Search clinical trials for: Pharmacokinetic medeling

Total 12739 results

Merck Sharp & Dohme LLC
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

A Pharmacokinetic Study of L-697,661 Alone and in Combination With Zidovudine

HIV Infections

United States
MediGene

Completed

Phase-I Study Evaluating the Pharmacokinetic Profile of RhuDex®

Pharmacokinetics

United Kingdom
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating Safety, Tolerability, Pharmacokinetics and 5 HT1A Receptor Occupancy

Alzheimer's Disease

Sweden
YM BioSciences

Completed

Study of Single and Multiple Doses of Inhaled AeroLEF (Liposome-Encapsulated Fentanyl)in Healthy Subjects (LEF-2495)

Healthy

Canada
YM BioSciences

Completed

Study Evaluating Inhaled AeroLEF (Liposome-Encapsulated Fentanyl)in Normal Healthy Subjects

Healthy

Canada
French Innovative Leukemia Organisation

Completed

Liposomal Anthracyclin in the Treatment of Elderly ALL

Acute Lymphoblastic Leukemia

France
AstraZeneca

Completed

Study to Investigate Safety, Tolerability and Pharmacokinetics of a Single Ascending Dose of AZD1704

Pain

United Kingdom
Novartis

Completed

Safety, Tolerability, Pharmacodynamic and Pharmacokinetic Effects of Single and Multiple-Doses of ATF936 and AXT914 Administered Orally in Healthy Subjects.

Healthy

United States
Acrux DDS Pty Ltd

Completed

Pharmacokinetics of Testosterone Lotion in the Treatment of Hypogonadal Males

Hypogonadism

United States
ArQule, Inc. (a wholly owned subsidiary of Merck...

Completed

A Study of ARQ 197 in Healthy Volunteers to Assess the Pharmacokinetic (PK) Profile in Extensive and Poor Metabolizers as Defined by Cytochrome P450 2C19 (CYP 2C19) Genotype

Healthy

United States
AstraZeneca

Completed

Pharmacokinetic Study of Esomeprazole Magnesium in Patients 1 to 11 Years-Old With Endoscopically-Proven Gastroesophageal Reflux Disease (GERD)

Reflux | Endoscopically-Proven GERD
Novartis

Completed

Safety and Pharmacokinetics of Indacaterol in Healthy Subjects and Those With Impaired Liver Function

Hepatic Insufficiency

United States
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Study With Repeated Doses of Stalevo

Pharmacokinetics

Finland
Millennium Pharmaceuticals, Inc.
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Completed

Open-Label Study to Assess the Effect of Omeprazole on the Pharmacokinetics of VELCADE in Patients With Either Advanced Solid Tumors or Non-Hodgkin's Lymphoma.

Tumors | Non-Hodgkins's Lymphoma

United States
NexMed (U.S.A.), Inc. (subsidiary of Apricus Biosciences...

Completed

Safety and Pharmacokinetics of Terbinafine Hydrogen Chloride (HCl) Nail Lacquer in Patients With Onychomycosis

Onychomycosis/Onycholysis and Tinea Pedis

United States
NanoBio Corporation

Completed

Safety, Pharmacokinetics, and Efficacy Study of NB-001 to Treat Recurrent Herpes Labialis

Herpes Labialis

United States
Rennes University Hospital

Unknown

Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers (HEPEPO)

Iron Metabolism Disorders

France
CONRAD
Gilead Sciences; International Partnership for Microbicides, Inc.

Completed

Pharmacokinetic Study of the Vaginal Microbicide Agent 1% Tenofovir Gel

HIV Infections

United States, Dominican Republic
Federal Office of Sports, Switzerland

Completed

Cannabis Cigarettes Used for Doping: Delta-9-Tetrahydrocannabinol (THC) Urine Detection

Healthy

Switzerland
Children's National Research Institute
Actelion

Completed

Pharmacokinetics, Safety and Tolerability of Zavesca (Miglustat) in Patients With Infantile Onset Gangliosidosis: Single and Steady State Oral Doses

Sandhoff Disease | GM2 Gangliosidoses | Tay-Sachs

United States
Protalex, Inc.

Completed

Phase 1 Study Evaluating the Safety, Pharmacokinetics and Pharmacodynamics of PRTX-100 in Healthy Adult Volunteers

Healthy Volunteers

United States
POZEN

Completed

PK Study to Evaluate Esomeprazole Plasma Levels Following Administration of PN 400

Healthy
Oregon Health and Science University
Boehringer Ingelheim

Completed

Effects of a Dopamine Agonist on Pharmacodynamics of Levodopa in Parkinson's Disease (DALI)

Parkinson's Disease

United States
University of Aarhus

Terminated

Lamotrigine and Oral Contraceptives

Epilepsy

Denmark
Immutep S.A.S.
SGS Aster-Cephac (CRO)

Completed

Phase I Study of IMP321 Given Alone or as an Adjuvant to a Reference Flu Antigen

Healthy

France
Ministry of Health, Labour and Welfare, Japan
Japan Cardiovascular Research Foundation

