Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II

Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II

Sponsors

Lead Sponsor: Beijing Tiantan Hospital

Collaborator: Ministry of Science and Technology of the People´s Republic of China

Source Beijing Tiantan Hospital
Brief Summary

The primary objective of this trial is to assess the effects of ticagrelor plus aspirin versus clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.

Detailed Description

According to the Global Burden of Disease(GBD) Study 2016, China bears the greatest lifetime risk of stroke from 25-year-age onward. Minor ischemic events, including minor stroke and TIA, were major parts of stroke manifestations. Events (CHANCE) has shown that 21-day dual antiplatelet therapy (clopidogrel and aspirin) compared to aspirin alone which initiated within 24 hours after symptoms onset would reduce 32% risk of stroke recurrence within 90 day, but not in carriers of CYP2C19 loss-of-function (LOF) alleles. The primary purpose of this study is to compare ticagrelor plus aspirin with clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.

Both intent analysis (ITT) and compliance program set (PPS) were used for analysis.

We will use Kaplan-Meier estimates of the cumulative risk of stroke (ischemic or hemorrhagic) event during maximum 90-day follow-up, with hazards ratios and 95% CI calculated using Cox proportional hazards methods and the log-rank test to evaluate the treatment effect. All statistics will be 2-sided with P<0.05 considered significant, accounting for interim analyses.

All patients who received study drugs and with at least one safety follow-up record will be included in the safety population. The data for safety evaluation included adverse reactions observed during the trial and changes in laboratory data before and after treatment.

Overall Status Recruiting
Start Date September 23, 2019
Completion Date June 2022
Primary Completion Date September 2021
Phase Phase 3
Study Type Interventional
Primary Outcome
Measure Time Frame
Any new stroke events (ischemic stroke or hemorrhagic stroke) within 3 months 3 months after randomization
Secondary Outcome
Measure Time Frame
Any new stroke events (ischemic stroke or hemorrhagic stroke) within 1 year 1 year after randomization
3-month and 1 year new clinical vascular events 3 months and 1 yearafter randomization
3-month and 1 year new ischemic stroke events 3 months and 1 year after randomization
mRS change 3 months and 1 year after randomization
Further efficacy exploratory analysis: NIHSS change at 3 months 3 months after randomization
Further efficacy exploratory analysis: Quality of Life 3 months and 1 year after randomization
Enrollment 6396
Condition
Intervention

Intervention Type: Drug

Intervention Name: Ticagrelor and Aspirin

Description: Day of randomization: Day1:Ticagrelor 180mg; placebo of clopidogrel 300mg; aspirin 75-300mg (open label) Day2-21st: Ticagrelor 90mg bid/day; placebo of clopidogrel 75mg; aspirin 75mg (open label) Day 22nd-3 months:Ticagrelor 90mg bid/day; placebo of clopidogrel 75mg

Arm Group Label: Ticagrelor plus Aspirin Group

Intervention Type: Drug

Intervention Name: Clopidogrel and Aspirin

Description: Day of randomization: Day 1: Clopidogrel 300mg; placebo of ticagrelor 180mg; aspirin 75-300mg (open label) Day2-21st: Clopidogrel 75mg/day; placebo of ticagrelor 90mg bid/day; aspirin 75mg (open label) Day 22nd-3 months:Clopidogrel 75mg; placebo of ticagrelor 90mg bid/day

Arm Group Label: Clopidogrel plus Aspirin Group

Eligibility

Criteria:

Inclusion Criteria:

1. Older than 40 Years ;

2. Acute onset of cerebral ischemia due to

- Acute non-disabling ischemic stroke (NIHSS≤3 at the time of randomization)or

- TIA with moderate-to-high risk of stroke recurrence (ABCD2 score ≥ 4 at the time of randomization)

3. Can be treated with study drug within 24 hours of symptoms onset*(*Symptom onset is defined by the "last see normal" principle)

4. CYP2C19 LOF alleles carriers

5. Informed consent signed

Exclusion Criteria:

1. malformation, tumor, abscess or other major non-ischemic brain disease (e.g., multiple sclerosis) on baseline head CT or MRI

2. Isolated or pure sensory symptoms (e.g., numbness), isolated visual changes, or isolated dizziness/vertigo without evidence of acute infarction on baseline head CT or MRI

