Search clinical trials for: somatic mutations

Total 1483 results

University of Wisconsin, Madison
National Cancer Institute (NCI)

Unknown

Study of Biomarkers in Tissue Samples From Patients With Breast Cancer

Breast Cancer
Institut National de la Santé Et de la Recherche...

Terminated

PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors (PRECARDIA)

Dilated Cardiomyopathy

France, Denmark, Germany, Italy, Netherlands, Spain, United Kingdom
Health Decisions
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

A Phase I Study to Evaluate the PK and PD of a Single Injection of Levonorgestrel Butanoate for Female Contraception (CCN011)

Contraceptive Usage

United States
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Mutations, Hormone Therapy (HRT) and Venous Thromboembolism

Cardiovascular Diseases | Venous Thromboembolism | Postmenopause
Hoffmann-La Roche

Completed

A Study of Tarceva (Erlotinib) in Patients With Locally Advanced, Metastatic or Recurrent Non-Small Cell Cancer Who Present Epidermal Growth Factor Receptor Mutations

Non-Squamous Non-Small Cell Lung Cancer

Bulgaria
Fudan University

Unknown

Mutation of BRCA1/2 and Other Potential Genes in Triple-negative Breast Cancer

Breast Cancer

China
Hoffmann-La Roche

Completed

A Study of Tarceva (Erlotinib) in First Line in Patients With Locally Advanced or Metastatic Lung Adenocarcinoma With EGFR Mutations

Non-Squamous Non-Small Cell Lung Cancer

Hungary, Latvia, Turkey
Memorial Sloan Kettering Cancer Center

Withdrawn

Clinical Outcomes in Hereditary Cancer

Breast Cancer | Pancreatic Cancer

United States
Memorial Sloan Kettering Cancer Center

Completed

Phase II Trial to Correlate Radiographic Response Induced By Gefitinib With Mutations in the Protein-Tyrosine Kinase Domain of the EGF Receptor Gene

Lung Cancer | Non-small Cell Lung Cancer | Bronchioloalveolar Cancer

United States
GenoSaber
Sun Yat-sen University; Shanghai Chest Hospital; Shanghai Pulmonary Hospital,...

Unknown

Human EGFR Mutations Quantitative Detection Kit (Real-time Fluorescent PCR Method)

Non Small Cell Lung Cancer | EGFR-TKI Resistant Mutation | EGFR-TKI Sensitizing Mutation
University of Washington
National Cancer Institute (NCI); National Institute of Nursing Research (NINR)

Completed

Group-Based Lifestyle Intervention in Measuring Biomarker Levels in Participants at High Risk for Breast Cancer (DEEM)

Ductal Breast Carcinoma in Situ | BRCA1 Mutation Carrier | BRCA2 Mutation Carrier | Atypical Ductal Breast Hyperplasia | Lobular Breast Carcinoma in Situ | Atypical Lobular Breast Hyperplasia

United States
National Cancer Institute (NCI)

Completed

Selumetinib in Cancers With BRAF Mutations

Adult Solid Neoplasm

United States
Massachusetts General Hospital
Boston Children's Hospital

Unknown

Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia

Congenital Diaphragmatic Hernia

United States
Wayne State University

Completed

Stress and Health Interview for Primary Care Patients With Medically Unexplained Symptoms

Somatoform Disorders

United States
AstraZeneca

Completed

A Non-interventional Study (NIS) Registry for the Epidemiological and Scientific Evaluation of Epidermal Growth Factor Receptor (EGFR) Mutation Status in Patients With Newly Diagnosed Locally Advanced or Metastatic Non Small Cell Lung Cancer (NSCLC) (Stage IIIB/IV Non-small Cell Lung Cancer). (REASON)

Non Small Cell Lung Cancer

Greece
University of Cincinnati
Merck Sharp & Dohme LLC

Completed

Evaluating the Role of Immune Responses in the Emergence of Protease Inhibitor Mutations

Hepatitis C

United States
Memorial Sloan Kettering Cancer Center
Ascenta Therapeutics

Terminated

Erlotinib and AT-101 in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients With Epidermal Growth Factor Receptor (EGFR) Activating Mutations

Lung Cancer

United States
Marie Luise Bisgaard, MD

Unknown

Assessment of Residual VHL Function in Tumors - Can it Predict the Patients' Individual Course of Disease?

Von Hippel-Lindaus Disease

Denmark
Karolinska Institutet

Completed

Cognitive Behavior Therapy for Health Anxiety: A Comparison of Three Forms of Self-help

Illness Anxiety Disorder | Somatic Symptom Disorder | Severe Health Anxiety

Sweden
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S0424 - Carcinogens in Lung Tissue From Smokers (Closed to Entry as of 7/15/07) and Non-Smokers With Newly Diagnosed Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer

Lung Cancer

United States
Duke University
National Cancer Institute (NCI)

Completed

Genetic Study in Patients Receiving Treatment for Hodgkin's Disease or Childhood Brain Tumor

Lymphoma | Brain and Central Nervous System Tumors

United States
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Withdrawn

Identifying Early Lung Cancer Cells in Malignant Pleural Effusion Samples From Patients With Primary Lung Cancer

