Search clinical trials for: Dose limiting toxicity

Total 22595 results

Ottawa Hospital Research Institute

Recruiting

Evaluating an Endocrine Therapy Dose-frequency Escalation Strategy and Its Effects on Tolerability and Compliance (REaCT-TEMPO)

Breast Cancer

Canada
Instituto Brasileiro de Controle do Cancer

Recruiting

Efficacy and Safety of Ultra_HYPofractionated RadiotHerapy in Women With BrEast CaNcer Receiving Regional Nodal Radiation vs Nodal Moderate Hypofractionated Radiotherapy (HYPHEN)

Malignant Breast Neoplasm

Brazil
Brigham and Women's Hospital

Recruiting

First in Human Phase 1 Ascending Dose Study of PanChol in Healthy Volunteers

Cholera | Cholera Vaccine Toxicity

United States
SRI International

Recruiting

Study of Single Oral Doses of HOPO 14-1 Evaluating Safety, Tolerability, Pharmacokinetics

Toxicity;Chemical

United States
University of Rochester
Medical College of Wisconsin

Recruiting

A Study to Determine the Preferred Dose of the Drug, Lisinopril, for Preventing Urinary Toxicity Following Radiotherapy for Prostate Cancer

Prostate Cancer | Radiation Toxicity | Urinary Complication

United States
Amsterdam UMC, location VUmc
Dutch Cancer Society

Recruiting

Single-dose Preoperative Partial Breast Irradiation in Low-risk Breast Cancer Patients (ABLATIVE-2)

Breast Cancer

Netherlands
Central Hospital, Nancy, France
PAPE Elise

Not yet recruiting

Peritoneal Diffusion and Efficacy of Antibiotic Therapy in Pediatric Peritonitis (DIFFUPERPED)

Appendicitis | Peritonitis | Children, Only | Antibiotic Toxicity
Medical College of Wisconsin

Recruiting

High Dose Re-Irradiation Utilizing Advanced Deformable Image Registration (DIR) and Individualized Organ At Risk (OAR) Dose Calculations With Organ Specific Toxicity Analysis (REDIRICT)

Solid Tumor

United States
Anhui Provincial Hospital

Recruiting

Hypofraction Radiotherapy for Locally Advanced Non-small Cell Lung Cancer

Non-small Cell Lung Cancer | Toxicity Due to Radiotherapy

China
Hospital General de Mexico

Recruiting

Efficacy of the Use of Bortezomib for the Treatment of Relapsed Leukemia or Positive MRD

Acute Lymphoblastic Leukemia, in Relapse | Chemotherapeutic Toxicity | Minimal Residual Disease

Mexico
Sheba Medical Center
Rambam Health Care Campus; AstraZeneca; Tel-Aviv Sourasky Medical Center

Recruiting

Concomitant Radiotherapy, Tremelimumab & Durvalumab for Advanced NSCLC Patients Progressing on First-line Immunotherapy (CORAL-Lung)

Metastatic or Locally Advanced NSCLC

Israel
National Cheng-Kung University Hospital
China Medical University Hospital; Taipei Veterans General Hospital, Taiwan; Kaohsiung... and other collaborators

Recruiting

Perioperative Leucovorin, Oxaliplatin, Docetaxel and S-1 (LOTS) For Locally Advanced Gastric or Gastroesophageal Junction Cancer (LOTS)

Gastric Cancer | Gastric Adenocarcinoma | Toxicity Due to Chemotherapy | Effects of Chemotherapy

Taiwan
Fudan University

Recruiting

Research on Risk Factors and Interventions of Polycystic Ovary Syndrome Complicated With Depression and Anxiety (PCOS)

Depression, Anxiety | PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries

China
Vejle Hospital

Recruiting

Shared Decision Making on Radiation Dose for Lung Malignancies

Lung Cancer, Non-small Cell | Lung Metastases | Radiation Toxicity | Stereotactic Body Radiation Therapy | Decision Making, Shared

Denmark
Hospices Civils de Lyon

Recruiting

NIRAPK : Study of the Relationship(s) Between Clinical, Biological and Pharmacokinetic Metrics and Toxicities When Niraparib is Used as Maintenance Treatment for Ovarian Cancer Patients. (NIRAPK)

Adult Patients With Platinum-sensitive, Relapsed, High Grade Serous Epithelial Ovarian Cancer

France
Lutris Pharma Ltd.

