Clinical Trials Sponsored by Direct Therapeutics

Total 6456 results

TorreyPines Therapeutics

Completed

Study of NGX267 Oral Capsules in Patients With Xerostomia Associated With Sjorgren's Syndrome

Sjogren's Syndrome | Xerostomia

United States
Aegera Therapeutics

Terminated

Study of XIAP Antisense for Advanced Cancers

Advanced Cancer

United Kingdom
Amicus Therapeutics

Completed

A Study to Evaluate the Effects of Pharmacological Chaperones in Cells From Patients With Pompe Disease

Glycogen Storage Disease Type II | Pompe Disease

United States
Alaunos Therapeutics

Suspended

Study of Oral Palifosfamide Tris in Solid Tumors

Advanced Cancer
ImaRx Therapeutics

Terminated

Transcranial Ultrasound in Clinical SONothrombolysis (TUCSON)

Acute Ischemic Stroke

United States, France
Bayhill Therapeutics

Completed

Immunotherapy With BHT-3009 Alone or Combined With Atorvastatin in Patients With Multiple Sclerosis

Multiple Sclerosis

United States, Canada
Introgen Therapeutics

Unknown

Study to Compare the Overall Survival of Patients Receiving INGN 201 (Study Drug) With Patients Receiving Methotrexate

Carcinoma, Squamous Cell

United States
Critical Therapeutics

Completed

Assessment of PFT, Safety, and PK of Zileuton Injection in Asthma Patients

Asthma
Aeris Therapeutics

Terminated

Israeli 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1/2 Emphysema Study - Initial Formulation

Pulmonary Emphysema

Israel
Aeris Therapeutics

Completed

US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study

Pulmonary Emphysema

United States
Halozyme Therapeutics

Completed

Study of a Large Protein Molecule Administered With Escalating Doses of Recombinant Human Hyaluronidase

Rheumatoid Arthritis
Wellstat Therapeutics

Completed

Effects of PN2034 in Insulin-Dependent Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus

United States
Wellstat Therapeutics

Completed

Safety and Efficacy Study of PN2034 in Type 2 Diabetes Patients on Concomitant Rosiglitazone and Metformin (or Avandamet)

Type 2 Diabetes Mellitus

United States
Intarcia Therapeutics

Completed

Omega Interferon Alone or in Combination With Ribavirin in Subjects With Hepatitis C

Hepatitis C

Russian Federation
Point Therapeutics

Completed

Study of Talabostat and Cisplatin in Advanced Melanoma

Melanoma | Skin Cancer

United States
Point Therapeutics

Completed

Study of Talabostat in Advanced Melanoma

Melanoma | Skin Cancer

United States
MediQuest Therapeutics

Completed

Dose Response Study of a Topical Gel for the Treatment of Raynaud's Phenomenon

Raynaud's Disease | Raynaud's Disease Secondary to Scleroderma | Raynaud's Disease Secondary to Autoimmune Disease

United States
Cure Therapeutics

Unknown

Phase II Dose-Ranging Study of OrthoDerm Patch for Patients With Tennis Elbow

Tendonitis

Poland
Critical Therapeutics

Terminated

CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB)

Coronary Disease | Heart Valve Diseases

United States
Wellstat Therapeutics

Terminated

Phase I Study of PN401, Fluorouracil, Leucovorin and CPT-11 in Patients With Solid Tumors

Solid Tumors

United States
CRISPR Therapeutics AG
ViaCyte

Recruiting

An Open-Label, FIH Study Evaluating the Safety, Tolerability, and Efficacy of VCTX211 Combination Product in Subjects With T1D

Glucose Metabolism Disorders | Immune System Diseases | Autoimmune Diseases | Diabetes Mellitus | Endocrine System Diseases | Diabetes Mellitus, Type 1 | Metabolic Disease

Canada
iCell Gene Therapeutics
iCar Bio Therapeutics

Not yet recruiting

Anti-CD33 CAR-T Cells for the Treatment of Relapsed/Refractory CD33+ Acute Myeloid Leukemia

High Risk Hematologic Malignancies | Relapsed and/or Refractory Acute Myeloid Leukemia

China
Melinta Therapeutics, LLC

Recruiting

Open-Label, Dose-Finding, Pharmacokinetics, Safety and Tolerability Study of Oritavancin in Pediatric Patients With Suspected or Confirmed Bacterial Infections

Gram Positive Bacterial Infections

United States
TenNor Therapeutics Limited

Completed

TNP-2092 to Treat Acute Bacterial Skin and Skin Structure Infection (P2_ABSSSI)

Gram-Positive Bacterial Infections | Skin and Subcutaneous Tissue Bacterial Infections

United States
CRISPR Therapeutics AG
ViaCyte

Completed

An Open-Label, FIH Study Evaluating the Safety and Tolerability of VCTX210A Combination Product in Subjects With T1D

Glucose Metabolism Disorders | Immune System Diseases | Autoimmune Diseases | Diabetes Mellitus | Endocrine System Diseases | Diabetes Mellitus, Type 1 | Metabolic Disease

Canada
BlackThorn Therapeutics, Inc.
Neumora Therapeutics, Inc.

Completed

Study in Major Depressive Disorder With BTRX-335140 (NMRA-335140) vs Placebo

Major Depressive Disorder

United States
Sirion Therapeutics, Inc.
ReVision Therapeutics, Inc.

