Clinical Trials Sponsored by Aestus Therapeutics

Total 6387 results

Bausch Health Americas, Inc.
Galderma R&D; Oceana Therapeutics, Inc.

Completed

A Randomized, Blinded, Multicenter Study to Evaluate NASHA/Dx for the Treatment of Fecal Incontinence

Fecal Incontinence

United States, Germany, Sweden, United Kingdom
Vanderbilt-Ingram Cancer Center
Astex Pharmaceuticals, Inc.; Forma Therapeutics, Inc.

Withdrawn

ASTX727 and FT-2102 in Treating IDH1-Mutated Recurrent/Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

Acute Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome
Roswell Park Cancer Institute
National Cancer Institute (NCI); Nektar Therapeutics

Completed

Pegylated Irinotecan NKTR 102 in Treating Patients With Relapsed Small Cell Lung Cancer

Recurrent Small Cell Lung Carcinoma

United States
Abramson Cancer Center of the University of Pennsylvania
Halozyme Therapeutics

Withdrawn

MRI Effects of Pegvorhyaluronidase Alfa (PEGPH20) in Pancreatic Ductal Adenocarcinoma

Pancreatic Ductal Adenocarcinoma

United States
Viela Bio
MedImmune LLC

Completed

A Phase 1 Study of MEDI7734 in Type I Interferon-Mediated Autoimmune Diseases

Dermatomyositis, Polymyositis, Sjogren's, SLE, SSc

United States
Acorda Therapeutics
United States Department of Defense; DP Clinical, Inc.

Terminated

AC105 in Patients With Acute Traumatic Spinal Cord Injury (AC105)

Acute Spinal Cord Injury
VA Office of Research and Development
Helsinn Therapeutics (U.S.), Inc

Terminated

The Role of Ghrelin in Cancer Cachexia

Cancer Cachexia

United States
Johns Hopkins University
Juvenile Diabetes Research Foundation; iCo Therapeutics Inc.

Terminated

A Randomized, Multi-center, Phase II Study of the Safety, Tolerability and Bioactivity of Repeated Intravitreal Injections of iCo-007 as Monotherapy or in Combination With Ranibizumab or Laser Photocoagulation in the Treatment of Diabetic Macular Edema (the iDEAL Study) (iDEAL)

Diabetic Macular Edema

United States
Galera Therapeutics, Inc.
INC Research Australia Pty Ltd; Nucleous Network

Completed

A Study of the Safety, Tolerability and Pharmacokinetics of Orally-administered GC4702 in Healthy Volunteers

Healthy Volunteer

Australia
Schön Klinik Berchtesgadener Land
Grifols Therapeutics LLC; Alpha-1 Foundation

Completed

Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients

Chronic Obstructive Pulmonary Disease | Alpha-1-antitrypsin-deficiency

Germany
Radboud University Medical Center
Dutch Heart Foundation; Synvista Therapeutics, Inc

Completed

Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function

Cardiovascular Disease | Physical Activity | Aging | Endothelial Dysfunction

Netherlands
University of Washington
National Institute on Aging (NIA); ASCEND Therapeutics

Completed

Effect of Dihydrotestosterone (DHT) on Prostate Tissue [Short Title: DHT-3] (DHT-3)

Healthy

United States
Rheumatology Therapeutics Medical Center
Kochan Institute for Healing Arts Research

Unknown

Safety and Efficacy Study of Bee Venom to Treat Knee Osteoarthritis

Persons With Mild to Moderate Knee Osteoarthritis

United States
Hepatitis Resource Network
Integrated Therapeutics Group; Subsidiary of Schering-Plough

Completed

PEG-Interferon a-2b + Ribavirin for Treatment of Chronic HRN 005 Hepatitis C Infection in HIV-Infected Persons Not Previously Treated With Interferon

HIV Infections | Chronic Hepatitis C Infection in HIV-Infected Persons

United States
Intira Sriprasert
TherapeuticsMD

Completed

Effect of Oral Estradiol and Progesterone Therapy on Vaginal Cytokines in Postmenopausal Women

Menopause

United States
Regend Therapeutics
Peking Union Medical College Hospital; Ruijin Hospital; The First Affiliated... and other collaborators

Completed

Treatment of Idiopathic Pulmonary Fibrosis(IPF) by REGEND001

Idiopathic Pulmonary Fibrosis

China
Sight Medical Doctors PLLC
Ocular Therapeutix, Inc.

