- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02508532
(NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors
A Phase 1 Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors
Study Overview
Status
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Phase 1
Expanded Access
Contacts and Locations
Study Locations
-
-
-
Leuven, Belgium, 3000
- Leuven Cancer Institute University Hospitals Leuven
-
-
-
-
-
Lyon, France, 69008
- Centre Léon Bérard
-
Paris, France, 94805
- Institut Gustave Roussy
-
-
-
-
-
Essen, Germany, 45122
- University of Duisburg-Essen
-
-
-
-
-
Milan, Italy, 20133
- Fondazione IRCCS - Istituto Nazinale dei Tumori
-
-
-
-
-
Seoul, Korea, Republic of, 05505
- Asan Medical Center
-
-
-
-
-
Rotterdam, Netherlands, 3015
- Erasmus MC Cancer Institute
-
-
-
-
-
Warsaw, Poland, 02-781
- Centrum Onkologii-Instytut im. Marii Skłodowskiej-Curie w Warszawie
-
-
-
-
-
Barcelona, Spain, 08305
- Vall d' Hebron Institute of Oncology (VHIO)
-
-
-
-
-
London, United Kingdom, SW3 6JJ
- Royal Marsden Hospital
-
-
-
-
Arizona
-
Scottsdale, Arizona, United States, 85258
- Scottsdale Healthcare Hospitals DBA HonorHealth
-
-
California
-
Santa Monica, California, United States, 90403
- Sarcoma Oncology Center
-
-
Florida
-
Miami, Florida, United States, 33136
- Sylvester Comprehensive Cancer Center
-
-
Georgia
-
Atlanta, Georgia, United States, 30256
- Cancer Treatment Centers of America
-
-
Massachusetts
-
Boston, Massachusetts, United States, 02215
- Dana Farber Cancer Institute
-
-
New York
-
New York, New York, United States, 10065
- Memorial Sloan Kettering Cancer Center
-
-
Oregon
-
Portland, Oregon, United States, 97239
- Oregon Health and Science University
-
-
Pennsylvania
-
Philadelphia, Pennsylvania, United States, 19111
- Fox Chase Cancer Center
-
-
Texas
-
Houston, Texas, United States, 77030
- MD Anderson Cancer Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- For Part 1: Histologically- or cytologically-confirmed diagnosis of unresectable GIST or another advanced solid tumor. Patients with unresectable GIST must have disease that has progressed following imatinib and at least 1 of the following: sunitinib, regorafenib, sorafenib, dasatinib, pazopanib or an experimental kinase-inhibitor agent, or disease with a D842 mutation in the PDGFRα gene. Patients with an advanced solid tumor other than GIST must have relapsed or refractory disease without an available effective therapy.
OR For Part 2:
- Group 1: Patients must have a confirmed diagnosis of unresectable GIST that has progressed following imatinib and at least 1 of the following: sunitinib, regorafenib, sorafenib, dasatinib, pazopanib, or an experimental kinase-inhibitor agent, and the patient does not have a D842V mutation in PDGFRα.
- Group 2: Patients must have a confirmed diagnosis of unresectable GIST with a D842V mutation in the PDGFRα gene. The PDGFRα mutation will be identified by local or central assessment, either in an archival tissue sample or a new tumor biopsy obtained prior to treatment with avapritinib.
- Group 3: Patients must have a confirmed diagnosis of unresectable GIST that has progressed and/or patients must have experienced intolerance to imatinib and not received additional kinase-inhibitor therapy. Patients must not have a known D842V mutation in PDGFRα.
- Groups 1, 2 and 3: At least 1 measurable lesion defined by mRECIST 1.1 for patients with GIST.
- Groups 1 and 2: A tumor sample (archival tissue or a new tumor biopsy) has been submitted for mutational testing.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
Exclusion Criteria:
- QT interval corrected using Fridericia's formula (QTcF) >450 milliseconds
- Platelet count <90,000/mL
- Absolute neutrophil count <1000/mL
- Hemoglobin <9 g/dL
- Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) >3 x the upper limit of normal (ULN) if no hepatic metastases are present; >5 × ULN if hepatic metastases are present
- Total bilirubin >1.5 × ULN; >3 × ULN with direct bilirubin, >1.5 × ULN in the presence of Gilbert's Disease
- Estimated (Cockroft-Gault formula) or measured creatinine clearance <40 mL/min Brain malignancy or metastases to the brain
- History of a seizure disorder or requirement for anti-seizure medication
- Group 3: Patients known to be KIT wild type.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Sequential Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Part 1 Avapritinib (formerly BLU-285) 30 mg QD
Part 1: Patients received a starting dose of 30 mg QD for 28 days and they were assessed for dose limiting toxicities (DLT). If no DTLs were observed the dose escalation continued. Patients received avapritinib in continuous 28 day cycles until discontinuation. |
avapritinib tablets
Other Names:
|
Experimental: Part 1 Avapritinib (formerly BLU-285) 60 mg QD
Part 1: Patients received a starting dose of 60 mg QD for 28 days and they were assessed for dose limiting toxicities (DLT). If no DTLs were observed the dose escalation continued. Patients received avapritinib in continuous 28 day cycles until discontinuation. |
avapritinib tablets
Other Names:
|
Experimental: Part 1 Avapritinib (formerly BLU-285) 90 mg QD
Part 1: Patients received a starting dose of 90 mg QD for 28 days and they were assessed for dose limiting toxicities (DLT). If no DTLs were observed the dose escalation continued. Patients received avapritinib in continuous 28 day cycles until discontinuation. |
avapritinib tablets
Other Names:
|
Experimental: Part 1 Avapritinib (formerly BLU-285) 135 mg QD
Part 1: Patients received a starting dose of 135 mg QD for 28 days and they were assessed for dose limiting toxicities (DLT). If no DTLs were observed the dose escalation continued. Patients received avapritinib in continuous 28 day cycles until discontinuation. |
avapritinib tablets
Other Names:
|
Experimental: Part 1 Avapritinib (formerly BLU-285) 200 mg QD
Part 1: Patients received a starting dose of 200 mg QD for 28 days and they were assessed for dose limiting toxicities (DLT). If no DTLs were observed the dose escalation continued. Patients received avapritinib in continuous 28 day cycles until discontinuation. . |
avapritinib tablets
Other Names:
|
Experimental: Part 1 Avapritinib (formerly BLU-285) 300 mg QD
Part 1: Patients received a starting dose of 300 mg QD for 28 days and they were assessed for dose limiting toxicities (DLT). If no DTLs were observed the dose escalation continued. Patients received avapritinib in continuous 28 day cycles until discontinuation. Patients that received at least one dose of avapritinib were included in the Part 2 analysis. |
avapritinib tablets
Other Names:
|
Experimental: Part 1 Avapritinib (formerly BLU-285) 400 mg QD
Part 1: Patients received a starting dose of 400 mg QD for 28 days and they were assessed for dose limiting toxicities (DLT). If no DTLs were observed the dose escalation continued. Patients received avapritinib in continuous 28 day cycles until discontinuation. Patients that received at least one dose of avapritinib were included in the Part 2 analysis. |
avapritinib tablets
Other Names:
|
Experimental: Part 1 Avapritinib (formerly BLU-285) 600 mg QD
Part 1: Patients received a starting dose of 600 mg QD for 28 days and they were assessed for dose limiting toxicities (DLT). If no DTLs were observed the dose escalation continued. Patients received avapritinib in continuous 28 day cycles until discontinuation. |
avapritinib tablets
Other Names:
|
Experimental: Part 1 and Part 2 Avapritinib (formerly BLU-285) 300 mg or 400 mg QD
Part 1 and Part 2: Patients enrolled in Part 1 and Part 2 at a starting dose of 300 or 400 mg QD were included in the Part1/Part 2 safety and efficacy analysis. Patients received avapritinib in continuous 28 day cycles until discontinuation. |
avapritinib tablets
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Part 1: Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of Avapritinib
Time Frame: Cycle 1 (28 days) of treatment
|
Patients with event(s) of dose-limiting toxicity
|
Cycle 1 (28 days) of treatment
|
Parts 1 and 2: Number of Patients With Adverse Events (AE) and Serious Adverse Events (SAE)
Time Frame: AEs were collected from the start of study drug until 30 days after the last dose, SAEs were collected from the date of the informed consent signature until 30 days after the last dose of study drug, up to 5 years
|
The overall safety profile of the drug was assessed by reviewing the number of patients with AEs, SAEs and other events.
There was no formal statistical analysis.
