Search clinical trials for: Somatic mutation

Total 3524 results

Lei Li

Recruiting

Chromosomal Instability in Ovarian Cancer

Epithelial Ovarian Cancer | High-grade Serous Ovarian Carcinoma | Survival Outcomes | Overall Survival | Progression-free Survival | Chromosomal Instability | Somatic Copy Number Distortion | Minimal Residual Lesions

China
Amsterdam UMC, location VUmc

Recruiting

Combining Afatinib and Concurrent Chemotherapy, Followed by Osimertinib and Concurrent Chemotherapy, in Untreated EGFR Positive NSCLC Tumors (COMBINATION)

Non-Small Cell Lung Cancer

Netherlands
Latin American Cooperative Oncology Group
Janssen, LP

Recruiting

Amivantamab, Lazertinib, and Pemetrexed for First-line Treatment of Recurrent/Metastatic Non-small Cell Lung Cancers With Epidermal Growth Factor Receptor Mutations (AMIGO-1)

Metastatic Non-small Cell Lung Cancers

Brazil
Fudan University

Recruiting

ZR-CHOP in DLBCL With Specific Gene Abnormality

Diffuse Large B Cell Lymphoma

China
Jacobio Pharmaceuticals Co., Ltd.

Recruiting

Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation

Colorectal Cancer | Non-small Cell Lung Cancer | Pancreatic Ductal Carcinoma | KRAS P.G12C

China
Stanford University
Celgene Corporation

Recruiting

Enasidenib in MDS &Non-proliferative Chronic Myelomonocytic Leukemia w/o IDH2 Mutation

Leukemia | Leukemia, Myeloid | Monocytic Leukemia

United States
Innovent Biologics (Suzhou) Co. Ltd.

Not yet recruiting

First-line Treatment of P53 Mutation With PD-L1 Expression in DLBCL With Anti-PD-1 Mab and R-CHOP

Diffuse Large B-Cell Lymphoma
Yonsei University

Not yet recruiting

Lazertinib for Patients With NSCLC Harboring Uncommon EGFR Mutations (LU21-16)

NSCLC

Korea, Republic of
Tata Memorial Hospital

Recruiting

Local Consolidative Radiation Therapy Plus TKI Versus TKI Alone in Driver Mutated OM-NSCLC (TARGET-01)

Non-small Cell Lung Cancer | Oligometastatic Disease | Driver Mutation

India
Kristoffer Rohrberg

Recruiting

Thiopurine Enhanced Mutations for PD-1/Ligand-1 Efficacy (TEMPLE)

Metastatic Cancer | Solid Tumor, Adult

Denmark
Xynomic Pharmaceuticals, Inc.

Not yet recruiting

XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation (ENHANCE)

Melanoma | Cancer | Colorectal Cancer | Nonsmall Cell Lung Cancer | Thyroid Cancer | BRAF V600 Mutation
Jacobio Pharmaceuticals Co., Ltd.

Recruiting

A Study of JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11 Co-mutation and Wild-type KEAP1

Non-small Cell Lung Cancer

China
TransThera Sciences (Nanjing), Inc.

Recruiting

Study to Evaluate the Safety and Tolerability of TT-01488 in Patients With B-Cell Malignancies

B-Cell Malignancies

United States
Università degli Studi di Ferrara

Recruiting

Molecular Biomarkers Predicting Early Development of Endometrial Carcinoma

Cancer of Endometrium

Italy
Centre Hospitalier Universitaire de la Réunion

Recruiting

Impact on Risk Stratification of Overlap Syndrome Phenotype in Patients With E1784K Mutation in SCN5A (RISKOVER)

Arrhythmias, Cardiac | Cardiac Conduction System Disease | Brugada Syndrome | Long QT Syndrome

Réunion
Zhongshan Hospital Xiamen University

Not yet recruiting

An Exploratory Basket Study of Pyrotinib Maleate Tablets in HER2 Mutated or Amplified of Metastatic Solid Tumors

Solid Tumor
Shanghai Chest Hospital

Recruiting

First-line Treatment With Dacomitinib Plus Anlotinib for Patients With Advanced NSCLC With EGFR 21L858R Mutations

Non-Small Cell Lung Cancer (NSCLC)

China
Washington University School of Medicine
National Institute on Aging (NIA); Alzheimer's Association; Eisai Inc.; Accelerating...

Recruiting

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, Italy, Argentina, Australia, Colombia, Netherlands, Puerto Rico, Spain, United Kingdom, France, Ireland, Mexico, Brazil, Japan, Germany
Hunan Province Tumor Hospital

Recruiting

Pembrolizumab Plus Bevacizumab and Chemotherapy for ALK-rearranged NSCLC With Persistent 5'ALK (BEYOND)

Lung Adenocarcinoma | ALK Gene Mutation | Immunotherapy

China
Qingdao Central Hospital

Recruiting

Phase II Study of Afatinib Plus Bevacizumab in the Treatment Epidermal Growth Factor Receptor (EGFR) Exon G719X, S768I, and L861Q Mutation Metastatic Non-Small Cell Lung Cancer

PFS

China
Tianjin Medical University Cancer Institute and...

