Search clinical trials for: second line

Total 22710 results

University of Liverpool
European and Developing Countries Clinical Trials Partnership (Funder); Joint... and other collaborators

Active, not recruiting

Dose Escalation Study to Determine the Pharmacokinetics of Atazanavir Administered With RIfampicin to HIV Positive Adults on sEcond-line ART Regimen With Suppressed HIV-1 Viral Load (DERIVE)

HIV/AIDS | Tuberculosis

Uganda
Samsung Medical Center

Completed

Pembrolizumab in Advanced Hepatocellular Carcinoma as Second-line Treatment After Failure of Sorafenib

Hepatocellular Carcinoma

Korea, Republic of
National Cancer Institute (NCI)

Completed

Busulfan, Fludarabine Phosphate, and Anti-Thymocyte Globulin Followed By Donor Stem Cell Transplant and Azacitidine in Treating Patients With High-Risk Myelodysplastic Syndrome and Older Patients With Acute Myeloid Leukemia

Acute Myeloid Leukemia | Recurrent Adult Acute Myeloid Leukemia | Myelodysplastic Syndrome | Myelodysplastic Syndrome With Excess Blasts | Secondary Myelodysplastic Syndrome | de Novo Myelodysplastic Syndrome | Adult Acute Monoblastic Leukemia | Adult Acute Monocytic Leukemia | Adult Acute Myeloid Leukemia... and other conditions

United States
Ente Ospedaliero Ospedali Galliera

Completed

Prevalence of Pulmonary Hypertension (PAH) in Patients With Thalassemia (PAH2010)

Pulmonary Arterial Hypertension | Thalassemia Major | Thalassemia Intermedia

Italy
Roswell Park Cancer Institute
Novartis

Completed

Dovitinib Lactate, Gemcitabine Hydrochloride, and Capecitabine in Treating Patients With Advanced or Metastatic Solid Tumors, Pancreatic Cancer and Biliary Cancers

Unspecified Adult Solid Tumor, Protocol Specific | Adenocarcinoma of the Pancreas | Stage III Pancreatic Cancer | Stage IV Pancreatic Cancer

United States
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy

HIV Infections

United States, Puerto Rico, Thailand, Botswana, Argentina, Brazil, Tanzania, South Africa
Fan Yun, MD

Completed

Apatinib for Extensive Stage Small Cell Lung Cancer After Second/Third Line Chemotherapy.

Small Cell Lung Cancer

China
SCRI Development Innovations, LLC
Celgene

Completed

Study of Nab-Paclitaxel and Ramucirumab as Second-line Treatment for Patients With Metastatic Gastroesophageal Cancer

Gastroesophageal Cancer

United States
Bristol-Myers Squibb
ICON Clinical Research

Completed

Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting (SIMPLICITY)

Chronic Myeloid Leukemia

Germany, United States, Italy, Spain, France, Netherlands, Puerto Rico, Russian Federation
Celgene

Completed

Quality of Life in Metastatic Breast Cancer (MBC) Patients in Second Line Monochemotherapy (DD-CMM)

Breast Neoplasms

Spain
Cellxpert Biotechnology Corp.
Medigen Biotechnology Corporation

Completed

Trial of PI-88 With Docetaxel in Advanced Non-Small-Cell Lung Cancer (NSCLC)

Carcinoma, Non-Small-Cell Lung

Australia
Boehringer Ingelheim

Completed

BI 2536 Second Line Monotherapy in SCLC

Carcinoma, Small Cell

United States, Canada
Blueprint Medicines Corporation

Completed

(NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors

Gastrointestinal Stromal Tumors (GIST) | Other Relapsed or Refractory Solid Tumors

United States, United Kingdom, France, Korea, Republic of, Belgium, Germany, Italy, Netherlands, Poland, Spain
Samsung Medical Center

Completed

Study of Pembrolizumab in Metastatic Biliary Tract Cancer as Second-line Treatment After Failing to at Least One Cytotoxic Chemotherapy Regimen: Integration of Genomic Analysis to Identify Predictive Molecular Subtypes

Biliary Tract Cancer

Korea, Republic of
Samsung Medical Center

Completed

Study of AZD1775 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harboring TP53 Mutation as a Second-line Chemotherapy

Advanced Gastric Adenocarcinoma

Korea, Republic of
Samsung Medical Center

Completed

Phase Ib, Single-arm Study of AZD6094 (Volitinib) in Combination With Docetaxel, in Any Solid Cancer and Sequential Phase II, Single-arm Study of AZD6094 (Volitinib) in Combination With Docetaxel in Advanced Gastric Adenocarcinoma Patients With MET Amplification as a Second Line Treatment

