Search clinical trials for: UGT1A1 genotype

Total 1430 results

Merck Sharp & Dohme LLC

Completed

Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and GT2 Infection (MK-3682-011)

Hepatitis C
Baylor College of Medicine
National Institute on Drug Abuse (NIDA)

Completed

Pharmacogenetics of Doxazosin for Cocaine Dependence

Cocaine Dependence

United States
University of Minnesota
National Institute of General Medical Sciences (NIGMS)

Completed

Effects of Genotype on CYP2C9 Drug Interactions

Healthy

United States
University of Colorado, Denver
Sigma Theta Tau

Completed

Ion Channel Genetic Biomarkers: Diagnostic Capabilities in the Assessment of Bipolar Disorder

Bipolar Disorder

United States
National Cancer Institute (NCI)

Withdrawn

IFNL4 Genotype for Predicting Response to Ledipasvir/Sofosbuvir

Hepatitis C Virus
Assiut University

Unknown

Genetic Study of CYP2D6 Enzyme and Therapeutic Drug Monitoring of Tamoxifen

Breast Cancer
Third Military Medical University

Completed

Adrenal Artery Ablation Treats Primary Aldosteronism

Hypertension | Primary Aldosteronism

China
Ginkgopharma CO., LTD

Unknown

Study of Seraprevir in Combination With Sofosbuvir in Chronic Genotype 1 Hepatitis C Virus Infection Patients

Hepatitis C Virus Infection

China
Merck Sharp & Dohme LLC

Terminated

Efficacy and Safety of Uprifosbuvir (MK-3682) With Ruzasvir (MK-8408) in Adults With Chronic Hepatitis C Genotype 1, 2, 3, 4, 5 or 6 Infection (MK-3682-035)

Hepatitis C, Chronic
Postgraduate Institute of Medical Education and...
Directorate of Health and Family Welfare, Punjab

Unknown

DAA Therapy in Pediatric Patients With Chronic Hepatitis C

Chronic Hepatitis c

India
Kirby Institute

Completed

A Phase IV Trial of Paritaprevir/Ritonavir, Ombitasvir, Dasabuvir for Chronic Hepatitis C Genotype 1 Virus Infection (D3FEAT)

Hepatitis C, Chronic

Australia
The University of Texas Medical Branch, Galveston
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Indomethacin PK and PD Therapy in Pregnancy

Premature Birth | Pregnancy | Premature Labor

United States
University of Mississippi Medical Center
Mississippi State Department of Health

Completed

Trichomoniasis: Genotype and Phenotype Correlations in African American Women

Trichomonas Infections

United States
Mayo Clinic
AssureRx Health, Inc.

Completed

Clinical Impact of the Antidepressant Pharmacogenomic Algorithm in an Outpatient Therapy-based Clinical Setting (HAMM)

Major Depressive Disorder
AbbVie

Completed

Real World Evidence of the Effectiveness of Paritaprevir/r - Ombitasvir, ± Dasabuvir, ± Ribavirin and Patient Support Program in Patients With Chronic Hepatitis C (3DUTCH)

Chronic Hepatitis C

Netherlands
Vera HM Deneer
Federico II University; University Medical Center Groningen; UMC Utrecht; Onze... and other collaborators

Completed

Cost-effectiveness of Genotype Guided Treatment With Antiplatelet Drugs in STEMI Patients: Optimization of Treatment (POPular Genetics)

Myocardial Infarction | STEMI

Netherlands, Italy, Belgium
Janssen Research & Development, LLC

Completed

An Efficacy, Safety and Pharmacokinetics Study of Simeprevir, Daclatasvir and Sofosbuvir in Participants With Chronic Hepatitis C Virus Genotype 1 or 4 Infection and Decompensated Liver Disease

Hepatitis C, Chronic

United States
Tools4Patient

Completed

A Study to Investigate the Genetic Variation of Dopamine Pathway in Patients With Chronic Pain

Osteoarthritis | Peripheral Neuropathy

France, Belgium
AbbVie

Completed

The Effectiveness of ABT-450/r - Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C -An Observational Study in Ireland (REACH)

Chronic Hepatitis C
Pediatrix

Completed

Multicenter Evaluation of Children and Young Adults With Genotype Positive Long QT Syndrome

Long QT Syndrome

United States
AbbVie
IST GmbH, Germany

Completed

Effectiveness of Paritaprevir/Ritonavir - Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C - An Observational Study in Belgium

Chronic Hepatitis C, Genotype 1 or 4
Gilead Sciences

Completed

Safety and Efficacy of Sofosbuvir + Ribavirin in Adolescents and Children With Genotype 2 or 3 Chronic HCV Infection

Hepatitis C Virus Infection

United States, Italy, United Kingdom, Germany, Belgium, Russian Federation, New Zealand, Australia
Tarek I. Hassanein, M.D., FACP, FAG, AGAF

Completed

Study to Evaluate the Safety and Efficacy of Daclatasvir/Sofosbuvir/Ribavirin for 16 Versus 24 Weeks for HCV Genotype 3 Cirrhotics

Hepatitis C | Cirrhosis

United States
University of Chicago
IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale...

Completed

A Genotype-guided Study of Irinotecan Administered in Combination With 5-fluorouracil/Leucovorin (FOLFIRI) and Bevacizumab in Advanced Colorectal Cancer Patients

Metastatic Colorectal Cancer

United States, Italy
University of Miami
Genentech, Inc.

Terminated

Vinorelbine With Trastuzumab Emtansine in Pre-Treated HER2-Positive Metastatic Breast Cancer

Breast Cancer | Metastatic Breast Cancer

United States
University of Dundee

Completed

Trough Bronchoprotection Conferred by Levosalbutamol and Racemic Salbutamol (NAI009)

Asthma

United Kingdom
Children's Hospital of Philadelphia
Children's Anesthesiology Associates, Ltd.

Completed

Pharmacogenomics Analysis of Morphine Pharmacokinetics in Pediatric Tonsillectomy and Adenoidectomy

Pharmacokinetics | Tonsillectomy | Adenoidectomy

United States
Janssen Sciences Ireland UC

Completed

A Study to Investigate the Pharmacokinetic Interactions Between Simeprevir and Ledipasvir in a Treatment Regimen Consisting of Simeprevir, Sofosbuvir, and Ledipasvir in Treatment-naive Participants With Chronic Hepatitis C Virus Genotype 1 Infection

Hepatitis C, Chronic

Belgium
AbbVie
Cato Research; IST GmbH, Germany

Completed

Effectiveness of Paritaprevir/r - Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C in Canada (AMBER)

Chronic Hepatitis C
Janssen R&D Ireland

Terminated

A Study of the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of JNJ-47910382 at Different Doses and Dose Regimens in Asian Genotype-1, Chronic, HCV-Infected Patients

Chronic Hepatitis C Infection

Taiwan
Tongji Hospital

Unknown

Visual Study of Molecular Genotype in Glioma Evolution

Glioma of Brain

China
AbbVie

Completed

Real World Evidence of the Effectiveness of Paritaprevir/r - Ombitasvir, ± Dasabuvir, ± Ribavirin in Participants With Chronic Hepatitis C

Chronic Hepatitis C
AbbVie

Completed

Real World Evidence of the Effectiveness of Paritaprevir/Ritonavir (r) - Ombitasvir, + Dasabuvir Without Ribavirin in Participants With Chronic Hepatitis C and Compensated Liver Cirrhosis in the Russian Federation (CITRIN)

Chronic Hepatitis C

Russian Federation
Nabriva Therapeutics AG

Completed

4-way Crossover QT Evaluation in Healthy Subjects

Cardiac Repolarization in Healthy Subjects

United States
Gilead Sciences

Completed

Safety and Efficacy of SOF/VEL/VOX FDC for 8 Weeks and SOF/VEL for 12 Weeks in Adults Chronic Genotype 3 HCV Infection and Cirrhosis (POLARIS-3)

