Search clinical trials for: smoothened (SMO) inhibitors

Total 64419 results

Ain Shams University

Completed

Effect of Progesterone on Latent Phase Prolongation in Patients With Preterm Premature Rupture of Membranes

Preterm Premature Rupture of Membrane

Egypt
Eli Lilly and Company
SCRI Development Innovations, LLC

Terminated

A Study of LY3023414 and Necitumumab in Squamous Lung Cancer

Non-small Cell Lung Cancer Metastatic

United States
Glaxo Wellcome

Unknown

Comparison of GW433908 and Nelfinavir in HIV Patients Who Have Not Had Antiretroviral Therapy

HIV Infections

United States
Takeda

Completed

A Study of Moderate to Severe Inflammatory Bowel Disease, Including Ulcerative Colitis (UC) and Crohn's Disease (CD) (RISE-MX)

Inflammatory Bowel Diseases | Crohn Disease | Colitis, Ulcerative

Mexico
Eli Lilly and Company

Completed

A Study LY2228820 for Recurrent Ovarian Cancer

Fallopian Tube Cancer | Epithelial Ovarian Cancer | Primary Peritoneal Cancer

United States, Australia, Germany, Belgium
Norgine

Completed

Constipation Associated With Irritable Bowel Syndrome (IBS-C)

Constipation

United Kingdom, Italy, Czech Republic, France, Germany, Poland, Sweden
St. Jude Children's Research Hospital
Novartis Pharmaceuticals

Completed

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Glioma | Neoplasms | Glioblastoma | Neoplasms, Neuroepithelial | Central Nervous System Neoplasms | Brain Cancer | Brain Tumor | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Ganglioglioma | Anaplastic Ependymoma | Anaplastic Oligodendroglioma | Pineoblastoma | Recurrent Medulloblastoma | CNS Tumor | Pediatric... and other conditions

United States
Kowa Research Europe

Completed

Follow-On Study of Pitavastatin Versus Atorvastatin in Patients With Type II Diabetes Mellitus and Combined Dyslipidemia

Dyslipidemia | Type II Diabetes Mellitus

India, Denmark, Germany, Netherlands, Poland, United Kingdom
Kowa Research Europe

Completed

Study Comparing Pitavastatin and Atorvastatin in Patients With Type II Diabetes Mellitus and Combined Dyslipidemia

Dyslipidemia | Type II Diabetes Mellitus

India, Germany, Netherlands, Poland, Denmark, United Kingdom
IBSA Institut Biochimique SA

Completed

A Study to Evaluate the Clinical Performance and Safety of an Intra-articular Hyaluronic Acid in Knee Osteoarthritis

Knee Osteoarthritis

Poland, Germany, Italy, Belgium, Hungary
Eli Lilly and Company

Completed

A Neoadjuvant Study of Abemaciclib (LY2835219) in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast Cancer (neoMONARCH)

Breast Cancer | Early-Stage Breast Carcinoma | Hormone Receptor Positive Tumor

United States, Canada, Korea, Republic of, Italy, Austria, Belgium, Germany, Netherlands, Spain, Taiwan
Eli Lilly and Company

Completed

A Study of Ramucirumab (LY3009806) in Combination With Capecitabine and Cisplatin in Participants With Stomach Cancer (RAINFALL)

Metastatic Gastric Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma

Germany, Italy, Spain, United States, Hungary, Russian Federation, Poland, Belgium, Netherlands, France, Czechia, Mexico, Argentina, Canada, Denmark, Finland, Israel, Japan, Puerto Rico, United Kingdom
Basilea Pharmaceutica

Completed

Ceftobiprole in the Treatment of Pediatric Patients With Pneumonia

Community-acquired Pneumonia (CAP) | Hospital-acquired Pneumonia (HAP)

Bulgaria, Hungary, Georgia, Romania
Syndax Pharmaceuticals

Completed

Study to Evaluate Exemestane With and Without Entinostat (SNDX-275) in Treatment of Postmenopausal Women With Advanced Breast Cancer (ENCORE301)