Completed

Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study

Postoperative Pain | Keratoconus, Unstable | Collagen Crosslinking

United States
Sight Medical Doctors PLLC
Ocular Therapeutix, Inc.

Recruiting

Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing FLACS With Premium IOL (ENHANCE)

Dry Eye Syndromes

United States
Eye Surgeons of Indiana
Ocular Therapeutix, Inc.

Completed

Lipiflow Treatment Alone vs. Lipiflow + Dextenza Treatment for Dry Eye Disease

Dry Eye Syndromes

United States
Eye Surgeons of Indiana
Ocular Therapeutix, Inc.

Terminated

Xiidra vs. Xiidra + Dextenza Treatment for Dry Eye Disease

Dry Eye Syndromes

United States
Therapeutic Advances in Childhood Leukemia Consortium
Bristol-Myers Squibb

Active, not recruiting

Nivolumab in Combination With 5-azacytidine in Childhood Relapsed/Refractory AML

AML, Childhood

United States
Lambda Therapeutic Research Ltd.
Intas Pharmaceutical Limited (Biopharma Division)

Recruiting

Denosumab Biosimilar Injection in Post Menopausal Women With Osteoporosis

Osteoporosis, Postmenopausal

India
Colorado State University
Hearts and Horses Therapeutic Riding Center

Completed

Piloting an Enhanced Protocol of Occupational Therapy in an Equine Environment for Youth With Autism

Autism Spectrum Disorder

United States
China Medical University, China
Beijing Bio-Targeting Therapeutics Technology Co., Ltd

Not yet recruiting

A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer

Gastric Cancer, Metastatic
The First Affiliated Hospital of Soochow University
CARsgen Therapeutics Co., Ltd.

Recruiting

CT0594CP CAR-T Cells in Patients With Relapsed/Refractory Multiple Myeloma or Plasma Cell Leukemia

Multiple Myeloma | Plasma Cell Leukemia

China
Modulation Therapeutics, Inc.
H. Lee Moffitt Cancer Center and Research Institute

Recruiting

Targeted Alpha Particle Radiotherapy for Metastatic Uveal Melanoma

Uveal Melanoma | Metastatic

United States
Karen Reckamp, MD, MS
Enviro Therapeutics, Inc.

Recruiting

Study of Osimertinib With Carotuximab in Advanced, EGFR-mutated Non-Small Cell Lung Cancer

Lung Cancer | Non Small Cell Lung Cancer

United States
The First Affiliated Hospital of Soochow University
CARsgen Therapeutics Co., Ltd.

Recruiting

A Study to Access the Safety and Efficacy of CT0590 in Patients With Relapsed and/or Refractory Multiple Myeloma

Relapsed and/or Refractory Multiple Myeloma

China
The First Affiliated Hospital of Soochow University
CARsgen Therapeutics Co., Ltd.

Recruiting

PBMC Collection for Production of UCAR T Cells

Peripheral Blood Mononuclear Cell

China
IVI Vigo
Instituto Valenciano de Infertilidad, IVI VALENCIA; Juno Therapeutics, Inc.

Not yet recruiting

Embryos With Preimplantation Genetic Testing for Aneuploidies (PGT-A) Inconclusive Result: Clinical Implications

Embryo Disorder
CorrectSequence Therapeutics Co., Ltd
First Affiliated Hospital of Guangxi Medical University

Enrolling by invitation

CS-101 in Patients With β-thalassemia

Beta-Thalassemia

China
Barbara Parker, MD
Oncternal Therapeutics, Inc

Completed

Study of Cirmtuzumab and Paclitaxel for Metastatic or Locally Advanced, Unresectable Breast Cancer

Breast Neoplasms

United States
Vivoryon Therapeutics N.V.
Amsterdam UMC, location VUmc; Nordic Bioscience A/S

Completed

A Study to Evaluate Safety and Tolerability of Different Doses and Efficacy of PQ912 in Subjects With MCI and Mild AD (VIVIAD)

Early Alzheimers Disease | Mild Cognitive Impairment Due to AD

Netherlands, Spain, Denmark, Germany, Poland
Lawson Health Research Institute
St. Joseph's Health Care London; Urobiome Therapeutics

Terminated

Cranberry and Quillaja on Symptoms of Uncomplicated UTI

Urinary Tract Infections | UTI | UTI - Lower Urinary Tract Infection

Canada
Memorial Sloan Kettering Cancer Center
Y-mAbs Therapeutics; Band of Parents

