Clinical Trials Sponsored by National Institutes of Health Clinical Center (CC)

Total 8119 results

National Cancer Institute (NCI)

Recruiting

The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation | Peripheral Blood Stem Cell Transplantation

United States
National Cancer Institute (NCI)

Recruiting

Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis

Glioma

United States
National Cancer Institute (NCI)

Recruiting

Pomalidomide and Dose-Adjusted EPOCH +/- Rituximab for HIV-Associated Lymphomas

Burkitt Lymphoma | Plasmablastic Lymphoma | Non-Hodgkin Lymphoma | Diffuse Large Cell Lymphoma | B-Cell Neoplasm

United States
National Cancer Institute (NCI)

Recruiting

Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial

Neurofibromatosis 1 | Noonan Syndrome | Legius Syndrome | Cardiofaciocutaneous Syndrome | Costello Syndrome

United States
National Cancer Institute (NCI)

Recruiting

Rare Tumors and Cancer Predisposition in Individuals and Families

Cancer | Hereditary Neoplasms | Genetic Predisposition to Cancer | Environment

United States
National Cancer Institute (NCI)

Recruiting

M9241 in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer or Intrahepatic Cholangiocarcinoma

Colorectal Neoplasms | Colorectal Cancer | Cholangiocarcinoma | Bile Duct Cancer | Bile Duct Neoplasms | Metastatic Colorectal Cancer (Mcrc) | Intrahepatic Cholangiocarcinoma (Icc) | Intrahepatic Bile Duct Cancer

United States
National Cancer Institute (NCI)

Recruiting

Olaparib in Subjects With Advanced Pancreatic Acinar Cell Carcinoma

Pancreatic Acinar Cell Carcinoma

United States
National Cancer Institute (NCI)

Recruiting

Study of Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis From Colorectal, Appendiceal, Small Bowel, Gastric, Cholangiocarcinoma, Breast, Ovarian, or Other Gynecologic Primary Cancer

Gynecologic Cancer | Colorectal Neoplasms | Colorectal Cancer | Ovarian Neoplasms | Peritoneal Neoplasms | Ovarian Cancer | Peritoneal Carcinomatosis | Appendiceal Neoplasms | Appendiceal Cancer | Gynecologic Neoplasms

United States
National Cancer Institute (NCI)

Recruiting

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

Metastatic Renal Cell Carcinoma | Metastatic Melanoma | Advanced Locoregional Melanoma | Clear Cell Histology

United States
National Cancer Institute (NCI)

Recruiting

Hyperspectral Analysis of Sweat Metabolite Biometrics for Real-Time Detection of COVID-19

COVID-19

United States
National Cancer Institute (NCI)

Recruiting

GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Hepatocellular Carcinoma (HCC)

Hepatocellular Carcinoma | Hepatocellular Cancer | Metastatic Hepatocellular Carcinoma

United States
National Cancer Institute (NCI)

Recruiting

Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies

Hematologic Neoplasms

United States
National Cancer Institute (NCI)

Recruiting

Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma

Kaposi Sarcoma

United States
National Cancer Institute (NCI)

Recruiting

A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies

Urogenital Neoplasms | Bladder Cancer | Urothelial Cancer | Genitourinary Cancer | Urogenital Cancer

United States
National Cancer Institute (NCI)

Recruiting

Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV

Kaposi Sarcoma | Viral Associated Malignancies | EBV/KSHV-associated Lymphomas

United States
National Cancer Institute (NCI)

Not yet recruiting

Vincristine and Temozolomide in Combination With PEN-866 for Adolescents and Young Adults With Relapsed or Refractory Solid Tumors

Sarcoma, Ewing | Rhabdomyosarcoma

United States
National Cancer Institute (NCI)

Recruiting

Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies

Noonan Syndrome | Legius Syndrome | Cardiofaciocutaneous Syndrome | Costello Syndrome | Capillary Arteriovenous Malformation Syndrome | RASopathy

United States
National Cancer Institute (NCI)

Recruiting

Lurbinectedin With Berzosertib, an ATR Kinase Inhibitor in Small Cell Cancers and High-Grade Neuroendocrine Cancers

SCLC | Advanced Solid Tumor | Small Cell Cancer | High Grade Neuroendocrine Cancers

United States
National Cancer Institute (NCI)

Recruiting

Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas

Neurofibromatosis 1

United States
National Cancer Institute (NCI)

Recruiting

A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers

Cervical Cancer | Vulvar Cancer | Colon Cancer | Anal Cancer | Vaginal Cancer | Oropharyngeal Cancer | Penile Cancer | HPV | Human Papillomavirus | Neck Cancer

United States
National Cancer Institute (NCI)

Recruiting

Precision-Based Genomics in Prostate Cancer

Prostate Cancer

United States, Spain
National Cancer Institute (NCI)

Recruiting

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

Gastric Cancer | Gastric Neoplasm | Gastrointestinal Stromal Tumor (GIST) | Gastrointestinal Stromal Sarcoma | Gastrointestinal Stromal Neoplasm

United States
National Cancer Institute (NCI)

Recruiting

Olaparib (LYNPARZA) Plus Durvalumab (IMFINZI) in EGFR-Mutated Adenocarcinomas That Transform to Small Cell Lung Cancer (SCLC) and Other Neuroendocrine Tumors

EGFR-Mutated Non-Small-Cell Lung Carcinoma | Small Cell/Neuroendocrine

United States
National Cancer Institute (NCI)

Recruiting

Phase II Randomized Trial of Bethesda Protocol Compared to Cambridge Method for Detection of Early Stage Gastric Cancer in CDH1 Mutation Carriers

Gastric Cancer | Gastric Adenocarcinoma | Gastric Neoplasms

United States
National Cancer Institute (NCI)

