Search clinical trials for: Lp-PLA2- inhibitor

Total 68793 results

Biogen

Completed

A Study to Assess the Potential for Gastric-pH Dependent Drug-Drug Interactions of BIIB122 With a Proton Pump Inhibitor in Healthy Participants

Healthy Volunteer

United States
Alexion
PPD; ERT: Clinical Trial Technology Solutions

Completed

A Study of the Cardiac Effects of ALXN1840 in Healthy Adults

Healthy

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Safety, Tolerability, Drug Levels and Drug Effects of Single and Multiple Doses of BMS-986209 in Healthy Participants

Health Participants

United States
Bristol-Myers Squibb

Completed

A Study to Assess Administration of an Oral Anti-thrombotic With Antiplatelet Therapy in Healthy Subjects

Healthy Volunteers

United States
Kowa Research Institute, Inc.

Completed

Pharmacokinetic Drug-Drug Interaction Study Between K-877 and CSG452 in Healthy Adult Volunteers

Healthy

United States
Bristol-Myers Squibb

Completed

Bioavailability of Apixaban Sprinkle Compared to Apixaban Capsules

Healthy Volunteers

United States
Bristol-Myers Squibb

Completed

A Study to Assess the Effect of BMS-986142 on Pharmacokinetics (PK) of Probe Substrates

Rheumatoid Arthritis

United States
AstraZeneca

Completed

Bioequivalence Study of the Fixed Dose Combination of 5 mg Saxagliptin and 500 mg Metformin XR Tablet (Manufactured in Mt Vernon, IN) Relative to 5 mg Saxagliptin Tablet and 500 mg Metformin XR Tablet (Manufactured in Evansville, IN)

Diabetes Mellitus

United States
AstraZeneca

Completed

Bioequivalence Study of the Fixed Dose Combination of 5 mg Saxagliptin/1000 mg Metformin XR (Manufactured in Mt Vernon, IN) Relative to 5 mg of Onglyza and 2 × 500 mg Glucophage XR

Diabetes Mellitus

United States
AstraZeneca

Completed

Bioequivalence Study of 2.5-mg Saxagliptin and 500-mg Glucophage in Tablets and a Fixed-dose Combination Tablet in Healthy Participants

Type 2 Diabetes Mellitus

United States
AstraZeneca

Unknown

ZD 1839 Plus Combination Chemotherapy in Treating Patients With Non-Small Cell Lung Cancer

Lung Cancer

United States
Silence Therapeutics plc
Medpace, Inc.

Completed

Study to Investigate Safety, Tolerability, PK and PD Response of SLN360 in Subjects With Elevated Lipoprotein(a)

Dyslipidemias | Hyperlipidemias | Elevated Lp(a)

United States, Australia, United Kingdom, Netherlands
Bristol-Myers Squibb

Completed

A Study to Examine the Acceptable Taste and to Estimate the Amount of Atazanavir and Cobicistat in the Body When Taken as a Combination Product Versus When Taken as Separate Products at the Same Time

Healthy Participants

United States
Bristol-Myers Squibb

Completed

Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin

Rheumatoid Arthritis

United States
Celgene Corporation

Completed

Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibition and Induction on the Pharmacokinetics of CC-220 in Healthy Subjects

Pharmacokinetics

United States
AstraZeneca
Bristol-Myers Squibb

Completed

Study to Evaluate the Potential Pharmacokinetic Interaction and Pharmacodynamic Effects on Renal Parameters of Bumetanide (1mg) and Dapagliflozin (10 mg) When Co-administered in Healthy Subjects

Type 2 Diabetes Mellitus

United States
AstraZeneca
Bristol-Myers Squibb

Completed

Bioavailability Study of Fixed Dose Combination (FDC) Formulations of Dapagliflozin and Metformin XR Versus Individual Component Coadministered to Healthy Subjects in a Fasted State

Type 2 Diabetes Mellitus (T2DM)

United States
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Effect of Mipomersen on Cardiac Repolarization Conducted in Healthy Subjects

Healthy

United States
AstraZeneca

Completed

Pharmacokinetics and Pharmacodynamics Study of Saxagliptin in Healthy Subjects

Type 2 Diabetes Mellitus

United States
AstraZeneca

Unknown

ZD 1839 Plus Chemotherapy in Treating Patients With Non-Small Cell Lung Cancer

Lung Cancer

United States
Bristol-Myers Squibb

Completed

Drug-Drug Interaction (DDI) w/Ketoconazole or Fluconazole

Alzheimer Disease

United States
Array Biopharma, now a wholly owned subsidiary...

Completed

A Safety Study of ARRY-300 in Healthy Subjects

Healthy

United States
Kowa Research Institute, Inc.

Completed

Evaluate the Safety, Tolerability, & Pharmacokinetics of K-285 Compared With Indomethacin Capsule in Healthy Adults

Healthy

United States
AstraZeneca
Bristol-Myers Squibb

Completed

Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of Ultra Low Doses of Dapagliflozin in Healthy Subjects (ULDS)

Type 2 Diabetes

United States
Bristol-Myers Squibb

Completed

Multiple Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of BMS-986120 in Healthy Subjects and the Effects of Co-Administration of Midazolam and BMS-986120

Healthy Adult Volunteers

United States
AstraZeneca

Completed

Bioequivalence Study of Fixed Dose Combination of 2.5 mg Saxagliptin/850 mg Metformin Tablet Relative to 2.5 mg Onglyza and 850 mg Glucophage Tablets Co-Administered

