Search clinical trials for: CYP2C19 Polymorphism

Total 2197 results

Vera HM Deneer
Federico II University; University Medical Center Groningen; UMC Utrecht; Onze... and other collaborators

Completed

Cost-effectiveness of Genotype Guided Treatment With Antiplatelet Drugs in STEMI Patients: Optimization of Treatment (POPular Genetics)

Myocardial Infarction | STEMI

Netherlands, Italy, Belgium
Osaka University

Withdrawn

Randomized Trial for Pharmacogenomics-based Proton Pump Inhibitor Therapy in Children

Gastroesophageal Reflux

Japan
University of Belgrade
Clinical Centre of Serbia; Military Medical Academy, Belgrade, Serbia; Institute...

Recruiting

Personalized Sertraline Dosing in Patients With Depression (PsyCise-S)

Depressive Disorder, Major

Serbia
University of Belgrade
Clinical Centre of Serbia; Military Medical Academy, Belgrade, Serbia; Institute...

Recruiting

Personalized Escitalopram Dosing in Patients With Depression (PsyCise-E)

Depressive Disorder, Major

Serbia
University of Pennsylvania

Completed

Assessment of Prospective CYP2C19 Genotype Guided Dosing of Anti-Platelet Therapy in Percutaneous Coronary Intervention (ADAPT)

Cardiovascular Diseases | Acute Coronary Syndrome

United States
University Hospital, Geneva

Recruiting

Risk of CYP2C19 Phenoconversion in Healthy Volunteers With Rapid, Normal, and Intermediate Predicted Metabolizers' Status (Switch19)

Healthy

Switzerland
University of Puerto Rico
National Institute on Minority Health and Health Disparities (NIMHD); Icahn...

Active, not recruiting

A Genomic Approach for Clopidogrel in Caribbean Hispanics

Myocardial Infarction | Coronary Artery Disease | Stroke | Peripheral Arterial Disease | Acute Coronary Syndrome | Cardiovascular Disease (CVD)

Puerto Rico
J.P.S Henriques

Not yet recruiting

Rivaroxaban Monotherapy After CYP2C19 Genotype Testing in Patients With Atrial Fibrillation and Percutaneous Coronary Intervention (IMPACT AF-PCI)

Coronary Artery Disease | Atrial Fibrillation
AstraZeneca
Quintiles, Inc.

Completed

Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer

Solid Tumours

United States
University Hospitals, Leicester

Recruiting

Pharmacokinetics of Voriconazole in Adult ECMO Patients

Covid19 | Influenza | Aspergillosis

United Kingdom
Radboud University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development; Rijnstate... and other collaborators

Recruiting

Genotype-guided Strategy for Antithrombotic Treatment in Peripheral Arterial Disease. (GENPAD)

Peripheral Arterial Disease

Netherlands
Novartis Pharmaceuticals

Completed

Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors

Advanced Solid Tumors, Excluding Breast Cancer

United States
Janssen Korea, Ltd., Korea

Completed

An Efficacy Study to Compare the Treatment Effects of Rabeprazole and Lansoprazole Depending on the Genotyping of CYP2C19 in Treating Reflux Esophagitis

Reflux Esophagitis
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants

Healthy

United States
R-Pharm International, LLC
IQVIA RDS Ireland Ltd; Thermo Fisher Scientific FS

Completed

Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4

Rheumatoid Arthritis

Bulgaria, Moldova, Republic of
National Neuroscience Institute
Singapore General Hospital

Recruiting

Genotype Guided Antiplatelet Therapy In Ischemic Stroke

Ischemic Stroke | Transient Ischemic Attack

Singapore
First Affiliated Hospital of Zhejiang University
The First Affiliated Hospital with Nanjing Medical University; Peking Union... and other collaborators

Unknown

A Multi-center Study for Individual Treatment of Helicobacter Pylori Infection

Gastritis | Gastric Ulcer
Victoria Rollason

Active, not recruiting

PROGRESSive Withdrawal Esomeprazole and Acid-related Symptoms (PROGRESS)

Stomach Diseases

Switzerland
Celgene
Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation

Completed

Effect of Rifampin and Efavirenz on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects

Healthy Volunteers

United States
Mahidol University

Unknown

Influence of Cytochrome P2B6 on Efavirenz Dose in HIV-infected Thai Patients

HIV | Cytochrome P-450 CYP2B6 | Efavirenz

Thailand
Indiana University

Completed

Effects of CYP2B6 Genetic Polymorphisms on Efavirenz Pharmacokinetics

HIV

United States
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Efavirenz (EFV) in HIV-Infected and HIV/Tuberculosis (TB) Coinfected Children

HIV Infections | Tuberculosis

South Africa, Zimbabwe, India, Uganda
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Oral Doses of JNJ-54175446 on the Inhibition of Cytochrome P450 CYP3A4, CYP2C9, CYP1A2 and CYP2D6 Activity and the Induction of CYP2B6 and CYP2C19 Activity Using a Multiple Probe Substrate Cocktail in Healthy Subjects

Healthy

Belgium
Daiichi Sankyo, Inc.