Recruiting

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity

Immune System Diseases | Lymphoproliferative Disorders | Common Variable Immunodeficiency | Primary T-cell Immunodeficiency Disorders | Autoimmune Lymphoproliferative

United States
National Cancer Institute (NCI)

Recruiting

Encorafenib Plus Binimetinib for People With BRAF V600 Mutated Relapsed/Refractory HCL

Hairy Cell Leukemia

United States
National Cancer Institute (NCI)

Recruiting

Binimetinib for People With Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and Variant

Hairy Cell Leukemia

United States
National Cancer Institute (NCI)

Recruiting

NHS-IL12 Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma

Kaposi Sarcoma

United States
National Cancer Institute (NCI)

Recruiting

Radium-223 in Biochemically Recurrent Prostate Cancer

Biochemical Recurrent Prostate Cancer

United States
National Cancer Institute (NCI)

Recruiting

National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer

Hepatocellular Carcinoma | Cholangiocarcinoma | Liver Cancer

United States
National Cancer Institute (NCI)

Recruiting

Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)

Neuroendocrine Tumors | Neuroendocrine Neoplasms | Gastroenteropancreatico Tumors

United States
National Cancer Institute (NCI)

Recruiting

Pediatric cGVHD Symptom Scale

Graft vs Host Disease

United States, Canada
National Cancer Institute (NCI)

Recruiting

Children and Adults With Chordoma

Chordoma

United States
National Cancer Institute (NCI)

Recruiting

Long Term Follow-up of Mesothelioma Patients and Their Family Members With Germline Mutations in BAP1 and Other Genes

Mesothelioma | Families

United States
National Cancer Institute (NCI)

Recruiting

Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation

Immune System Diseases | Lymphoproliferative Disorders | Common Variable Immunodeficiency | Primary T-cell Immunodeficiency Disorders | Autoimmune Lymphoproliferative

United States
National Cancer Institute (NCI)

Recruiting

M7824 and Topotecan or Temozolomide in Relapsed Small Cell Lung Cancers

Small Cell Lung Cancer | Lung Cancer | Carcinoma, Small Cell

United States
National Cancer Institute (NCI)

Recruiting

Recombinant Interleukin-15 in Combination With Checkpoint Inhibitors Nivolumab and Ipilimumab in People With Refractory Cancers

Metastatic Solid Tumors | Treatment-Refractory Cancers

United States
National Cancer Institute (NCI)

Recruiting

Profiling of Radiological Factors in Treatment and Outcomes in Prostate Cancer

Prostatic Hyperplasia | Prostate Cancer | Cancer Of Prostate | Prostatic Cancer | Prostatic Neoplams

United States
National Cancer Institute (NCI)

Recruiting

Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma

Neuroendocrine Tumors | Pheochromocytoma | Paraganglioma | Neuroendocrine Neoplasms

United States
National Cancer Institute (NCI)

Recruiting

E7 TCR T Cells for Human Papillomavirus-Associated Cancers

Cervical Intraepithelial Neoplasia | Papillomavirus Infections | Vulvar Neoplasms | Vulvar Diseases | Carcinoma In Situ

United States
National Cancer Institute (NCI)

Recruiting

Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy People for the Expansion of T Cells for Adoptive Cell Therapy

Healthy Volunteer

United States
National Cancer Institute (NCI)

Recruiting

Collection of Tissue Blocks or Slides From Patients With Cancer

Cancer | Tumor | Benign Neoplasms | Carcinogens | Neoplasm, Benign

United States
National Cancer Institute (NCI)

Recruiting

Trial of EP0057, a Nanoparticle Camptothecin With Olaparib in People With Relapsed/Refractory Small Cell Lung Cancer

Lung Neoplasms | Small Cell Lung Cancer | Prostate Cancer | Urothelial Carcinoma | Urothelial Cancer

United States
National Cancer Institute (NCI)

Recruiting

Care of the Prostate Cancer Patient and Prospective Procurement of Prostate Cancer Tissue

Prostate Cancer

United States
National Cancer Institute (NCI)

Recruiting

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

Immune System Diseases | Lymphoproliferative Disorders | Common Variable Immunodeficiency | Primary T-cell Immunodeficiency Disorders | Autoimmune Lymphoproliferative

United States
National Cancer Institute (NCI)

Recruiting

Phase I/II Study of the Anti-Programmed Death Ligand-1 Durvalumab Antibody (MEDI4736) in Combination With Olaparib and/or Cediranib for Advanced Solid Tumors and Advanced or Recurrent Ovarian, Triple Negative Breast, Lung, Prostate and Colorectal Can...

Breast Neoplasms | Colorectal Neoplasms

United States
National Cancer Institute (NCI)

Recruiting

Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue

Healthy Volunteers | Bladder Cancer | Urothelial Cancer | Urinary Tract Cancer

United States
National Cancer Institute (NCI)

Recruiting

Trial of the Combination of Bortezomib and Clofarabine in Adults With Relapsed Solid Tumors

Neoplasms | Myelodysplastic Syndromes | Lymphomas

United States
National Cancer Institute (NCI)

Recruiting

Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Small Cell Lung Cancer | Non-Small Cell Lung Cancer | Extrapulmonary Small Cell Cancer | Pulmonary Neuroendocrine Tumors | Thymic Epithelial Tumors

United States
National Cancer Institute (NCI)

Recruiting

DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study

Pleuropulmonary Blastoma | Cystic Nephroma | Nasal Chondromesenchymal Hamartoma | Ovarian Sertoli-Leydig Cell Tumors | Ocular Medulloepithelioma

United States

Clinical Trials Sponsored by National Institutes of Health Clinical Center (CC)

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Serbia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations