Search clinical trials for: Single ascending doses

Total 11941 results

Ardana Bioscience Ltd

Completed

Study of 3 Doses of ARD-0403 in Testosterone Deficient Men (ARD-0403-001)

Hypogonadism

Belarus
Halozyme Therapeutics

Completed

Study of a Large Protein Molecule Administered With Escalating Doses of Recombinant Human Hyaluronidase

Rheumatoid Arthritis
Hospital of Navarra
Dr. Enrique Martínez López

Unknown

Study of 3D Radiotherapy With or Without Erlotinib (Tarceva®) in Patients With Localized Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

Spain
Novartis

Completed

Safety and Tolerability of Multiple Inhaled NVA237 Doses in Chronic Obstructive Pulmonary Disease (COPD) Patients

Chronic Obstructive Pulmonary Disease (COPD)

Germany, Denmark
Javelin Pharmaceuticals

Completed

Study to Compare the Pharmacokinetics of IV Diclofenac Sodium (2 Doses)Versus Oral Diclofenac Potassium

Healthy

United States
AstraZeneca

Completed

High Doses of Candesartan Cilexetil on the Reduction of Proteinuria

Proteinuria

Canada
University of Pittsburgh
Elan Pharmaceuticals

Completed

Pharmacodynamic Parameters of Two Different Doses of Cefepime

Pneumonia | Bacteremia | Infection

United States
Novartis

Completed

A Study to Evaluate the Safety and Efficacy of Single Day or Single Dose Famciclovir for the Treatment of Recurrent Herpes Labialis

Recurrent Herpes Labialis
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evalutating the Pharmacokinetics (PK) and Safety of a Single Dose of Desvenlafaxine Sustained Release (DVS SR)

Depressive Disorder, Major

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

A Study Evaluating 10 mg and 25 mg Doses of Etanercept in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

Japan
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating Multiple Oral Doses of PPM-204 in Healthy Japanese Male Subjects

Diabetes Mellitus

Japan
GE Healthcare

Completed

Comparison of Diagnostic Rest/Stress SPECT Results for Patients With Myocardial Ischemia and Infarction Using Myoview in Both Single and Dual Isotope Acquisition Approaches

Coronary Artery Disease

United States
Novartis

Completed

Single Dose Study to Assess the Safety, Tolerability, Concentration in Body and Effect of BAF312

Healthy

United States
Novartis

Completed

Study of the Safety, Tolerability and Efficacy of BCT194 in Healthy Volunteers and Patients With Psoriasis.

Psoriasis

Austria
Mount Sinai Hospital, Canada

Unknown

Delayed Umbilical Cord Clamping in Infants Less Than 32 Weeks (DUC)

Premature Birth

Canada
Eli Lilly and Company

Completed

Gemcitabine Plus Cisplatin Single Dose Versus Split Dose in the Treatment of Patients With Locally Advanced or Metastatic Breast Cancer After Failure of Anthracyclines and/or Taxanes

Metastatic Breast Cancer

Saudi Arabia
National Institute of Allergy and Infectious Diseases...
Johns Hopkins Bloomberg School of Public Health

Completed

Single Group Study of the Safety of and Immune Response to a Bird Flu Virus Vaccine (H5N1) in Healthy Adults

Virus Diseases | Influenza

United States
Grünenthal GmbH

Terminated

Single Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations (Protocol ID 297307)

Healthy

Germany
University of Washington
University of Nairobi; Kenyatta National Hospital; Kenya Medical Research Institute

Completed

Treatment of Helminth co-Infection: Short-Term Effects on HIV-1 Progression Markers and Immune Activation

HIV Infections | Helminthiasis

Kenya
Deutsches Herzzentrum Muenchen
Technical University of Munich

Completed

75 or 150 mg Clopidogrel Maintenance Doses Following PCI (ISAR-CHOICE-2)

Coronary Disease

Germany
Novacea
Schering-Plough

Suspended

A Study of Gemcitabine ± Erlotinib and DN-101 Versus Gemcitabine ± Erlotinib and Placebo in Patients With Advanced Pancreatic Cancer

Pancreatic Cancer

United States
Sanofi

Completed

Assessment of Duration of Metabolic Effect of a Single Bolus of sc Injected Lantus Compared to NPH Insulin in Patients With Type 2 Diabetes

Diabetes Mellitus, Type 2
Karolinska University Hospital
Muhimbili University of Health and Allied Sciences

Completed

Treatment of Uncomplicated Childhood Malaria in Tanzania by Artemether+Lumefantrine - Efficacy and Genotyping

Malaria

Tanzania
Eli Lilly and Company

Completed

Guiding Dose Increases in Patients Incompletely Responsive to Usual Doses of Atomoxetine

Attention Deficit Hyperactivity Disorder

Canada, United States
Eli Lilly and Company
ICOS Corporation

Completed

To Determine How Different Doses of Tadalafil Work on Getting and Keeping an Erection 26 or 36 Hours After Taking

