Search clinical trials for: amendement du facteur C5 du complément

Total 371376 results

Zentrum für Integrative Psychiatrie

Unknown

Effect of Intranasal Administration of Orexine A on IL-6-System, Sleep-Wake-Regulation and Neurocognition (NARKOREX)

Narcolepsy

Germany
Ability Pharmaceuticals SL
Centre Leon Berard; Institut Català d'Oncologia; Institut Paoli-Calmettes; Gustave... and other collaborators

Completed

A Study to Assess the Efficacy and Safety of ABTL0812 (Endolung)

Endometrial Cancer | Squamous Non-Small Cell Lung Cancer

Spain
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of Twice Daily Oral LNP023 in Adult PNH Patients With Residual Anemia Despite Anti-C5 Antibody Treatment (APPLY-PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Italy, Japan, Taiwan, Germany, France, United Kingdom, Spain, Korea, Republic of, Czechia, Brazil, Netherlands, United States
AO GENERIUM

Completed

A Safety and Immunogenicity Study in Long-term Treatment of Eculizumab (JSC "GENERIUM", Russian Federation) (NAP)

Paroxysmal Nocturnal Hemoglobinuria

Russian Federation
Cairo University

Completed

Mobilization With Movement vs. Neural Mobilization on Nerve Root Function in Patients With Cervical Radiculopathy

Cervical Radiculopathy | Disc Herniation | Cervical Radiculopathy at C5 Nerve Root | Cervical Radiculopathy at C6 Nerve Root | Cervical Radiculopathy at C7 Nerve Root

Egypt
National University Hospital, Singapore
KK Women's and Children's Hospital; National Cancer Centre, Singapore; Australia...

Unknown

Vinorelbine in Relapsed Platinum Resistant or Refractory C5 High Grade Serous, Endometrioid, or Undifferentiated Primary Peritoneum, Fallopian Tube or Ovarian Cancer

Ovarian Cancer | Fallopian Tube Cancer

Singapore, Australia
Novartis Pharmaceuticals

Recruiting

Single Arm, Open Label Trial With Iptacopan Treatment for 24 Weeks, in Patients on Stable Regimen of Anti-C5 Who Switch to Iptacopan. (APPULSE)

Paroxysmal Nocturnal Hemoglobinuria

France, Spain, Italy, Turkey, Germany, United States, Korea, Republic of, United Kingdom
Ophthotech Corporation

Completed

A Study of ARC1905 (Anti-C5 Aptamer) in Subjects With Dry Age-related Macular Degeneration

Age-Related Macular Degeneration

United States
Zentrum für Integrative Psychiatrie
German Research Foundation

Unknown

Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression

Major Depression

Germany
Cedars-Sinai Medical Center
Alexion Pharmaceuticals

Completed

The De-novo Use of Eculizumab in Presensitized Patients Receiving Cardiac Transplantation (DUET)

Cardiac Allograft Vasculopathy | Antibody-mediated Rejection | Left Ventricular Dysfunction | Hyperacute Rejection of Cardiac Transplant | Heart Graft Dysfunction

United States
Novartis Pharmaceuticals

Recruiting

Efficacy and Safety of Switching From Anti-C5 Antibody Treatment to Iptacopan Treatment in Study Participants With Atypical Hemolytic Uremic Syndrome (aHUS)

Atypical Hemolytic Uremic Syndrome

Japan, Turkey
Jinnah Postgraduate Medical Centre

Active, not recruiting

Comparison Of Efficacy Of Combination Of TAM Formula Vs Kligman Formula For Melasma.

Melasma

Pakistan
Alexion Pharmaceuticals

No longer available

COVID-19 Soliris Expanded Access Protocol

Covid19
University of Dublin, Trinity College
Alzheimer's Association

Recruiting

Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment

Mild Cognitive Impairment | Memory Impairment | Memory Disorders in Old Age

Ireland
University of Wisconsin, Madison
National Eye Institute (NEI)

Recruiting

Moderators and Mediators of Perceptual Learning

Cognitive Change

United States
Ophthotech Corporation

Completed

ARC1905 (ANTI-C5 APTAMER) Given Either In Combination Therapy With Lucentis® 0.5 mg/Eye In Subjects With Neovascular Age-Related Macular Degeneration

