance for Hereditary Breast Cancer

Breast Cancer

United States
Oxford University Hospitals NHS Trust

Unknown

Biomarkers in Patients at Risk of Developing Myelodysplastic Syndrome or Other Disorders and in Healthy Participants

Myelodysplastic Syndromes | Leukemia

United Kingdom
National Institute of Arthritis and Musculoskeletal...

Unknown

The Effects of Exercise Versus Inactivity on People With Mitochondrial Muscle Disease

Mitochondrial Myopathy

United States

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