Breast Cancer | ER+ Breast Cancer | Estrogen Receptor-Positive Breast Cancer | Breast Cancer, Estrogen Receptor-Positive

United States, Czechia, Canada, Hungary, Russian Federation
Glaxo Wellcome

Unknown

Comparison of GW433908/Ritonavir to Nelfinavir When Used With Abacavir and Lamivudine in Patients That Have Not Taken Antiretroviral Drugs

HIV Infections

United States
Eli Lilly and Company

Recruiting

A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer (EMBER-3)

Breast Neoplasms | Neoplasm Metastasis

Japan, United States, China, Czechia, Belgium, Brazil, Germany, Netherlands, Russian Federation, Ukraine, Taiwan, France, Korea, Republic of, Italy, Spain, Australia, Turkey, India, Argentina, Greece, Austria, Mexico
Purdue Pharma LP

Terminated

Buprenorphine Transdermal Patches (BTDS) in Subjects With Osteoarthritis Pain. Includes a 52-week Extension Phase.

Osteoarthritis

United States
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Fixed Combination Therapy of Vildagliptin and Metformin (25/1000 mg Bid) in Patients With Type 2 Diabetes Inadequately Controlled With Prior Metformin Monotherapy (HbA1c 7.0-9.5%)

Diabetes Mellitus, Type 2

United States, Hungary, Poland, Germany, France
BioCryst Pharmaceuticals
Department of Health and Human Services

Terminated

A Study to Evaluate the Efficacy and Safety of IV Peramivir in Addition to Standard of Care Compared to Standard of Care Alone in Adults and Adolescents Who Are Hospitalized Due to Influenza

Cough | Fever | Headache | Nasal Congestion | Seasonal Influenza | Sore Throat

United States, Poland, Ukraine, Germany, Belgium, Argentina, Israel, Bulgaria, Serbia, South Africa, Brazil, Canada, Chile, Peru, Russian Federation, Hungary, Czech Republic, India, United Kingdom, Latvia, Bosnia and Herzegovina, ... and more
Eli Lilly and Company

Completed

A Study of Ramucirumab (LY3009806) Plus Docetaxel in Participants With Urothelial Cancer (RANGE)

Urothelial Carcinoma

Spain, United States, Poland, Romania, Taiwan, Ukraine, Netherlands, Mexico, Japan, France, Germany, Belgium, Greece, Russian Federation, Turkey, Canada, Israel, Italy, United Kingdom, Denmark, Korea, Republic of, Australia, Hungary
Pfizer

Completed

Prospective Multicenter Doubleblind Randomized Study of NXL104/Ceftazidime + Metronidazole vs. Meropenem in Treatment of Complicated Intra-abdominal Infections

Complicated Intra-abdominal Infections

United States, Lebanon, France, Romania, Bulgaria, India, Poland, Russian Federation
Boehringer Ingelheim

Active, not recruiting

A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer

Head and Neck Squamous Cell Carcinoma (HNSCC)

Spain, United States, United Kingdom, France, Thailand, Malaysia, Mexico, Romania, Poland, Japan, Moldova, Republic of
Bayer

Completed

A Study to Learn How Safe BAY2395840 is and How Well it Works in Participants Who Have Diabetic Nerve Pain

Diabetes Mellitus | Neuropathic Pain Associated With Diabetic Peripheral Neuropathy | Peripheral Neuropathic Pain

Hungary, Spain, Germany, Czechia, Slovakia, United Kingdom
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Drug Levels, Efficacy and Safety of Deucravacitinib in Pediatric Participants With Moderate to Severe Plaque Psoriasis

Plaque Psoriasis

Australia, Mexico, Canada, United Kingdom, France, Argentina, Japan, Poland, Spain, Korea, Republic of, Brazil, Germany, Romania
Eli Lilly and Company

Active, not recruiting

A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer (JUNIPER)

