Clinical Trials Sponsored by Enliven Therapeutics

Total 6353 results

PIQUR Therapeutics AG
Hospital Universitari Vall d'Hebron Research Institute; Institut Català d'Oncologia and other collaborators

Completed

PQR309 and Eribulin in Metastatic HER2 Negative and Triple-negative Breast Cancer (PIQHASSO)

Metastatic Breast Cancer

Spain, United Kingdom
National Human Genome Research Institute (NHGRI)
National Center for Advancing Translational Sciences (NCATS); Therapeutics...

Completed

Phase I Clinical Trial of ManNAc in Patients With GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM)

GNE Myopathy | Hereditary Inclusion Body Myopathy (HIBM)

United States
University of Manchester
University College, London; Manchester University NHS Foundation Trust; Orchard... and other collaborators

Active, not recruiting

Gene Therapy With Modified Autologous Hematopoietic Stem Cells for Patients With Mucopolysaccharidosis Type IIIA

Mucopolysaccharidosis Type IIIA

United Kingdom
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Terminated

Serum-Free Thymus Transplantation in DiGeorge Anomaly (SerumFree)

DiGeorge Anomaly
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Thymus Transplantation Dose in DiGeorge #932

DiGeorge Syndrome | DiGeorge Anomaly | Complete DiGeorge Anomaly | Complete DiGeorge Syndrome

United States
University of California, Los Angeles
National Institute of Allergy and Infectious Diseases (NIAID); National Heart... and other collaborators

Completed

Autologous CD34+ Hematopoietic Stem Cells Transduced ex Vivo With Elongation Factor 1 Alpha Shortened (EFS) Lentiviral Vector Encoding for the Human ADA Gene

ADA-SCID

United States
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Approved for marketing

Thymus Transplantation Safety-Efficacy

DiGeorge Syndrome | DiGeorge Anomaly | Complete DiGeorge Anomaly | Complete DiGeorge Syndrome

United States
ScandiBio Therapeutics AB
Göteborg University; Helsinki University Central Hospital; Sahlgrenska University... and other collaborators

Unknown

Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease (NAFLD)

Non-alcoholic Fatty Liver Disease (NAFLD)

Turkey
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Thymus Transplantation With Immunosuppression (884)

DiGeorge Syndrome | DiGeorge Anomaly | Complete DiGeorge Anomaly | Complete DiGeorge Syndrome

United States
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Phase I/II Thymus Transplantation With Immunosuppression #950 (#950)

DiGeorge Anomaly | Complete DiGeorge Anomaly | Complete DiGeorge Syndrome | Complete Atypical DiGeorge Anomaly | Complete Atypical DiGeorge Syndrome

United States
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Thymus Transplantation in DiGeorge Syndrome #668

DiGeorge Syndrome | Complete Typical DiGeorge Anomaly

United States
Tuscaloosa Research & Education Advancement Corporation
Baylor College of Medicine; James J. Peters Veterans Affairs Medical Center; Acorda... and other collaborators

Completed

Nepicastat for Posttraumatic Stress Disorder (PTSD) in OIF/OEF Veterans (Nepicastat)

Posttraumatic Stress Disorder

United States
Johns Hopkins University
Eli Lilly and Company; National Heart, Lung, and Blood Institute (NHLBI); The... and other collaborators

Completed

A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis (ATPAHSS)

Systemic Sclerosis | Pulmonary Arterial Hypertension | Pulmonary Hypertension | Connective Tissue Disease | Scleroderma Spectrum of Diseases

United States
Pharmacotherapies for Alcohol and Substance Use...
Yale University; United States Department of Defense; VA Connecticut Healthcare... and other collaborators

Not yet recruiting

Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study

Post Traumatic Stress Disorder (PTSD) | Alcohol Use Disorder (AUD)

United States
Pharmacotherapies for Alcohol and Substance Use...
Yale University; United States Department of Defense; VA Connecticut Healthcare... and other collaborators

Completed

Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) - Alcohol Interaction Study

