Search clinical trials for: metronomic 5fluorouracil

Total 208 results

Emory University
Cannonball Kids' Cancer Foundation; Hyundai Hope On Wheels

Recruiting

Sirolimus in Combination With Metronomic Chemotherapy in Children With Recurrent and/or Refractory Solid and CNS Tumors (AflacST1502)

Cancer

United States
Miller Children's & Women's Hospital Long Beach
Children's Hospital of Orange County

Recruiting

Metronomic Therapy for Pediatric Patients With Solid Tumors at High Risk of Recurrence (Metronomic)

Solid Tumor

United States
Medical University of Vienna

Recruiting

Antiangiogenic Therapy for Children With Recurrent Medulloblastoma, Ependymoma and ATRT (MEMMAT)

Medulloblastoma Recurrent | Ependymoma Recurrent | ATRT Recurrent

Austria, Sweden, France, Spain, United States, Czechia, Denmark, Norway
University of California, Davis

Enrolling by invitation

Efficacy and Safety of Cryotherapy Versus 5-Fluorouracil in the Treatment of Actinic Keratosis

Actinic Keratoses

United States
Ipsen

Active, not recruiting

A Study to Assess the Effectiveness and Safety of Irinotecan Liposome Injection, 5-fluorouracil/Leucovorin Plus Oxaliplatin in Patients Not Previously Treated for Metastatic Pancreatic Cancer, Compared to Nab-paclitaxel+Gemcitabine Treatment (NAPOLI 3)

Metastatic Adenocarcinoma of the Pancreas

United States, Spain, Hungary, France, Portugal, Korea, Republic of, Germany, United Kingdom, Austria, Italy, Israel, Australia, Brazil, Czechia, Belgium, Russian Federation, Canada, Greece
University of Birmingham
University of Oslo; The Leeds Teaching Hospitals NHS Trust; University of Padova and other collaborators

Active, not recruiting

Paediatric Hepatic International Tumour Trial (PHITT)

Carcinoma, Hepatocellular | Hepatoblastoma

United Kingdom, France, Austria, Israel, Spain, Belgium, Czechia, Finland, Germany, Ireland, Netherlands, Norway, Poland, Switzerland
University of Cologne

Completed

Metronomic Treatment in Children and Adolescents With Recurrent or Progressive High Risk Neuroblastoma (METRO-NB2012)

Recurrent Neuroblastoma

Germany
Centre Oscar Lambret
Bristol-Myers Squibb; Anticancer Fund, Belgium; CTD-CNO; ECS-Progastrin SA

Active, not recruiting

Nivolumab in Combination With Metronomic Chemotherapy in Paediatrics Refractory / Relapsing Solid Tumors

Childhood Solid Tumor

France, Belgium
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Major De-escalation to 30 Gy for Select Human Papillomavirus Associated Oropharyngeal Carcinoma

HPV-Associated Oropharyngeal Squamous Cell Carcinoma | Squamous Cell Carcinoma of the Neck

United States
Sun Yat-sen University

Completed

Metronomic Chemotherapy in a Real-world Population of Advanced Breast Cancer Patients

Breast Cancer

China
BeiGene

Active, not recruiting

Study of Ociperlimab (BGB-A1217) in Combination With Tislelizumab in Advanced Solid Tumors

Locally Advanced and Metastatic Solid Tumors

China, Taiwan, United States, Australia
ETOP IBCSG Partners Foundation

Completed

MEtronomic TrEatment Option in Advanced bReast cAncer (METEORA-II)

Breast Cancer

Italy
Sun Yat-sen University

Active, not recruiting

Metronomic Capecitabine Plus Aromatase Inhibitor for First Line Treatment in HR(+), Her2(-) Metastatic Breast Cancer (MECCA)

Breast Cancer

China
Fujian Cancer Hospital

Enrolling by invitation

Metronomic Oral Vinorelbine Combination With Tislelizumab in EGFR/ALK-negative Advanced NSCLC

EGFR/ ALK-negative Advanced NSCLC

China
Capital Medical University

Completed

Study in Letrozole Combined With Metronomic Oral Cyclophosphamide in Elderly Metastasis Breast Cancer Patients

Breast Neoplasms | Neoplasm Metastasis

China
Washington University School of Medicine

Completed

Anti-Angiogenic Therapy Post Transplant (ASCR) for Pediatric Solid Tumors (ASCR)

Glioma | Neuroectodermal Tumors, Primitive | Osteosarcoma | Sarcoma, Ewing | Retinoblastoma | Rhabdomyosarcoma | Wilms Tumor

United States
Baylor College of Medicine
Center for Cell and Gene Therapy, Baylor College of Medicine

Active, not recruiting

Allogeneic Tumor Cell Vaccination With Oral Metronomic Cytoxan in Patients With High-Risk Neuroblastoma (ATOMIC)