Non Small Cell Lung Cancer

Italy, United States, Spain, Germany, Korea, Republic of, Poland, Romania, Taiwan, Ukraine, France, Japan, Russian Federation, Austria, Israel, Greece, Brazil, Argentina, Turkey, Canada, Puerto Rico, China
Bayer

Terminated

A 2-part Trial to Learn More About How BAY1817080 Works, How Safe it is, and What the Right Dose is for Participants With Diabetic Neuropathic Pain

Neuropathic Pain Associated With Diabetic Peripheral Neuropathy

Germany, Denmark, France, Poland, Finland, Czechia, Hungary, Norway, Slovakia, Sweden
Eisai Limited

Terminated

A Study to Evaluate the Safety and Tolerability and Explore the Efficacy of Zonisamide as add-on Therapy in Elderly Patients With Refractory Partial Seizures

Epilepsy

United Kingdom, Germany, Hungary, Switzerland, Italy, Netherlands, Poland
Ironwood Pharmaceuticals, Inc.
Medpace, Inc.

Terminated

A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment

Gout | Chronic Kidney Disease (CKD)

United States, Hungary, Poland, Czechia
AiCuris Anti-infective Cures AG
Medpace, Inc.

Recruiting

Trial on Efficacy and Safety of Pritelivir Tablets for Treatment of Acyclovir-resistant Mucocutaneous HSV (Herpes Simplex Virus) Infections in Immunocompromised Subjects (PRIOH-1)

HSV Infection

United States, Italy, Belgium, France, United Kingdom, Germany, Switzerland, Argentina, Australia, Georgia, Greece, Mexico, Israel, Canada
Ardelyx

Completed

Study to Evaluate the Efficacy of Tenapanor as Adjunctive Therapy to Phosphate Binder Therapy

Hyperphosphatemia

United States
Bayer
Merck Sharp & Dohme LLC

Recruiting

A Study to Learn How Safe Starting Vericiguat at a Dose of 5 Milligrams is in Participants With Chronic Heart Failure With Reduced Ejection Fraction

Chronic Heart Failure With Reduced Ejection Fraction

Spain, United States, Argentina, Italy, Hungary, Poland, Sweden
Gemin X
Cephalon

Completed

A Phase I/II Study of Carboplatin and Etoposide With or Without Obatoclax in Extensive-stage Small Cell Lung Cancer (ES-SCLC)

Extensive-stage Small Cell Lung Cancer

Canada, United States, United Kingdom, Serbia, Bulgaria, India, Hungary, Czech Republic, Poland, Romania
Eli Lilly and Company

Completed

A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer, Non-small Cell Lung Cancer, or Melanoma That Has Spread to the Brain

Melanoma | Breast Cancer | Non-small Cell Lung Cancer | Brain Metastases

Spain, United States, Australia, Italy, France, Belgium, Canada, Austria, Israel
Norgine

Completed

A Multi-centre, Phase II, Double-blind, Randomised, Placebo-controlled, Parallel Group, Dose-ranging Study in Patients With Faecal Incontinence; to Evaluate the Efficacy, Safety and Tolerability of Locally Applied NRL001 Over an 8 Week Treatment Period

Faecal Incontinence

Spain, Poland, United Kingdom, Czech Republic, France, Germany, Hungary, Italy, Sweden
Amgen

Completed

PALACE 2: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PALACE2)

Psoriatic Arthritis

United States, Italy, Belgium, France, Canada, Taiwan, United Kingdom, Czechia, Russian Federation, Hungary, Germany, Bulgaria, Estonia, South Africa, Poland, Spain
Chiesi Farmaceutici S.p.A.
Chiesi USA, Inc.