Post Traumatic Stress Disorder (PTSD) | Alcohol Use Disorder (AUD)

United States
ERP Biomarker Qualification Consortium
Merck Sharp & Dohme LLC; Novartis; Takeda; H. Lundbeck A/S; Astellas Pharma Inc; Alkermes... and other collaborators

Completed

Effects of Ketamine on ERP/EEG Measures in Healthy Volunteers

Healthy

United States
Canadian Cancer Trials Group
Canadian Cancer Society (CCS); ATGen Canada Inc; Ontario Institute for Cancer... and other collaborators

Active, not recruiting

Immunization With IMM-101 vs Observation for Prevention of Respiratory and Severe COVID-19 Related Infections in Cancer Patients at Increased Risk of Exposure (COV-IMMUNO)

Covid-19 | Cancer

Canada
Society of Minimally Invasive Neurological Therapeutic...
Egyptian Stroke Society; Egyptian Society of Neurological Surgeons; Egyptian... and other collaborators

Unknown

Stroke in Egyptian Clinical REgisTry (SECRET)

Stroke, Acute | Stroke Hemorrhagic | Stroke, Cardiovascular | Stroke, Complication | Stroke Spinal Cord

Egypt
GCP-Service International West GmbH
Saint-Louis Hospital, Paris, France; University of Florence; Medical University... and other collaborators

Not yet recruiting

RVU120 for Treatment of Anemia in Patients With Lower-risk Myelodysplastic Neoplasms ((MDS))

Low Risk Myelodysplastic Syndromes

Spain, Poland, Italy, Germany, France
Australian & New Zealand Children's Haematology...
The Hospital for Sick Children; Kazia Therapeutics Limited; Day One Biopharmaceuticals... and other collaborators

Not yet recruiting

Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

Childhood Cancer | Refractory Cancer | Recurrent Cancer | Childhood Solid Tumor | Childhood Brain Tumor

Australia, Canada
Kyoto University
Osaka University; Mie University; Tokushima University; Tokyo Metropolitan Geriatric... and other collaborators

Completed

Repurposing Bromocriptine for Abeta Metabolism in Alzheimer's Disease (REBRAnD)

Familial Alzheimer Disease (FAD) | PSEN1 Mutation

Japan
PIQUR Therapeutics AG
M.D. Anderson Cancer Center; Mayo Clinic; University College London Hospitals; Hospital... and other collaborators

Completed

Study of Oral PQR309 in Patients With Advanced Solid Tumors

Cancer

United States
University of Rochester
Johns Hopkins University; Massachusetts General Hospital; University of California... and other collaborators

Completed

Safety and Tolerability Study of Phenylbutyrate in Huntington's Disease (PHEND-HD)

Huntington's Disease

United States
Children's Hospital of Philadelphia
Eli Lilly and Company; University of Pennsylvania; Takeda; National Institute of... and other collaborators

Recruiting

The Myelin Disorders Biorepository Project (MDBP)

Mucopolysaccharidoses | Leukoencephalopathies | Leukodystrophy | Adrenoleukodystrophy | Adrenomyeloneuropathy | X-linked Adrenoleukodystrophy | Gangliosidoses | Metachromatic Leukodystrophy | Krabbe Disease | Refsum Disease | Cadasil | Sjogren-Larsson Syndrome | Allan-Herndon-Dudley Syndrome | White Matter Disease | GM2... and other conditions

United States
Albert Einstein College of Medicine
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Enrolling by invitation

ScreenPlus: A Comprehensive, Flexible, Multi-disorder Newborn Screening Program (ScreenPlus)

Mucopolysaccharidosis II | Fabry Disease | Niemann-Pick Disease, Type C | Mucopolysaccharidosis VI | Lysosomal Acid Lipase Deficiency | Metachromatic Leukodystrophy | Gaucher Disease | Cerebrotendinous Xanthomatosis | Mucopolysaccharidosis IV A | GM1 Gangliosidosis | Mucopolysaccharidosis VII | Acid Sphingomyelinase... and other conditions