3. Iatrogenic causes (angioplasty or surgery) of minor stroke or TIA.

4. Preceding moderate or severe dependency (modified Rankin scale [mRS] score 3-5).

5. Contraindication to clopidogrel, ticagrelor or ASA (• Known allergy •Severe renal or hepatic insufficiency • Severe cardiac failure • History of Hemostatic disorder or systemic bleeding • History of thrombocytopenia or neutropenia • History of drug-induced hematologic disorder or hepatic dysfunction

6. Hematokrit(HCT)<30%

7. Clear indication for anticoagulation(presumed cardiac source of embolus, e.g., atrial fibrillation, prosthetic cardiac valves known or suspected endocarditis)

8. History of intracranial hemorrhage or amyloid angiopathy

9. HIstory of aneurysm (intracranial aneurysm and peripheral aneurysm)

10. History of asthma or COPD (chronic obstructive pulmonary disease)

11. High-risk for bradyarrhythmia (first-degree or second-degree AV block caused by sinus node disease, and bradyarrhythmic syncope without pacemaker)

12. History of hyperuricemia nephropathy

13. Anticipated requirement for long-term (>7 days) non-steroidal anti-inflammatory drugs (NSAIDs)

14. Planned or likely revascularization (any angioplasty or vascular surgery) within the next 3 months

15. Scheduled for surgery or interventional treatment requiring study drug cessation

16. Severe non-cardiovascular comorbidity with life expectancy < 3 months

17. Inability to understand and/or follow research procedures due to mental, cognitive, or emotional disorders

18. Dual antiplatelet treatment (or more than two antiplatelet agents) in 72 hours before randomization

19. Current treatment (last dose given within 10 days before randomization) with heparin therapy or oral anti coagulation

20. Intravenous thrombolytic therapy (such as intravenous rtPA) or mechanical thrombectomy within 24 hours prior to randomization

21. Gastrointestinal bleed within 3 months or major surgery within 30 days

22. Diagnosis or suspicious diagnosis of acute coronary syndrome

23. Participation in another clinical study with an experimental product during the last 30 days.

24. Currently receiving an experimental drug or device

25. Pregnant, currently trying to become pregnant, or of child-bearing potential and not using birth control.

Gender: All

Minimum Age: 40 Years

Maximum Age: N/A

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Yongjun Wang, M.D Principal Investigator Beijing Tian Tan Hospital, Capital Medical University, Beijing, China
Overall Contact

Last Name: Xia Meng, PhD

Phone: 00861059976699

Email: [email protected]

