Search clinical trials for: advanced disease.

Total 111163 results

Novartis Pharmaceuticals

Terminated

Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine Origin

Pituitary Neoplasm | Pancreatic Neoplasm | Ectopic ACTH Syndrome | Nelson Syndrome

Germany, Italy, Australia, Russian Federation, Spain, Thailand, France, Canada, Brazil, United States, Argentina, Mexico
Sidney Kimmel Comprehensive Cancer Center at Johns...

Terminated

Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors

Nasopharyngeal Cancer | Gastric Cancer | Hodgkin Lymphoma | Castleman Disease | Non-Hodgkin Lymphoma | Kaposi Sarcoma | EBV

United States
Tejs Ehlers Klug
Statens Serum Institut

Unknown

Microbiology of Severe Acute Tonsillitis, Peritonsillar Cellulitis, and Infectious Mononucleosis

Acute Tonsillitis | Infectious Mononucleosis | Peritonsillar Cellulitis

Denmark
National Cancer Institute (NCI)

Completed

AZD2171 in Treating Patients With Recurrent Ovarian, Peritoneal, or Fallopian Tube Cancer

Fallopian Tube Cancer | Primary Peritoneal Serous Adenocarcinoma | Recurrent Ovarian Epithelial Cancer | Stage I Ovarian Epithelial Cancer | Stage II Ovarian Epithelial Cancer

United States
City of Hope Medical Center
National Cancer Institute (NCI); National Institute of Allergy and Infectious...

Completed

Measuring Changes in Blood in Patients at High Risk of Cytomegalovirus Infection After Undergoing Donor Bone Marrow Transplant or Peripheral Blood Stem Cell Transplant

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm | Nonneoplastic Condition | Myelodysplastic/Myeloproliferative Neoplasms
Bio Products Laboratory

Completed

A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency

Common Variable Immunodeficiency | Wiskott-Aldrich Syndrome | X-linked Agammaglobulinemia | Primary Immune Deficiency Disorders | Hyper-IgM Syndrome

United States, Chile, Israel
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Wilm's Tumor 1 (WT1) Peptide Vaccine for High Risk Hematologic Malignancy

Myelodysplastic Syndrome | Acute Myeloid Leukemia (AML) | Chronic Myeloid Leukemia (CML)

United States
National Cancer Institute (NCI)

Completed

Bevacizumab and Erlotinib in Treating Patients With Recurrent or Metastatic Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer

Fallopian Tube Cancer | Stage IV Ovarian Epithelial Cancer | Primary Peritoneal Cavity Cancer | Recurrent Ovarian Epithelial Cancer

United States
National Cancer Institute (NCI)

Completed

Tipifarnib in Treating Patients With Myelodysplastic Syndromes

Chronic Myelomonocytic Leukemia | Previously Treated Myelodysplastic Syndromes | de Novo Myelodysplastic Syndromes | Refractory Anemia | Refractory Anemia With Excess Blasts | Refractory Cytopenia With Multilineage Dysplasia | Refractory Anemia With Excess Blasts in Transformation | Refractory Anemia...

United States
Bristol-Myers Squibb

Completed

Pharmacokinetic Study of BMS-914143 in Participants With Normal Renal Function and Mild, Moderate, Severe and End-stage Renal Dysfunction (PK)

Chronic Hepatitis C Virus Infection | Chronic Hepatitis B Virus Infection

United States
Northside Hospital, Inc.
Blood and Marrow Transplant Group of Georgia

Completed

Early Administration of ATG Followed by Cyclophosphamide, Busulfan and Fludarabine Before a Donor Stem Cell Transplant in Patients With Hematological Cancer

Lymphoma | Kidney Cancer | Myelodysplastic Syndromes | Leukemia | Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm | Myelodysplastic/Myeloproliferative Diseases

United States
University Hospital Inselspital, Berne
Merck Sharp & Dohme LLC; Pfizer

Completed

Prevalence of Sexually Transmitted Infections (STIs) in HIV-infected Patients (CTNG)

HIV Infections | Herpes Simplex | Chlamydia Trachomatis | Neisseria Gonorrhoeae

Switzerland
Summa Health System

Completed

Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain

Irritable Bowel Syndrome | Fibromyalgia | Post Traumatic Stress Disorder | Interstitial Cystitis | Chronic Pelvic Pain

United States
Pfizer

Completed

An Open, Multicenter, Randomized, Dose-Ranging Study of Azithromycin in the Treatment of Disseminated Mycobacterium Avium-Intracellulare Complex Infection (MAC) in Patients With Acquired Immune Deficiency Syndrome (AIDS)

HIV Infections | Mycobacterium Avium-Intracellulare Infection

United States
Memorial Sloan Kettering Cancer Center
Varian Medical Systems

Recruiting

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

Melanoma | Sarcoma | Renal Cell Carcinoma | Pancreatic Cancer | NSCLC | Non Small Cell Lung Cancer | Bladder Cancer | Metastatic Solid Tumor | Gastrointestinal Cancer | Lobular Breast Carcinoma | Invasive Ductal Breast Carcinoma | Gastrointestinal Adenocarcinoma | Invasive Ductal Breast Carcinoma Stage IV | Lobular... and other conditions

