Clinical Trials Sponsored by Broad Institute

Total 74385 results

Institut Cancerologie de l'Ouest
National Cancer Institute, France

Active, not recruiting

Evaluation of Different Smoking Cessation Protocols: Nicotine Replacement, Motivational Interviewing (MI), Cognitive Behavioural Therapy (CBT) or Hypnotherapy in Cancer Patients Scheduled for Surgery (RESPIRE)

Melanoma | Breast Cancer | Gynecologic Cancer | Digestive Cancer

France
Institut Curie
National Cancer Institute, France; Fondation ARC

Terminated

PF-05212384 (PKI-587) for t-AML/MDS or de Novo Relapsed or Refractory Acute Myeloid Leukemia (AML) (LAM-PIK)

Acute Myeloid Leukemia, in Relapse | Therapy-related Acute Myeloid Leukemia and Myelodysplastic Syndrome | de Novo Acute Myeloid Leukemia at Diagnostic

France
Institut Català d'Oncologia
Institut d'Investigació Biomèdica de Bellvitge; Carlos III Health Institute

Not yet recruiting

eHealth Interventions for Breast Cancer Cognitive Impairment (ICOgnition)

Breast Cancer | Cognitive Dysfunction
OHSU Knight Cancer Institute
National Cancer Institute (NCI); National Institutes of Health (NIH)

Enrolling by invitation

Pathogenesis of Hematologic Malignancies

Lymphoproliferative Disorders | Myelodysplastic Syndromes | Myeloproliferative Disorders | Acute Leukemia

United States
Karolinska Institutet
Norwegian Institute of Public Health; Finnish Institute for Health and Welfare

Completed

Tobacco Use and the Risk of COVID-19 and Adverse Outcomes

Infections | Virus Diseases | Respiratory Tract Infections | COVID-19 | Pneumonia, Viral | Pneumonia | SARS-CoV-2 Infection

Sweden
Scripps Translational Science Institute
Quest Diagnostics-Nichols Insitute

Completed

THE GIRAFFE Study: Genomic Risk Markers for Atrial Fibrillation Following Extended Cardiac Rhythm Monitoring (GIRAFFE)

Patients With Symptoms of Cardiac Arrhythmia at Risk for Atrial Fibrillation

United States
Institut Cancerologie de l'Ouest

Completed

Cetuximab and Combination Chemotherapy in Treating Patients With Advanced or Metastatic Colorectal Cancer

Colorectal Cancer

France
Institut Cancerologie de l'Ouest

Unknown

Biomarkers in Predicting Neurotoxicity in Patients With Colorectal Cancer Receiving Oxaliplatin

Colorectal Cancer | Neurotoxicity | Chemotherapeutic Agent Toxicity

France
Finnish Institute for Health and Welfare
Norwegian Institute of Public Health; Karolinska Institutet

Active, not recruiting

Tobacco Use and Uptake of COVID-19 Vaccinations

Smoking | COVID-19 | Tobacco Use | Vaccination Refusal

Finland
Finnish Institute for Health and Welfare
Norwegian Institute of Public Health; Karolinska Institutet

Completed

Tobacco Use and COVID-19 Incidence in the Finnish General Population (Tobrisk-CoV)

Covid19 | SARS-CoV-2 Infection

Finland
Saint John's Cancer Institute
National Cancer Institute (NCI); National Institutes of Health (NIH)

Completed

Multicenter Selective Lymphadenectomy Trial II (MSLT-II)

Melanoma

United States, Australia, Italy, Spain, Canada, Netherlands, Germany, Finland, Israel, Sweden, Switzerland, United Kingdom
Institut Guttmann
Instituto de Salud Carlos III

Completed

Non-invasive Brain Stimulation for Gait Improvement in Patients With Spinal Cord Injury (SCI)

Functional Improvement
Dana-Farber Cancer Institute
National Cancer Institute (NCI); National Institutes of Health (NIH)

Completed

Individualizing Surveillance Mammography for Older Breast Cancer Survivors

Breast Cancer

United States
Dana-Farber Cancer Institute
National Cancer Institute (NCI); National Institutes of Health (NIH)

Completed

Impact of Cerebellar Mass Resection on Pain Processing

Cerebellar Neoplasm

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); National Institutes of Health (NIH)

Completed

Analyzing a New Mechanism in Response to Tamoxifen Therapy in Breast Cancer Patients