Location
Facility: Status: Contact:
Anqing Municipal Hospital | Anqing, Anhui, 246003, China Recruiting Xueying Shi 13966993701 [email protected]
The First Affiliated Hospital of Bengbu Medical College | Bengbu, Anhui, 233004, China Recruiting Peng Shi 18715241692 [email protected]
Beijing Chaoyang Hospital, Capital MedicalUniversity(west Hospital) | Beijing, Beijing, 100043, China Recruiting Lichun Zhou 13701279076 [email protected]
Beijing Tian tan Hospital | Beijing, Beijing, 100070, China Recruiting xingquan zhao, M.D. 13501031486 [email protected] yongjun wang, M.D. Principal Investigator xingquan zhao, M.D. Sub-Investigator
Beijing Shunyi Airport Hospital | Beijing, Beijing, 101318, China Recruiting Dongli Cheng 13311269392 [email protected]
The First Hospital of Fangshan District | Beijing, Beijing, 102488, China Recruiting Jianhua Li 13552375686 [email protected]
Chongqing People's Hospital | Chongqing, Chongqing, 400010, China Recruiting Zhiyou Cai 18523189930 [email protected]
The Second Affiliated Hospital of Chongqing Medical University | Chongqing, Chongqing, 400010, China Recruiting Yangmei Chen 13608348562 [email protected]
Chongqing Sanbo Chang 'an Hospital | Chongqing, Chongqing, 400023, China Recruiting Xianwen Han 15998950681 [email protected]
Daping Hospital of Army Military Medical University | Chongqing, Chongqing, 400042, China Recruiting Meng Zhang 13708332600 [email protected]
The First Affiliated Hospital of Chongqing Medical University | Chongqing, Chongqing, 400060, China Recruiting Yongli He 13883431962 [email protected]
Chongqing Fifth People's Hospital | Chongqing, Chongqing, 400062, China Recruiting Qunling Zhan 17754979593 [email protected]
The Third Affiliated Hospital of Chongqing Medical University | Chongqing, Chongqing, 401120, China Recruiting Yundong Zhang 13996300689 [email protected]
People's Hospital of Rongchang District, Chongqing, | Chongqing, Chongqing, 402460, China Recruiting Hongyuan Cao 13883722476 [email protected]
Chongqing Three Gorges Central Hospital | Chongqing, Chongqing, 404000, China Recruiting Shengli Chen 13896226960 [email protected]
Liang ping district people's hospital | Chongqing, Chongqing, 405200, China Recruiting Ziguang Chen 13668475543 [email protected]
Chongqing Kaizhou District People's Hospital | Chongqing, Chongqing, 405400, China Recruiting Liang Wei 18323571233 [email protected]
Chongqing Fuling Central Hospital | Chongqing, Chongqing, 408000, China Recruiting De Yang 18589707908 [email protected]
Chongqing Nanchuan District People's Hospital | Chongqing, Chongqing, 408400, China Recruiting Hua Zhong 13609478678 [email protected]
Xiushan Tujia and Miao Autonomous County People's Hospital | Chongqing, Chongqing, 409900, China Recruiting Xiaopeng Feng 18696980280 [email protected]
The Third Affiliated Hospital of Fujian University of Traditional Chinese Medicine | Fuzhou, Fujian, 350025, China Recruiting Lufeng Yin 13960720255 [email protected]
Fuzhou Second Hospital | Fuzhou, Fujian, China Recruiting Xiaoling Jiang, 350007 13763879070 [email protected]
Sanming First Hospital Affiliated to Fujian Medical University | Sanming, Fujian, 100043, China Recruiting Weimin Hong 13701279076 [email protected]
Zhangzhou Hospital affiliated to Fujian Medical University | Zhangzhou, Fujian, 363000, China Recruiting Yuehong Chen 13806906963 [email protected]
Wuwei People's Hospital | Wuwei, Gansu, 733000, China Recruiting Yumei Wang 13893516899 [email protected]
Zhangye People's Hospital Affiliated to Hexi College | Zhangye, Gansu, 734000, China Recruiting Xia Wang 13993636868 [email protected]
Dongguan People's Hospital | Dongguan, Guangdong, 523000, China Recruiting Yangkun Chen 13713135765 [email protected]
The Second Affiliated Hospital of Guangzhou Medical University | Guangzhou, Guangdong, 510260, China Recruiting Qingchun Gao 13928947877 [email protected]
Nanfang Hospital Of Southern Medical University | Guangzhou, Guangdong, 510515, China Recruiting Jia Yin 13802964883 [email protected]
The First Affiliated Hospital of Jinan University | Guangzhou, Guangdong, 510632, China Recruiting Anding Xu 13392692160 [email protected]