Recruiting

LUT014 for the Reduction of Dose-Limiting Acneiform Lesions Associated With EGFRI Treatment of mCRC

EGFRI Induced Acneiform Lesions

United States, Israel
Radboud University Medical Center
UMC Utrecht; Catharina Ziekenhuis Eindhoven; Amsterdam UMC, location VUmc; Academisch... and other collaborators

Recruiting

Aerobic Fitness or Muscle Mass Training to Improve Colorectal Cancer Outcome (AMICO)

Colorectal Cancer | Chemotherapeutic Toxicity | Lifestyle | Survivorship

Netherlands
Kiyuk Chang, MD,PhD

Recruiting

Low Dose Rosuvastatin Plus Ezetimibe Versus High-dose Rosuvastatin in AMI (ROSUZET-AMI)

Myocardial Infarction | Statin Adverse Reaction | HMG-CoA Reductase Inhibitor Toxicity

Korea, Republic of
Tata Memorial Centre

Recruiting

Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma. (FOR-WNT2)

Medulloblastoma, WNT-activated

India
Asan Medical Center

Recruiting

Salvage Hypofractionated Accelerated Versus Standard Radiotherapy for Biochemical Failure After Prostatectomy (SHARE)

Quality of Life | Prostate Cancer | Radiation Toxicity | Biochemical Recurrence | Survival | Radiation | Hypofractionation | Dose Escalation

Korea, Republic of
Robert Nickel
The Hospital for Sick Children; Ann & Robert H Lurie Children's Hospital of... and other collaborators

Recruiting

Minimizing Toxicity in HLA-identical Related Donor Transplantation for Children With Sickle Cell Disease (SUN)

Sickle Cell Disease

United States, Canada
Centre Georges Francois Leclerc

Recruiting

Study Evaluating the Efficacy and the Tolerance of Pelvic-prostatic Hypo-fractionated Radiotherapy Followed by Boost in Patients With Prostate Adenocarcinoma Adverse Intermediate Risk or High Localized Risk (SHORT)

To Evaluate the Rate of Digestive and Urinary Toxicity

France
Instituto Nacional de Cancerologia de Mexico

Recruiting

Impact of Fat-free Mass in the Carboplatin Calculated Dose and Chemotherapeutic Toxicity in Patients With Advanced NSCLC

Lung Cancer | Sarcopenia | Toxicity

Mexico
S.Biomedics Co., Ltd.
Yonsei University

Active, not recruiting

Study to Evaluate the Safety and Efficacy of ESC-derived Dopamine Progenitor Cell Therapy in PD Patients

Parkinson's Disease

Korea, Republic of
AstraZeneca
Parexel

Active, not recruiting

Safety and Preliminary Efficacy Assessment of AZD7789 in Patients With Relapsed or Refractory Classical Hodgkin Lymphoma

Relapsed or Refractory Classical Hodgkin Lymphoma

Italy, United States, United Kingdom, Canada, Spain, France, Denmark
Beth Israel Deaconess Medical Center
Society for Obstetric Anesthesia and Perinatology

Active, not recruiting

IV Ketorolac on Platelet Function Post-Cesarean Delivery (KetoPltAgg)

Postoperative Pain | Postpartum Hemorrhage | Blood Loss, Postoperative | Analgesia, Obstetrical | Coagulation Defect; Postpartum | Nonsteroidals (NSAIDs)Toxicity | Ketorolac Adverse Reaction

United States
Radboud University Medical Center
UMC Utrecht; Amsterdam UMC, location VUmc; Maastro Clinic, The Netherlands; Rad...

Completed

Uniform FDG-PET Guided Gradient Dose Prescription to Reduce Late Radiation Toxicity (UPGRADE-RT)

Head and Neck Neoplasms | Carcinoma, Squamous Cell

Netherlands
University of Maryland, Baltimore

Active, not recruiting

Pegcrisantaspase in Combination With Venetoclax for Treatment of Relapsed or Refractory Acute Myeloid Leukemia (R/R AML)

Relapsed or Refractory Acute Myeloid Leukemia

United States
University of Maryland, Baltimore

Active, not recruiting

Belantamab Mafodotin, Cyclophosphamide, and Dexamethasone in Relapsed/Refractory Multiple Myeloma

Relapsed/Refractory Multiple Myeloma

United States
University Hospital, Lille

Active, not recruiting

Compare Lenalidomide and Subcutaneous Daratumumab vs Lenalidomide and Dexamethasone in Frail Subjects With Previously Untreated Multiple Myeloma Who Are Ineligible for High Dose Therapy (IFM2017_03)

Multiple Myeloma

France
Baylor College of Medicine
National Cancer Institute (NCI)

Completed

Dose Adjusted EPOCH-R, to Treat Mature B Cell Malignancies (DA-EPOCH-R)

Diffuse Large B Cell Lymphoma | Post Transplant Lymphoproliferative Disorder | Primary Mediastinal (Thymic) Large B-cell Lymphoma

United States
Institut de cancérologie Strasbourg Europe

Completed

Effect of Irradiation Doses < 10 Gy and of Irradiated Bone Volume on the Variation of Blood Elements of the Complete Blood Count During and After Pelvic Irradiation (MIFADORESOL)

Vaginal Cancer | Prostate Carcinoma | Radiotherapy | Rectum Carcinoma | Cervix Carcinoma | Anal Canal Carcinoma | Endometrium Carcinoma

