Clinical Trials Sponsored by GlycoMimetics Incorporated

Total 1172 results

Vertex Pharmaceuticals Incorporated
CRISPR Therapeutics

Enrolling by invitation

A Long-term Follow-up Study in Participants Who Received CTX001

Hematologic Diseases | Genetic Diseases, Inborn | Sickle Cell Disease | Hemoglobinopathies | Sickle Cell Anemia | Thalassemia | Beta-Thalassemia

United States, Canada, Italy, United Kingdom, Germany
Indiana University
Erbe USA Incorporated

Completed

Post-resection Treatment of Large Colon Polyps (SAP)

Recurrence

United States
Mayo Clinic
Erbe USA Incorporated

Completed

Feasibility of Performing Peripheral Pulmonary Lesion Biopsy Using Robotic Bronchoscopy-Guided Cryoprobe

Lung Diseases, Obstructive | Bronchi--Diseases | Lesions Mass

United States
Encore Medical, L.P.
DJO Incorporated

Terminated

Post Market Study of the 3DKnee™ With E-plus Insert (e-plus)

Osteoarthritis | Traumatic Arthritis | Degenerative Joint Disease

United States
Duke University
Bausch & Lomb Incorporated

Completed

Photodynamic Therapy for PDA in NV AMD

Macular Degeneration | Neovascular Age-related Macular Degeneration

United States
Parion Sciences
Vertex Pharmaceuticals Incorporated

Completed

A Study to Evaluate the Safety and Efficacy of VX-371 in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation

Cystic Fibrosis

United Kingdom, United States, France, Ireland
Parion Sciences
Vertex Pharmaceuticals Incorporated

Completed

Clearing Lungs With Epithelial Sodium Channel (ENaC) Inhibition in Cystic Fibrosis (CF) (CLEAN-CF)

Cystic Fibrosis

United States
Northwestern University
Bausch & Lomb Incorporated

Terminated

Comparison of Topical 0.15% Gancyclovir Gel Versus 0.3% Hypromellose Gel for the Treatment of Herpes Zoster Keratitis

Herpes Zoster Keratitis

United States
Orthopaedic Research Foundation
DJO Incorporated

Completed

Early Postoperative Compex Rehab NMES Use for Total Knee Arthroplasty Patients

Knee Osteoarthritis

United States
Niconovum USA
Inflamax Research Incorporated

Completed

Oral Mucosal Effects In Adult Smokers Associated With Two Nicotine Lozenge Formulations

Safety Issues

United States
Boston Scientific Corporation
VertiFlex, Incorporated

Completed

Investigating Superion™ In Spinal Stenosis

Intermittent Claudication | Lumbar Spinal Stenosis

United States
Bausch & Lomb Incorporated
NicOx Inc.

Completed

Dose-Finding Study Comparing the Safety and Efficacy of Latanoprost to a Novel Treatment for Glaucoma

Primary Open Angle Glaucoma | Ocular Hypertension | Pigmentary Glaucoma | Pseudoexfoliative Glaucoma

United States
Bausch & Lomb Incorporated
Synteract, Inc.

Completed

Lotemax® Gel 0.5% and Restasis 0.05% in Participants With Mild or Moderate Keratoconjunctivitis Sicca (Dry Eye Disease)

Keratoconjunctivitis Sicca

United States
Duke University
Bausch & Lomb Incorporated

Completed

Neovascular Morphology and Persistent Disease Activity Among Patients With NV AMD

Neovascular Age-Related Macular Degeneration

United States
Bausch & Lomb Incorporated
ORA, Inc.

Completed

Pharmacokinetics and Safety of Topical Administration of Brimonidine Tartrate Ophthalmic Solution 0.025%.

Hyperemia

United States
Duke University
Bausch & Lomb Incorporated

Completed

Re-implantation of a Fluocinolone Acetonide Implant for Non-infectious Uveitis Affecting the Posterior Segment

Uveitis

United States
Encore Medical, L.P.
DJO Incorporated

Completed

Encore Revelation Hip Stem

Osteoarthritis, Hip | Complications; Arthroplasty

United States
Vertex Pharmaceuticals Incorporated
ViroChem Pharma

Completed

A Proof-of-concept Study of VCH-759 for the Treatment of Hepatitis C-infection.