Safety assessments continued for the duration of treatment.
|
AEs were collected from the start of study drug until 30 days after the last dose, SAEs were collected from the date of the informed consent signature until 30 days after the last dose of study drug, up to 5 years
|
Part 2: Objective Response Rate (ORR) Determined by Central Radiology Assessment Per mRECIST, Version 1.1
Time Frame: Tumor assessments were performed at screening, Cycle 3 Day 1, then every 2 cycles through Cycle 13, then every 3 cycles thereafter up to approximately 4 years. Each cycle is 28 days.
|
To evaluate objective response rate (ORR) determined by central radiology assessment per mRECIST, version 1.1 in patients with advanced GIST treated with avapritinib.
A complete response per modified Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) is defined as complete disappearance of all target lesions.
A partial response is defined as at least 30% decrease in the sum of diameters of target lesions taking as reference the baseline sum of diameters.
Overall Response (OR) = CR + PR
|
Tumor assessments were performed at screening, Cycle 3 Day 1, then every 2 cycles through Cycle 13, then every 3 cycles thereafter up to approximately 4 years. Each cycle is 28 days.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Maximum Plasma Drug Concentration (Cmax)
Time Frame: Cycle 1 Day 1
|
Maximum plasma drug concentration (Cmax) following a single dose of avapritinib
|
Cycle 1 Day 1
|
Time to Maximum Plasma Drug Concentration (Tmax)
Time Frame: Cycle 1 Day 1
|
Cycle 1 Day 1 PK time to maximum plasma drug concentration (Tmax)
|
Cycle 1 Day 1
|
Plasma Drug Concentration at 24 Hours Postdose Prior to the Next Daily Dose (C24)
Time Frame: Cycle 1 Day 1
|
Plasma drug concentration at 24 hours postdose prior to the next daily dose (C24) following a single dose of avapritinib
|
Cycle 1 Day 1
|
Area Under the Plasma Concentration-time Curve From Time 0 to 24 Hours (AUC 0-24)
Time Frame: Cycle 1 Day 1
|
Area under the plasma concentration-time curve from time 0 to 24 hours (AUC 0-24) following a single dose of avapritinib
|
Cycle 1 Day 1
|
Apparent Oral Clearance Unadjusted for Bioavailability (CL/F)
Time Frame: Cycle 1 Day 1
|
Apparent oral clearance unadjusted for bioavailability (CL/F) following a single dose of avapritinib
|
Cycle 1 Day 1
|
Apparent Volume of Distribution, Unadjusted for Bioavailability (Vz/F)
Time Frame: Cycle 1 Day 1
|
Apparent volume of distribution, unadjusted for bioavailability (Vz/F) following a single dose of avapritinib
|
Cycle 1 Day 1
|
Terminal Elimination Half-life (t1/2)
Time Frame: Cycle 1 Day 1
|
Terminal elimination half-life (t1/2) following a single dose of avapritinib
|
Cycle 1 Day 1
|
Maximum Plasma Drug Concentration (Cmax) at Steady State
Time Frame: Cycle 1 Day 15
|
Maximum plasma drug concentration (Cmax) at steady state following 15 days of QD dosing
|
Cycle 1 Day 15
|
Time of Maximal Concentration (Tmax) at Steady State
Time Frame: Cycle 1 Day 15
|
Time of maximal concentration (Tmax) at steady state following 15 days of QD dosing
|
Cycle 1 Day 15
|
Plasma Drug Concentration at 24 Hours Postdose Prior to the Next Daily Dose at Steady State (C24,ss)
Time Frame: Cycle 1 Day 15
|
Plasma Drug Concentration at 24 Hours Postdose Prior to the Next Daily Dose at steady state (C24,ss) following 15 days of QD dosing
|
Cycle 1 Day 15
|
Area Under the Plasma Concentration-time Curve Over the Dosing Interval at Steady Sate (AUC0-τ,ss) (τ=24 h)
Time Frame: Cycle 1 Day 15
|
Area under the plasma concentration-time curve over the dosing interval at steady sate (AUC0-τ,ss) (τ=24 h) following 15 days of QD dosing
|
Cycle 1 Day 15
|
Progression-free Survival Per mRECIST Version 1.1
Time Frame: Tumor assessments were performed at screening, Cycle 3 Day 1, then every 2 cycles through Cycle 13, then every 3 cycles thereafter up to approximately 4 years. Each cycle is 28 days.
|
Progression-free survival is defined as the time in months from the start of treatment to the date of first documented progression or death due to any cause.