France
M.D. Anderson Cancer Center

Completed

A Prospective Study Using Implanted Fiducial Markers to Assess Treatment Accuracy and Esophageal Toxicity in Spinal Stereotactic Body Radiation Therapy

Spinal Tumor

United States
Philipps University Marburg Medical Center

Active, not recruiting

Viral Load Guided Immunosuppression After Lung Transplantation (VIGILung)

Transplantation Lung

Austria, Germany
NovoCure GmbH

Active, not recruiting

Effect of Tumor Treating Fields (TTFields) (150 kHz) Concurrent With Standard of Care Therapies for Treatment of Stage 4 Non-small Cell Lung Cancer (NSCLC) Following Platinum Failure (LUNAR)

NSCLC | Nonsmall Cell Lung Cancer

United States, Poland, Hong Kong, China, Spain, Serbia, Croatia, France, Canada, Netherlands, Austria, Belgium, Bulgaria, Czechia, Germany, Hungary, Italy, Switzerland
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Completed

Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma

Lymphoma | Neurotoxicity | Radiation Toxicity | Cognitive/Functional Effects | Chemotherapeutic Agent Toxicity

United States, Israel
Sinew Pharma Inc.

Completed

A Randomized, Single-blind, Parallel Group and Multiple - Dose Design Study

Acetaminophen Toxicity

Taiwan
University of Alabama at Birmingham

Enrolling by invitation

Identifying Ideal Reimbursement "Dose" to Reduce Clinical Trial-related Financial Toxicity

Breast Cancer

United States
GWT-TUD GmbH

Completed

ASTRAL- a Clinical Study to Assess the Efficacy and Toxicity of High-dose Chemotherapy

Lymphoma, B-Cell | Lymphoma, T-Cell | Aggressive Non-hodgkin Lymphoma (aNHL)

Germany
Whanin Pharmaceutical Company

Completed

Bioequivalence Study in Patients With Schizophrenia by Using Clozaril 100 mg Tablet (Clozapine) and WID-CLZ18

Schizophrenia

Korea, Republic of
National Cancer Institute (NCI)

Completed

Phase II Study of Dose-Adjusted EPOCH-Rituximab in Adults With Untreated Burkitt Lymphoma and c-MYC+ Diffuse Large B-Cell Lymphoma

Burkitt Lymphoma | Plasmablastic Lymphoma | Diffuse Large B-cell Lymphoma, c-MYC Positive

United States
University of Pittsburgh

Terminated

Pharmacokinetics of Sirolimus and Tacrolimus in Liver Transplant Recipients With Tacrolimus Toxicity (Sirolimus)

Hypertension
Grupo Espanol de Investigacion en Sarcomas

Active, not recruiting

Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST) (SeliGIST)

Drug Use | GIST | Drug Toxicity | Metastatic Adult Soft Tissue Sarcoma | Maximum Tolerated Dose

Spain
National Cancer Institute, Naples

Active, not recruiting

STAD-1 Small Cell Lung Cancer Toxicity Adjusted Dosing Study (STAD-1)

Small Cell Lung Cancer

Italy
German Oncology Center, Cyprus

Active, not recruiting

Hypo-Combi Trial: Hypofractionated EBRT Plus HDR-BT Boost for Prostate Cancer (Hypo-Combi)

Prostate Adenocarcinoma | Radiation Toxicity

Cyprus
Mersin University

Completed

Comparison of Two Different Norepinephrine Bolus Doses for Management of Spinal Anesthesia-Induced Maternal Hypotension

Cesarean Section Complications | Hypotension Drug-Induced | Spinal Anesthetic Toxicity

Turkey
Linda Van Eldik
National Institute on Aging (NIA); Duke Clinical Research Institute

Completed

MW151-101: First-in-human Study of MW151

Drug Toxicity

United States
Ruijin Hospital
RenJi Hospital; Shanghai 10th People's Hospital; Xinhua Hospital, Shanghai Jiao... and other collaborators

Active, not recruiting

The Safety Management of Cardiac Toxicity in Breast Cancer Patients Under Multidiscipline Therapy.

Breast Neoplasms | Cardiotoxicity

China
Mayo Clinic
National Cancer Institute (NCI)

Completed

Doxorubicin and Cyclophosphamide Followed By Trastuzumab, Paclitaxel, and Lapatinib in Treating Patients With Early-Stage HER2-Positive Breast Cancer That Has Been Removed By Surgery

Breast Cancer | Cardiac Toxicity

United States
Kaiser Permanente
Dana-Farber Cancer Institute; Penn State University

Completed

FOcus on Reducing Dose-limiting Toxicities in Colon Cancer With Resistance Exercise Study (FORCE)

Colon Cancer | Chemotherapy Effect | Resistance Training

United States

Search clinical trials for: Dose limiting toxicity

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