Completed

Dose Finding Study of CHF 4226 for Treating Patients With COPD

Chronic Obstructive Pulmonary Disease

United States, Czech Republic, Germany, Poland, Romania, South Africa
BioCryst Pharmaceuticals

Completed

A Phase II, Multicenter, Randomized, Placebo -Controlled, Study To Evaluate The Efficacy and Safety Of Intramuscular Peramivir 600 mg In Subjects With Uncomplicated Acute Influenza

Acute, Uncomplicated Human Influenza

United States, Australia, New Zealand, South Africa
Pfizer

Recruiting

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

COVID-19

United States, United Kingdom, Mexico, South Africa, Japan, Bulgaria, Hungary, Puerto Rico
Amgen

Completed

Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA) (PALACE4)

Psoriatic Arthritis

United Kingdom, Belgium, United States, Canada, Australia, Taiwan, Czechia, Russian Federation, Hungary, Poland, Korea, Republic of, Italy, New Zealand, France, Bulgaria, Estonia, Romania, Lithuania
Eli Lilly and Company

Recruiting

Effect of Retatrutide Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1)

Diabetes Type 2

United States, India, Mexico, Puerto Rico
Eli Lilly and Company

Active, not recruiting

A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin or Basal Insulin or Both (SURPASS-PEDS)

Glucose Metabolism Disorders | Diabetes Mellitus, Type 2 | Diabetes Mellitus | Endocrine System Diseases | Type2 Diabetes | Metabolic Disease | T2DM (Type 2 Diabetes Mellitus) | T2D

United States, India, Australia, United Kingdom, Mexico, Brazil, Israel, France, Italy
GE Healthcare
ABX CRO; H2O Clinical LLC; TransPerfect; Advanced Clinical, LLC; TFS; AG Mednet Inc.; ICON CEAC and other collaborators

Terminated

International Study to Determine if AdreView Heart Function Scan Can be Used to Identify Patients With Mild or Moderate Heart Failure (HF) That Benefit From Implanted Medical Device (ADMIRE-ICD)

Heart Failure

United States, Spain, Canada, France, Netherlands, Poland, Czechia, Italy, Germany, Hungary
Eli Lilly and Company

Completed

Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea (SURMOUNT-OSA)

Obesity | Sleep Apnea

United States, China, Taiwan, Germany, Mexico, Brazil, Japan, Czechia, Australia, Puerto Rico
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumors

Metastatic Lung Non-Small Cell Carcinoma | Refractory Lung Non-Small Cell Carcinoma | Metastatic Melanoma | Stage IV Lung Cancer AJCC v8 | Unresectable Malignant Solid Neoplasm | Recurrent Head and Neck Squamous Cell Carcinoma | Metastatic Malignant Solid Neoplasm | Unresectable Melanoma | Clinical... and other conditions

United States
Endeavor Biomedicines, Inc.

Completed

A Drug-Drug Interaction Study of ENV-101 (Taladegib) on Nintedanib Pharmacokinetics in Healthy Subjects

Idiopathic Pulmonary Fibrosis

Australia
Mayo Clinic
National Cancer Institute (NCI); Novartis Pharmaceuticals

Completed

Sonidegib and Lenalidomide After Stem Cell Transplant in Treating Patients With Multiple Myeloma

Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Azacitidine and Sonidegib or Decitabine in Treating Patients With Myeloid Malignancies

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Chronic Myelomonocytic Leukemia | Previously Treated Myelodysplastic Syndrome | Recurrent Adult Acute Myeloid Leukemia | Untreated Adult Acute Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Childhood Acute Myeloid Leukemia and other conditions

United States
Anne Chang
Novartis

Completed

Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors

Basal Cell Carcinoma

United States
Shire

Completed

Evaluation of Long-term Prucalopride Treatment With Chronic Constipation in Subjects Aged ≥ 18 Years (SPD555-401)

Constipation

Spain, Romania, Italy, Poland, Czechia, Hungary, Slovakia, Sweden, Belgium
OSE Immunotherapeutics

Recruiting

Study of OSE-127 vs Placebo in Patients With Moderate to Severe Active Ulcerative Colitis (CoTikiS)

Ulcerative Colitis

Belgium, Latvia, Bulgaria, Belarus, Croatia, Georgia, Hungary, Poland, Russian Federation, South Africa, Ukraine

Search clinical trials for: smoothened (SMO) inhibitors

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