The first Affiliated Hospital of Shantou University Medical College | Shantou, Guangdong, 515041, China Recruiting Weiduan Zhuang 13802717292 [email protected]
Guiyang Second People's Hospital | Guiyang, Guizhou, 550000, China Recruiting Ping Sun 13985140155 [email protected]
Affiliated Hospital of Guizhou Medical University | Guiyang, Guizhou, 550004, China Recruiting Lan Chu 13885181667 [email protected]
Hainan West Central Hospital | Danzhou, Hainan, 571799, China Recruiting Kaiyi Wu 13976292866 [email protected]
The First Affiliated Hospital of Hainan Medical University | Haikou, Hainan, 570102, China Recruiting Yan Wang 13322013300 [email protected]om
Second hospital in Baoding | Baoding, Hebei, 071000, China Recruiting Fengli Zhao 17732288689 [email protected]
The Affiliated Hospital of Chengde Medical College | Chengde, Hebei, 067000, China Recruiting Xiaoxuan Zhang 18503141169 [email protected]
Hejian People's Hospital | Hejian, Hebei, 062450, China Recruiting Yanxia Wang 18631733332 [email protected]
HaLixun InternationalPeace Hospital | Hengshui, Hebei, 053000, China Recruiting Yan Wei 18003188568 [email protected]
Hengshui fourth People Hospital(Department of Neurology ward 2) | Hengshui, Hebei, 053000, China Recruiting Jianling Zhang 13191905169 [email protected]
The Fourth People's Hospital of Hengshui City(Department of Neurology ward 1) | Hengshui, Hebei, 053000, China Recruiting Aisheng Wu 18803286996 [email protected]
Qinhuangdao First Hospital | Qinhuangdao, Hebei, 66000, China Recruiting Xifa Lan 15833356517 [email protected]
The Second Hospitalof Hebei Medical University | Shijiazhuang, Hebei, 050000, China Recruiting Dan He 18603112970 [email protected]
The First Affiliated Hospital of Hebei North University | Zhangjiakou, Hebei, 75000, China Recruiting Yu'an Zou 15530330012 [email protected]
Second Central Hospital of Baoding | Zhuozhou, Hebei, 072750, China Recruiting Shuangxia Du 15632229686 [email protected]
Daqing Oilfield Gengeal Hospital | Daqing, Heilongjiang, 163001, China Recruiting Xuhai Gong 13349491212 [email protected]
Daqing People's Hospital | Daqing, Heilongjiang, 163361, China Recruiting Dexin Luo 13359608879 [email protected]
The First Hospital of Harbin Medical University | Harbin, Heilongjiang, 150001, China Recruiting Guozhong Li 13804606966 [email protected]
The Second Hospital of Harbin Medical University(Department of Neurology ward 1) | Harbin, Heilongjiang, 150086, China Recruiting Yulan Zhu 13069870810 [email protected]
The Second Hospital of Harbin Medical University(Department of Neurology ward ) | Harbin, Heilongjiang, 150086, China Recruiting Lihua Wang 13100881600 [email protected]
The First Affiliated Hospital of Jiamusi University | Jiamusi, Heilongjiang, 154002, China Recruiting Baoying Sheng 13836605279 [email protected]
Hongqi Hospital affiliated to Mudanjiang Medical University | Mudanjiang, Heilongjiang, 157000, China Recruiting Xiaofan Yang 13945306306 [email protected]
Anyang People's Hospital | Anyang, Henan, 455000, China Recruiting Qingcheng Yang 13503728378 [email protected]
Changge People's Hospital | Changge, Henan, 461500, China Recruiting Gexia Liu 13503899368 [email protected]
Xiuwu County People's Hospital | Jiaozuo, Henan, 454350, China Recruiting Guangming Kang 13839146566 [email protected]
Jiyuan People's Hospital | Jiyuan, Henan, 459000, China Recruiting Hongqin Yang 13938170576 [email protected]
Kaifeng Central Hospital | Kaifeng, Henan, 475000, China Recruiting Xinshen Han 18603780505 [email protected]
weishi county Central Hospital | Kaifeng, Henan, 475500, China Recruiting Weifeng Lu 13938602168 [email protected]
Luohe Central Hospital | Luohe, Henan, 462000, China Recruiting Chunling Zheng 13949870107 [email protected]
Luoyang Central Hospital | Luoyang, Henan, 471000, China Recruiting Haitao Zhou 13213571982 [email protected]
The first Affiliated Hospital of Henan University of Science and Technology | Luoyang, Henan, 471000, China Recruiting Ganqin Du 13613882922 [email protected]