Progression-free survival determined by central radiological assessment per modified Response Evaluation Criteria in Solid Tumors (mRECIST), version 1.1 in patients with advanced GIST.
A progressively growing tumor must meet the following criteria: a) the target lesions must be greater or equal to 2cm in size and be a new GIST active lesion or b) the target lesions must be expanding on at least 2 sequential imaging studies.
|
Tumor assessments were performed at screening, Cycle 3 Day 1, then every 2 cycles through Cycle 13, then every 3 cycles thereafter up to approximately 4 years. Each cycle is 28 days.
|
Apparent Oral Clearance at Steady State, Unadjusted for Bioavailability (CLss/F)
Time Frame: Cycle 1 Day 15
|
Apparent oral clearance at steady state, unadjusted for bioavailability (CLss/F) following 15 days of QD dosing
|
Cycle 1 Day 15
|
Clinical Benefit Rate Determined by Central Radiology Assessment Per mRECIST, Version 1.1
Time Frame: Tumor assessments were performed at screening, Cycle 3 Day 1, then every 2 cycles through Cycle 13, then every 3 cycles thereafter up to approximately 4 years. Each cycle is 28 days.
|
Percent of patients with a complete response, partial response or stable disease lasting more than 16 weeks.
A complete response per modified Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) is defined as complete disappearance of all target lesions.
A partial response is defined as at least 30% decrease in the sum of diameters of target lesions taking as reference the baseline sum of diameters.
Stable disease is defined as a tumor that does not meet the criteria for progression or for response.
A progressively growing tumor must meet the following criteria: a) the target lesions must be greater or equal to 2cm in size and be a new GIST active lesion or b) the target lesions must be expanding on at least 2 sequential imaging studies.
|
Tumor assessments were performed at screening, Cycle 3 Day 1, then every 2 cycles through Cycle 13, then every 3 cycles thereafter up to approximately 4 years. Each cycle is 28 days.
|
Response Rate Determined by Central Radiology Assessment Per Choi Criteria
Time Frame: Tumor assessments were performed at screening, Cycle 3 Day 1, then every 2 cycles through Cycle 13, then every 3 cycles thereafter up to approximately 4 years. Each cycle is 28 days.
|
A complete response is defined as complete disappearance of all target lesions.
A partial response is ≥10% decrease tumor size at computed tomography (CT) or ≥15% decrease in tumor attenuation at computed tomography (CT) and no new lesions.
The response rate is defined as complete response plus partial response.
|
Tumor assessments were performed at screening, Cycle 3 Day 1, then every 2 cycles through Cycle 13, then every 3 cycles thereafter up to approximately 4 years. Each cycle is 28 days.
|
Duration of Response Determined by Central Radiology Assessment Per mRECIST, Version 1.1
Time Frame: Tumor assessments were performed at screening, Cycle 3 Day 1, then every 2 cycles through Cycle 13, then every 3 cycles thereafter up to approximately 4 years. Each cycle is 28 days.
|
Duration from time to first documented CR/PR to date of first documented disease progression or death. A complete response per modified Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) is defined as complete disappearance of all target lesions. A partial response is defined as at least 30% decrease in the sum of diameters of target lesions taking as reference the baseline sum of diameters. Overall Response (OR) = CR + PR |
Tumor assessments were performed at screening, Cycle 3 Day 1, then every 2 cycles through Cycle 13, then every 3 cycles thereafter up to approximately 4 years. Each cycle is 28 days.
|
Median PFS on Last Prior Anti-cancer Therapy
Time Frame: Historical data collected at enrollment, all available data on prior therapy was collected
|
Progression Free Survival (PFS) is defined as the time in months from the start of treatment to the date of first documented disease progression or death due to any cause, which ever occurs first.
PFS on last prior anti-cancer therapy is defined as the time in months from the start of last prior anti-cancer therapy to progression on that therapy.
|
Historical data collected at enrollment, all available data on prior therapy was collected
|
Change From Baseline in Levels of KIT and PDGFRα Mutant Allele Fractions in Peripheral Blood
Time Frame: Baseline and End of treatment
|
Change of mutant allele fraction (MAF) summarizes the largest fold change.
Change from baseline only displayed for patients with pre and post treatment MAF measurements.
A positive number represents an increase in MAF.
Data is only provided for patients that had both a baseline measurement and an end of treatment measurement.
|
Baseline and End of treatment
|
KIT, PDGFRA, and Other Cancer-relevant Mutations Present in Tumor Tissue at Baseline and EOT
Time Frame: Baseline and end of treatment
|
Change in mutations in tumor tissue at baseline and end of treatment (EOT).
EOT tumor biopsies were optional and there were no EOT samples collected.
|
Baseline and end of treatment
|
Collaborators and Investigators
Sponsor
Publications and helpful links
General Publications
- Kang YK, George S, Jones RL, Rutkowski P, Shen L, Mir O, Patel S, Zhou Y, von Mehren M, Hohenberger P, Villalobos V, Brahmi M, Tap WD, Trent J, Pantaleo MA, Schoffski P, He K, Hew P, Newberry K, Roche M, Heinrich MC, Bauer S. Avapritinib Versus Regorafenib in Locally Advanced Unresectable or Metastatic GI Stromal Tumor: A Randomized, Open-Label Phase III Study. J Clin Oncol. 2021 Oct 1;39(28):3128-3139. doi: 10.1200/JCO.21.00217. Epub 2021 Aug 3.
- von Mehren M, Heinrich MC, Shi H, Iannazzo S, Mankoski R, Dimitrijevic S, Hoehn G, Chiroli S, George S. Clinical efficacy comparison of avapritinib with other tyrosine kinase inhibitors in gastrointestinal stromal tumors with PDGFRA D842V mutation: a retrospective analysis of clinical trial and real-world data. BMC Cancer. 2021 Mar 19;21(1):291. doi: 10.1186/s12885-021-08013-1.
- Jones RL, Serrano C, von Mehren M, George S, Heinrich MC, Kang YK, Schoffski P, Cassier PA, Mir O, Chawla SP, Eskens FALM, Rutkowski P, Tap WD, Zhou T, Roche M, Bauer S. Avapritinib in unresectable or metastatic PDGFRA D842V-mutant gastrointestinal stromal tumours: Long-term efficacy and safety data from the NAVIGATOR phase I trial. Eur J Cancer. 2021 Mar;145:132-142. doi: 10.1016/j.ejca.2020.12.008. Epub 2021 Jan 16.
- Joseph CP, Abaricia SN, Angelis MA, Polson K, Jones RL, Kang YK, Riedel RF, Schoffski P, Serrano C, Trent J, Tetzlaff ED, Si TD, Zhou T, Doyle A, Bauer S, Roche M, Havnaer T. Optimal Avapritinib Treatment Strategies for Patients with Metastatic or Unresectable Gastrointestinal Stromal Tumors. Oncologist. 2021 Apr;26(4):e622-e631. doi: 10.1002/onco.13632. Epub 2021 Jan 5.
- Heinrich MC, Jones RL, von Mehren M, Schoffski P, Serrano C, Kang YK, Cassier PA, Mir O, Eskens F, Tap WD, Rutkowski P, Chawla SP, Trent J, Tugnait M, Evans EK, Lauz T, Zhou T, Roche M, Wolf BB, Bauer S, George S. Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR): a multicentre, open-label, phase 1 trial. Lancet Oncol. 2020 Jul;21(7):935-946. doi: 10.1016/S1470-2045(20)30269-2. Erratum In: Lancet Oncol. 2020 Sep;21(9):e418.