Recruiting

Bevacizumab Combined With Double Dose Icotinib in Patients With EGFR Exon 21-L858R Mutation

Carcinoma, Non-Small-Cell Lung | EGF-R Positive Non-Small Cell Lung Cancer | Bevacizumab | Tyrosine Kinase Inhibitor

China
Ohio State University Comprehensive Cancer Center

Recruiting

Usefulness of Video-Based Intervention in Helping Participants Encourage Their Families to Get Tested for BRCA Gene Mutations

BRCA1 Gene Mutation | BRCA2 Gene Mutation

United States
Shanghai Kechow Pharma, Inc.

Recruiting

HL-085+Vemurafenib to Treat Advanced Melanoma Patients With BRAF V600E/K Mutation

Melanoma

China
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
AstraZeneca

Recruiting

The Study of Olaparib in Newly Diagnosed mCRPC Patients With HRR Gene Mutation (PROspect)

Prostate Cancer | Prostate Carcinoma | Metastatic Castration-resistant Prostate Cancer

China
Centre Hospitalier Universitaire de Besancon

Not yet recruiting

Molecular Markers in Cancers and Precancers (MOCA) (MOCA)

Healthy | Cancer | Precancerous Lesion
British Columbia Cancer Agency

Recruiting

CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease

Non Small Cell Lung Cancer | EGFR Activating Mutation | Leptomeningeal Metastasis

Canada
Black Diamond Therapeutics, Inc.

Recruiting

Phase 1/2 Study of BDTX-1535 in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations

Non-Small Cell Lung Cancer | NSCLC | Metastatic Lung Cancer | Metastatic Lung Non-Small Cell Carcinoma | EGF-R Positive Non-Small Cell Lung Cancer | Advanced Lung Carcinoma | EGFR-TKI Resistant Mutation | Advanced Non-Small Cell Squamous Lung Cancer | Epidermal Growth Factor Receptor C797S | Epidermal...

United States
Shaare Zedek Medical Center

Recruiting

Prodromal Parkinsonian Features in GBA1 Mutation Carriers

Healthy | Gaucher Disease, Type 1

Israel
Nuvation Bio Inc.

Recruiting

NUV-868 as Monotherapy and in Combination With Olaparib or Enzalutamide in Adult Patients With Advanced Solid Tumors

Breast Cancer | Pancreatic Cancer | Ovarian Cancer | Prostate Cancer | Breast Carcinoma | Triple Negative Breast Cancer | Triple Negative Breast Neoplasms | Advanced Solid Tumor | Cancer of the Ovary | Pancreas Cancer | Triple-negative Breast Cancer | Cancer of Pancreas | Pancreas Neoplasm | Prostate Neoplasm | Cancer... and other conditions

United States, Australia
Rigshospitalet, Denmark
Odense University Hospital; Zealand University Hospital; Aarhus University Hospital and other collaborators

Recruiting

Danish Elder Lymphoma Patient Hematopoietic Investigation (DELPHI)

Lymphoma | Chemotherapeutic Toxicity | Chemotherapy-induced Neutropenia | Chemotherapy-Related Leukemia

Denmark
Seoul National University Bundang Hospital

Recruiting

Prevalence and Trends of Antimicrobial Resistance of Helicobacter Pylori in Korea

Helicobacter Pylori Infection | Helicobacter Pylori 23S rRNA Clarithromycin Resistance Mutation | Helicobacter Pylori Associated Gastrointestinal Disease | Helicobacter Pylori Infection, Susceptibility to

Korea, Republic of
Guangdong Provincial People's Hospital

Recruiting

Neoadjuvant Immunotherapy in EGFR-mutant Localized NSCLC (NEOTIDE)

Non-small Cell Lung Cancer | EGFR Activating Mutation

China
Hasselt University
University Hospital, Antwerp; Universiteit Antwerpen; University of Regensburg

Recruiting

The CATT Trial: Cost-effectiveness of a Smartphone Application for Tinnitus Treatment (CATT)

Tinnitus

Belgium
Michio Hirano, MD
United States Department of Defense

Recruiting

Study of N-acetylcysteine in the Treatment of Patients With the m.3243A>G Mutation and Low Brain Glutathione Levels

Mitochondrial Disease

United States
Wei Xu

Recruiting

Tislelizumab Combined With Chemotherapy in the Treatment of Bone Metastases of Unknown Primary

Chemotherapy Effect | Gene Mutation-Related Cancer | Tislelizumab | Cancer of Unknown Primary | Bone Cancer Metastatic | Immune Evasion, Tumor

China
Tata Memorial Hospital

Recruiting

Observation or Upfront Cranial RT in Oncogene Mutated NSCLC With Asymptomatic BM: A Phase III RCT

Asymptomatic Brain Metastases | Driver Mutation Positive Non-small Cell Lung Cancer

India
University Hospital Center of Martinique

Recruiting

Prevalence of the c.853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique (HOXB13_Mart)

Prostate Cancer

Martinique
Asklepios Biopharmaceutical, Inc.