Breast Cancer

United States
Regina Elena Cancer Institute
Istituti Fisioterapici Ospitalieri

Recruiting

Biobanking and New Biomolecular Metrics (Melamoma4p)

Melanoma (Skin) | Liquid Biopsy

Italy
Scientific Institute San Raffaele
Istituto Ortopedico Galeazzi

Recruiting

Sarcopenia and Physical Activity Intervention: a Randomized-controlled Trial

Sarcopenia

Italy
European Institute of Oncology
Istituto Clinico Humanitas

Terminated

Allogenic Haematopoietic Cell Transplantation for Patients With Refractory "Triple Negative" Breast Cancer

Breast Cancer

Italy
Brigham and Women's Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants

Genetic Predisposition to Disease | Hereditary Diseases

United States
Wihuri Research Institute
Karolinska Institutet; University of Helsinki; Minerva Foundation Institute for...

Unknown

The Effect of E-EPA on Circulating LDL and Plasma Lipid Metabolism (EPA&LDL)

Cardiovascular Diseases | Atherosclerosis | Low-density Lipoproteins Aggregation Susceptibility | Low-density Lipoprotein Lipid Composition

Finland
Montreal Heart Institute
Canadian Institutes of Health Research (CIHR)

Enrolling by invitation

Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository (HiRO-HCM)

Cardiomyopathies | Hypertrophic Cardiomyopathy | Hypertrophic Obstructive Cardiomyopathy | Familial Hypertrophic Cardiomyopathy

Canada
Karolinska Institutet
Region Stockholm; KTH Royal Institute of Technology

Active, not recruiting

Medication Repurposing to Stop Cognitive Decline in Dementia

Alzheimer Dementia | Dementia Disorders

Sweden
Montreal Heart Institute
Canadian Institutes of Health Research (CIHR)

Completed

Non-isotope Based Imaging Modalities vs Technetium-99m Single-Photon Emission Computed Tomography(99mTcSPECT) (MITNECB5)

Myocardial Ischemia

Canada
Karolinska Institutet
University of Nairobi; Kenya Medical Research Institute

Completed

Post-abortion Care and Contraceptive Counselling by Midwives or Physicians

Pregnancy

Kenya
Saint John's Cancer Institute
National Institutes of Health (NIH)

Completed

Multicenter Selective Lymphadenectomy Trial (MSLT)

Melanoma
National Institute of Cancerología
Instituto Nacional de Enfermedades Respiratorias

Completed

K-RAS Oncogene Mutation in Patients With Advanced Non-Small Cell Lung Cancer Associated With Exposure to Wood Smoke and Tobacco Smoking: Therapeutic Implications (007/055/OMI)

Non-Small Cell Lung Cancer

Mexico
National Institute of Cancerología
Instituto Nacional de Enfermedades Respiratorias

Completed

Effect of All-trans Retinoic Acid With Chemotherapy Based in Paclitaxel and Cisplatin as First Line Treatment of Patients With Advanced Non-small Cell Lung Cancer

Non-Small-Cell Lung Carcinoma

Mexico
Roswell Park Cancer Institute
National Institutes of Health (NIH)

Completed

Nicotine Vapor Specific Sensory Measurement

Substance-Related Disorder

United States
National Institute of Cancerología
Instituto Nacional de Enfermedades Respiratorias

Completed

Impact of Valganciclovir on Severe IRIS-Kaposi Sarcoma Mortality: an Open-label, Parallel, Randomized Controlled-trial.

Kaposi Sarcoma | Human Immunodeficiency Virus | Immune Reconstitution Syndrome

Mexico
Children's National Research Institute
National Institutes of Health (NIH)

Completed

Myocardial Perfusion and Scarring in Adults With Congenital Heart Disease

Cardiac Disease

United States
Instituto Nacional de Cardiologia Ignacio Chavez
Renal Research Institute

Unknown

Effect of Hemodiafiltration Plus MCOs on Uremic Toxins Removal

Chronic Kidney Disease Requiring Chronic Dialysis | Hemodiafiltration

Mexico
Toronto Rehabilitation Institute
Canadian Institutes of Health Research (CIHR)

Unknown

Fit for Dialysis: Research-based Film as a Knowledge Translation Strategy

End-Stage Renal Disease

Canada
OHSU Knight Cancer Institute
National Institutes of Health (NIH)

Completed

CROSSROAD II: Activating Rural Clinics and Women With Disabilities to Improve Cancer Screening