United States
M.D. Anderson Cancer Center
Sanofi

Completed

Fludarabine-IV Busulfan ± Clofarabine and Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

Leukemia | Transplantation Infection | Disorder Related to Bone Marrow Transplantation

United States
Gilead Sciences

Completed

Safety and Efficacy of E/C/F/TDF Versus RTV-Boosted ATV Plus FTC/TDF in HIV-1 Infected, Antiretroviral Treatment-Naive Women (WAVES)

HIV Infections | Acquired Immunodeficiency Syndrome

United States, Thailand, France, Uganda, United Kingdom, Belgium, Portugal, Mexico, Dominican Republic, Italy, Puerto Rico, Russian Federation
Michael Hoelscher
European and Developing Countries Clinical Trials Partnership (EDCTP)

Active, not recruiting

Early Risk Assessment in Household Contacts (≥10 Years) of TB Patients by New Diagnostic Tests in 3 African Countries (ERASE-TB)

Tuberculosis

Tanzania, Mozambique, Zimbabwe
University of Florida
RTI International; Centers for Medicare and Medicaid Services; Econometrica,...

Completed

Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project (WIN)

Chronic Mental Illness | Chronic Physical Illness

United States
Allergan

Terminated

Study to Evaluate the Safety and Efficacy of Relamorelin in Participants With Diabetic Gastroparesis Study 02

Diabetes Mellitus | Gastroparesis

United States, Canada, United Kingdom, Russian Federation, Mexico, Belgium, South Africa, Denmark, Brazil, Austria, Argentina, Colombia, Germany, Hungary, Latvia
Vertex Pharmaceuticals Incorporated

Recruiting

A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1) (Galileo)

Myotonic Dystrophy Type 1 (DM1)

United Kingdom, Canada, Australia
M.D. Anderson Cancer Center

Completed

Utility of Endobronchial Ultrasound Guided Needle Biopsy in Early Stage Non- Small Cell Lung Cancer (NSCLC)

Lung Cancer

United States
Samuel Kim, MD

Completed

Human Ovarian Autotransplantation

Ovarian Autotransplantation Using Cryopreserved Ovarian Tissue in Women Treated for Cancer

United States
University of Virginia
National Institute on Drug Abuse (NIDA)

Completed

Medications Development for the Treatment of Cannabis Related Disorders (MTC)

Cannabis Dependence | Nicotine Dependence | Marijuana Dependence | Cannabis Abuse | Nicotine Withdrawal

United States
Alleviant Medical, Inc.

Enrolling by invitation

Alleviant ALLAY-HF Study

Heart Failure

United States, Spain, Austria, New Zealand, Israel, Germany, Australia, Belgium, Canada, Poland, Georgia, Greece, Italy
Medical University Innsbruck

Completed

Evaluation of Acute Lower Limb Ischemia (PROMOTE-ALI)

Acute Limb Ischemia

Croatia, United Kingdom, Germany, Austria, France, Hungary, Moldova, Republic of, Netherlands, Serbia, Switzerland
Novartis

Completed

Safety and Tolerability of Vildagliptin Versus Sitagliptin in Patients With Type 2 Diabetes and Severe Renal Insufficiency (28-week Extension Study)

Diabetes Mellitus, Type 2 | Renal Insufficiency

United States
Actelion

Completed

Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the PAH-SYMPACT Instrument

Pulmonary Arterial Hypertension

United States
United Therapeutics

Completed

Study of Incidence of Respiratory Tract AEs in Patients Treated With Tyvaso® Compared to Other FDA Approved PAH Therapies (Aspire)

Pulmonary Arterial Hypertension

United States
Novartis Pharmaceuticals

Completed

Canakinumab in the Treatment of Acute Gout Flares and Prevention of New Flares in Patients Unable to Use Non-steroidal Anti-inflammatory Drugs (NSAIDs) and/or Colchicines Including a 12 Week Extension and a 1 Year Open-label Extension Study. (β-RELIEVED-II)

Acute Gout

United States, Canada, Russian Federation, Netherlands, China
Grifols Therapeutics LLC

Recruiting

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency

Alpha1-Antitrypsin Deficiency

United States
SI-BONE, Inc.

Completed

LOIS: Long-Term Follow-Up in INSITE/SIFI (LOIS)

Sacroiliac Joint Disruption | Degenerative Sacroilitis

United States
SI-BONE, Inc.

Completed

Investigation of Sacroiliac Fusion Treatment (INSITE) (INSITE)

Sacroiliac Joint Disruption | Degenerative Sacroiliitis

United States
SI-BONE, Inc.