Neuroblastoma

United States
Centre Hospitalier Universitaire de Besancon

Completed

Metastatic or Refractory Soft Tissue Sarcomas and Metronomic Cyclophosphamide: Further Assessment of Efficacy and Safety (MeRCY)

Sarcoma | Soft Tissue Sarcoma
Vastra Gotaland Region

Completed

Effect of Low Dose Metronomic Chemotherapy in Metastatic Breast Cancer (METRO)

Chemotherapy Effect | Breast Cancer Metastatic

Sweden
Spanish Lung Cancer Group

Completed

Study of Vinorelbine and Cisplatin as Induction Therapy With Radiotherapy in Patients With Unresectable NSCLC (NORA)

Lung Cancer

Spain
UNICANCER
AstraZeneca; National Cancer Institute, France; Pierre Fabre Laboratories

Active, not recruiting

Metronomic Oral Vinorelbine Plus Anti-PD-L1/Anti-CTLA4 ImmunothErapy in Patients With Advanced Solid Tumours (MOVIE)

Breast Cancer | Head and Neck Cancer | Prostate Cancer | Cervix Cancer | Advanced Solid Tumours

France
Centre Hospitalier Universitaire de Besancon
Bayer

Completed

Regorafenib in Combination With Metronomic Chemotherapies, and Low-dose Aspirin in Metastatic Colorectal Cancer (REPROGRAM-01)

Metastatic Cancer | Colo-rectal Cancer

France
Ashwin Somasundaram
EMD Serono; University of North Carolina, Chapel Hill

Completed

Trial of mFOLFOX6 + Trastuzumab + Avelumab in Gastric and Esophageal Adenocarcinomas

Gastric Adenocarcinoma | Metastasis | Esophageal Adenocarcinoma | HER-2 Gene Amplification

United States
Incyte Corporation

Completed

A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors

Ovarian Cancer | Endometrial Cancer | Solid Tumors | Biliary Tract Cancer (BTC) | Colorectal Cancer (CRC) | Gastroesophageal Cancer (GC)

United Kingdom, United States, Belgium
Sumitomo Pharma America, Inc.

Completed

Rollover Study to Provide Continued Access to Napabucasin for Patients Enrolled in Boston Biomedical-sponsored Protocols

Oncology

United States, Taiwan, Japan, France
National Cancer Institute (NCI)

Terminated

T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery

Breast Cancer | Brain Cancer | Brain Metastasis

United States
Gruppo Oncologico del Nord-Ovest

Active, not recruiting

AVELUMAB and CETUXIMAB and mFOLFOXIRI as Initial Therapy for Unresectable Metastatic Colorectal Cancer Patients (AVETRIC)

Metastatic Colorectal Cancer

Italy
Medical College of Wisconsin
University of Cincinnati

Completed

Pancreas Cancer: Molecular Profiling as a Guide to Therapy Before and After Surgery ("Personalized Medicine")

Pancreatic Adenocarcinoma

United States
Federation Francophone de Cancerologie Digestive
UNICANCER; GERCOR - Multidisciplinary Oncology Cooperative Group

Active, not recruiting

PHASE III RANDOMISED TRIAL TO EVALUATE FOLFOX WITH OR WITHOUT DOCETAXEL (TFOX) AS 1st LINE CHEMOTHERAPY FOR LOCALLY ADVANCED OR METASTATIC OESOPHAGO-GASTRIC CARCINOMA (GASTFOX)

OESOPHAGO-GASTRIC CARCINOMA

France, Martinique
South Valley University

Completed

Comparative Study Between Topical 5-fluorouracil and Latanoprost in Vitiligo.

Vitiligo

Egypt
Spanish Cooperative Group for the Treatment of...
Sanofi

Completed

Study to Assess the Efficacy and Safety of Treatment With FOLFIRI-aflibercept Compared to Initial Treatment With FOLFIRI-aflibercept (for 6 Cycles) Followed by Maintenance With 5FU-aflibercept, in an Elderly Population With mCRC After Failure of an Oxaliplatin-based Regimen (AFEMA)

Metastatic Colorectal Cancer

Spain
Institut Bergonié
PharmaMar

Completed

Targeting Microenvironment and Cellular Immunity in Sarcomas Weekly Trabectedin Combined With Metronomic Cyclophosphamide (TARMIC)

Soft-tissue Sarcomas

France
Assistance Publique Hopitaux De Marseille

Completed

A Clinical Trial Using Metronomic Oral Low-dose Cyclophosphamide Alternating With Low-dose Oral Methotrexate With Continuous Celecoxib and Weekly Vinblastine in Children and Adolescents With Relapsed or Progressing soliD Tumours. (SFCE METRO 01)