The Second Affiliated Hospital of Henan University of Science and Technology | Luoyang, Henan, 471000, China Recruiting Wen Shangguan 13608467154 [email protected]
Luoyang New District People's Hospital | Luoyang, Henan, 471023, China Recruiting Jie Liu 13653793287 [email protected]
Pingdingshan First People's Hospital | Pingdingshan, Henan, 467000, China Recruiting Wenjun Xue 13393796518 [email protected]
Sanmenxia Central Hospital | Sanmenxia, Henan, 472000, China Recruiting Shufang Yao 15138163911 [email protected]
Shangqiu Fourth People's Hospital | Shangqiu, Henan, 476000, China Recruiting Haichao Liu 13937042922 [email protected]
Suixian county Hospital of Traditional Chinese Medicine | Shangqiu, Henan, 476900, China Recruiting Hong Chen 13837070051 [email protected]
Xingyang People's Hospital | Xingyang, Henan, 450100, China Recruiting Weifeng Chen 13700878675 [email protected]
The first Affiliated Hospital of Xinxiang Medical University | Xinxiang, Henan, 453100, China Recruiting Jianhua Zhao 13803800541 [email protected]
Fengqiu County People's Hospital | Xinxiang, Henan, 453300, China Recruiting Yinguo Wan 13837337556 [email protected]
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine | Zhengzhou, Henan, 450000, China Recruiting Min Zhao 13526539201 [email protected]
Gongyi People's Hospital | Zhengzhou, Henan, 451200, China Recruiting Yanzeng Cui 13783627666 [email protected]
Zhoukou Yongshan Hospital | Zhoukou, Henan, 461300, China Recruiting Jinqi Fan 18638083426 [email protected]
Zhumadian Hospital of Traditional Chinese Medicine | Zhumadian, Henan, 463000, China Recruiting Xia Wei 17603962061 [email protected]
Shiyan Taihe Hospital | Shiyan, Hubei, 442000, China Recruiting Jun Chen 13971930236 [email protected]
Wuhan No.1 Hospital | Wuhan, Hubei, 430000, China Recruiting Guohua Chen 13971318512 [email protected]
Wuhan Central Hospital | Wuhan, Hubei, 430014, China Recruiting Ping Jing 13667216889 [email protected]
First hospital of Changsha city | Changsha, Hunan, 410005, China Recruiting Hong Tan 13975154497 [email protected]
Hunan Brain Hospital | Changsha, Hunan, 410207, China Recruiting Xiaosong Huang 13907319975 [email protected]
Chenzhou First People's Hospital | Chenzhou, Hunan, 423000, China Recruiting Haipeng Li 18007357008 [email protected]
Fourth People's Hospital of Chenzhou | Chenzhou, Hunan, 423000, China Recruiting Yongqian Lei 18975721025 [email protected]
The First Affiliated Hospital of Nanhua University | Hengyang, Hunan, 421001, China Recruiting Heng Wu 18143371327 [email protected]
Loudi Central Hospital | Loudi, Hunan, 417000, China Recruiting Changmao Li 13507386077 [email protected]
shaoyang Central Hospital | Shaoyang, Hunan, China Recruiting Chunhua Zhang 13973961018 [email protected]
Xiangtan Central Hospital | Xiangtan, Hunan, 411100, China Recruiting Jinshen Lin 13975205621 [email protected]
Yueyang Second People's Hospital | Yueyang, Hunan, 414000, China Recruiting Ke Deng 13787306483 [email protected]
The first Affiliated Hospital of Baotou Medical College | Baotou, Inner Mongolia Autonomous Region, 014010, China Recruiting Lie Wu 13848271804 [email protected]
Baotou CentralHospital | Baotou, Inner Mongolia Autonomous Region, 014040, China Recruiting Baojun Wang 13384858794 [email protected]
The second Affiliated Hospital of Baotou Medical College | Baotou, Inner Mongolia Autonomous Region, 14030, China Recruiting Wenwei Gao 13947252056 [email protected]
Wuyuan County People's Hospital | Bayan Nur, Inner Mongolia Autonomous Region, 15100, China Recruiting Yongming Chen 15647811211 [email protected]
Hulun Buir People's Hospital | Buri, Inner Mongolia Autonomous Region, 21000, China Recruiting Hua Bao 13804709791 [email protected]
Chifeng City Hospital | Chifeng, Inner Mongolia Autonomous Region, 024000, China Recruiting Yi An 18047660559 [email protected]
Affiliated Hospital of Chifeng University | Chifeng, Inner Mongolia Autonomous Region, 024005, China Recruiting Weili Zhao 13948162665 [email protected]
Inner Mongolia People's Hospital | Hohhot, Inner Mongolia Autonomous Region, 010017, China Recruiting Runxiu Zhu 18047191885 [email protected]
