Clinical Trials Sponsored by Merck Foundation

Total 20625 results

Merck KGaA, Darmstadt, Germany
Merck Serono S.P.A., Italy

Completed

A Pilot Trial of Interferon Beta-1a in Alzheimer's Disease (REAL)

Alzheimer's Disease

Italy
Merck KGaA, Darmstadt, Germany
Merck Serono Limited, UK

Completed

Assessment of Subject Use of the Rebiject II Injection Device According to Nurse Examination of Subject Accuracy in 10 Steps as a Dummy Demonstration

Multiple Sclerosis
Merck KGaA, Darmstadt, Germany
Merck Serono S.A., Geneva

Completed

First Year Growth Response Associated Genetic Markers Validation Phase IV Open-label Study in Growth Hormone Deficient and Turner Syndrome Pre-pubertal Children: the PREDICT Pharmacogenetics Validation Study

Turner Syndrome | Idiopathic Growth Hormone Deficiency

Spain, France, Canada, United Kingdom, Czech Republic, Argentina, Germany, Italy, Sweden
Merck KGaA, Darmstadt, Germany
Merck Serono S.P.A., Italy

Terminated

A Trial to Evaluate the Correlation Between Spontaneous Catch-up Growth, Clinical Response to Saizen (Recombinant Human Growth Hormone, r-hGH) and Gene Expression Profiling in Children Small for Gestational Age (SGA) (SAIZEN in SGA)

Infant, Small for Gestational Age

Italy
Merck KGaA, Darmstadt, Germany
Merck Quimica Argentina S.A.I.C

Completed

Sexual Dysfunction, Disability and Quality of Life in Patients With Multiple Sclerosis (MS)

Multiple Sclerosis, Relapsing Remitting

Argentina
Merck KGaA, Darmstadt, Germany
Merck Serono S.A., Geneva

Completed

An Observational Study for the Assessment of Adherence, Effectiveness and Convenience of Rebif® Treatment in Relapsing Multiple Sclerosis Patients Using RebiSmart™. (SMART)

Multiple Sclerosis, Relapsing-Remitting

Netherlands
Merck KGaA, Darmstadt, Germany
Merck Serono S.A., Geneva

Completed

Trial of MSC1936369B in Subjects With Solid Tumors

Cancer | Solid Tumors

France, Belgium, Australia, Netherlands
Merck KGaA, Darmstadt, Germany
Merck spol.s.r.o., Czech Republic

Completed

Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Czech Republic (ECOS CZ)

Growth Disorders

Czechia
Merck KGaA, Darmstadt, Germany
Merck Gesellschaft mbH, Austria

Completed

To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Austria (ECOS AUT)

Growth Disorders

Austria
Merck KGaA, Darmstadt, Germany
Merck Serono Limited, UK

Completed

A Retrospective Review of Liver Resection Rate in Metastatic Colorectal Cancer Patients Following Downsizing Treatment With Chemotherapy Plus Cetuximab in Normal UK National Health Service Clinical Practice (RESECT)

Metastatic Colorectal Cancer

United Kingdom
Merck KGaA, Darmstadt, Germany
Merck Serono S.P.A., Italy

Terminated

Study to Evaluate if the Addition of r-hLH (Luveris®) to FSH From Day 8 of Ovarian Stimulation is Able to Decrease Total FSH Dose and to Improve Cycle Outcome in Infertile Women Undergoing ART, Who Required High FSH Dose in a Previous Cycle (Luveris in ART)

Reproductive Techniques, Assisted

Italy
Merck KGaA, Darmstadt, Germany
Merck Pte. Ltd., Singapore

Completed

A Study Using Recombinant Human Luteinizing Hormone (r-hLH, Luveris®) in the Treatment of Chinese Women With Hypogonadotropic Hypogonadism

Hypogonadism

China
Merck KGaA, Darmstadt, Germany
Merck spol.s.r.o., Czech Republic

Completed

Post-Authorization Observational Study to Evaluate Cognition and Fatigue in Relapsing-remitting Multiple Sclerosis (RRMS) Patients Treated With Rebif® (SKORE)

Multiple Sclerosis, Relapsing-Remitting

Czech Republic
Merck KGaA, Darmstadt, Germany
Merck Serono Co., Ltd.

