Search clinical trials for: homologous recombination deficiency (HRD)

Total 9858 results

National Institute of Allergy and Infectious Diseases...
Genentech, Inc.

Completed

A Phase I Multicenter Study of the Safety and Immunogenicity of MN rgp120/HIV-1 Vaccine Given Either Alone or in Combination With IIIB rgp120/HIV-1 Vaccine in Healthy Adult Subjects (NOTE: Original Study Extended ONLY for Patients Previously Enrolled on VEU 009)

HIV Infections

United States
Centaur Pharmaceuticals

Unknown

Safety and Effectiveness of Giving CPI-1189 to HIV-Infected Patients With AIDS Dementia

HIV Infections

United States
Gilead Sciences

Completed

Tenofovir Disoproxil Fumarate (TDF) in HIV-1 Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States
Merck Sharp & Dohme LLC

Completed

Safety and Effectiveness of an Anti-HIV Drug Combination in HIV-Positive Patients Who Have Failed Previous Treatment With Protease Inhibitors

HIV Infections

United States
PPD

Unknown

Differences Between Women and Men Taking a Combination of Indinavir, Ritonavir, Enteric-Coated Didanosine, and Stavudine Who Previously Took Anti-HIV Drugs

HIV Infections

United States, Puerto Rico
Glaxo Wellcome

Unknown

Comparison of GW433908 and Nelfinavir in HIV Patients Who Have Not Had Antiretroviral Therapy

HIV Infections

United States
Triangle Pharmaceuticals

Completed

A Randomized, Double-Blind Study of MKC-442 Combined With Viracept in Patients Who Are Epivir + Retrovir Experienced and Are Protease Inhibitor- and Non-Nucleoside Reverse Transcriptase Inhibitor-Naive

HIV Infections

United States
Unimed Pharmaceuticals

Completed

A Study of Nitazoxanide in the Treatment of AIDS-Related Diarrhea

HIV Infections

United States
Fairview University Medical Center

Unknown

Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders

Hemophagocytic Lymphohistiocytosis | Graft Versus Host Disease | Chediak-Higashi Syndrome | Virus-Associated Hemophagocytic Syndrome | X-Linked Lymphoproliferative Syndrome | Familial Erythrophagocytic Lymphohistiocytosis

United States
National Center for Research Resources (NCRR)
UNC Lineberger Comprehensive Cancer Center

Completed

Study of Phosphatidylcholine in a Patient With Methionine Adenosyltransferase Deficiency

Metabolism, Inborn Errors | Methionine Adenosyltransferase Deficiency
National Center for Research Resources (NCRR)

Completed

Biological Significance of the Bloom's Syndrome Protein

Bloom Syndrome

United States
National Institute of Allergy and Infectious Diseases...
Genentech, Inc.

Completed

A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in HIV-1 Seropositive Women During the Last Trimester of Pregnancy and Their Newborns

HIV Infections | Pregnancy

United States
Genelabs Technologies

Completed

A Randomized Phase II Efficacy, Activity and Safety Study of GLQ223 Alone and in Combination With Zidovudine in Symptomatic HIV-Infected Patients Without Prior Treatment With GLQ223 or Trichosanthin

HIV Infections

United States
Ortho Pharmaceuticals

Completed

A Double-Blind, Placebo-Controlled Study With Open-Label Follow-Up To Determine the Safety and Efficacy of r-HuEPO in AIDS and Advanced ARC Patients With Anemia

HIV Infections | Cytopenias

United States
Sarawak MediChem Pharmaceuticals

Completed

A Study to Evaluate the Safety and Effectiveness of a New Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI), (+)-Calanolide A, in HIV-Positive Patients Who Have Never Received Anti-HIV Treatment

HIV Infections

United States
Sandoz

Completed

A Multicenter Placebo-Controlled Double Blind Study to Evaluate the Efficacy and Safety of Sandostatin ( SMS 201-995 ) in Patients With Acquired Immunodeficiency Related Diarrhea Who Were Either "Responders" or "Non-Responders" in a Prior Placebo-Controlled Double-Blind Sandostatin Study.

HIV Infections | Diarrhea

United States
Amgen

Completed

An Open-Label Phase I/II Study of Recombinant Granulocyte Colony Stimulating Factor (r-metHuG-CSF) and Recombinant Erythropoietin (rHuEPO) Given Subcutaneously Along With Zidovudine (AZT) to Patients With the Acquired Immune Deficiency Syndrome (AIDS) or Severe AIDS-Related Complex (ARC)

HIV Infections

United States
Dupont Merck

Completed

A Study of Three Different Anti-HIV Drug Combinations in HIV-Infected Patients

HIV Infections

United States, Puerto Rico
Triangle Pharmaceuticals

Completed

A Study of MKC-442 in Combination With Other Anti-HIV Drugs

HIV Infections

United States
Agouron Pharmaceuticals

Completed

Safety and Effectiveness of Treating HIV-Positive Patients With an HIV Vaccine (Remune)

HIV Infections

United States
Celgene Corporation

Completed

Compassionate Use Study of Two Dose Levels of Thalidomide in Adults With HIV Wasting Syndrome

HIV Infections | HIV Wasting Syndrome

United States
Chiron Corporation

Completed

Safety and Efficacy of Polyethylene Glycolated IL-2 (PEG IL-2) Plus Zidovudine or Dideoxyinosine in HIV Positive, Asymptomatic and Symptomatic Individuals

HIV Infections

United States
St. Vincent's Medical Center

Completed

Depot Disulfiram for AIDS and ARC

HIV Infections

United States
Purdue Frederick
Walter Reed Army Institute of Research (WRAIR); Henry M. Jackson Foundation...