Advanced Gastric Adenocarcinoma

Korea, Republic of
Eli Lilly and Company

Completed

A Study of Paclitaxel With or Without Ramucirumab (LY3009806) in Participants With Gastric or Gastroesophageal Cancer

Gastric Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma

China, Malaysia, Thailand, Philippines
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100)

Unresectable, Locally Advanced or Metastatic, Adenocarcinoma of the Stomach, or of the Gastro Esophageal Junction

United States, Spain, Italy, Australia, Russian Federation, Taiwan, Korea, Republic of, Thailand, Canada, Turkey, Germany, Romania, United Kingdom, Hungary, Brazil, France, Japan
National Taiwan University Hospital

Completed

Comparison of the Levofloxacin Sequential Therapy and Quadruple Therapy in Second Line Treatment for HP

Helicobacter

Taiwan
University of Virginia
University of Tennessee

Completed

Enhancing the Efficacy of Smoking Quit Line in the Military (AFIII Renewal) (Freedom)

Initial Efficacy of Quit Line | Efficacy of Secondary Reengagement Intervention

United States
Brigham and Women's Hospital

Active, not recruiting

Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial

Postpartum Hemorrhage | Uterine Atony

United States
Kadmon Corporation, LLC

Terminated

KD019 Versus Erlotinib in Subjects With Stage IIIB/IV Non Small Cell Lung Cancer With Progression After First- or Second-Line Chemotherapy

Carcinoma, Non-Small-Cell Lung

United States
University Hospital, Brest
Roche Farma, S.A; Pierre Fabre Medicament; Groupe Français de Pneumo-Cancérologie

Completed

Trial to Evaluate Safety and Efficacy of Vinorelbine With Metronomic Administration in Combination With Atezolizumab as Second-line Treatment for Patients With Stage IV Non-small Cell Lung Cancer (VinMetAtezo)

Non-small Cell Lung Cancer

France
Pfizer

Completed

Axitinib (AG-013736) For the Treatment of Metastatic Renal Cell Cancer

Kidney Neoplasms

United States, China, Malaysia, India, Taiwan, Russian Federation, Mexico, Bosnia and Herzegovina, South Africa, Bulgaria, Chile, Philippines, Romania, Ukraine
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Withdrawn

A Study of Second-line Treatment of Postoperative Recurrence and Metastasis of Esophageal Cancer Treated With Apatinib

Esophageal Neoplasms
The Netherlands Cancer Institute

Completed

Optimal Sequencing of Treatment Options for Poor Risk mCRPC Previously Treated With Docetaxel (OSTRICh)

Metastasis | Prostate Cancer Metastatic

Netherlands
NewLink Genetics Corporation

Terminated

Immunotherapy Combination Study in Advanced Previously Treated Non-Small Cell Lung Cancer

Non-small Cell Lung Cancer | Non-small Cell Lung Cancer Recurrent | Progression of Non-small Cell Lung Cancer

United States
Medical Center Alkmaar
Foreest Medical School; Pulmoscience

Completed

Reduction of Antibiotic Therapy by Biomakers in Patients With CAP Episodes (REDUCE Study) (REDUCE)

Community Acquired Pneumonia

Netherlands
Brigham and Women's Hospital
Patient-Centered Outcomes Research Institute; McGill University; VA Boston Healthcare...

Active, not recruiting

Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study (CER-4-T2D)

Type2 Diabetes | Renal Disease | Cardiovascular Events

United States
Norwegian University of Science and Technology
Helse Midt-Norge

Active, not recruiting

A Longitudinal Study of Colorectal Cancer Patients With Metastatic Disease in Middle-Norway

Neoplasm Metastasis | Neoplasms, Colorectal

Norway
National Cancer Institute (NCI)

Completed

Pemetrexed and/or Sunitinib as Second-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer

Recurrent Non-Small Cell Lung Carcinoma | Stage IV Non-Small Cell Lung Cancer AJCC v7 | Stage IIIB Non-Small Cell Lung Cancer AJCC v7

United States
University of Nairobi
ViiV Healthcare

Completed

Second-line Switch to Dolutegravir Study (2SD)

HIV-1-infection

Kenya
Boehringer Ingelheim

Completed

A Study in the United States Using Electronic Medical Records (EMR) to Assess Effectiveness of Afatinib (Gilotrif) Following Pembrolizumab and Chemotherapy in the Treatment of Metastatic Squamous Cell Carcinoma of the Lung

Squamous Non-small Cell Lung Cancer

United States
UNICANCER

Completed

Efficacy of Chemotherapy, Associated to Either Cetuximab or Bevacizumab, in KRAS Wild-type Metastatic Colorectal Cancer Patients With Progressive Disease After Receiving First-line Treatment With Bevacizumab

