- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00975871
Correlation of Genetic Polymorphism and Livedo Vasculitis
October 21, 2009 updated by: National Taiwan University Hospital
Livedo vasculitis is disease with recurrent courses of painful foot or ankle ulcerations, followed by healed white scars.
The actual mechanism of its pathophysiology is not yet clear.
It has been reported to be associated with some gene mutations, for example, factor V Leiden gene.
This study is aimed to find the possible relation of these gene mutations in Taiwanese patients.
Study Overview
Status
Completed
Detailed Description
Livedo vasculitis is a chronic, recurrent painful ulcerations on the ankles and feet.
This chronic disease is characterized by healed white, atrophic scars named atrophie blanche.
The histopathological exam on the lesion site reveals fibrin deposition within the vessel walls.
It has been reported to be related to factor V Leiden mutation (heterozygous) (22.2%), prothrombin G20210A gene mutation (8.3%), PAI promotor 4G/4G genotype and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in about total 30% livedo vasculitis patients.
This study is trying to find the correlation between Taiwanese patients and these four genes.
Study Type
Observational
Enrollment (Actual)
50
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Taipei, Taiwan, 100
- National Taiwan University Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
General population
Description
Inclusion Criteria:
- Clinical diagnosis of livedo vasculitis
Exclusion Criteria:
- No special exclusion criteria
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Case-Only
- Time Perspectives: Prospective
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 2007
Primary Completion (Actual)
April 1, 2009
Study Completion (Actual)
April 1, 2009
Study Registration Dates
First Submitted
September 11, 2009
First Submitted That Met QC Criteria
September 11, 2009
First Posted (Estimate)
September 14, 2009
Study Record Updates
Last Update Posted (Estimate)
October 23, 2009
Last Update Submitted That Met QC Criteria
October 21, 2009
Last Verified
October 1, 2009
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 0961172000
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Livedo Vasculitis
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University Hospital, Strasbourg, FranceRecruiting
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Xiangya Hospital of Central South UniversityThe Third Xiangya Hospital of Central South University; Hunan Provincial People... and other collaboratorsRecruiting
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National Institute of Allergy and Infectious Diseases...Immune Tolerance Network (ITN)TerminatedANCA-Associated VasculitisUnited Kingdom
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Chinese SLE Treatment And Research GroupThe First Affiliated Hospital of Anhui Medical University; Shanghai Zhongshan... and other collaboratorsRecruitingANCA Associated Vasculitis | Maintenance TherapyChina
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University Hospital, BrestNot yet recruitingOccupational Diseases | ANCA Associated Vasculitis | Environmental ExposureFrance
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University Hospital Birmingham NHS Foundation TrustMerck Sharp & Dohme LLCRecruitingANCA Associated VasculitisUnited Kingdom
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University Hospital, BrestRecruiting
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Nantes University HospitalINSERM UMRS-1064CompletedANCA-associated VasculitisFrance
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Shanghai Zhongshan HospitalCompletedDrug Use | ANCA Associated Vasculitis | JAK-STAT Pathway DeregulationChina
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Second Affiliated Hospital, School of Medicine,...RecruitingANCA Associated VasculitisChina