Completed

Sacroiliac Joint Fusion With iFuse Implant System (SIFI) (SIFI)

Sacroiliac Joint Disruption | Degenerative Sacroiliitis

United States
Aerovate Therapeutics

Active, not recruiting

Inhaled Imatinib Pulmonary Arterial Hypertension Clinical Trial - Follow Up Long Term Extension (IMPAHCT-FUL) (IMPAHCT-FUL)

Pulmonary Arterial Hypertension

United States, Belgium, Spain, Australia, Canada, Singapore, China, Germany, Latvia, Italy, United Kingdom, Portugal, France, Mexico, Argentina, Poland, Chile, Israel, South Africa, Colombia
National Cancer Institute (NCI)
NRG Oncology

Suspended

Study to Test the Drug Darolutamide Along With the Drugs Leuprolide Acetate and Exemestane in Patients With Recurrent Ovarian Granulosa Cell Tumors

Adult Ovarian Granulosa Cell Tumor

United States
Amgen

Active, not recruiting

Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects With Overweight or Obesity, With or Without Type 2 Diabetes Mellitus

Obesity | Overweight | Type 2 Diabetes Mellitus

United States, Czechia, Taiwan, Canada, Japan, Korea, Republic of, Germany, Hungary, Australia, Hong Kong, Spain, Poland
United Therapeutics

Completed

FREEDOM - M: Oral Treprostinil as Monotherapy for the Treatment of Pulmonary Arterial Hypertension (PAH)

Pulmonary Hypertension

United States, China, Israel, Belgium, Canada, France, India, Mexico, Austria, Italy, Netherlands, Poland, Puerto Rico
Mitsubishi Tanabe Pharma America Inc.

Completed

Safety Study of Oral Edaravone Administered in Subjects With ALS

ALS

United States, Canada, Japan, France, Germany, Italy
Chiesi Farmaceutici S.p.A.

Completed

Efficacy and Tolerability of Beclomethasone Plus Salbutamol in HFA pMDI Fixed Combination vs Beclomethasone Plus Salbutamol in CFC pMDI Fixed Combination in a 12-week Treatment Period of Adult Patients With Uncontrolled Asthma

Bronchial Asthma

Spain, Italy, Russian Federation, Ukraine
Fred Hutchinson Cancer Center
Mustang Bio

Active, not recruiting

A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphomas

Recurrent Mantle Cell Lymphoma | Recurrent Marginal Zone Lymphoma | Refractory B-Cell Non-Hodgkin Lymphoma | Recurrent Small Lymphocytic Lymphoma | Recurrent B-Cell Non-Hodgkin Lymphoma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Refractory Chronic Lymphocytic... and other conditions

United States
National Cancer Institute (NCI)

Active, not recruiting

Lenalidomide and Blinatumomab for the Treatment of Relapsed Non-Hodgkin Lymphoma

Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Grade 3 Follicular Lymphoma | Recurrent Mantle Cell Lymphoma | Recurrent Marginal Zone Lymphoma | Recurrent Small Lymphocytic Lymphoma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell... and other conditions

United States
National Cancer Institute (NCI)

Completed

Rebeccamycin Analog in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia

Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) and other conditions

United States
Schrödinger, Inc.

Recruiting

Study of SGR-1505 in Mature B-Cell Neoplasms

Follicular Lymphoma | Splenic Marginal Zone Lymphoma | Burkitt Lymphoma | Plasmablastic Lymphoma | Waldenstrom Macroglobulinemia | Mantle Cell Lymphoma | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Non Hodgkin Lymphoma | Primary Effusion Lymphoma | DLBCL | High-grade B-cell Lymphoma | Primary Mediastinal... and other conditions

United States, Moldova, Republic of
Masonic Cancer Center, University of Minnesota

Recruiting

Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

Follicular Lymphoma | Multiple Myeloma | Myelofibrosis | Lymphoblastic Lymphoma | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Non-Hodgkin Lymphoma | Mantle-Cell Lymphoma | Diffuse Large B Cell Lymphoma | Chronic Myelogenous Leukemia | Prolymphocytic Leukemia | Myelodysplasia | Acute Myeloid Leukemia... and other conditions

United States
Kyowa Kirin, Inc.

Recruiting

Study to Assess the Efficacy & Safety of KHK4951 in Patients With Neovascular Age-Related Macular Degeneration

Neovascular Age-Related Macular Degeneration (nAMD)

United States, Japan, Australia, Korea, Republic of
Zensun Sci. & Tech. Co., Ltd.

Recruiting

Survival Study of the Recombinant Human Neuregulin-1β in Subjects With Chronic Heart Failure.

Chronic Heart Failure

China
Italfarmaco
Cromsource

Enrolling by invitation

Givinostat in Duchenne's Muscular Dystrophy Long-term Safety and Tolerability Study

Duchenne Muscular Dystrophy

Spain, United States, Canada, Belgium, France, Israel, Italy, Netherlands, Serbia, Germany, United Kingdom
Reistone Biopharma Company Limited

Completed

A Phase II Study in Patients With Moderate to Severe Active Ulcerative Colitis.

Ulcerative Colitis

China, Poland, Ukraine, United States, Puerto Rico
Shire

Completed

A Study of Icatibant in Patients With Acute Attacks of Hereditary Angioedema (FAST-3)

Hereditary Angioedema

United States, Australia, Israel, Canada, Hungary, Romania, Russian Federation, South Africa, Ukraine

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