Cervical Cancer | Breast Cancer | Colorectal Cancer

United States
National Cancer Institute (NCI)
National Institutes of Health (NIH)

Completed

Defined Green Tea Catechin Extract in Treating Women With Hormone Receptor Negative Stage I-III Breast Cancer

Stage I Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Estrogen Receptor-negative Breast Cancer | Progesterone Receptor-negative Breast Cancer

United States
Karolinska Institutet
The George Institute for Global Health, India

Not yet recruiting

ATLS vs Standard Care Trial

Wounds and Injuries
Children's National Research Institute
National Institutes of Health (NIH)

Completed

MRI Assessment of Arrythmia Ablation Lesions

Ventricular Tachycardia | Cardiac Arrhythmia

United States
Instituto Nacional de Cancer, Brazil
Dana-Farber Cancer Institute

Completed

Study of Neoadjuvant Treatment of Locally Advanced Breast Cancer With CAP Regimen (CAPneo)

Triple Negative Breast Cancer Patients
Bruyere Research Institute
Canadian Institutes of Health Research (CIHR)

Unknown

The PIP-STOPP Study (PIP-STOPP)

Potentially Inappropriate Prescribing (PIP)
Instituto Mexicano del Seguro Social
National Polytechnic Institute, Mexico

Completed

Ketamine and Changes of the Short Portable Mental Status Questionnaire (SPMSQ-E)

Postoperative Cognitive Dysfunction

Mexico
Instituto Nacional de Cancerologia, Columbia

Unknown

Trastuzumab or Observation After Combination Chemotherapy and Trastuzumab in Treating Patients Undergoing Surgery for Stage II or Stage III Breast Cancer

Breast Cancer

Mexico
National Institute of Hygiene and Epidemiology,...
Karolinska Institutet

Completed

HIV Vertical Transmission in Vietnam

HIV Infections

Vietnam
Lawson Health Research Institute
Canadian Institutes of Health Research (CIHR); Ottawa Hospital Research Institute and other collaborators

Completed

Promoting Organ Donor Registration in Family Physician Offices

Organ Donation | Registration for Deceased Organ Donation

Canada
Montreal Heart Institute
Institut de Recherches Cliniques de Montreal

Recruiting

Assessing Pharmacokinetics and Pharmacodynamics of Daily Enteric-coated Aspirin in Patients With StablE Diabetes II (APPEASEDII)

Diabetes Mellitus, Type 2 | Type 2 Diabetes | Platelet Aggregation | Aspirin | Platelet Aggregation Inhibitors

Canada
Montreal Heart Institute
Institut de Recherches Cliniques de Montreal

Recruiting

Assessing Pharmacokinetics and Pharmacodynamics of Daily Enteric-coated Aspirin in Patients With StablE Diabetes (APPEASED)

Diabetes Mellitus, Type 2

Canada
UNICANCER
Institut Bergonié; National Cancer Institute, France; Institut du Cancer de Montpellier...

Completed

Treatment of Metastatic Castrate Resistant Prostate Cancer Patients According to Circulating Tumor Cells Kinetic (TACTIK)

Chemotherapy | Castration-resistant Prostate Cancer | Prostate Carcinoma | Circulating Tumor Cells

France
National Eye Institute (NEI)
National Cancer Institute (NCI)

Recruiting

Stargardt-like Macular Dystrophy (STDG3) Secondary to Mutations in ELOVL4

Stargardt-Like Macular Dystrophy

United States
Lawson Health Research Institute
Canadian Institutes of Health Research (CIHR); Berry Consultants; Weston Brain...

Active, not recruiting

Intranasal Oxytocin for Frontotemporal Dementia (FOXY)

Frontotemporal Dementia

United States, Canada
New York State Psychiatric Institute
National Institutes of Health (NIH); National Institute on Aging (NIA)

Completed

Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Elderly

Alzheimer Disease | Mild Cognitive Impairment | Delirium, Dementia, Amnestic, Cognitive Disorders

United States
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR); Institute for Clinical Evaluative...

Completed

Assessing Dementia Risk in the Community: The Dementia Population Risk Tool (DemPoRT)

Dementia
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR); Institute for Clinical Evaluative...

Completed

Risk Evaluation for Support: Predicting Elder Life in the Community Tool (RESPECT) (RESPECT)

Death

Clinical Trials Sponsored by Broad Institute

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