Unknown

Hypertension Control Based on Home Blood Pressure

Hypertension

Japan
Wyeth is now a wholly owned subsidiary of Pfizer
ViroPharma

Completed

Study Evaluating the Pharmacokinetics of the Potential Drug Interaction Between HCV-796 and Desipramine

Healthy

United States
MediQuest Therapeutics

Completed

MQX-503 vs Nitroglycerin Ointment: A Pharmacokinetic Comparison in Normal Subjects

Healthy

United States
BioWest Therapeutics Inc

Unknown

A Study to Evaluate the Safety, Antiviral Effect, and Pharmacokinetics of Celgosivir in Combination With Peginterferon Alfa-2b and Ribavirin in Treatment-Naïve Patients With Chronic Hepatitis C

Chronic Hepatitis C

Canada
Solvay Pharmaceuticals

Completed

A Multinational, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Investigate the Efficacy, Safety and Duration of Effect of a Single Administration of Various Doses of Cetrorelix SR in Subjects With Histologically Confirmed Endometriosis

Endometriosis

Russian Federation, Australia, Belgium, Bulgaria, Germany, Romania, South Africa, Ukraine
Gilead Sciences

Completed

Open Label Study of Pharmacokinetics and Safety of Dose of Adefovir Dipivoxil in Children and Adolescents With HBV

Hepatitis B

Belgium, Germany, Poland, United Kingdom
STEBA France
STEBA LABORATORIES LTD.

Completed

Dose-Effect of S-Tenatoprazole-Na(STU-Na) 30 mg, 60 mg, 90 mg and 120 mg in Healthy Volunteers

Gastroesophageal Reflux | Esophagitis | Duodenal Ulcer | Stomach Ulcer

United States
Azevan Pharmaceuticals

Completed

Safety Study of SRX251 Capsules in Healthy Female Volunteers (AVN001)

Healthy

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of GAP-134 Administered Intravenously

Arrhythmia

United States
Biosynexus Incorporated
GlaxoSmithKline

Completed

Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity Study in VLBW Neonates of BSYX-A110 (N003)

Staphylococcal Sepsis

United States
Biosynexus Incorporated
GlaxoSmithKline

Completed

Safety and Pharmacokinetics Study in VLBW Neonates With BSYX-A110 (N002)

Neonatal Staphylococcal Sepsis

United States
Dey

Completed

A Study in Healthy Volunteers to Evaluate Serum and Urine Levels of the Investigational Product Versus Comparator.

Healthy

United States
National Cancer Institute (NCI)

Completed

A Phase I Trial of Continuous Infusion UCN-01 in Patients With Refractory Neoplasms

Lymphoma | Breast Cancer | Neoplasm | Prostatic Neoplasm

United States
National Cancer Institute (NCI)

Completed

A Phase I Study of Weekly Gemcitabine in Combination With Infusional Fluorodeoxyuridine and Oral Calcium Leucovorin in Adult Cancer Patients

Neoplasms

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Study of Inherited Changes of Receptors Located on Blood Vessels

Cardiovascular Disease

United States
National Cancer Institute (NCI)

Completed

A Phase I Study of Continuous Intravenous Infusion of PSC 833 and Vinblastine in Patients With Metastatic Renal Cancer

Kidney Neoplasms | Neoplasm Metastasis

United States
National Cancer Institute (NCI)

Completed

A Trial of Carboxypeptidase-G2 (CPDG2) and Thymidine for the Management of Patients With Methotrexate Toxicity and Renal Dysfunction

Kidney Diseases

United States
National Cancer Institute (NCI)

Completed

Phase I and Pharmacokinetic Trial of Paclitaxel (Taxol) Given as a 3-Hour Infusion in Pediatric Patients With Refractory Malignancy

Neoplasms

United States
National Cancer Institute (NCI)

Completed

SU5416 and Carboplatin to Treat Ovarian Cancer

Ovarian Cancer | Peritoneal Neoplasm | Fallopian Tube Neoplasm

United States
National Institute of Mental Health (NIMH)

Completed

Dynamics of Leptin and Endocrine Function

Healthy | Involutional Depression

United States
National Cancer Institute (NCI)

Completed

A Phase I Study of Infusional Chemotherapy With the P-Glycoprotein Antagonist PSC 833

Lymphoma | Breast Cancer | Neoplasm Metastasis | Ovarian Cancer | Kidney Neoplasm

United States
National Cancer Institute (NCI)

Completed

A Pilot Study of the Combination of Retinoic Acid and Interferon-Alpha2a for the Treatment of Lymphoproliferative Disorders in Children With Immunodeficiency Syndromes

HIV Infections | Immunologic Deficiency Syndromes | Lymphoproliferative Disorders

United States
National Cancer Institute (NCI)

Completed

A Randomized Phase II Study of Oral Thalidomide in Patients With Hormone-Refractory Prostate Cancer

Prostatic Neoplasm

United States
National Cancer Institute (NCI)

Completed

Oxaliplatin to Treat Advanced Cancers With Liver Dysfunction

Liver Disease

United States
National Cancer Institute (NCI)

Completed

Phase I and Pharmacokinetic Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Refractory Malignancy

Brain Neoplasms | Neuroblastoma

United States

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