Search clinical trials for: Impaired Hepatic Function

Total 28100 results

Emory University

Terminated

Conjugated Hyperbilirubinemia and Pulse Oximetry

Liver Disease | Hyperbilirubinemia

United States
First Affiliated Hospital, Sun Yat-Sen University
Guangdong Province, Department of Science and Technology

Unknown

Enumeration and Function Analysis of Treg Cells in Peripheral Blood of HCC Patients Before and After Ablation Therapy

Hepatocellular Carcinoma

China
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Safety and Efficacy of Piperacillin/Tazobactam and Ampicillin/Sulbactam in Patients With Diabetic Foot Infections

Diabetes Mellitus | Diabetic Foot
Shanghai Jiao Tong University School of Medicine

Unknown

Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion

Preterm Infants

China
Weill Medical College of Cornell University

Unknown

Development of an Imaging Biomarker for Hepatic Fibrosis Using Gadoxetate Disodium

Hepatic Fibrosis

United States
National Cancer Institute (NCI)

Completed

Temsirolimus in Treating Patients With Metastatic Solid Tumor or Lymphoma That Cannot Be Removed By Surgery Who Have Different Levels of Liver Function

Lymphoma | Unspecified Adult Solid Tumor, Protocol Specific | Hepatic Complications

United States
Pfizer

Completed

Pharmacokinetics Of CP-690,550 In Patients With Impaired Renal Function

Renal Impairment

United States
National Cancer Institute (NCI)

Completed

Sorafenib in Treating Patients With Metastatic or Unresectable Solid Tumors, Multiple Myeloma, or Non-Hodgkin's Lymphoma With or Without Impaired Liver or Kidney Function

Stage II Multiple Myeloma | Stage III Multiple Myeloma | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma and other conditions

United States
University of Cologne

Unknown

Longterm Follow-up After Remote Ischemic Preconditioning for Prevention of Contrast-induced Nephropathy (RenProLong)

Impaired Renal Function

Germany
Seattle Institute for Biomedical and Clinical Research
VA Puget Sound Health Care System

Completed

Study to Evaluate the Effects of Colesevelam on Insulin Sensitivity and ß-Cell Function in Subjects With Impaired Fasting Glucose (Prediabetes)

Prediabetes | Impaired Fasting Glucose
Assistance Publique - Hôpitaux de Paris

Completed

Computer Prescribing System and Impaired Renal Function (Ordoclic-IR)

Impaired Renal Function

France
Cougar Biotechnology, Inc.

Completed

A Pharmacokinetic Study of Abiraterone Acetate in Male Participants With Impaired Renal Function Compared to Individuals With Normal Renal Function

Renal Insufficiency

United States
Jawaharlal Institute of Postgraduate Medical Education...

Completed

Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy

Pain, Postoperative | Stress Response | Inadequate or Impaired Respiratory Function | Analgesic Requirement | Return of Bowel Activity

India
Chonbuk National University Hospital

Completed

A Human Trial to Evaluate the Efficacy and Safety of Fermented Turmeric in Subjects Showing Mild Hepatic Injury

Mild Hepatic Injury

Korea, Republic of
Pfizer

Completed

A Study to Evaluate The Pharmacokinetics Of Crizotinib (PF-02341066) In Subjects With Impaired Renal Function

Renal Impairment

United States
Mutual Pharmaceutical Company, Inc.

Terminated

Comparative Study of Quinine Sulfate in Healthy Patients and in Patients With Renal Impairment

Healthy | Renal Impairment

United States
Kennon Heard
McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Completed

Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days (Non-Drinker)

Drug Induced Liver Injury

United States
Tel-Aviv Sourasky Medical Center

Unknown

The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers (Nanoexposure)

Inadequate or Impaired Respiratory Function
Cephalon

Completed

A Study to Evaluate the Pharmacokinetics of the Hydrocodone Extended-Release Tablet (CEP-33237) in Subjects With Normal Hepatic Function and Subjects With Moderate Hepatic Impairment

Hepatic Impairment

United States
Movetis

Completed

Evaluation of Prucalopride in Subjects With Moderate and Severe Hepatic Impairment (HI)

Hepatic Impairment

Russian Federation
Li Chen

Unknown

Comparison of Liver and Renal Function After Transarterial Chemoembolization for Primary Hepatocellular Carcinoma With Iso-osmolar Contrast Media and Low Osmolar Contrast Media

Primary Hepatocellular Carcinoma

China
Eisai Inc.