Impotence

United States
Bristol-Myers Squibb

Completed

A Study of Different Doses of Megestrol Acetate in Patients With AIDS Who Have Anorexia and Malnutrition

HIV Infections | Anorexia | Cachexia

United States
National Institute of Cancerología

Unknown

Hydralazine Valproate for Ovarian Cancer

Ovarian Cancer

Mexico
Herlev Hospital

Unknown

Does a Single Steroid Injection Reduce the Formation of Postmastectomy Seroma

Breast Neoplasms | Mastectomy

Denmark
Medicines for Malaria Venture
Ranbaxy Laboratories Limited; Swiss Tropical & Public Health Institute

Completed

RBx11160 Phase II Dose Ranging Study RBx/MMV05-06

Plasmodium Falciparum Malaria

India, Tanzania, Thailand
Christian Medical College, Vellore, India
Ministry of Science and Technology, India

Unknown

Single Agent Arsenic Trioxide in the Treatment of Newly Diagnosed Acute Promyelocytic Leukemia (IAPLSG04)

Acute Promyelocytic Leukemia

India
Profil Institut für Stoffwechselforschung GmbH
Novo Nordisk A/S

Completed

Metabolic Effect of Insulin Aspart and Human Insulin in Different Doses

Diabetes Mellitus

Germany
Adherex Technologies, Inc.

Completed

A Study of the Safety and Effects of ADH-1 Given Intravenously as a Single Agent

Neoplasms

United States, Canada
Grünenthal GmbH

Terminated

Single Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations

Healthy

Germany
University Hospital, Bordeaux
Ministry of Health, France

Unknown

Role of Left Ventricular Pacing Site

Heart Failure | Coronary Disease | Cardiomyopathy, Dilated

France
Tianjin Medical University

Unknown

A Prospective, Single-Arm Study to Evaluate the Efficacy and Safety of Zoladex 3.6mg Combined With CEF Chemotherapy as Neo-Adjuvant Therapy in Hormone Responsive, Premenopausal, Operable Breast Cancer

Breast Cancer

China
Novartis
Schering-Plough

Completed

Study of Mometasone Furoate/Formoterol Fumarate Inhalation Combination in Healthy Volunteers

Healthy

United Kingdom
Novartis

Completed

Effect of Moderate Hepatic Impairment on the Pharmacokinetics and Metabolism of a Single Dose of Licarbazepine

Healthy

Czech Republic
Novartis

Completed

Bioavailability of Aliskiren and Valsartan Combined as a Single Tablet vs. the Same Medications Given Separately to Healthy Subjects.

Healthy

United States
Novartis

Completed

Safety and Tolerability of AQW051 in Elderly Healthy Volunteers.

Healthy

United Kingdom
Novartis

Completed

Effect of Severe Renal Impairment on Pharmacokinetics and Metabolism of a Single Administration of Licarbazepine

Healthy

Czech Republic
Pfizer

Completed

12 Week Evaluation of the Safety and Efficacy of 3 Doses of CP-526,555 and Placebo for Smoking Cessation

Smoking Cessation

Japan
National Center for Research Resources (NCRR)
University of Texas

Completed

Randomized Study of Two Doses of Oral Valacyclovir in Immunocompromised Patients With Uncomplicated Herpes Zoster

Immunologic Deficiency Syndromes | Herpes Zoster

United States
Children's Healthcare of Atlanta

Terminated

Intra-Atrial vs. Extra-Cardiac Technique During Fontan Operation

Congenital Disorders

United States
National Institute of Neurological Disorders and...

Completed

Reduced Manipulation of the Aorta and Neurobehavioral Outcome Trial

Coronary Disease

United States
Ondine Research Laboratories
Loma Linda University

Completed

PerioWave Re-Treatment Protocol Compared to Scaling and Root Planing (SRP) and a Single Treatment With PerioWave

Periodontitis

China
Eli Lilly and Company

Completed

A Randomized Study Comparing Single Agent Gemcitabine Intravesical Therapy Versus Mitomycin C in Patients With Intermediate Risk Superficial Bladder Cancer

Superficial Bladder Cancer

Israel
Trans Tasman Radiation Oncology Group
Cancer Council New South Wales

Completed

SuperDEX Trial (Comparison of Two Doses of Dexamethasone for Malignant Spinal Cord Compression Treated by Radiotherapy).

Spinal Cord Compression From Neoplasm Metastasis

Australia
Pfizer

Completed

Treatment Of Short Stature With Genotropin In Children Born Small For Gestational Age Until Final Height

Growth Disorder
Hospices Civils de Lyon

Unknown

AFR10 - Combination Therapy of Imatinib Mesylate (IM) + Alpha-2A Interferon for Chronic Phase CML Patients Resistant or Refractory to IM Used as Single Therapy for at Least One Year

Chronic Myeloid Leukemia

France
Grupo Gallego de Cancer de Pulmon

Unknown

Phase II Trial of Tarceva in Patients With Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

Spain

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