Search clinical trials for: Multiple oral doses

Total 32089 results

Murdoch Childrens Research Institute

Completed

A Phase II Dose-ranging Study of Oral RV3-BB Rotavirus Vaccine

Rotavirus Infections

Malawi
ViiV Healthcare

Completed

First-Time-in-Human (FTIH) Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PK) of VH4011499 in Healthy Participants

HIV Infections

United States
Bugworks Research Inc.
Avance Clinical Pty Ltd.

Completed

A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of BWC0977 in Healthy Volunteers

Bacterial Infections | Infectious Diseases

Australia
Griffin Hospital
Yale-Griffin Prevention Research Center; Multiple Sclerosis Treatment Center...

Active, not recruiting

Oral FMT (Fecal Microbial Transplant) in Subjects With Multiple Sclerosis

Multiple Sclerosis

United States
Anelixis Therapeutics, LLC

Completed

Multiple Doses of AT-1501-A201 in Adults With ALS

Amyotrophic Lateral Sclerosis

United States, Canada
Radius Pharmaceuticals, Inc.
Benuvia Therapeutics Inc.

Terminated

A Study to Assess the Long-Term Safety of Pharmaceutical Grade Synthetic Cannabidiol Oral Solution in Participants With Prader-Willi Syndrome

Prader-Willi Syndrome

United States
Keymed Biosciences Co.Ltd

Completed

A Multiple Ascending Doses Study of CM326 Injection in Healthy Subjects

Asthma

China
Bayer

Completed

The Aim of This Study is to Estimate the Discontinuation Rate of Low-dose Levonorgestrel-releasing Intrauterine System Due to Self-reported Unacceptable Menstrual Bleeding Pattern in Spanish Women Who Are Using it for the First Time How Intrauterine System for Long Acting Contraception (CORA)

Hormonal Intrauterine Contraception

Spain
Celgene

Completed

Safety and Efficacy of Pomalidomide, Bortezomib and Low-dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma (OPTIMISMM)

Multiple Myeloma

United States, Spain, United Kingdom, Italy, Israel, Portugal, Germany, Turkey, Greece, Ireland, Austria, Norway, Netherlands, Denmark, Poland, France, Russian Federation, Canada, Finland, Japan, Puerto Rico, Sweden
Biogen

Withdrawn

Study to Evaluate Oral BIIB061 Added to Interferon-beta1 (IFN-β1) or Glatiramer Acetate in Relapsing Multiple Sclerosis (RMS)

Relapsing Multiple Sclerosis
Nantes University Hospital

Active, not recruiting

A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse." (I2D IFM2021_03)

Multiple Myeloma at First Relapse

France
Taipei Medical University Shuang Ho Hospital
University of Southern California

Enrolling by invitation

Atorvastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease

Chronic Kidney Diseases | Autosomal Dominant Polycystic Kidney Disease

Taiwan
Daiichi Sankyo, Inc.

Completed

A Study to Assess the Safety and Pharmacokinetics of Multiple Ascending Subcutaneous Doses of DS-2325a in Healthy Subjects

Netherton Syndrome

United States
Bayer

Completed

A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses

Hypertension | Chronic Kidney Disease

Germany, Bulgaria
SNIPR Biome Aps.
Wellcome Trust; Biomedical Advanced Research and Development Authority

Completed

A Study Investigating the Safety, Recovery, and Pharmacodynamics of Multiple Oral Administrations of SNIPR001 in Healthy Subjects

Bloodstream Infection | E.Coli Infections

United States
Galmed Pharmaceuticals Ltd
Quotient Sciences

Completed

A First-in-Human Study of Single and Multiple Doses of Amilo-5MER in Healthy Subjects

Inflammatory Disease

United Kingdom
Alexion

Completed

A Study of Multiple Doses of ALXN1210 in Healthy Adult Participants

Healthy

United Kingdom
Pfizer

Completed

First-In-Human Study To Evaluate Safety, Tolerability, And Pharmacokinetics Following Single Ascending And Multiple Ascending Doses of PF-07304814 In Hospitalized Participants With COVID-19.

Viral Disease

United States, Spain, Brazil, Belgium
Johns Hopkins University

Completed

A Trial of Bile Acid Supplementation in Patients With Multiple Sclerosis

Progressive Multiple Sclerosis

United States
Aligos Therapeutics

Terminated

A Study of ALG-020572 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single Doses in Healthy Volunteers and Multiple Doses in CHB Subjects

Chronic Hepatitis B

United Kingdom, New Zealand
Janssen Research & Development, LLC

Completed

A Phase 1b Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of JNJ-64565111 in Participants With Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2

United States
National Institute of Allergy and Infectious Diseases...

Withdrawn

The Safety and Effectiveness of Different Doses of Vitamin C in HIV-Infected Patients

HIV Infections
Sunshine Lake Pharma Co., Ltd.

Completed

HEC53856 Phase 1 Study - Single and Multiple Oral Dosing in Healthy Volunteers

Healthy

China
Slovak Academy of Sciences
Comenius University

Completed

Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance (MS-MIDY)

Multiple Sclerosis | Mitochondrial Alteration

Slovakia
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Serum Concentrations of a Human Monoclonal Antibody, VRC-HIVMAB075-00-AB (VRC07-523LS), Administered in Multiple Doses and Routes to Healthy, HIV-uninfected Adults

HIV Infections

United States, Switzerland
Guangdong Hengrui Pharmaceutical Co., Ltd

Completed

A Trial of HRS-2261 in Healthy Subjects After Single and Multiple Oral Administration

Chronic Cough

China
Cairo University

Completed

OHRQoL and Parental Perception in a Group of Children and Adolescents With Down Syndrome: A Cross

Quality of Life | Down Syndrome | Oral Health

Egypt
Pyramid Biosciences

Completed

A Phase 1 Study to Assess Single and Multiple Ascending Doses of PBI-100 Topical Cream

Psoriasis | Healthy Volunteers

United States
Leiden University Medical Center
Erasmus Medical Center; Academisch Medisch Centrum - Universiteit van Amsterdam... and other collaborators

Withdrawn

Bezlotoxumab Versus FMT for Multiple Recurrent CDI (BSTEP)

Clostridium Infections | Enterocolitis, Pseudomembranous | Clostridioides Difficile

Netherlands
AstraZeneca

Completed

A Clinical Trial in Healthy Volunteers and Patients With Mild Asthma to Investigate a New Medicine (AZD4604) for the Treatment of Asthma

Asthma

United Kingdom
Centre Hospitalier Universitaire de Nice
Genzyme, a Sanofi Company

Completed

Randomized, Double-blinded Study of Treatment:Teriflunomide, in Radiologically Isolated Syndrome (TERIS)

Multiple Sclerosis

Turkey, France, Switzerland
GuiBin Qiao

Active, not recruiting

Dynamic Evolution of Pulmonary Nodules and Influence Factors of Its Clinical Decision-making (DEPICT)

Pulmonary Nodule, Solitary | Pulmonary Nodule, Multiple

China
Takeda

Completed

A Phase 3 Study Comparing Oral Ixazomib Plus Lenalidomide and Dexamethasone Versus Placebo Plus Lenalidomide and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma

Refractory Multiple Myeloma | Relapsed Multiple Myeloma

United States, Canada
Daiichi Sankyo, Inc.

Completed

A Study to Assess the Safety and Pharmacokinetics of Single Ascending Subcutaneous and Intravenous Doses of DS-2325a in Healthy Subjects

Netherton Syndrome

United States
AbbVie

Terminated

Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Lemzoparlimab With or Without Oral/IV Dexamethasone and in Combination With Oral/IV/Subcutaneous Anti-Myeloma Regimens in Adult Participants With Multiple Myeloma

Multiple Myeloma

United States, Australia, France, Germany, Israel, Japan, Spain
Kira Pharmacenticals (US), LLC.

Completed

To Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Escalating Single and Multiple Doses of KP104

Paroxysmal Nocturnal Hemoglobinuria

Australia
Inhibikase Therapeutics, Inc.

Completed

A Study to Assess Single and Multiple Doses of IkT-148009 in Healthy Elderly Participants and Parkinson's Patients

Parkinson Disease | Healthy Elderly

United States
Institute Franci

Active, not recruiting

Dimensional Alterations of the Edentulous Ridge Following Removal of Multiple Adjacent Teeth

Multiple Adjacent Teeth | Bone Remodelling

Italy
Bayer

Completed

A Study to Learn More About How Safe BAY2586116 is, How it Affects the Body, How it Moves Into, Through and Out of the Body at Different Doses in Healthy Japanese Male Participants After Taking Single and Multiple Doses Through the Nose

Obstructive Sleep Apnea

Japan
GlaxoSmithKline

Terminated

Safety, Tolerability and Pharmacokinetics (PKs) Investigation of GSK3186899 in Healthy Subjects

Leishmaniasis

United Kingdom
NEXTGEN Bioscience

Completed

A First-in-Human Study to Assess Single and Multiple Doses of NXC736 in Healthy Participants

Healthy

Korea, Republic of
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

Randomized, Open Label Safety Trial of Dapivirine Vaginal Ring and Oral TRUVADA® Use in Pregnancy

HIV Infections

South Africa, Uganda, Malawi, Zimbabwe
SoftOx Solutions AS

Completed

Safety and Tolerability of Single and Multiple Doses of SoftOx Biofilm Eradicator (SBE) in Chronic Leg Wounds

Venous Leg Ulcer | Chronic Leg Ulcer

Denmark
H. Lee Moffitt Cancer Center and Research Institute
Bristol-Myers Squibb; National Cancer Institute (NCI); Medarex

Completed

Multiple Class I Peptides & Montanide ISA 51 VG w Escalating Doses of Anti-PD-1 ab BMS936558

Melanoma (Skin)

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Safety, Tolerability, and Drug Levels of MYK-224 Administered in Single and Multiple Doses in Healthy Adult Japanese Participants

Healthy Volunteers

United States
Actelion

Completed

Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis (OPTIMUM)

Multiple Sclerosis

United States, Belarus, Bosnia and Herzegovina, Bulgaria, Canada, Croatia, Czechia, Finland, France, Georgia, Germany, Greece, Hungary, Israel, Italy, Latvia, Lithuania, Mexico, Poland, Portugal, Romania, Russian Federation, Serbia, S... and more
Hackensack Meridian Health
Millennium Pharmaceuticals, Inc.

Completed

Escalating Doses of Thalidomide in Conjunction With Bortezomib and HIgh Dose Melphalan for BSCT (Thal/Mel/Vel)

Multiple Myeloma

United States
Armata Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Safety and Microbiology of C16G2 Varnish Administered in Multiple Doses to Dental Subjects

Dental Caries

United States
Haisco Pharmaceutical Group Co., Ltd.

Completed

Safety, Tolerability,PK/PD, Food Effect of Single and Multiple Ascending Doses of HSK31858 in Healthy Volunteers

Healthy Volunteers

China
Bayer

Completed

PROMES: A Clinical Study in Which Researchers Want to Learn More About the Safety Profile of MESIGYNA (Norethisterone Enantate 50 mg and Estradiol Valerate 5 mg) Used as a Medication to Prevent Pregnancy for Adult Women in Reproductive Age in the Peruvian Population at the Outpatient Clinic. (PROMES)

Contraceptive

Peru

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