Completed

Study Of Eribulin (E7389) In Patients With Advanced Solid Tumors And Normal Or Reduced Hepatic Function As Per Child-Pugh System

Cancer

Netherlands
Anthera Pharmaceuticals

Terminated

A Study of the Pharmacokinetics and Safety of Varespladib in Subjects With Normal or Impaired Renal Function

Renal Impairment

United States
Genta Incorporated

Completed

Pharmacokinetic Study of Genasense in Subjects With Normal Renal Function, Mildly Impaired Renal Function, and Moderately Impaired Renal Function

Normal Renal Function | Mildly Impaired Renal Function | Moderately Impaired Renal Function

United States
Novartis Pharmaceuticals

Completed

A Study of Patupilone in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Function

Advanced Malignancies | Tumors

United States
Bristol-Myers Squibb

Completed

Hepatic Impaired Subjects Compared to Healthy Subjects Receiving Multi-dose BMS-650032

Hepatic Insufficiency

United States
NicOx

Completed

A Phase 1 Study to Compare the PK and Safety of Naproxcinod in Hepatic Impaired Patients and Matching Healthy Subjects

Liver Disease

United States
AstraZeneca

Completed

A Study of Fostamatinib in Subjects With Impaired Kidney Function

Rheumatoid Arthritis | Renal Impairment

United States
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study of the Pharmacokinetics of ER OROS Paliperidone in Volunteers With Normal or Impaired Renal Function

Schizophrenia | Renal Impairment
Peking Union Medical College Hospital

Unknown

Functional-three-dimensional Reconstruction of Liver by 99MTc-GSA-SPECT Scan (GSA)

Cirrhosis | Hepatic Carcinoma

China
Bristol-Myers Squibb

Completed

A Study of Dasatinib to See How Liver Impaired and Healthy Subjects Process and React to the Study Drug

Liver Diseases

United States
Baermed

Unknown

Hepatocyte Matrix Implant Study (HMI)

Liver Cirrhosis | Liver Disease

Switzerland
Roswell Park Cancer Institute

Completed

Surgery and Photodynamic Therapy in Treating Patients With Malignant Mesothelioma

Malignant Mesothelioma

United States
National Taiwan University Hospital

Unknown

Dynamic Contrast-enhanced Magnetic Resonance Imaging in Evaluation of Liver Functional Status and Treatment Efficacy in Patients With Hepatocellular Carcinoma After Locoregional Therapy

Hepatocellular Carcinoma

Taiwan
VIVUS LLC

Completed

To Assess the Safety of Avanafil in Healthy and Hepatically Impaired Male Subjects. (avanafil)

Erectile Dysfunction
ViiV Healthcare
Pfizer

Completed

Pharmacokinetics, Safety And Toleration Of Maraviroc Administered To Subjects With Various Degrees Of Renal Impaired And Normal Renal Function

Human Immunodeficiency Virus (HIV) Infection

Germany
University of Zurich
University of Texas Southwestern Medical Center; Swiss Federal Institute of...

Completed

Metabolic Acidosis in Renal Transplant Patients (MART)

Bone Disease | Metabolic Acidosis | Physical Capacity | Renal Transplant Patients | Mineral Metabolism

Switzerland
Griffin Hospital
Yale University; National Center for Complementary and Integrative Health (NCCIH)

Completed

Chromium Effects on Insulin and Vascular Function in People at Risk for Diabetes

Obesity | Insulin Resistance | Impaired Glucose Tolerance | Pre-diabetes | Impaired Fasting Glucose

United States
Astellas Pharma Inc

Completed

A Study to Assess the Effect of Hepatic Function on the Pharmacokinetics and Safety of ASP1941

Liver Disease

United States
Ruhr University of Bochum

Completed

Effects of Exenatide (Byetta®) on Liver Function in Patients With Nonalcoholic Steatohepatitis (NASH)

Nonalcoholic Fatty Liver Disease

Germany
Pacira Pharmaceuticals, Inc

Completed

Hepatic Impairment Study: Pharmacokinetics in Healthy and Hepatically Impaired Subjects

Pain | Hepatic Impairment

Poland
Göteborg University
The Swedish Research Council; Swedish Heart Lung Foundation; The Swedish Heart...

Completed

A Dangerous Triad in Ageing and in Chronic Obstructive Pulmonary Disease (COPD) - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition

Pulmonary Disease, Chronic Obstructive

Sweden
Pfizer

Terminated

A Single Dose Study Investigating the Elimination as Well as the Tolerability of PD 0332334 in Healthy Subjects as Compared to Patients With Impaired Kidney Function.

Renal Insufficiency | Pharmacokinetics

United States
National Institute of Diabetes and Digestive and...

Completed

Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes

Type 2 Diabetes Mellitus | Insulin Resistance

United States
Pfizer

Completed

A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Insufficiency

United States
Luzerner Kantonsspital
Pfizer

Completed

Pharmacokinetics of Dalteparin in Patients With Impaired Renal Function

Renal Insufficiency

Switzerland
Isfahan University of Medical Sciences
Shahid Motahari Hospital of Fooladshahr, Isfahan Steel Company, Isfahan

Completed

The Effect of DASH Diet on the Cardiometabolic Risks and Hepatic Function Among Type 2 Diabetic Patients

Type 2 Diabetic Patients

Iran, Islamic Republic of
Pfizer
Medivation, Inc.

Completed

A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function

Alzheimer's Disease | Huntington's Disease

United States
Klinikum Ludwigshafen

Completed

Influence of of a Lipid Emulsion on Inflammatory Response and Hepatic Function

Inflammatory Response | Hepatic Function

Germany
Shahid Beheshti University of Medical Sciences
Tarbiat Modarres University

Completed

Improvement of Liver Function in Liver Cirrhosis Patients After Autologous Mesenchymal Stem Cell Injection:a Phase I-II Clinical Trial

Liver Failure | Cirrhosis

Iran, Islamic Republic of

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