Completed

Phase I Study of Alferon N Injection in Persons With Asymptomatic Human Immunodeficiency Virus (HIV) Infection

HIV Infections

United States
Pharmacia and Upjohn

Completed

A Double-Blind, Randomized, Comparative Study of Delavirdine Mesylate (U-90152S) in Combination With Didanosine (ddI) Versus ddI Alone in HIV-1 Infected Individuals With CD4 Counts of <= 300/mm3

HIV Infections

United States, Puerto Rico
Gilead Sciences

Completed

A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Adefovir Dipivoxil When Added to Standard Antiretroviral Therapy for the Treatment of HIV-Infected Patients With CD4 Cell Counts >= 200/mm3

HIV Infections

United States
Glaxo Wellcome

Completed

A Comparison of Two Multi-Drug Therapies in HIV-Infected Patients Who Have Never Received Anti-HIV Treatment

HIV Infections

United States
Pharmacia and Upjohn

Completed

A Study to Find the Best Dosing Schedule for Delavirdine, Zidovudine, and Indinavir in HIV-Positive Patients

HIV Infections

United States
Lederle Laboratories

Completed

A Multi-Center, Open-Label, Ascending, Multiple Oral Dose, Safety, Tolerance and Pharmacokinetic Study of 3'-Deoxy-3'-Fluorothymidine (FLT) in Patients With Acquired Immune Deficiency Syndrome (AIDS) or AIDS-Related Complex (ARC)

HIV Infections

United States
Glaxo Wellcome

Completed

The Safety and Effectiveness of Retrovir in HIV-Infected Patients Who Have Problems Related to the Nervous System

HIV Infections

United States
LyphoMed

Completed

A Study of Two Forms of Pentamidine in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Pharmacia and Upjohn

Completed

The Safety and Effectiveness of U-90152 in HIV-1 Infected Patients Who Take Zidovudine

HIV Infections

United States
Gilead Sciences

Completed

The Safety and Effectiveness of Bis-POM PMEA in HIV-Infected Patients

HIV Infections

United States
Apollon

Completed

A Phase I Trial of APL 400-003 Vaccine: Safety and Immune Response Evaluations of Multiple Injections at Escalating Doses in Asymptomatic HIV-Infected Patients

HIV Infections

United States
Hoechst Marion Roussel

Completed

The Safety and Effectiveness of HBY 097 Used With or Without AZT in HIV-Infected Patients Who Have Mild or No Symptoms

HIV Infections

United States
Triangle Pharmaceuticals

Suspended

A Comparison of Emtricitabine and Abacavir Used in a Three-Drug Combination in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States
Hoffmann-La Roche

Completed

A Comparison of Three Anti-HIV Drug Combinations Containing Saquinavir Soft Gelatin Capsules Used in HIV-1 Infected Patients

HIV Infections

United States, Puerto Rico, Spain, Germany, Italy, United Kingdom
Gilead Sciences

Unknown

The Safety and Effectiveness of PMPA Prodrug in HIV-Infected Patients

HIV Infections

United States
National Center for Research Resources (NCRR)
Northwestern University

Completed

Phase II Randomized Study of Cidofovir for Peripheral Cytomegalovirus Retinitis

Acquired Immunodeficiency Syndrome | Cytomegalovirus Retinitis
Glaxo Wellcome

Completed

Safety and Effectiveness of a Combination Anti-HIV Drug Treatment

HIV Infections

United States
Hoffmann-La Roche
Trimeris

Completed

T-20 With Anti-HIV Combination Therapy for Patients With Prior Anti-HIV Drug Treatment and/or Drug Resistance to Each of the Three Classes of Approved Anti-HIV Drugs

HIV Infections

United States, Canada
National Center for Research Resources (NCRR)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and other collaborators

Completed

Descriptive Study of Recombinant Human Insulin-Like Growth Factor for Osteoporosis in Werner's Syndrome

Werner's Syndrome
Triangle Pharmaceuticals

Completed

Comparing FTC and Lamivudine in HIV-Infected Patients on a Stable Anti-HIV Drug Combination

HIV Infections

United States
Boehringer Ingelheim

Completed

The Safety and Effectiveness of Nevirapine Plus Lamivudine Plus Other Anti-HIV Drugs

HIV Infections

United States
Merck Sharp & Dohme LLC

Completed

A Study of Indinavir Sulfate Given Together With Stavudine to HIV-Positive Patients

HIV Infections

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effectiveness of AIDS Antibody Screening

HIV Infections | Acquired Immunodeficiency Syndrome | Blood Transfusion
National Institute of Allergy and Infectious Diseases...

Completed

A Study to Evaluate the Effect of Anti-HIV Therapy on Lean Tissue (Muscle) in HIV-Positive Patients

HIV Infections

United States, Puerto Rico
Hoffmann-La Roche

Completed

A Phase IIIB Open-Label, Comparative Study to Evaluate Saquinavir Soft Gel Capsule (SGC) Treatment in Combination With Other Antiretrovirals in HIV-1 Infected Antiretroviral-Naive Patients

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Detection of Human Immunodeficiency Virus Type 1 (HIV-1) in Vaginocervical Secretions: Correlation With Clinical Status, Virologic and Immunologic Parameters, and the Presence of Other Infections

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Study of Perinatal Transmission of Zidovudine-Resistant HIV Among Pregnant Women Treated With Zidovudine

HIV Infections | Pregnancy

United States, Puerto Rico

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