United States
Lawson Health Research Institute
Ontario Ministry of Health and Long Term Care; Canadian Mental Health Association and other collaborators

Completed

Diabetes Screening, Risk Management and Disease Management in a High-Risk Mental Health Population

Psychotic Disorders | Diabetes Mellitus | Schizophrenia

Canada
University of Nebraska
Bnai Zion Medical Center; InCor Heart Institute; Microvascular Therapeutics, LLC and other collaborators

Withdrawn

Utilization of Diagnostic Ultrasound in the Detection and Therapy of Acute Coronary Syndromes

Myocardial Infarction | Acute Coronary Syndrome

United States
ERP Biomarker Qualification Consortium
Merck Sharp & Dohme LLC; Novartis; Takeda; H. Lundbeck A/S; Columbia University; Astellas... and other collaborators

Completed

Event-Related Potential (ERP) Biomarkers in Subjects With Schizophrenia and Healthy Volunteer Subjects

Schizophrenia

United States
LUNGevity Foundation
Bristol-Myers Squibb; Eli Lilly and Company; Merck Sharp & Dohme LLC; Novartis; T... and other collaborators

Recruiting

Project PEER: Understanding the Lung Cancer Patient ExperiEnce in the Real-World Setting (PEER)

Caregivers | Lung Cancer Patients

United States
AIDS Clinical Trials Group
Bristol-Myers Squibb; National Institute of Allergy and Infectious Diseases... and other collaborators

Completed

Comparative Study of Three NNRTI-Sparing HAART Regimens

HIV Infection

United States, Puerto Rico
Tufts Medical Center
Brigham and Women's Hospital; Poznan University of Medical Sciences; Baystate... and other collaborators

Completed

Efficacy of Recombinant Human Clara Cell 10 Protein (rhCC10) Administered to Premature Neonates With Respiratory Distress Syndrome

Bronchopulmonary Dysplasia | Respiratory Distress Syndrome in Premature Infant

United States
University of Southern California
National Institute on Aging (NIA); Alzheimer's Therapeutic Research Institute; Brigham and Women's Hospital and other collaborators

Completed

TRC-PAD Program: In-Clinic Trial-Ready Cohort (TRC-PAD)

Dementia | Alzheimer Disease | Prodromal Alzheimer's Disease | Preclinical Alzheimer's Disease

United States
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Parathyroid and Thymus Transplantation in DiGeorge #931

DiGeorge Syndrome | Hypoparathyroidism | Complete DiGeorge Syndrome

United States
University of Kansas Medical Center
Hoffmann-La Roche; Seattle Children's Hospital; University of Rochester; University... and other collaborators

Recruiting

Motor Outcomes to Validate Evaluations in FSHD (MOVE FSHD) (MOVE FSHD)

FSHD

United States, Canada, United Kingdom
University of Warmia and Mazury
National Center for Research and Development, Poland; Medical University of... and other collaborators

Unknown

Personalized CAPTEM Radiopeptide Therapy of Advanced, Non-resectable Neuroendocrine Cancer

Neuroendocrine Tumors

Poland
University of Southern California
United States Department of Defense; Northern California Institute of Research... and other collaborators

Completed

A Study of Brain Aging in Vietnam War Veterans (DOD-ADNI)

Traumatic Brain Injury | Post Traumatic Stress Disorder | Mild Cognitive Impairment | Alzheimer's Disease

United States
Relation Therapeutics
Barts & The London NHS Trust; Royal Free Hospital NHS Foundation Trust; Chelsea... and other collaborators

Recruiting

OSTEOMICS: Identifying Regulators of Bone Homeostasis (OSTEOMICS)

Osteoarthritis | Bone Diseases | Osteoporosis | Bone Marrow Disease | Bone Fracture

United Kingdom
Society of Minimally Invasive Neurological Therapeutic...
Pakistani Society of Neuroradiology; Middle east North Africa Stroke & interventional... and other collaborators