Hepatitis C, Chronic

Canada
Angitia Incorporated Limited

Recruiting

A First-in-Human Study Evaluating AGA2115 in Adult Healthy Volunteers

Osteogenesis Imperfecta

United States
University of Georgia
Cotton Incorporated

Recruiting

Cottonseed Oil Dose Response

Dyslipidemias | Overweight and Obesity | Nutrition, Healthy

United States
Vertex Pharmaceuticals Incorporated
CRISPR Therapeutics

Recruiting

Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

Hematologic Diseases | Genetic Diseases, Inborn | Sickle Cell Disease | Hemoglobinopathies | Sickle Cell Anemia | Thalassemia | Beta-Thalassemia

United States, Italy, Germany, Saudi Arabia
Vertex Pharmaceuticals Incorporated
CRISPR Therapeutics

Recruiting

Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dependent β-Thalassemia (TDT)

Hematologic Diseases | Genetic Diseases, Inborn | Hemoglobinopathies | Thalassemia | Beta-Thalassemia

United States, Germany, Italy, United Kingdom, Canada
Centre Francois Baclesse
Accuray Incorporated

Active, not recruiting

Study of SIB-IMRT in Combination With 5-FU and Mitomycin-C Among Patients With Locally Advanced Anal Canal Cancer: Efficacy, Safety and Quality of Life (CANAL-IMRT-01)

Locally Advanced Anal Canal Cancer

France
Insmed Incorporated
Muscular Dystrophy Association

Completed

Safety and Efficacy Study of Recombinant Human Insulin-Like Growth Factor-I/Recombinant Human Insulin-Like Growth Factor Binding Protein-3 (rhIGF-I/rhIGFBP-3) In Myotonic Dystrophy Type 1

Myotonic Dystrophy Type 1

United States
Parion Sciences
Vertex Pharmaceuticals Incorporated

Completed

Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia (CLEAN-PCD)

Primary Ciliary Dyskinesia

United States, United Kingdom, Netherlands, Denmark, Canada, Italy, Germany, Poland
Accuray Incorporated
University of Pittsburgh

Unknown

CyberKnife Radiosurgical Treatment of Inoperable Early Stage Non-Small Cell Lung Cancer

Non-small Cell Lung Cancer

United States, China
Toyos Clinic
Bausch & Lomb Incorporated

Completed

Clinical Outcomes of Bromday (Bromfenac Ophthalmic Solution) 0.09% QD vs. Nevanac (Nepafenac Ophthalmic Suspension) 0.1%

Inflammation | Pseudophakia
Bausch & Lomb Incorporated
ORA, Inc.

Completed

Safety of Brimonidine Tartrate Ophthalmic Solution in a Population of Pediatric, Adult, and Geriatric Participants

Hyperemia

United States
Ingredion Incorporated
KGK Science Inc.

Completed

Post-prandial Glycemic Response to Fiber in Healthy Adults

Glucose, Low Blood | Glucose, High Blood | Meals
Vertex Pharmaceuticals Incorporated
Janssen Pharmaceuticals

Terminated

An Open-Label Study of the Effect of Telaprevir in Combination With Peginterferon Alfa-2b and Ribavirin in Pediatric Subjects Infected With Hepatitis C Virus

Hepatitis C

United States, United Kingdom, Spain, Belgium, Italy, Germany
Vertex Pharmaceuticals Incorporated
ViroChem Pharma

Completed

Pharmacokinetics of Multiple Ascending Doses of VCH-222 in Subjects With Chronic Hepatitis C Infection

Hepatitis C

Canada, United States, Argentina, Puerto Rico
Hvidovre University Hospital
DJO Incorporated

Completed

Non-operative Treatment of Acute Achilles Tendon Rupture Using Dynamic Rehabilitation. Influence of Early Weight-bearing Compared With Non-weight-bearing