Age-Related Macular Degeneration

United States
Novartis Pharmaceuticals

Completed

Intravitreal LFG316 in Patients With Advanced Age-related Macular Degeneration

Advanced Age-related Macular Degeneration

United States
Boehringer Ingelheim

Completed

Relative Bioavailability of Two Fixed Dose Combination Tablets of Linagliptin/Pioglitazone Compared With Single Linagliptin and Pioglitazone Tablets Administered Together to Healthy Male and Female Subjects

Healthy
Ophthotech Corporation

Completed

A Study to Establish the Safety and Tolerability of Zimura® (Anti-C5 Aptamer) in Combination With Anti-VEGF Therapy in Subjects With Idiopathic Polypoidal Choroidal Vasculopathy (IPCV)

Idiopathic Polypoidal Choroidal Vasculopathy

United States
Regeneron Pharmaceuticals

Recruiting

A C5 Inhibitor-controlled Study to Evaluate the Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Are Complement Inhibitor Treatment-Naive or Have Not Recently Received Complement Inhibitor Therapy (ACCESS-1)

Paroxysmal Nocturnal Hemoglobinuria

Mexico, Korea, Republic of, Turkey, Italy, United Kingdom, Thailand, Poland, Singapore, Spain, Taiwan, Canada, Japan, United States, Malaysia, Greece, Romania, Hungary
Shandong Cancer Hospital and Institute

Unknown

Study of Breast Cancer Shrinkage Modes After Neoadjuvant Chemotherapy With Whole-mount Serial Sections and Three-dimensional Pathological and MRI Reconstruction (BCSMANC)

Breast Cancer

China
British University In Egypt

Not yet recruiting

Efficacy of Thyme Honey in The Management of Oral Aphthous Ulcers

Treatment Compliance | Aphthous Stomatitis (Major) (Minor)

Egypt
Zhangfa Song

Not yet recruiting

Chemotherapy Plus Bevacizumab and Anti-PD-1 Followed by Induction Therapy of Chemotherapy Plus Bevacizumab

Metastatic Colorectal Cancer | MSS

China
GCS CIPS

Not yet recruiting

Correlates of Fatigue in People With Schizophrenia (FIZO-2)

Schizophrenia
Complement Theory Inc.

Recruiting

A Randomised Controlled Trial to Evaluate the Impact of Complement Theory's Live 1:1 Exercise Coaching and Personalised Digital Application on Cancer Survivors' Cost of Care

Breast Cancer | Colorectal Cancer | Lung Cancer | Prostate Cancer | Other Cancer

United States
I.R.C.C.S. Fondazione Santa Lucia

Not yet recruiting

Oral Supplementation Compared With Hyaluronic Acid Infiltration in Rotator Cuff Tendinopathies

Shoulder Pain | Dietary Supplements | Hyaluronic Acid | Tendinitis of Shoulder
Northern Michigan University

Recruiting

Climbing Lifestyle Intervention for Modifying Physical Activity Behaviors: Pilot Study (CLIMB)

Quality of Life | Physical Inactivity | Lifestyle Factors

United States
Peking University People's Hospital

Not yet recruiting

Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory cGVHD

cGVHD
Assiut University

Not yet recruiting

Effect of Coenzyme Q10 on Diabetic Children

Type 1 Diabetes Mellitus
Octapharma

Recruiting

Study of IV Human Plasma-derived C1 Esterase Inhibitor Concentrate in Patients With Congenital C1-INH Deficiency for Treatment and Pre-procedure Preventing of Acute Hereditary Angioedema Attacks

Acute Hereditary Angio Edema

Romania
Haaglanden Medical Centre
Takeda; Leiden University Medical Center

Not yet recruiting

Complement Inhibition: Attacking the Overshooting Inflammation @Fter Subarachnoid Hemorrhage (CIAO@SAH) (CIAO@SAH)

Subarachnoid Hemorrhage, Aneurysmal
Biocad

Recruiting

Study of the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of BCD-180 in Patients With Axial Spondyloarthritis (LEVENTA)

Axial Spondyloarthritis

Russian Federation, Belarus
Universidade Federal Fluminense
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.; Conselho Nacional... and other collaborators

Not yet recruiting

Green Propolis Extract and Royal Jelly in Hypertensive Patients and/or With Chronic Kidney Disease

Cardiovascular Diseases | Hypertension | Chronic Kidney Diseases

Brazil
National Institute of Allergy and Infectious Diseases...

