Search clinical trials for: SGLT2 inhibition

Total 1518 results

Assistance Publique - Hôpitaux de Paris

Completed

Lumbar Spinal Fibrosis and TNF Alpha Inhibition

Post Operative Sciatica by Lumbar Spinal Fibrosis

France
Indiana University School of Medicine
National Center for Research Resources (NCRR)

Terminated

Effects of Short Term, High Dose Atorvastatin Therapy on Periprocedural Myonecrosis and Platelet Inhibition After Percutaneous Coronary Intervention (PCI) (ESTATE)

Coronary Artery Disease

United States
University College, London

Completed

Effects of GABA Modulator AZD7325 on Cortical Excitability

Healthy

United Kingdom
Intarcia Therapeutics

Completed

Phase III Study of Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer

Breast Neoplasms | Neoplasms, Hormone-dependent

United States, Canada, Russian Federation, Ukraine
Centre Hospitalier Universitaire de Saint Etienne
Sanofi; Ministry of Health, France; LivaNova

Terminated

Prevention of Atrial Fibrillation by Inhibition Conversion Enzyme (ICE) After Radiofrequency Ablation of Atrial Flutter (PREFACE)

Atrial Fibrillation | Atrial Flutter

France
Vanderbilt University

Completed

Comparison of Perineural Catheter Depth for the Continuous Popliteal Nerve Block Using Ultrasound Guidance and Dermabond

Neuromuscular Inhibition

United States
Bayer

Completed

Safety and Efficacy of Oral BAY85-8501 in Patients With Non-CF (Cystic Fibrosis) Bronchiectasis

Bronchiectasis

Italy, Spain, Germany, United Kingdom, France
University Health Network, Toronto
Anesthesia Patient Safety Foundation

Completed

The Association Between Platelet Inhibition and Perioperative Major Adverse Cardiac Events In Post-Percutaneous Coronary Intervention (PCI) Patients Undergoing Non-Cardiac Surgery

Thrombosis

Canada
The Hospital for Sick Children
Canadian Institutes of Health Research (CIHR)

Completed

Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention

Fetal Alcohol Spectrum Disorders
University of Oxford
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

A Study to Assess Safety, Immunogenicity and Parasite Growth Inhibition of an Asexual Blood Stage Vaccine for P. Falciparum Malaria

Malaria

United Kingdom
Texas Tech University Health Sciences Center

Withdrawn

Aliskiren and Renin Inhibition in Diastolic Heart Failure (ARID-HF)

Diastolic Heart Failure

United States
Les Laboratoires des Médicaments Stériles
University Hospital Fattouma Bourguiba

Completed

Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Body Mass Index ≥ 27 (PLATO-dose)

Cardiovascular Disease | Overweight

Tunisia
Khon Kaen University

Completed

Comparative Pharmacodynamics and Pharmacokinetics Study of Generic and Reference Clopidogrel Products

Pharmacodynamics

Thailand
National Taiwan University Hospital

Unknown

Explore the Association Between Neuropsychological Functions and ADHD Diagnosis and Comorbid Using Longitudinal Study in Preschool Children

Attention Deficit/Hyperactivity Disorder

Taiwan
HealthCore-NERI
Massachusetts General Hospital; National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Phosphodiesterase Type 5 Inhibition With Tadalafil Changes Outcomes in Heart Failure (PITCH-HF)

Heart Failure | Pulmonary Hypertension

United States, Canada
Josep M Cruzado

Terminated

Effect of the Inhibition of the Mammalian Target of Rapamycin on Metabolism and Exercise (EXETOR)

Muscle Strength | Disorder Related to Renal Transplantation | Exercise, Aerobic

Spain
Academisch Medisch Centrum - Universiteit van Amsterdam...
Erasmus Medical Center

Withdrawn

Study of Everolimus in the Treatment of Advanced Malignancies in Patients With Peutz-Jeghers Syndrome (EVAMP)

Neoplasm Metastasis | Neoplastic Processes | Peutz-Jeghers Syndrome

Netherlands
Karolinska Institutet

Completed

Arginase Inhibition in Ischemia-reperfusion Injury

Coronary Artery Disease | Type 2 Diabetes Mellitus

Sweden
University Hospital, Basel, Switzerland

Completed

Pharmacokinetic Study to Characterize Phenotyping Metrics of the "Basel" Cocktail After CYP Induction or Inhibition

Metabolic Detoxication, Phase I

Switzerland
Ram Weiss

Unknown

DPP-IV Inhibition Prior to Development of Diabetes in Patients With Cystic Fibrosis

Cystic Fibrosis

Israel
First Affiliated Hospital of Harbin Medical University

Unknown

Safety and Efficacy of Low-Dose Ticagrelor in Chinese Patients With NSTE-ACS

Non ST Segment Elevation Acute Coronary Syndrome

United States
Imperial College London
Medical Research Council

Completed

Angiotensin-converting Enzyme (ACE)-Inhibition and Mechanisms of Skeletal Muscle Weakness in Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

United Kingdom
Inotek Pharmaceuticals Corporation

Terminated

A Trial of INO-1001 in Patients Undergoing Heart Surgery That Involves Heart-lung Bypass

Heart Diseases | Postoperative Complications

United States, Israel, Australia, India
Bayer

Completed

Study to Compare Gastric Inhibition of Two Proton Pump Inhibitors (CL2008-18)(P07815)(COMPLETED)

Human Experimentation
Fundacja Ośrodek Badań Medycznych
KCRI

Withdrawn

Effect of the Repeated Loading Dose of Clopidogrel and High Dose of Clopidogrel Continuous Therapy on the Platelet Aggregation Inhibition in Patients With Myocardial Infarction Undergoing Interventional Treatment. (REL-0609)

Acute Myocardial Infarction

Poland
Medical University of Vienna

Completed

On the Impact of Therapeutic Tumor Necrosis Factor-alpha Inhibition on Anogenital Human Papillomavirus Infection

Inflammatory Bowel Diseases | Psoriasis
Robert Bosch Gesellschaft für Medizinische Forschung...