- Gebreyohannes YK, Wozniak A, Zhai ME, Wellens J, Cornillie J, Vanleeuw U, Evans E, Gardino AK, Lengauer C, Debiec-Rychter M, Sciot R, Schoffski P. Robust Activity of Avapritinib, Potent and Highly Selective Inhibitor of Mutated KIT, in Patient-derived Xenograft Models of Gastrointestinal Stromal Tumors. Clin Cancer Res. 2019 Jan 15;25(2):609-618. doi: 10.1158/1078-0432.CCR-18-1858. Epub 2018 Oct 1.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
- gastrointestinal stromal tumor
- PDGFRA
- Avapritinib
- BLU-285
- 2L GIST
- GIST second line
- GIST gleevec
- GIST imatinib
- Second-line GIST clinical trial
- BLU 285
- BLUE-285
- BLUE 285
- GIST imatinib relapse
- GIST gleevec relapse
- GIST KIT
- GIST relapse
- GIST refractory
- GIST imatinib intolerance
- GIST TKI treatment
- GIST tyrosine kinase inhibitor treatment
- GIST TKI
- GIST tyrosine kinase inhibitor
- Advanced GIST
- GIST mutations
- GIST treatments
- Blueprint GIST
- Relapsed GIST clinical trial
- Refractory GIST clinical trial
- KIT-mutant GIST
- cancer gist
- gist cancer
Additional Relevant MeSH Terms
Other Study ID Numbers
- BLU-285-1101
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Gastrointestinal Stromal Tumors (GIST)
-
Centre Leon BerardRecruitingC-KIT Mutation | Metastatic Gastrointestinal Stromal Tumor (GIST) | Advanced Gastrointestinal Stromal Tumor (GIST)France
-
Centre Leon BerardRecruitingMetastatic Gastrointestinal Stromal Tumor | Unresectable Gastrointestinal Stromal Tumor (GIST) | Locally Advanced Gastrointestinal Stromal Tumor (GIST)France
-
Centre Leon BerardGustave Roussy, Cancer Campus, Grand ParisCompletedSarcoma | Gastro-intestinal Stromal Tumors (GIST)France
-
Novartis PharmaceuticalsCompleted
-
National University Hospital, SingaporeUnknownAsian Patients With Advanced Gastro-intestinal Stromal Tumors (GIST) Treated With ImatinibSingapore
-
Novartis PharmaceuticalsCompleted3rd Line GISTFrance, United Kingdom, Belgium, Canada, Spain, Netherlands, Japan, United States
-
Novartis PharmaceuticalsCompleted3rd Line GISTItaly, Belgium, Spain, Netherlands, Germany, United Kingdom, France, United States
-
National Health Research Institutes, TaiwanNational Taiwan University Hospital; Mackay Memorial Hospital; China Medical... and other collaboratorsRecruitingGastrointestinal Stromal Tumor (GIST)Taiwan
-
Kristen GanjooGlaxoSmithKlineTerminatedGastrointestinal Stromal Tumor (GIST)United States
-
Instituto Ecuatoriano de Enfermedades DigestivasRecruitingGastrointestinal Stromal Tumor (GIST)Ecuador
Clinical Trials on Avapritinib
-
The First Affiliated Hospital of Soochow UniversityRecruitingCore Binding Factor Acute Myeloid Leukemia | KIT Mutation-Related TumorsChina
-
Blueprint Medicines CorporationCompletedMast Cell Leukemia | Aggressive Systemic Mastocytosis | Systemic Mastocytosis-associated Hematologic Non-mast Cell Disease | Relapsed or Refractory Myeloid MalignanciesUnited States, United Kingdom
-
Blueprint Medicines CorporationRecruitingCNS Tumor | Solid Tumor, Unspecified, Child | Relapsed Solid NeoplasmUnited States, Korea, Republic of, United Kingdom, France, Canada, Australia, Austria, Germany, Italy
-
Blueprint Medicines CorporationActive, not recruitingGastrointestinal Stromal TumorsFrance
-
Blueprint Medicines CorporationApproved for marketing
-
Centre Leon BerardBlueprint Medicines CorporationActive, not recruitingGIST, Malignant | GIST | PDGFR-Alpha D842VFrance
-
Blueprint Medicines CorporationActive, not recruitingMast Cell Leukemia | Aggressive Systemic Mastocytosis | Advanced Systemic Mastocytosis | Systemic Mastocytosis With an Associated Hematologic NeoplasmUnited States, Canada, United Kingdom, France, Netherlands, Italy, Spain, Austria, Denmark, Germany, Norway, Poland
-
Blueprint Medicines CorporationActive, not recruitingIndolent Systemic MastocytosisCanada, United States, Spain, United Kingdom, Germany, Belgium, Switzerland, Italy, Netherlands, Denmark, France, Norway, Sweden
-
Blueprint Medicines CorporationCompletedGISTUnited States, Korea, Republic of, Netherlands, China, France, Spain, Italy, Belgium, United Kingdom, Singapore, Australia, Canada, Germany, Sweden, Hungary, Austria, Czechia, Poland