Terminated

Efficacy and Safety of Crinone Versus Combination Medication (ACCESS)

Infertility

China
Merck KGaA, Darmstadt, Germany
Merck Serono Limited, UK

Completed

To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in the UK (ECOS UK)

Growth Disorders

United Kingdom
Merck KGaA, Darmstadt, Germany
Merck Serono S.P.A., Italy

Terminated

Clinical Performance and Safety Investigation of ENDOmetrial Washing MEdical DEvice Forielle (ENDOMEDE)

Infertility

Italy
Merck KGaA, Darmstadt, Germany
Merck Serono S.A.S, France

Completed

Efficacy and Safety Evaluation of Recombinant Human Growth Hormone (r-hGH), Saizen®, on a Population of Children With Hypochondroplasia, Treated at Least 3 Years or Until Near Final Height, When Applicable, in Comparison With a Historic Cohort of Non-treated Children

Hypochondroplasia

France
Merck KGaA, Darmstadt, Germany
Merck Serono S.A.S, France

Completed

A Multicentre Study of the Efficacy and Safety of Supplementary Treatment With Cholecalciferol in Patients With Relapsing Multiple Sclerosis Treated With Subcutaneous Interferon Beta-1a 44 µg 3 Times Weekly (CHOLINE)

Multiple Sclerosis

France
Merck KGaA, Darmstadt, Germany
Merck Serono S.A.S, France

Completed

A Pharmaco-epidemiological Study of Short Patients Born Small for Gestational Age (SGA), Treated With Saizen® (Recombinant Somatropin) (SEPAGE)

Infant, Small for Gestational Age

France
Merck KGaA, Darmstadt, Germany
Merck Serono Limited, UK

Completed

Impact of Disease Modifying Therapies (DMTs) and Associated Support Services in Relapsing Multiple Sclerosis (RMS) Patients

Relapsing Multiple Sclerosis

United Kingdom
Merck KGaA, Darmstadt, Germany
Merck Serono S.A., Geneva

Completed

Study of AS902330 (rhFGF-18) Administered Intra-articularly in Patients With Knee Primary Osteoarthritis Who Are Candidates for Total Knee Replacement

Knee Osteoarthritis

Denmark, Finland, Sweden, United Kingdom, Bulgaria, South Africa
Merck KGaA, Darmstadt, Germany
Merck Serono GmbH, Germany

Completed

To Evaluate the Convenience, Safety and Efficacy of Follitropin Alfa Liquid Pen Compared With Follitropin Beta Liquid Pen

Infertility | Ovulation Induction
Merck KGaA, Darmstadt, Germany
Merck Gesellschaft mbH, Austria

Completed

Bisoprolol in Hypertension: Effect on Concomitant Elevated Heart Rate

Hypertension

Austria
Merck KGaA, Darmstadt, Germany
Merck Quimica Argentina S.A.I.C

Completed

Prevalence of the Mutational Status of V-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) in Metastatic Colorectal Cancer (mCRC) in Argentine Patients

Colorectal Neoplasms

Argentina
Merck KGaA, Darmstadt, Germany
Merck Pte. Ltd., Singapore

Completed

An Observational Study of Cetrotide® Gonadotropin-releasing Hormone Antagonist (GnRH Antagonist) With GONAL-f® in Assisted Reproductive Technologies (ART)

Infertility

Singapore
Merck KGaA, Darmstadt, Germany
Merck Serono Limited, UK

Completed

An Observational, Retrospective, UK & Ireland Audit of Patient Adherence to Rebif® Injections Using the RebiSmart™ Injection Device (READER)

Relapsing Multiple Sclerosis

United Kingdom
Merck KGaA, Darmstadt, Germany
Merck Serono S.A.S, France

Terminated

EXpression PRofile Endometrium Samples Study (EXPRESS)

In Vitro Fertilization

France
Merck KGaA, Darmstadt, Germany
Merck Serono S.A.S, France

Completed

Evaluation of Emotional Disorders During Treatment by Interferon Beta in Relapsing-remitting Multiple Sclerosis Patients (SEPTIME)

Multiple Sclerosis, Relapsing, Remitting
Merck KGaA, Darmstadt, Germany
Merck Serono S.A., Geneva

Completed

Saizen in Intra-uterine Growth Retardation

Children Born With Serious Intra-uterine Growth Retardation
Merck KGaA, Darmstadt, Germany
Merck Serono S.A.S., an affiliate of Merck KGaA, Darmstadt, Germany

Completed

Optimization of the Dosage Regimen of Growth Hormone Therapy in Children Born Small for Gestational Age (SGA OPTIMIS)

Small Gestational Age (SGA)
Rigshospitalet, Denmark
Merck Sharp & Dohme LLC; Roche Pharma AG; Beckett Foundation; Onkologisk Forskningsfond

Unknown

The Importance of Muscle Function in Patients With Disseminated Bladder Cancer

Urinary Bladder Neoplasm

Denmark
Sorlandet Hospital HF
Merck KGaA, Darmstadt, Germany; Frontier Science & Technology Research Foundation...