Inner Mongolia International Mongolian Hospital | Hohhot, Inner Mongolia Autonomous Region, 010069, China Recruiting Bing Wu 18847138336 [email protected]
Huaian Hospital of Traditional Chinese Medicine | Huai'an, Jiangsu, 223001, China Recruiting Bing Wang 13813347793 [email protected]
Jingjiang People's Hospital | Jingjiang, Jiangsu, 214500, China Recruiting Xiaojun Xu 13812393670 [email protected]
The Second People's Hospital of Lianyungang | Lianyungang, Jiangsu, 222023, China Recruiting Jiechun Chen 13776598025 [email protected]
The Second Affiliated Hospital of Nanjing Medical University | Nanjing, Jiangsu, 210003, China Recruiting Jin Wu 18951762859 [email protected]
Nanjing Gulou Hospital | Nanjing, Jiangsu, 210008, China Recruiting Yun Xu 13914764479 [email protected]
BenQ Hospital affiliated to Nanjing Medical University | Nanjing, Jiangsu, 210019, China Recruiting Min Ye 13770580050 [email protected]
Jiangsu Provincial Hospital of Traditional Chinese Medicine | Nanjing, Jiangsu, 210029, China Recruiting Minghua Wu 13951786719 [email protected]
Nanjing Brain Hospital | Nanjing, Jiangsu, 210029, China Recruiting Hui Cao 13951981878 [email protected]
The Fourth Affiliated Hospital of Nanjing Medical University | Nanjing, Jiangsu, 210031, China Recruiting Hongfei Li 15951662007 [email protected]
Nanjing Jiangbei People's Hospital | Nanjing, Jiangsu, 210048, China Recruiting Liqin Luan 18951766367 [email protected]
Nanjing Gaochun People's Hospital | Nanjing, Jiangsu, 211300, China Recruiting Shoucheng Zhang 13915912198 [email protected]
Nantong 6th People's Hospital | Nantong, Jiangsu, 226000, China Recruiting Hongliang Wang 17768696866 [email protected]
Nantong Hospital of Traditional Chinese Medicine | Nantong, Jiangsu, 226000, China Recruiting Baojian Geng 13861940369 [email protected]
The Third People's Hospital in Tongzhou District, Nantong | Nantong, Jiangsu, 226000, China Recruiting Panbing Huang 13814746200 [email protected]
Affiliated Hospital of Nantong University | Nantong, Jiangsu, 226001, China Recruiting Qiuhong Ji 13962916293 [email protected]
Nantong First People's Hospital | Nantong, Jiangsu, 226001, China Recruiting Xiangyang Zhu 13962978278 [email protected]
Nantong Second People's Hospital | Nantong, Jiangsu, 226002, China Recruiting Dan Ma 13585222369 [email protected]
Nantong Fourth People's Hospital | Nantong, Jiangsu, 226005, China Recruiting Wei Chen 18706297356 [email protected]
Nantong Third People's Hospital | Nantong, Jiangsu, 22600, China Recruiting Chunhua Dong 13962942307 [email protected]
Tongzhou District People's Hospital of Nantong City | Nantong, Jiangsu, 226300, China Recruiting Peining Shao 18962798202 [email protected]
Rudong County People's Hospital | Nantong, Jiangsu, 226400, China Recruiting Jun Gu 13962776599 [email protected]
Rugao People's Hospital | Nantong, Jiangsu, 226500, China Recruiting Yueqiang Gao 13626298698 [email protected]
Hai 'an People's Hospital | Nantong, Jiangsu, 226600, China Recruiting Haiyang Xie 13506296090 [email protected]
Tongzhou District 8th People's Hospital of Nantong City | Nantong, Jiangsu, China Recruiting Yi Zhao 13813756558 [email protected]
Siyang County People's Hospital | Suqian, Jiangsu, 223700, China Recruiting Wei Tan 13705243721 [email protected]
Siyang Kangda Hospital | Suqian, Jiangsu, 223700, China Recruiting Yanan Zhu 15152869372 [email protected]
Suqian People's Hospital | Suqian, Jiangsu, 223800, China Recruiting Xueling Zhang 18012186808 [email protected]
Suzhou Municipal Hospital | Suzhou, Jiangsu, 215000, China Recruiting Zhong Zhao 13962157887 [email protected]
The Second Affiliated Hospital of Soochow University | Suzhou, Jiangsu, 215004, China Recruiting Chunfeng Liu 13606210609 [email protected]
Taizhou People's Hospital | Taizhou, Jiangsu, 225300, China Recruiting Zhenggang Wu 13815955775 [email protected]
Xinghua People's Hospital | Taizhou, Jiangsu, 225700, China Recruiting Guodong Cai 13815919618 [email protected]
Wuxi People's Hospital | Wuxi, Jiangsu, 214000, China Recruiting Jianping Zhang 13358111978 [email protected]
Wuxi Second People's Hospital | Wuxi, Jiangsu, 214000, China Recruiting Tao Ma 15251643918 [email protected]