Lung Cancer | Metastatic Cancer

United States
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Withdrawn

Lapatinib Resistance in Patients With Breast Cancer

Breast Cancer

United States
Massachusetts General Hospital
Novartis Pharmaceuticals

Withdrawn

BKM120 in Cancers With PIK3CA Activating Mutations

Breast Cancer | Colorectal Cancer | Lung Cancer | Cholangiocarcinoma | Solid Tumors
Hospital Universitari de Bellvitge

Terminated

Continuation Electroconvulsive Therapy (C-ECT) for Relapse Prevention in Major Depression

Depression

Spain
Medical College of Wisconsin

Withdrawn

Genetic Markers as Predictors of Phenotypes in Pediatric Onset Crohn's Disease

Crohn's Disease | Ulcerative Colitis | Inflammatory Bowel Disease

United States
Hadassah Medical Organization

Withdrawn

Improving the Reproductive Outcome of Poor Quality Ova by Injection of Autologous Somatic Mitochondria

Low Ovarian Reserve | Poor Quality Oocytes

Israel
Brock University
Ontario Neurotrauma Foundation

Completed

The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury

Depression | Cognitive Impairment | Neuropathic Pain | Autonomic Dysfunction | Somatic Neuropathy

Canada
University Hospital, Montpellier

Terminated

Prevalence of POU4F3 and SLC17A8 Mutations

Familial Deafness

France
National Institute of Allergy and Infectious Diseases...

Terminated

Boceprevir Drug Combination for Hepatitis C Treatment in People With and Without HIV

Hepatitis | HIV/AIDS

United States
M.D. Anderson Cancer Center

Completed

Study of Erlotinib in Combination With Dasatinib

Advanced Cancer

United States
M.D. Anderson Cancer Center

Completed

Study of Erlotinib in Combination With Bortezomib

Advanced Cancer

United States
National Cancer Institute (NCI)

Completed

ABT-888 and Gemcitabine Hydrochloride in Treating Patients With Advanced Solid Tumors

Adult Solid Neoplasm | BRCA1 Mutation Carrier | BRCA2 Mutation Carrier

United States
Hoffmann-La Roche

Completed

A Study of Tarceva (Erlotinib) in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer Who Present EGFR Mutations

Non-Small Cell Lung Cancer

Finland
Italian Network for Tumor Biotherapy Foundation
Bristol-Myers Squibb

Unknown

A Study of Fotemustine(FTM) Vs FTM and Ipilimumab (IPI) or IPI and Nivolumab in Melanoma Brain Metastasis (NIBIT-M2)

Brain Metastases

Italy
National Cancer Institute (NCI)

Completed

Veliparib, Carboplatin, and Paclitaxel in Treating Patients With Advanced Solid Cancer

Hereditary Breast and Ovarian Cancer Syndrome | Adult Solid Neoplasm | BRCA1 Mutation Carrier | BRCA2 Mutation Carrier

United States
National Institute of Allergy and Infectious Diseases...
Glaxo Wellcome

Completed

Four-Drug Combination Therapy With Zidovudine, Lamivudine, 1592U89 (Abacavir), and 141W94 (Amprenavir) in HIV-Infected Patients

HIV Infections

United States
Italian Network for Tumor Biotherapy
Bristol-Myers Squibb

Completed

A Combination of Ipilimumab and Fotemustine for Treat Unresectable Locally Advanced or Metastatic Melanoma (NIBIT-M1)

Metastatic Malignant Melanoma

Italy
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Biomarkers in Tissue Samples From Patients With Ewing Sarcoma

Sarcoma
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Biomarkers in Tumor Tissue Samples From Young Patients With Very Low Risk Wilms Tumors

Kidney Cancer
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Studying Biomarkers in Cell Samples From Patients With Acute Myeloid Leukemia

Leukemia
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Studying DNA in Tumor Tissue Samples From Patients With Localized or Metastatic Osteosarcoma

Sarcoma
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Biomarkers in Patients With Acute Myeloid Leukemia

Leukemia
Genzyme, a Sanofi Company

Completed

Screening Protocol to Evaluate Acid Alpha-Glucosidase (GAA) Activity and GAA Gene Mutations in Patients With Late Onset Pompe Disease

Pompe Disease

United States
National Cancer Institute (NCI)

Completed

Study of a Polymorphism in Patients With Prostate Cancer

Prostate Cancer
National Cancer Institute (NCI)

Completed

Genetic Study of Patients Previously Treated With Flavopiridol on Clinical Trial NCI-97-C-0171C

Unspecified Adult Solid Tumor, Protocol Specific

United States
Igenomix

Unknown

Somatic Stem Cells in Endometriosis

Endometriosis

Spain
National Cancer Institute (NCI)

Completed

Pertuzumab and Cetuximab in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal Cancer

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer | Adenocarcinoma of the Rectum | Stage III Colon Cancer | Stage III Rectal Cancer | Adenocarcinoma of the Colon

United States
Zhejiang University
Beta Pharma, Inc.; Jiangsu Simcere Pharmaceutical Co., Ltd.

Unknown

Rh-Endostatin in Combination With Icotinib for Advanced NSCLC With EGFR Mutations

Lung Cancer

China
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S9031-9333-0106-0112-A Study of Biomarkers in Samples From Patients With Acute Myeloid Leukemia Treated With Standard Chemotherapy With or Without Gemtuzumab Ozogamicin

Leukemia

Search clinical trials for: somatic mutations

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