Completed

A PHASE 1, OPEN-LABEL, CROSS-OVER, FIXED SEQUENCE STUDY TO EVALUATE THE EFFECT OF MULTIPLE DOSES OF DS-1971A ON THE SINGLE DOSE PHARMACOKINETICS OF PROBE SUBSTRATES FOR CYP2B6, CYP2C8, CYP2C9, CYP2C19 AND CYP3A4 ENZYMES IN HEALTHY MALE AND FEMALE SUBJECTS

Healthy

United Kingdom
Beijing Anzhen Hospital

Recruiting

Genotyping GUided Antiplatelet theRapy in pAtieNts Treated With Drug Eluting stEnts (GUARANTEE)

Angina, Stable | Acute Coronary Syndrome | Drug-Eluting Stents | Genotype

China
Alexion Pharmaceuticals

Completed

Drug Interaction Study of ALXN2050 With Fluconazole and Rifampin in Healthy Adult Participants

Healthy

United States
French National Agency for Research on AIDS and...
Medecins Sans Frontieres, Netherlands

Completed

Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patients (ANRS 12146 CARINEMO) (CARINEMO)

Tuberculosis | Aids | Hiv Infections

Mozambique
University of Minnesota
National Institute of General Medical Sciences (NIGMS)

Completed

Pharmacogenetics of Warfarin Induction and Inhibition

Healthy

United States
Eisai Inc.

Completed

Study to Assess Pharmacokinetic Drug-Drug Interaction Between Avatrombopag When Co-Administered With Fluconazole, Itraconazole, or Rifampin in Healthy Subjects

Healthy Participants

United States
Makerere University
Health Research Board, Ireland

Unknown

Drug Interaction Between Coartem® and Nevirapine, Efavirenz or Rifampicin in HIV Positive Ugandan Patients

HIV Infections | Tuberculosis

Uganda
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Drug Interaction of PA-824, an Investigational Tuberculosis Medication, Together With Efavirenz, Ritonavir-Boosted Lopinavir, or Rifampin

Tuberculosis

United States
University of California, San Francisco

Withdrawn

Interplay Between Organic Anion Transporting Polypeptide (OATP) Transporters Transporters and CYP2C9 in Glyburide Pharmacokinetics (PK)

Healthy
Epizyme, Inc.

Completed

Open-Label, Multicenter, Two-Part, Phase 1 Study to Characterize Effects of a Moderate CYP3A Inhibitor on PK of Tazemetostat, Effects of Tazemetostat on PK of CYP2C8 and CYP2C19 Substrates, and Effect of Increased Gastric pH on PK of Tazemetostat in B-cell Lymphoma or Advanced Solid Tumor Patients

Mantle Cell Lymphoma | Marginal Zone Lymphoma | Advanced Solid Tumor | Diffuse Large B Cell Lymphoma | Primary Mediastinal Lymphoma

United States
Beijing Tiantan Hospital
Ministry of Science and Technology of the People´s Republic of China

Completed

Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II (CHANCE-2)

Stroke | Transient Ischemic Attack

China
Pfizer

Completed

The Study Of Fluconazole For Vulvovaginal Candidiasis

Vulvovaginal Candidiasis

Japan
Pfizer

Completed

A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin B

HIV Infections | Meningitis, Cryptococcal

United States
Pfizer

Completed

Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis

HIV Infections | Meningitis, Cryptococcal

United States
Indian Council of Medical Research

Completed

Diabetes Mellitus and Vulvovaginal Candidiasis

Diabetes Mellitus | Vulvovaginal Candidiasis

India
National Center for Research Resources (NCRR)
National Institute of Allergy and Infectious Diseases (NIAID); University of...

Completed

Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis

Histoplasmosis | Sporotrichosis | Blastomycosis
Hutchmed

Completed

HMPL-689 Drug Interaction Study With CYP3A Inhibitor/CYP2C9 Inhibitor/CYP3A Inducer/PPI

Relapsed or Refractory Lymphoma

United States
Annemieke Geluk
The Leprosy Mission Bangladesh

Recruiting

Novel Interventions and Diagnostic Tests for Leprosy (INDIGO#2)

Leprosy

Bangladesh
Maastricht University Medical Center
Zuyderland Medical Centre

Recruiting

The Effect of Medical Grade Honey Formulation (L-Mesitran) Administration on Recurrent Vulvovaginal Candidiasis Symptoms

Candidiasis, Vulvovaginal | Recurrent Candidiasis of Vagina

Netherlands
Takeda

Completed

A Study of Soticlestat and Rifampin in Healthy Adults

Healthy Volunteers

United Kingdom
Jiangsu HengRui Medicine Co., Ltd.

Active, not recruiting

A Drug-drug Interaction Study of SHR2150 on Healthy Chinese Volunteers

Human Immunodeficiency Virus Infection

China
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Drug-Drug Interaction of Pyrotinib With a Moderate CYP3A Inducer

Healthy Subjects, Drug-drug Interaction, Pyrotinib

China
Johns Hopkins University

Withdrawn

Epidemiology and Treatment of Small-colony Variant Staphylococcus Aureus in Cystic Fibrosis

Cystic Fibrosis | MRSA

United States
Peking Union Medical College Hospital
National Key Technologies R&D Program for the 13th Five-year Plan; National... and other collaborators

Completed

Efavirenz 400mg in Treatment-naïve Chinese HIV-infected Patients

HIV-1-infection

China
Bristol-Myers Squibb

Completed

An Investigational Study to Evaluate the Effect of Rifampin on the Singe Dose of Experimental Medication BMS-986224 in Healthy Participants

Healthy Participants

United States
Viamet

Completed

A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Acute Vaginal Candidiasis (Yeast Infection)

Candidiasis, Vulvovaginal

United States
University of Oulu
Oulu University Hospital

Completed

The Effects of PXR Activation on Hepatic Fat Content

Non-alcoholic Fatty Liver Disease

Finland

Search clinical trials for: CYP2C19 Polymorphism

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