Completed

Study of Fenretinide in the Treatment of Geographic Atrophy Associated With Dry Age-Related Macular Degeneration

Geographic Atrophy | Dry Age Related Macular Degeneration
Melinta Therapeutics, LLC

Recruiting

Study to Evaluate the Safety and Tolerability of Single-Dose Intravenous (IV) Oritavancin

Acute Bacterial Skin and Skin Structure Infection

United States, Spain, Greece, Portugal, Bulgaria, Latvia, Romania, Lithuania, Poland
Windtree Therapeutics
CVie Therapeutics Co. Ltd.

Completed

The Clinical Study of the Safety and Efficacy of Istaroxime in Treatment of Acute Decompensated Heart Failure

Acute Decompensated Heart Failure

China, Italy
Millendo Therapeutics SAS

Terminated

Effects of Livoletide (AZP-531) on Food-related Behaviors in Patients With Prader-Willi Syndrome (ZEPHYR)

Hyperphagia | Prader-Willi Syndrome

United States, Belgium, Spain, France, Italy, United Kingdom, Australia, Netherlands
United Therapeutics
CVie Therapeutics Co. Ltd.

Withdrawn

An Open Label Extension Study to Evaluate the Safety of Continued Therapy of Subcutanous Remodulin® in Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension

China
United Therapeutics
CVie Therapeutics Co. Ltd.

Withdrawn

Safety, Tolerability, Pharmacokinetics and Efficacy of Two Different Rates of Subcutanous Remodulin® Dose Titration in Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension

China
Coapt, LLC
Congressionally Directed Medical Research Programs

Completed

Pattern Recognition Prosthetic Control (Adaptation)

Prosthesis User | Congenital Amputation of Upper Limb | Amputation; Traumatic, Limb

United States
Celldex Therapeutics

Not yet recruiting

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU) (EMBARQ-CSU2)

Chronic Spontaneous Urticaria
PYC Therapeutics

Not yet recruiting

MAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects (Wallaby)

Eye Diseases | Retinal Degeneration | Retinal Dystrophies | Retinal Disease | Retinitis Pigmentosa 11

United States
SURGE Therapeutics

Not yet recruiting

Study of STM-416p Administered to Patients Undergoing Radical Prostatectomy

Prostate Cancer
Celldex Therapeutics

Not yet recruiting

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (EMBARQ-CSU1)

Chronic Spontaneous Urticaria
Primoris Therapeutics

Not yet recruiting

A Study to Evaluate the Safety, Tolerability and Efficacy in Patients With Burn(s)

Burns | Burn Degree Second
Verismo Therapeutics

Recruiting

Long-Term Follow-Up Safety Study of Subjects Treated With SynKIR-110 in Cancer Studies

Cancer

United States
Adicet Therapeutics

Not yet recruiting

A Phase 1 Study of ADI-001 in Lupus Nephritis

Autoimmune Diseases | Lupus Nephritis
Ractigen Therapeutics.

Recruiting

A Study of RAG-01 in Patients With Non-muscle-invasive Bladder Cancer (NMIBC) Who Have Failed Bacillus Calmette Guérin (BCG) Therapy

Non-Muscle-Invasive Bladder Cancer (NMIBC)

Australia
NeuShen Therapeutics

Recruiting

First-into-human Study of NS-136 in Healthy Subjects

Healthy Subjects

Australia
Monopar Therapeutics

Recruiting

Diagnostic Efficacy and Dosimetry of MNPR-101-DFO*-89Zr in Patients With Solid Tumors

Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Lung Cancer | Bladder Cancer | Urothelial Carcinoma | Triple-negative Breast Cancer | Solid Tumor, Adult

Australia
vTv Therapeutics

Not yet recruiting

Cadisegliatin as Adjunctive Therapy in Type 1 Diabetes (CATT1)

Diabetes Mellitus, Type 1
Enliven Therapeutics

Recruiting

ELVN-002 With Trastuzumab +/- Chemotherapy in HER2+ Solid Tumors, Colorectal and Breast Cancer

Colorectal Cancer | HER2-positive Breast Cancer | HER2-positive Gastric Cancer | HER2 Amplification | HER2 Positive Solid Tumors

United States
OX2 Therapeutics

Recruiting

CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults

Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent High Grade Glioma

United States
Transcend Therapeutics

Recruiting

A Single, Ascending Dose Evaluation of the Safety, Pharmacokinetics of Methylone in Healthy Subjects

Post Traumatic Stress Disorder

Australia
Remix Therapeutics

Recruiting

Study of REM-422 in Patients With AML or Higher Risk MDS

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Acute Myeloid Leukemia Refractory | Higher Risk Myelodysplastic Syndromes

United States
Dianthus Therapeutics

Recruiting

A Phase 2 Study to Evaluate DNTH103 in Adults With Generalized Myasthenia Gravis (MAGIC) (MAGIC)

Myasthenia Gravis, Generalized

United States
Encoded Therapeutics

Recruiting

A Clinical Study to Evaluate the Safety and Efficacy of ETX101, an AAV9-Delivered Gene Therapy in Children With SCN1A-positive Dravet Syndrome (UK Only)

Dravet Syndrome

United Kingdom

Clinical Trials Sponsored by Direct Therapeutics

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