Acute Achilles Tendon Rupture

Denmark
Tibotec BVBA
Vertex Pharmaceuticals Incorporated

Completed

VX-950HEP1001 - Drug-drug Interaction Study Between Telaprevir and Raltegravir

Hepatitis C
University of Toronto
Ingredion Incorporated

Completed

Types of Starch and Their Effect on Blood Glucose, Appetite and Food Intake

Diabetes Prevention | Obesity Prevention

Canada
University of Toronto
Ingredion Incorporated

Completed

Types of Starch and Their Effect on Blood Glucose, Appetite and Food Intake

Diabetes Prevention | Obesity Prevention

Canada
William Cook Europe
Cook Group Incorporated; MED Institute, Incorporated; William Cook Australia

Completed

Clinical Study to Assess Safety and Effectiveness of the Zenith® Dissection Endovascular System in Patients With Aortic Dissection

Aortic Dissection Involving the Descending Thoracic Aorta

Italy, Germany, Australia, Czech Republic, France
Cook Group Incorporated
William Cook Europe; MED Institute, Incorporated; William Cook Australia

Completed

STARZ-TX2 Clinical Study: Study of Thoracic Aortic Aneurysm Repair With the Zenith TX2 Endovascular Graft (STARZ-TX2)

Thoracic Aortic Aneurysm

United States, Italy, Canada
Vertex Pharmaceuticals Incorporated
CRISPR Therapeutics

Recruiting

Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)

Sickle Cell Disease | Hemoglobinopathies | Hematological Diseases | Hydroxyurea Failure | Hydroxyurea Intolerance

United States, Italy, United Kingdom, Germany
Hollister Incorporated
Parexel; Technomics Research

Recruiting

Continence Care Registry (ConCaRe™)

Neurogenic Bladder | Non-Neurogenic Bladder

United States
Vertex Pharmaceuticals Incorporated
CRISPR Therapeutics

Active, not recruiting

A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell Disease

Sickle Cell Disease | Hemoglobinopathies | Hematological Diseases

United States, Belgium, Canada, France, Germany, Italy, United Kingdom
Bausch & Lomb Incorporated
ORA, Inc.

Completed

A Single-Center Evaluation of the Relative Efficacy of EM-100 Compared to Zaditor® (Ketotifen Fumarate Ophthalmic Solution 0.035%) and Vehicle

Allergic Conjunctivitis

United States
Encore Medical, L.P.
DJO Incorporated

Completed

Reverse Shoulder Prosthesis Prospective Multi-Center Study

Shoulder Arthropathy | Rotator Cuff Deficiency | Failed Shoulder Replacement

United States
Augusta University
Vertex Pharmaceuticals Incorporated

Completed

Longitudinal Assessment of Exercise Capacity and Vascular Function in Patients With CF

Cystic Fibrosis

United States
Bausch & Lomb Incorporated
ORA, Inc.

Completed

Efficacy and Safety of Brimonidine Tartrate Ophthalmic Solution in Adult and Geriatric Participants With Ocular Redness

Hyperemia

United States
Encore Medical, L.P.
DJO Incorporated

Terminated

Post-Market Study of the Modular Revision Hip System (MRHS)

Traumatic Fracture | Osteolysis | Aseptic Loosening | Failed Total Hip Implant

United States
The Cleveland Clinic
DJO Incorporated

Completed

Evaluation of Electrical Nerve Stimulation (TENS) Therapy for Pain Relief Following Total Knee Arthroplasty (TKA)

Pain | Arthritis | Osteoarthritis, Knee

United States
Mayo Clinic
Celerion; Anexon, Incorporated

Completed

ANX-042 Healthy Volunteer Dose Escalation Study

Healthy Volunteers

United States
Duke University
Bausch & Lomb Incorporated

Withdrawn

Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMD

Neovascular Age-related Macular Degeneration

United States
NIZO Food Research
Ingredion Incorporated

Completed

Trial on Short-chain Fructooligosaccharides, Microbiota, and Constipation in Adults (TOMCAT)

Functional Constipation

Netherlands
Duke University
Cook Group Incorporated

Completed

The Use of the Bakri Postpartum Balloon in the Management of Postpartum Hemorrhage Refractory to Conservative Measures

Postpartum Hemorrhage

Kenya

Clinical Trials Sponsored by GlycoMimetics Incorporated

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