Completed

Novel Treatment Option for Neuropathic Pain (NoTOPain)

Neuralgia | Complex Regional Pain Syndromes

Norway
Maternova Research
Merck for Mothers; HOPE Foundation for Women and Children of Bangladesh

Unknown

uChek Pilot Study for Urinalysis in the Antenatal Care Setting (uChekBangla)

Proteinuria | Pregnancy | Eclampsia | Preeclampsia

Bangladesh
University of Alberta
Merck Frosst Canada Ltd.; Heart and Stroke Foundation of Canada

Completed

Congestive Heart Failure Outreach Program (COPE)

Heart Failure

Canada
Merck KGaA, Darmstadt, Germany
Merck Romania SRL, an affiliate of Merck KGaA, Darmstadt, Germany

Completed

Effectiveness of Rebif® in Clinically Isolated Syndrome and Relapsing Multiple Sclerosis Using RebiSmart™ (PROCEED)

Clinically Isolated Syndrome | Relapsing Multiple Sclerosis

Germany
Royal Free Hospital NHS Foundation Trust
Merck Sharp & Dohme LLC; University College, London

Completed

Immunophenotyping of Melanoma Patients on Treatment With Pembrolizumab (PASIP)

Melanoma | Neoplasms

United Kingdom
Kirby Institute
Merck Sharp & Dohme LLC; amfAR, The Foundation for AIDS Research; Abbott

Completed

A Trial of 2 Options for Second Line Combination Antiretroviral Therapy Following Virological Failure of a Standard Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)+2N(t)RTI First Line Regimen (SECOND-LINE)

HIV Infections

Taiwan, Australia, Argentina, Singapore, India, France, South Africa, Chile, Germany, Hong Kong, Ireland, Malaysia, Mexico, New Zealand, Nigeria, Peru, United Kingdom
Merck KGaA, Darmstadt, Germany
Merck Serono Co., Ltd., China

Terminated

Efficacy Study of Oral Nicorandil on Improving Microvascular Function in Female Non-obstructive Coronary Artery Disease (CAD) Participants (SPET)

Non-obstructive Coronary Artery Disease

China
Merck KGaA, Darmstadt, Germany
Merck Serono Co., Ltd., China

Terminated

Efficacy of Oral Bisoprolol on Heart Rate Reduction in Chinese Chronic Heart Failure Participants (Biso-CHF)

Heart Failure

China
Merck KGaA, Darmstadt, Germany
Merck spol. s r.o., Slovakia

Completed

To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Slovakia (ECOS SVK)

Growth Disorders

Slovakia
Merck KGaA, Darmstadt, Germany
Merck S.A. de C.V., Mexico

Completed

To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Mexico (ECOS MEX)

Growth Disorders

Mexico
Merck KGaA, Darmstadt, Germany
Merck Serono Co., Ltd., China

Completed

A Randomized Controlled Study to Assess the Effects of Bisoprolol and Atenolol on Resting Heart Rate and Sympathetic Nervous System's Activity in Subjects With Essential Hypertension

Hypertension

China
Merck KGaA, Darmstadt, Germany
Merck Serono Australia Pty Ltd

Completed

Post Marketing Surveillance Study to Evaluate the Tolerability of Rebif® New Formulation in Patients With Relapsing Multiple Sclerosis in an Australian Clinical Setting. (ReNew)

Multiple Sclerosis

Australia
Merck KGaA, Darmstadt, Germany
Merck Serono Co., Ltd., China

Terminated

Colposeptine for the Treatment of Bacterial Vaginosis

Vaginosis, Bacterial

China
Merck KGaA, Darmstadt, Germany
Merck Serono Co., Ltd., China

Completed

Retrospective Study to Estimate the Current Status of Patients With Non-Obstructive coroNary Artery Disease (RESPOND)

Non-Obstructive Coronary Artery Disease

Germany
Merck KGaA, Darmstadt, Germany
Merck Serono Australia Pty Ltd

Completed

To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Australia (ECOS AUS)

Growth Disorders

Australia
Merck KGaA, Darmstadt, Germany
Merck Serono Co., Ltd., China

Completed

Research on Nicorandil Treatment of Patients Diagnosed as CHD (Coronary Heart Disease) With Stable Angina (SIGMART)

Coronary Disease | Stable Angina

China
Merck KGaA, Darmstadt, Germany
Merck Serono Co., Ltd., Japan

Completed

Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women

Polycystic Ovarian Syndrome | Anovulation | Oligo-ovulation | Hypothalamic-pituitary Dysfunction

Japan
Merck KGaA, Darmstadt, Germany
Merck Serono Co., Ltd., Japan

Completed

Study of Tecemotide (L-BLP25) in Participants With Stage III Unresectable Non-small Cell Lung Cancer (NSCLC) Following Primary Chemoradiotherapy

Non-small Cell Lung Cancer

Germany
Merck KGaA, Darmstadt, Germany
Merck S.A. de C.V., Mexico

Completed

Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management

Diabetic Peripheral Neuropathic Pain

Mexico

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