Recruiting

A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)

Muscular Dystrophy | Limb Girdle Muscular Dystrophy | LGMD2I | LGMD | Limb-Girdle Muscular Dystrophy Type 2 | LGMD2 | FKRP | FKRP Mutation | Fukutin Related Protein

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

PARP-inhibitor on Advanced Metastatic Breast Cancer in Germline PALB2 Mutations Carriers (PALB2-PARPi-01)

Metastatic Breast Cancer in Germline-PALB2 Mutations Carriers
Eisai Co., Ltd.

Recruiting

A Study of Tazemetostat on Safety in Participants With Relapsed or Refractory Follicular Lymphoma With Enhancer of Zeste Homolog 2 (EZH2) Gene Mutation in Japan

Lymphoma, Follicular

Japan
HonorHealth Research Institute
Jazz Pharmaceuticals

Recruiting

Lurbinectedin in Patients With Advanced Gastrointestinal Malignancies With DNA Repair Mutations

Gastrointestinal Malignancies

United States
Calcilytix Therapeutics, Inc., a BridgeBio company

Recruiting

ADH1 and ADH2 Disease Monitoring Study (DMS) (CLARIFY)

Autosomal Dominant Hypocalcemia

United States, France, Denmark, Australia, Japan, Belgium, Canada, Italy, Netherlands, United Kingdom, Portugal, Finland, Germany
Nuvectis Pharma, Inc.
GOG Foundation; European Network of Gynaecological Oncological Trial Groups...

Recruiting

A Phase 1 Clinical Study of NXP800 in Subjects With Advanced Cancers and Expansion in Subjects With Ovarian Cancer

Ovarian Cancer | Ovarian Endometrioid Adenocarcinoma | Advanced Solid Tumor | Ovarian Clear Cell Carcinoma | Ovarian Clear Cell Adenocarcinoma | Ovarian Clear Cell Tumor | Ovarian Endometrioid Tumor | ARID1A Gene Mutation

United States, United Kingdom
Shanghai Zhongshan Hospital
Guangzhou Burning Rock Bioengineering Ltd.

Recruiting

AssesSment of Early-deteCtion basEd oN liquiD Biopsy in GASTRIC Cancer, ASCEND-Gastric (ASCEND-Gastric)

Cancer

China
GeneScience Pharmaceuticals Co., Ltd.

Recruiting

A Study of Gentuximab in Combination With Almonertinib in EGFR Mutation-positive Metastatic NSCLC

Metastatic Non-Small Cell Lung Cancer

China
Erasmus Medical Center

Recruiting

ProSpecTive sAmpling in dRiver muTation Pulmonary Oncology Patients on Tyrosine Kinase Inhibitors (START-TKI) (START-TKI)

Non Small Cell Lung Cancer | Liquid Biopsy | Tyrosine Kinase Inhibitor

Netherlands
University of British Columbia
Vancouver Coastal Health Research Institute; Genome British Columbia

Recruiting

Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia (ACCURATE)

Acute Coronary Syndrome | Familial Hypercholesterolemia | STEMI | NSTEMI - Non-ST Segment Elevation MI | Familial Hypercholesterolemia - Heterozygous | Familial Hypercholesterolemia Due to Genetic Defect of Apolipoprotein B | Familial Hypercholesterolemia Due to Heterozygous LDL Receptor Mutation and other conditions

Canada
Pfizer
Eli Lilly and Company; Merck Sharp & Dohme LLC; Merck KGaA, Darmstadt, Germany

Recruiting

A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer (SEAMARK)

Metastatic Colorectal Cancer

United States, Denmark, Spain, Australia, France, Italy, Belgium, Slovakia, Canada, Czechia, Germany, Netherlands, Norway, Poland, Sweden, United Kingdom
Hospital das Clínicas de Ribeirão Preto
Bristol-Myers Squibb; Fundação de Amparo à Pesquisa do Estado de São Paulo

Recruiting

CLARA: Somatic and Germline Mechanisms That Impact Renal Cancer Immunotherapy

Renal Cancer Metastatic

Brazil
Relay Therapeutics, Inc.

Recruiting

First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Advanced Solid Tumor Patients and in Combination With Fulvestrant in Patients With Advanced Breast Cancer

Breast Cancer | Advanced Breast Cancer | Metastatic Breast Cancer | Solid Tumor, Adult | HER2-negative Breast Cancer | Unresectable Solid Tumor | PIK3CA Mutation

United States, Spain, France, Italy

Search clinical trials for: Somatic mutation

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