Affiliated Hospital of Jiangnan University | Wuxi, Jiangsu, 214041, China Recruiting Lingling Hu 13914151760 [email protected]
Yixing People's Hospital | Wuxi, Jiangsu, 214200, China Recruiting Junfeng Shi 18706152909 [email protected]
Jiangyin People's Hospital | Wuxi, Jiangsu, 214400, China Recruiting Bojun Han 13961618218 [email protected]
xuzhou Central Hospital | Xuzhou, Jiangsu, 221000, China Recruiting Guofang Chen 18952172823 [email protected]
Xuzhou coal mining group General Hospital | Xuzhou, Jiangsu, 221000, China Recruiting Xiu'e Wei 15005206672 [email protected]
Affiliated Hospital of Xuzhou Medical University(Department of Neurology ward 1) | Xuzhou, Jiangsu, 221002, China Recruiting Dunjing Wang 18052268202 [email protected]
Affiliated Hospital of Xuzhou Medical University(Department of Neurology ward 2) | Xuzhou, Jiangsu, 221002, China Recruiting Xinchu Ye 18052268829 [email protected]
Subei People's Hospital of Jiangsu province | Yangzhou, Jiangsu, 225009, China Recruiting Beilei Chen 18051060126 [email protected]
Affiliated Hospital of Yangzhou University | Yangzhou, Jiangsu, 225012, China Recruiting Tieyu Tang 15298458258 [email protected]
The fourth peoples hospital of zhenjiang city | Zhenjiang, Jiangsu, 212001, China Recruiting Jing Zhao 13952807762 [email protected]
Ganzhou city people's Hospital | Ganzhou, Jiangxi, 341000, China Recruiting Guoyong Zeng 13807079530 [email protected]
The First People's Hospital of Jingdehzne City | Jingdezhen, Jiangxi, 333000, China Recruiting Mingha Cao 13979881026 [email protected]
Affiliated Hospital of Jiujiang College | Jiujiang, Jiangxi, 332000, China Recruiting Xiangbin Wu 13507066417 [email protected]
Jiujiang first people's Hospital | Jiujiang, Jiangxi, 332000, China Recruiting Hebin Wan 13807928098 [email protected]
First Affiliated Hospital of Nanchang University | Nanchang, Jiangxi, 330000, China Recruiting Daojun Hong 13879187691 [email protected]
Jiangxi Provincial People's Hospital | Nanchang, Jiangxi, 330006, China Recruiting Lingfeng Wu 13870965608 [email protected]
Sino-Japanese Friendship Hospital Of Jilin University | Changchun, Jilin, 130031, China Recruiting Yansong Liu 13304322860 [email protected]
The First Hospital Of Jilin University | Changchun, Jilin, 130031, China Recruiting Jingyao Liu 13944831199 [email protected]
Xinhua Hospital affiliated to Dalian University | Dalian, Liaoning, 116023, China Recruiting Ying Bai 15541169243 [email protected]
Second People's Hospital of Huludao City | Huludao, Liaoning, China Recruiting Yefang Feng 13019990811 [email protected]
Shengjing Hospital of China Medical University | Shenyang, Liaoning, 110004, China Recruiting Juan Feng 18940257070 [email protected]
First People's Hospital of Shenyang | Shenyang, Liaoning, 110041, China Recruiting Bing Xu 13940142533‬ [email protected]
Guyuan people's hospital | Guyuan, Ningxia Hui Autonomous Region, 756000, China Recruiting Lujun Zhang 13519540405 [email protected]
The Fifth People's Hospital of Ningxia Hui Autonomous Region | Shizuishan, Ningxia Hui Autonomous Region, 753000, China Recruiting Renxiang Zhu 18995250388 [email protected]
The Second People's Hospital of Shizuishan | Shizuishan, Ningxia Hui Autonomous Region, 753000, China Recruiting Guangyao Peng 18795026626 [email protected]
Shizuishan First People's Hospital | Shizuishan, Ningxia Hui Autonomous Region, 753200, China Recruiting Wei Zhou 13709525682 [email protected]
Second people's Hospital of shizuishan | Shizuishan, Ningxia Hui Autonomous Region, 753400, China Recruiting Juyan Zhang 18152525995 [email protected]
General Hospital of Ningxia Medical University | Yinchuan, Ningxia Hui Autonomous Region, 750001, China Recruiting Qing Zhang 13995100667 [email protected]
Yinchuan First People's Hospital | Yinchuan, Ningxia Hui Autonomous Region, 750001, China Recruiting Xiangdong Bai 13909595823 [email protected]
Cardiovascular and Cerebrovoscular Hospital of General Hospital of Ningxia Med. Univ | Yinchuan, Ningxia Hui Autonomous Region, 750002, China Recruiting Xuewen Fan 13709575965 [email protected]