Completed

Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene

Anovulation | Cytochrome P450 CYP3A Enzyme Deficiency | Disorder Due Cytochrome P450 CYP2D6 Variant

Germany
Eisai Inc.

Completed

A Pharmacokinetic Study to Assess the Influence of P-glycoprotein Inhibition and Simultaneous CYP3A4 and P-glycoprotein Induction on E7080 Pharmacokinetics Following Single Dose Oral Administration of 24 mg E7080 to Healthy Volunteers

Healthy Volunteers | P-glycoprotein

United States
Eisai Inc.

Completed

A Pharmacokinetic Study to Assess the Influence of Simultaneous CYP3A4 and P-glycoprotein Inhibition on E7080 Pharmacokinetics Following Single Dose Oral Administration of 5 mg E7080 to Healthy Volunteers

Healthy Volunteers

United States
RWTH Aachen University

Unknown

Effects of Oxytocin on Emotion Recognition and Response Inhibition

The Impact of Oxytocin on Social Cognition

Germany
Vanderbilt University

Completed

Inhibition of Lipid Peroxidation During Cardiac Surgery

Cardiopulmonary Bypass Induced Lipid Peroxidation

United States
University of Wisconsin, Milwaukee
Tourette Association of America

Completed

Developing Cognitive Training for Tourette Syndrome

Tourette Syndrome | Chronic Tic Disorders

United States
Vanderbilt University

Withdrawn

Autonomic Phenotype Before and After Akt Inhibition

Diagnosis of Melanoma

United States
University of Regensburg

Completed

CNI-free de Novo Protocol in Patients Undergoing Liver Transplantation With Renal Impairment (PATRON07)

End Stage Liver Disease | Impaired Renal Function

Germany
University of Toledo Health Science Campus

Withdrawn

Study of Phenobarbital Inhibition of Catamenial Epilepsy

Epilepsy

United States
Assistance Publique - Hôpitaux de Paris
National Research Agency, France

Withdrawn

A PET Exploration of the Mechanism of Action of Dopamine Beta-hydroxylase Inhibition in Cocaine Addicts (RAPID)

Cocaine Dependence

France
University of Missouri, Kansas City
University of Kansas

Unknown

Cognitive Training for Post Traumatic Stress Disorder: Effects on Cognitive, Emotional, and Brain Function

Posttraumatic Stress Disorders

United States
University of Athens

Completed

Effects of Interleukin-1 Inhibition on Vascular and Left Ventricular Function in Rheumatoid Arthritis Patients With Coronary Artery Disease

Coronary Artery Disease | Inflammation | Rheumatoid Arthritis

Greece
Bayer

Completed

A Study to Evaluate Inhibition of Ovulation of Two Oral Estrogen/Progestogen Regimens in Healthy, Young Females Over a Period of 3 Treatment Cycles

Contraception

Germany
Bayer

Terminated

Inhibition of Ovulation, Patch, Ethinylestradiol and Gestodene

Contraception | Ovulation Inhibition

Germany
Tehran University of Medical Sciences

Unknown

Methylphenidate on Intracortical Inhibition in Methamphetamine Abusers Attention Deficit Hyperactivity Disorder (ADHD) (ADHD)

Attention Deficit Hyperactivity Disorder

Iran, Islamic Republic of
The University of Texas Health Science Center,...

Completed

Argatroban Stroke Treatment - A Pilot Safety Study

Ischemic Stroke

United States
Bayer

Completed

Investigation of Three Contraceptive Hormone Patches in Regard to Inhibition of Ovulation Following Application Over 3 Treatment Cycles in Healthy, Young Women.

Contraception

Netherlands, Germany
Astellas Pharma Inc

Completed

A Long-term, Open-label, Uncontrolled Trial of YM443 (Z-338) in Patients With Functional Dyspepsia

Functional Dyspepsia | Dyspepsia

Japan
Bayer

Completed

Inhibition of Ovulation and Pharmacokinetics of Transdermal Ethinylestradiol (EE) and Gestodene (GSD)

Contraception | Ovulation Inhibition

Germany
Medical University of Graz

Completed

Platelet Inhibition and Bleeding in Patients Undergoing Non-Cardiac Surgery (BIANCA)

Postoperative Bleeding

Austria
Paulista University

Completed

Effectiveness of the Kinesio Taping® in Muscle Activation (EKTAQRIH)

Muscle Atrophy

Brazil
Boehringer Ingelheim

Completed

Study to Investigate the Effect of Paroxetine Mediated CYP2D6 Inhibition on the Pharmacokinetics of Tamsulosin in Healthy Male Volunteers

Healthy
Boehringer Ingelheim

Completed

Effect of Cytochrome P 450 3A4 Inhibition by Itraconazole on the Single Oral Dose Pharmacokinetics of Cilobradine

Healthy
Boehringer Ingelheim

Completed

Study to Investigate the Effect of Ketoconazole Mediated CYP3A4 Inhibition on Pharmacokinetics of Tamsulosin in Healthy Male Volunteers

Healthy

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