Not yet recruiting

Expanding Liver Transplant Immunosuppression Minimization Via Everolimus (ELIMINATE)

Liver Transplant

United States
Xiaotong Hou

Not yet recruiting

Use of Nafamostat Mesilate for Anticoagulation in Patients With ECMO

Extracorporeal Membrane Oxygenation Complication

China
Kodiak Sciences Inc

Recruiting

A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer Compared With Sham Treatment in Participants With Moderately Severe to Severe Non-proliferative Diabetic Retinopathy (NPDR) (GLOW2)

Non-proliferative Diabetic Retinopathy

United States, Puerto Rico
Edward Geissler
Chiesi Pharmaceuticals GmbH

Recruiting

Tacrolimus C:D Ratio Measured in Renal Transplant Recipients Treated With Once-daily Prolonged-release Drugs (TaC:Drop)

Immunosuppression

Germany
Janssen Research & Development, LLC

Recruiting

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis (QUASAR Jr)

Colitis, Ulcerative

Belgium, United States, China, Denmark, Spain, Japan, Italy, Turkey, Poland, France, Portugal
AbbVie

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis

Ulcerative Colitis

United States
U.S. Army Medical Research and Development Command
National Institute of Allergy and Infectious Diseases (NIAID); Duke University and other collaborators

Not yet recruiting

Evaluation of Safety and Immunogenicity of Ad26.Mos4.HIV and CH505 TF chTrimer Combination in Healthy Adults (RV591)

Human Immunodeficiency Virus

Uganda
Chiang Mai University

Not yet recruiting

Low-intensity Physical-cognitive Exercise and Cognitive Function

Mild Cognitive Impairment

Thailand
University of Jaén
University Rovira i Virgili; Universidad Miguel Hernandez de Elche

Recruiting

Selective Prevention Transdiagnostic Intervention for At-risk Adolescents With Booster Sessions. (PROCARE+ 2.0)

Anxiety Disorders and Symptoms Depressive Symptoms | Risk Factors (Rejection, Bullying/Cyberbullying, Addictions, Healthy Lifestyle Habits, Exam Stress Management, Ecoanxiety, Expressed Emotion)

Spain
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Not yet recruiting

A Study of Recombinant Anti-IL-1β Humanized Monoclonal Antibody Injection in Chinese Participants With Acute Gout

Acute Gout
Industrial Farmacéutica Cantabria, S.A.

Not yet recruiting

A Pilot Study to Evaluate the Systemic Effect of Oral Supplementation With AM3 in Patients With Metabolic Syndrome.

Metabolic Syndrome
University of California, San Francisco
National Institute of Allergy and Infectious Diseases (NIAID); Baylor College... and other collaborators

Recruiting

PROmotion of COVID-19 BOOSTer VA(X)Ccination in the Emergency Department - PROBOOSTVAXED (PROBOOSTVAXED)

COVID-19

United States
DR. DIANE CHISESI NFS. MD. PHD.
IRB

Not yet recruiting

Anastrozole Adjuvant Trial - Study of Anastrozole Compared to NOLVADEX (Tamoxifen Citrate) for Adjuvant Treatment of Early Breast Cancer Clinical Studies), Adjunct Cytotoxic Chemotherapy and Malignant Joint Tumor (NASBP-B-09)

Chronic Pain | Metastatic Breast Cancer | Tumor | Muscle Neoplasms

United States
Ain Shams University

Not yet recruiting

Topical Erythropoietin Hydrogel in Management of Oral Lichen Planus

Oral Lichen Planus
Bio-Thera Solutions

Recruiting

Assessment of Safety, Tolerability and Pharmacokinetics With BAT4706 and BAT1308 in Advanced Solid Tumors Patients

Advanced Solid Tumor

China
Coventry University
The University of Hong Kong; Radboud University, Donders Institute for Brain... and other collaborators

Not yet recruiting

From the Heart: Comparing the Effects of Spiritual and Secular Meditation on Psychophysiology, Cognition, Mental Health, and Social Functioning in Healthy Adults

Depression | Pain | Stress | Anxiety | Mental Well-being | Prosocial Behavior | Attention | Empathy | Forgiveness

China, India
AstraZeneca

Recruiting

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of Subcutaneous AZD6912 in Healthy Participants

Rheumatoid Arthritis

United Kingdom, Canada

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