Colorectal Cancer

France
Gruppo Italiano Malattie EMatologiche dell'Adulto

Active, not recruiting

Front-line Treatment of BCR-ABL+ Chronic Myeloid Leukemia (CML) With Dasatinib (CML1113)

Chronic Myeloid Leukemia

Italy
Gruppo Italiano Malattie EMatologiche dell'Adulto

Active, not recruiting

Front-line Nilotinib Treatment of BCR-ABL+ Chronic Myeloid Leukaemia in Chronic Phase (CML0912)

Chronic Phase Philadelphia Positive | BCR-ABL Positive | Chronic Myeloid Leukaemia

Italy
Shanghai 10th People's Hospital

Completed

Ankle Brachial Index Combined With Serum Uric Acid Levels Improve Prediction All Cause Mortality and Cardiovascular Mortality in the Elderly Chinese Population (abilities)

Ankle Brachial Index
Bayer

Completed

Descriptive Analysis of Clinical Outcomes in Patients With Prostate Gland Cancer, Which Spreads to Other Parts of the Body, Who Were Treated First With Novel Anti-hormone Therapy Followed by a Second Line Treatment With Novel Anti-Hormone Therapy or RadIum-223 (Xofigo). (PHENIX)

Metastatic Castration-resistant Prostate Cancer (mCRPC)

United States
Cancer Trials Ireland
Novartis

Completed

Second-line Pazopanib Renal Cell Carcinoma (RCC) Study. CTRIAL-IE (ICORG) 10-01, V5

Renal Cell Carcinoma

Ireland, Sweden
Intergruppo Melanoma Italiano

Active, not recruiting

To Evaluate the Efficacy Beyond Progression of Vemurafenib+Cobimetinib Associated With Local Treatment Compared to Second-line Treatment in Patients With BRAFV600+ Metastatic Melanoma in Focal Progression With First-line+Vemurafenib+Cobimetinib.

BRAF V600 Mutation | Melanoma Metastatic

Italy
Celgene

Completed

A Study to Evaluate the Efficacy and Safety of Lenalidomide as Maintenance Therapy for Patients With B-Cell Chronic Lymphocytic Leukemia (CLL) Following Second Line Therapy

B-cell Chronic Lymphocytic Leukemia

United States, Spain, United Kingdom, Canada, Belgium, Czechia, Hungary, Italy, Poland, Israel, Germany, Ireland, France, New Zealand, Denmark, Australia, Netherlands, Romania, Russian Federation, Sweden, Austria, South Africa, Colo... and more
Pfizer
TFS Trial Form Support

Completed

Study On Fatigue- And Hand-Foot Syndrome-Related Quality Of Life In Patients With Metastatic Renal Cell Carcinoma Receiving A Tyrosine Kinase Inhibitor as First-Line Treatment (TROYA)

Metastatic Renal Cell Carcinoma

Spain
Fudan University

Completed

The Comparison of XELOX and EOX in the First-line Treatment of Advanced Gastric Cancer

Gastric Cancer

China
Spectrum Pharmaceuticals, Inc

Terminated

Phase II Study of SPI-1620 in Combination With Docetaxel as a Second-Line to Treat Biliary Cancer

Biliary Cancer

United States
Prince of Songkla University

Terminated

BKM120 in Esophageal Squamous Cell Carcinoma After Failure of First Line Chemotherapy

Esophageal Cancer

Thailand
Institut de Recherches Internationales Servier
ADIR, a Servier Group company

Completed

A Study Evaluating S 95005 Plus Bevacizumab and Capecitabine Plus Bevacizumab in Patients With Previously Untreated Colorectal Cancer Who Are Non-eligible for Intensive Therapy (TASCO1)

Metastatic Colorectal Cancer

United Kingdom, Spain, Germany, Poland, Australia, Belgium, Brazil, Denmark, France, Italy, Netherlands, Russian Federation
Bristol-Myers Squibb

Completed

A Study of Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Second-Line Nivolumab Monotherapy in Asia (CheckMate870)

Non-Small Cell Lung Cancer | Lung Cancer

China, Thailand
West Virginia University
West Virginia Clinical and Translational Science Institute

Terminated

Carvedilol With Chemotherapy in Second Line Glioblastoma and Response of Circulating Tumor Cells

Glioblastoma | Glioblastoma Multiforme

United States
Cheryl Pugh

Completed

Combination Chemotherapy and Cetuximab as First-Line Therapy in Treating Patients With Advanced and/or Metastatic Colorectal Cancer

Colorectal Cancer

United Kingdom, Cyprus
Fondazione IRCCS Istituto Nazionale dei Tumori,...

Completed

Study to Compare CAPTEM vs FOLFIRI as Second Line Treatment in Advanced, Colorectal Cancer Patients (CAPTEM)

Metastatic Colorectal Cancer

Italy

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