Survival Without Progression

France
Yuhong Li

Completed

Efficacy and Safety of TPF Induction Chemotherapy for Borderline-resectable Esophageal Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma

China
Brown University
Rhode Island Hospital; Merrimack Pharmaceuticals

Terminated

BrUOG 329 Onivyde & Metronomic Temozolomide in Recurrent Glioblastoma (329)

Glioblastoma | Glioblastoma Multiforme | GBM

United States
Centre Francois Baclesse
Accuray Incorporated

Active, not recruiting

Study of SIB-IMRT in Combination With 5-FU and Mitomycin-C Among Patients With Locally Advanced Anal Canal Cancer: Efficacy, Safety and Quality of Life (CANAL-IMRT-01)

Locally Advanced Anal Canal Cancer

France
Institut Bergonié
Pfizer; Reliable Cancer Therapies

Completed

Metronomic Chemotherapy in Patients With Advanced Solid Tumor With Bone Metastasis and Advanced Pretreated Osteosarcoma (METZOLIMOS)

Osteosarcoma | Solid Tumor

France
Assistance Publique Hopitaux De Marseille

Completed

Metronomic Chemotherapy Based on Adaptative Bio-mathematical Model of Oral Vinorelbine in Patients With NSCLC or MPM (NVB Metro)

Non Small Cell Lung Cancer (NSCLC) | Malignant Pleural Mesothelioma (MPM)

France
European Organisation for Research and Treatment...
Hoffmann-La Roche

Completed

Elderly Metastatic Breast Cancer: Pertuzumab-Herceptin vs Pertuzumab-Herceptin-Metronomic Chemotherapy, Followed by T-DM1

Elderly Metastatic Breast Cancer Population

Belgium, Italy, Netherlands, France, Poland, United Kingdom, Portugal, Sweden
Ipsen

Completed

Study of Nanoliposomal Irinotecan (Nal-IRI)-Containing Regimens Versus Nab-paclitaxel Plus Gemcitabine in Patients With Previously Untreated, Metastatic Pancreatic Adenocarcinoma

Pancreatic Cancer

United States, Spain, Australia
University Hospital, Brest
Roche Farma, S.A; Pierre Fabre Medicament; Groupe Français de Pneumo-Cancérologie

Completed

Trial to Evaluate Safety and Efficacy of Vinorelbine With Metronomic Administration in Combination With Atezolizumab as Second-line Treatment for Patients With Stage IV Non-small Cell Lung Cancer (VinMetAtezo)

Non-small Cell Lung Cancer

France
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Suspended

Trial of Neoadjuvant Docetaxel ± Metronomic Capecitabine/CTX Followed by FEC in Women With Operable Triple Negative Breast Cancer

Breast Cancer

China
ImmunityBio, Inc.

Withdrawn

QUILT-2.024: Phase 2 Neoadjuvant, Consolidation, and Adjuvant Combination NANT Immunotherapy Versus Standard of Care in Subjects With Resectable Non-small Cell Lung Cancer

Non Small Cell Lung Cancer

United States
Grupo Espanol Multidisciplinario del Cancer Digestivo
Amgen; Pivotal S.L.

Completed

Induction Therapy With Panitumumab + mFOLFOX-6 in Rectal Cancer and Quadruple Wild-type Mutation Before Surgery (PIER)

Rectal Cancer

Spain
National Cancer Institute (NCI)

Terminated

Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum

Melanoma | Sarcoma | Thoracic Sarcomas | Thorasic Cancers | Cancers of Non-thoracic Origin With Metastases to the Lungs or Pleura

United States
Dana-Farber Cancer Institute
Beth Israel Deaconess Medical Center; Genentech, Inc.; Brigham and Women's Hospital and other collaborators

Terminated

Bevacizumab, Metronomic Chemotherapy (CM), Diet and Exercise After Preoperative Chemotherapy for Breast Cancer (ABCDE)

Breast Cancer

United States
Chuangzhen Chen

Completed

Study of Simultaneous Modulated Accelerated Radiation Therapy Concurrent With Chemotherapy to Treat Esophageal Cancer

Esophageal Neoplasms

China
Fondazione Italiana Linfomi ONLUS

Completed

Metronomic Chemotherapy in Elderly Non-fit Patients With Aggressive B-Cell Lymphomas

Aggressive Non-Hodgkin Lymphoma

Italy
Hospices Civils de Lyon

Completed

Safety and Efficacy of Metronomic Cyclophosphamide, Metformin and Olaparib in Endometrial Cancer Patients (ENDOLA)

Recurrent Endometrial Cancer

France
University of Ulm
Anticancer Fund, Belgium; Reliable Cancer Therapies

Completed

A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma

Glioblastoma

Germany

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