Completed

Humanized 3F8 Monoclonal Antibody (Hu3F8) in Patients With High-Risk Neuroblastoma and GD2-Positive Tumors

Neuroblastoma

United States
Alice Mims
Karyopharm Therapeutics Inc

Completed

Selinexor and Chemotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8... and other conditions

United States
Kari Kendra
Karyopharm Therapeutics Inc

Completed

Evaluating SINE KPT-330 in Treating Patients With Melanoma That Cannot Be Removed By Surgery (KPT-330)

Recurrent Melanoma

United States
Insight Therapeutics, LLC
Brown University; Genentech, Inc.; Case Western Reserve University

Active, not recruiting

Baloxavir Versus Oseltamivir for Nursing Home Influenza Outbreaks

Influenza | Influenza, Human | Influenza -Like Illness

United States
H. Lee Moffitt Cancer Center and Research Institute
Karyopharm Therapeutics Inc

Completed

Selinexor (KPT-330) and Liposomal Doxorubicin For Relapsed and Refractory Multiple Myeloma

Multiple Myeloma

United States
H. Lee Moffitt Cancer Center and Research Institute
Karyopharm Therapeutics Inc

Completed

Selinexor Plus High-Dose Melphalan (HDM) Before Autologous Hematopoietic Cell Transplantation for Multiple Myeloma

Multiple Myeloma

United States
Joshua Brody
Celldex Therapeutics

Completed

In Situ Vaccine for Low-Grade Lymphoma: Combination of Intratumoral Flt3L and Poly-ICLC With Low-Dose Radiotherapy

Low-Grade B-cell Lymphoma

United States
University of North Carolina, Chapel Hill
Midmark Corporation; Monitored Therapeutics, Inc

Completed

Assessing Adherence to Home Telemedicine in Individuals With Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

United States
Johns Hopkins University
University of Wisconsin, Madison; Frantz Viral Therapeutics, LLC

Completed

Intra-Anally Administered Artesunate in Patients With High-Grade Anal Intraepithelial Neoplasia (AIN 2/3) (ART-AIN)

Precancerous Conditions | Human Papilloma Virus | Anal Dysplasia | HPV-Related Anal Intraepithelial Neoplasia | AIN2/3 | Artesunate | Alternative Treatment

United States
Great Ormond Street Hospital for Children NHS Foundation...
Orchard Therapeutics

Completed

Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency

Adenosine Deaminase Deficiency | Severe Combined Immunodeficiencies (SCID)

United Kingdom
H. Lee Moffitt Cancer Center and Research Institute
Karyopharm Therapeutics Inc

Completed

Phase 2 Trial of Selinexor (KPT-330) for Metastatic Triple Negative Breast Cancer (TNBC)

Breast Cancer

United States
PTC Therapeutics
Cystic Fibrosis Foundation; ECFS-Clinical Trial Network (ECFS-CTN)

Completed

Study of Ataluren in Nonsense Mutation Cystic Fibrosis (ACT CF)

Cystic Fibrosis

United States, Spain, United Kingdom, Netherlands, Germany, France, Belgium, Italy, Australia, Argentina, Brazil, Bulgaria, Canada, Greece, Israel, Poland
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Karyopharm Therapeutics Inc

Completed

Phase I/II, Study of Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330) + Sorafenib in Acute Myeloid Leukemia

Acute Myeloid Leukemia | Leukemia

United States
Imperial College London
Sarepta Therapeutics, Inc.; Department of Health, United Kingdom

Completed

Safety and Efficacy Study of Antisense Oligonucleotides in Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy

United Kingdom
Nohla Therapeutics, Inc.
National Cancer Institute (NCI); Fred Hutchinson Cancer Center

Terminated

Expanded Cord Blood Cell Infusion Following Combination Chemotherapy in Younger Patients With Relapsed or Refractory Acute Myeloid Leukemia

Acute Myeloid Leukemia | Acute Leukemia of Ambiguous Lineage

United States
Michael Vogelbaum, MD, PhD
Infuseon Therapeutics, Inc.

Withdrawn

Intratumorally-Administered Topotecan Using CED in High Grade Glioma Undergoing Stereotactic Biopsy

Glioma

Clinical Trials Sponsored by Aestus Therapeutics

Sponsors and Collaborators

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Drug Interventions

CROs by country

CROs in Togo

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Rare Diseases

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