A Dangerous Triad in Ageing and in Chronic Obstructive Pulmonary Disease (COPD) - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition

A Dangerous Triad in Ageing and in COPD - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition

The investigators have taken part in the development of simple muscle function tests and studied physical training and energy turnover in patients with chronic obstructive pulmonary disease, COPD. The investigators have found that muscle wasting in COPD is related to poor prognosis and that physical training might lead to improved, less energy-demanding muscle function. Elderly subjects also suffer from muscle wasting that leads to frailty, poor autonomy and, secondarily, fractures. In the planned study the investigators will validate simple muscle function tests (hand grip strength, heel rise test, voluntary quadriceps muscle strength, 30 m walking test and balance tests) in both groups by relating them to an involuntary, magnet stimulated, test of quadriceps force, HRQL, tests of body composition (impedance, DXA) and recordings of physical activity. The relation between food intake, systemic inflammation, muscle mass and function will be analysed.

The study has been ethically approved and started in COPD patients and will be expanded to a representative sample of elderly.

Simple, evaluated muscle function tests applied in primary care may be used for early detection of muscle dysfunction in COPD patients and elderly so that early intervention against impaired muscle function can be started. Analyses of food intake and of inflammatory markers might identify factors of special importance for muscle dysfunction, which eventually might lead to improved dietary therapy and pharmacological interventions.

Study Overview

• Status: Completed
• Conditions: Pulmonary Disease, Chronic Obstructive

• Study Type: Observational

Contacts and Locations

Study Locations

• Sweden
  • Göteborg, Sweden, 44232
    • Dept of Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years to 81 years (Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Outpatients (COPD) and older adults living in Gothenburg

Description

Inclusion Criteria:

• Women and men between 65 and 81 years of age, randomly selected from the national registration, are invited to take part in the study.
• Patients referred to the outpatient clinic of the lung unit at Sahlgrenska University Hospital with a diagnosis of COPD are asked for participation.
• Inclusion criteria for COPD patients:
• Clinical diagnosis of COPD
• FEV% < normal value minus 2 SD
• Smoking history; 10 pack years or more

Exclusion Criteria:

• Any specific muscular disease
• Severe disease or handicap making investigations impossible
• Exclusion criteria for COPD patients:
• Any specific muscular disease
• Any co-existing serious disease

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
COPD-patients
Older adults (65-81 y)

Collaborators and Investigators

• Sponsor: Göteborg University
• Collaborators: The Swedish Research Council; Swedish Heart Lung Foundation; The Swedish Heart and Lung Association

Study record dates

Study Major Dates

• Study Start: March 1, 2006
• Primary Completion (Actual): December 1, 2009
• Study Completion (Actual): December 1, 2009

Study Registration Dates

• First Submitted: August 9, 2010
• First Submitted That Met QC Criteria: August 10, 2010
• First Posted (Estimate): August 11, 2010

Study Record Updates

• Last Update Posted (Estimate): August 11, 2010
• Last Update Submitted That Met QC Criteria: August 10, 2010
• Last Verified: January 1, 2006

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Nutrition Disorders; Lung Diseases, Obstructive; Lung Diseases; Pulmonary Disease, Chronic Obstructive; Malnutrition
• Other Study ID Numbers: UGOTTriad; Grant (Other Grant/Funding Number: Juan Rodés Grant (JR23/00018))