Unknown

RNA Sequencing Analysis in Large Vessel Occlusion Stroke DATA Bank (RNASA-LVOSB)

Thrombosis | Stroke, Acute

Egypt
Sarepta Therapeutics, Inc.
University College, London; Catholic University of the Sacred Heart; University... and other collaborators

Completed

Phase I/II Study of SRP-4053 in DMD Patients

Duchenne Muscular Dystrophy

United Kingdom, United States, France, Italy
Jett Foundation, Inc.
Pfizer; Hoffmann-La Roche; Italfarmaco; Nationwide Children's Hospital; Capricor... and other collaborators

Completed

Your Voice; Impact of Duchenne Muscular Dystrophy (DMD) on the Lives of Families

Duchenne Muscular Dystrophy | Rare Diseases | Disability Physical | Burden, Dependency | Impairment | Disease Management

United States
University of Oxford
University College, London; KEMRI-Wellcome Trust Collaborative Research Program and other collaborators

Unknown

Optimising Antibiotic Treatment for Sick Malnourished Children (FLACSAM-PK)

Malnutrition

Kenya
US Department of Veterans Affairs
Bristol-Myers Squibb; Sanofi; GE Healthcare; Merck Sharp & Dohme LLC; Pfizer; Astra... and other collaborators

Completed

Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation

Myocardial Ischemia

United States, Canada
University of California, San Diego
The Cleveland Clinic; Augusta University; United States Naval Medical Center,... and other collaborators

Completed

Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Pilot Study

Rotator Cuff Repair | Anterior Cruciate Ligament Reconstruction | Ankle Arthrodesis or Arthroplasty | Hallux Valgus Correction

United States
Kevin Winthrop
Medical University of South Carolina; Mayo Clinic; University of Washington; National... and other collaborators

Not yet recruiting

Prevention of Ototoxicity in NTM Patients Treated With IV Amikacin

Ototoxicity, Drug-Induced

United States
Karyopharm Therapeutics Inc
GOG Foundation; Israeli Society of Gynecologic Oncology; Belgium and Luxembourg... and other collaborators

Active, not recruiting

Maintenance With Selinexor/Placebo After Combination Chemotherapy in Participants With Endometrial Cancer [SIENDO] (ENGOT-EN5)

Endometrial Cancer

United States, China, Israel, Spain, Belgium, Germany, Greece, Czechia, Italy, Canada
PIQUR Therapeutics AG
Royal Marsden NHS Foundation Trust; University College London Hospitals; Weill... and other collaborators

Completed

Open-Label, Non Randomized Phase 2 Study With Safety Run-In

Lymphoma, Malignant

United States, United Kingdom, Serbia, Bosnia and Herzegovina, France, Israel
Baxalta now part of Shire
National Heart, Lung, and Blood Institute (NHLBI); SAIC-Frederick, Inc.; Cato... and other collaborators

Completed

A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable Sickle Cell Disease

Sickle Cell Disease

United States
ScandiBio Therapeutics AB
Bakirkoy Dr. Sadi Konuk Research and Training Hospital; Kanuni Sultan Suleyman... and other collaborators

Unknown

Metabolic Cofactor Supplementation and Hydroxychloroquine Combination in Covid-19 Patients

COVID-19

Turkey
University of North Carolina, Chapel Hill
University of Colorado, Denver; Baylor College of Medicine; Washington University... and other collaborators

Terminated

Early Methicillin-resistant Staphylococcus Aureus (MRSA) Therapy in Cystic Fibrosis (CF) (STAR-Too)

Cystic Fibrosis | Methicillin-resistant Staphylococcus Aureus

United States
Karyopharm Therapeutics Inc
GOG Foundation; European Network of Gynaecological Oncological Trial Groups... and other collaborators

Recruiting

Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma (XPORT-EC-042)

Endometrial Cancer

United States, Belgium, Spain, Israel, Australia, Italy, Georgia, Ireland, Greece, Germany, Czechia, Slovakia, Canada, Hungary

Clinical Trials Sponsored by Enliven Therapeutics

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