Type 2 Diabetes Mellitus

United States
AstraZeneca

Completed

ZD9331 With or Without Topotecan in Treating Patients With Refractory or Recurrent Epithelial Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

Ovarian Cancer | Fallopian Tube Cancer | Primary Peritoneal Cavity Cancer

United States
Bristol-Myers Squibb

Completed

Drug-Drug Interaction Study in Healthy Subjects

Hepatitis C

United States
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Completed

Low Protein Diet in CKD Patients at Risk of Malnutrition

Chronic Kidney Diseases | Malnutrition

Italy
Novartis Pharmaceuticals

Completed

Lipoprotein(a) in Patients With Cardiovascular Disease (CVD)

Cardiovascular Disease and Lipoprotein(a)

China, Germany, United States, Colombia, South Africa, Italy, Spain, Belgium, Egypt, Hungary, Taiwan, Turkey, Japan, Netherlands, Australia, Austria, Canada, Czechia, France, Israel, Switzerland, United Kingdom, Korea, Republic of, Th... and more
Lipella Pharmaceuticals, Inc.
William Beaumont Hospitals

Completed

Evaluation of Intravesical LP08 in Patients With Interstitial Cystitis/Painful Bladder Syndrome

Interstitial Cystitis

United States
Guiding Right, Inc.
University of California, San Diego

Recruiting

LinkPositively+ A Mobile Health App Delivered Intervention to Improve HIV Care Outcomes Among Black Women Affected by Mental Health and Violence (LPP Plus)

HIV/AIDS | Mental Health Issue

United States
Guangzhou Lupeng Pharmaceutical Company LTD.

Recruiting

A Study of LP-168 in Participants With Relapse or Refractory B-Cell Lymphoma

B-cell Lymphoma

China
The First Affiliated Hospital with Nanjing Medical...
Guangzhou Lupeng Pharmaceutical Company LTD.; Newave Pharmaceutical Inc

Recruiting

A Phase I Study of LP-108 in Patients With Relapsed or Refractory B-cell Lymphoma

Chronic Lymphocytic Leukemia | Non-Hodgkin Lymphoma

China
Purdue Pharma LP

Completed

The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) on QT Intervals in Healthy Volunteers

Healthy Volunteers

United States
Fresenius Medical Care Deutschland GmbH

Completed

Safety and Efficacy of the DALI LDL-adsorber and MONET Lipoprotein Filter (LINET)

Hypercholesterolemia, Familial | LIPOPROTEIN TYPES--Lp SYSTEM Lp(a) HYPERLIPOPROTEINEMIA

Germany
Eli Lilly and Company

Completed

A Drug Drug Interaction (DDI) Study of Selpercatinib (LY3527723) and Rosuvastatin in Healthy Participants

Healthy

United States
Guangzhou Lupeng Pharmaceutical Company LTD.

Recruiting

A Study of LP-118 in Patients With Advanced Tumors

Lymphoma, Non-Hodgkin | Solid Tumor

China
University of Ioannina

Recruiting

Medical Students' Evaluation of Dyslipidemia and LIPoprotein(a) Study (MEDLIP)

Insight Into the Prevalence of Elevated Lp(a) Among Greek Medical Students

Greece
Shanghai Jiao Tong University School of Medicine

Completed

Effect of Protein-Restricted Diet on Nitrogen Balance and Residual Renal Function in Peritoneal Dialysis (PD) Patients

Peritoneal Dialysis | Chronic Kidney Disease
Maastricht University Medical Center

Completed

Macronutrients and Postprandial Vascular Function

Vascular Function | Carbohydrates | Postprandial Metabolism | Proteins | Dietary Fats | Macronutrients

Netherlands
jingxue

Recruiting

Lipoprotein a is an Independent Risk Factor for Overall Survival in Patients With Pancreatic Cancer: a Propensity Score Matching Analysis

Pancreatic Carcinoma; Lipoprotein a; Overall Survival; Prognosis

China
Shanxi Kangbao Biological Product Co., Ltd.
Institute of Pathogen Biology, Chinese Academy of Medical Sciences

Recruiting

Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of LP-98 Injection in Healthy Subjects

Hiv

China
Guangzhou Lupeng Pharmaceutical Company LTD.

Completed

A Food Effect Study of LP-168 Tablets in Healthy Subjects

Mantle Cell Lymphoma

China
Tartu University Hospital

Completed

Study Evaluating the Impact of Mesh Pore Size on Chronic Pain After Lichtenstein Hernioplasty

Inguinal Hernia
Abiomed Inc.

Completed

RECOVER I Impella RECOVER LP/LD 5.0 Support System Safety and Feasibility Study (RECOVER I)

Cardiac Surgery

United States
University of Pavia
IRCCS Policlinico S. Matteo

Withdrawn

Use of Apheretic Technologies in Cardiovascular Disease

Dyslipidemia

Italy
GenMont Biotech Incorporation
National Science Council, Taiwan

Completed

Probiotics and Allergic Diseases (probiotics)

Asthma | Atopic Dermatitis

Taiwan
Luis Monteiro

Recruiting

Clinical Tial of Er:YAG Laser Snoring Treatment

Snoring

Portugal
Atlantic Health System
Regeneron Pharmaceuticals

Not yet recruiting

Atlantic Lipid Lowering Treatment Optimization Program (ALLTOP)

Familial Hypercholesterolemia | High Density Lipoprotein Deficiency | Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia | Apolipoprotein B 100, Familial Defective | Low-Density-Lipoid-Type Hyperlipoproteinemia

United States

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