Hepatitis C Virus Infection

United States, France, United Kingdom, Germany, Australia, Canada, New Zealand, Puerto Rico
AbbVie

Completed

A Study to Evaluate the Efficacy and Safety of Glecaprevir/Pibrentasvir in Adults With Chronic Hepatitis C Virus Genotype 1 - 6 Infection and Renal Impairment (EXPEDITION-5)

Hepatitis C Virus (HCV)

United States, Canada, Germany, Greece, Italy, Korea, Republic of, Poland, Puerto Rico, Spain, Sweden
Manisha Shah
National Comprehensive Cancer Network

Completed

Dabrafenib and Pazopanib Hydrochloride in Treating Patients With Advanced Malignant Tumors

Unspecified Adult Solid Tumor, Protocol Specific

United States
Gilead Sciences

Completed

Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir Fixed-Dose Combination With or Without Ribavirin in Participants With Chronic Genotype 1 HCV Infection Previously Treated With a Direct Acting Antiviral Regimen

Hepatitis C Virus Infection

United States
Habit, LLC
University of California, San Diego; TNO

Completed

Personalized Dietary Program and Markers of Wellness

Healthy | Metabolism

United States
University Hospital, Bordeaux
University of Bordeaux; Poitiers University Hospital; Centre National de la Recherche... and other collaborators

Completed

Pathological and Non-pathological Aging, Physical Activity, Genotype and Cognition (VIAGECO)

Alzheimer's Disease

France
Idera Pharmaceuticals, Inc.

Completed

Study of Combination Treatment With IMO-2125 and Ribavirin in Naïve Hepatitis C-infected, Genotype 1 Patients

Hepatitis C, Treatment Naïve, Genotype 1 Patients

France
Hartford Hospital
Agency for Healthcare Research and Quality (AHRQ)

Unknown

Pharmacogenetic Decision Support IT System for Psychiatric Hospitalization: RCT (CYP-GUIDES)

Major Depressive Disorder

United States
R-Pharm

Completed

Efficacy and Safety of Narlaprevir Used in Combination With Ritonavir in Treatment-Naïve and Failed Prior Treatment With Pegylated Interferon/Ribavirin Patients With Chronic Hepatitis C Genotype 1 (PIONEER - Study) (PIONEER)

Hepatitis C

Russian Federation
Gilead Sciences

Completed

Use-Results Surveillance Study of Harvoni® in Japanese Patients With Chronic Genotype 1 Hepatitis C Virus Infection

Hepatitis C

Japan
Christoph Stein, MD
deCODE genetics

Completed

Analysis of Markers in the Blood Correlated With Neuropathic Pain

Neuropathy

Germany
Janssen Scientific Affairs, LLC

Completed

Family Intervention in Recent Onset Schizophrenia Treatment (FIRST) (FIRST)

Schizophrenia

United States
AHMED ABDULQADER HAMMOUDA ABOU SHALL
Assiut University; Kuwait University

Unknown

Study of The Association of Mutations in The NPHS2 Gene and Nephrotic Syndrome in Children and Adults in Middle East

Nephrotic Syndrome

Kuwait
Kaohsiung Medical University Chung-Ho Memorial...
National Taiwan University Hospital; China Medical University Hospital; Chang... and other collaborators

Completed

Daclatasvir, Asunaprevir Plus Ribavirin for HCV Genotype 1b Without NS5A RAV

Hepatitis C

Taiwan
AbbVie

Completed

Effectiveness of Paritaprevir/r - Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C - An Observational Study

Chronic Hepatitis C
Medical University of Warsaw
University of Pecs; Polish Cardiac Society

Unknown

Bedside Genetic or Pharmacodynamic Testing to Prevent Periprocedural Myonecrosis During PCI (ONSIDE TEST) (ONSIDE TEST)

Stable Angina

Poland, Hungary

3

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