People's Hospital of Ningxia Hui Autonomous Region | Yinchuan, Ningxia Hui Autonomous Region, 750002, China Recruiting Zhimin Shi 13895099133 [email protected]
Zhongwei People's Hospital | Zhongwei, Ningxia Hui Autonomous Region, 755000, China Recruiting Tianhui He 13723357138 [email protected]
Baoji High-tech People's Hospital | Baoji, Shaanxi, 721000, China Recruiting Jinsuo Yang 19992300001 [email protected]
weinan Central Hospital | Weinan, Shaanxi, 714000, China Recruiting Jirong Liu 13196330707 [email protected]
Xi 'an Hi-tech Hospital | Xi'an, Shaanxi, 710000, China Recruiting Yi Jia 13891996727 [email protected]
Xi 'an Fengcheng Hospital | Xi'an, Shaanxi, 710016, China Recruiting Aimei Wu 13319207439 [email protected]
Xian 141 Hospital | Xi'an, Shaanxi, 710089, China Recruiting Qiuwu Liu 13772198549 [email protected]
Dezhou People's Hospital | Dezhou, Shandong, 2530000, China Recruiting Shaohua Su 13905343895 [email protected]
Ningjin County People's Hospital | Dezhou, Shandong, 253400, China Recruiting Chunjie Yang 13869568655 [email protected]
Shandong Provincial Hospital | Jinan, Shandong, 250021, China Recruiting Yifeng Du 13583118172 [email protected]
Liaocheng City Third People's Hospital | Liaocheng, Shandong, 252000, China Recruiting Liguo Chang 13506354339 [email protected]
Liaocheng People's Hospital | Liaocheng, Shandong, 252000, China Recruiting Cunju Guo 13346256168 [email protected]
The Brain Hospital of Liaocheng People's Hospital | Liaocheng, Shandong, 252000, China Recruiting Xiafeng Yang 13326356005 [email protected]
Liaocheng City Second People's Hospital | Liaocheng, Shandong, 252601, China Recruiting Xinqiang Wang 13562062933 [email protected]
Dongchangfu people's Hospital | Liaocheng, Shandong, China Recruiting Peiru Liu 13181053917 [email protected]
Qingdao Municipal Hospital | Qingdao, Shandong, 266000, China Recruiting Lan Tan 13853205658 [email protected]
Affiliated Hospital of Qingdao University Medical College | Qingdao, Shandong, 266071, China Recruiting Aijun Ma 13687656836 [email protected]
Qingdao West Coast New Area People's Hospital | Qingdao, Shandong, 266400, China Recruiting Xiangting Chai 16678657537 [email protected]
Affiliated Hospital of Weifang Medical University | Weifang, Shandong, China Recruiting Xuemei Li 13963641983 [email protected]
weihai Central Hospital | Weihai, Shandong, 264400, China Recruiting Honghao Man 18306300858 [email protected]
Wendeng District People's Hospital | Weihai, Shandong, 264400, China Recruiting Jinguo Zhao 13561852177 [email protected]
Penglai People's Hospital | Yantai, Shandong, 265600, China Recruiting Guiru Zhang 18562169812 [email protected]
Yantai Beihai Hospita | Yantai, Shandong, 265701, China Recruiting Changbai Sui 15965195561 [email protected]
Putuo District Central Hospital | Shanghai, Shanghai, 200062, China Recruiting Yu Bai 13788938062 [email protected]
Shanghai 7th People's Hospital | Shanghai, Shanghai, 200137, China Recruiting Feng Wang 13301991888 [email protected]
Changzhi People's Hospital | Changzhi, Shanxi, 046000, China Recruiting Lifang Zhang 13935571969 [email protected]
Heping Hospital affiliated to Changzhi Medical College | Changzhi, Shanxi, 046000, China Recruiting Hong Liu 15235528796 [email protected]
Datong Fifth People's Hospital | Datong, Shanxi, 037000, China Recruiting Wei Zhang 13753266066 [email protected]
The Third People's Hospital of Datong | Datong, Shanxi, 037008, China Recruiting Zhigang Cui 18503528899 [email protected]
Shanxi Bethune Hospital | Taiyuan, Shanxi, 30000, China Recruiting Xinyi Li 13903462254 [email protected]
Taiyuan Iron and Steel (Group) Co, Ltd,General Hospital | Taiyuan, Shanxi, 30001, China Recruiting Xuemei Wu 13485360389 [email protected]
Shenzhen Integrated Chinese and Western Medicine Hospital | Shenzhen, Shenzhen, 100191, China Recruiting Qizhang Wang 13510286781 [email protected]
Shenzhen Luohu People's Hospital | Shenzhen, Shenzhen, 518001, China Recruiting Zhishan Zhu 13537782087 [email protected]
Shenzhen Second People's Hospital | Shenzhen, Shenzhen, 518035, China Recruiting Lijie Ren 13631605966 [email protected]
Huazhong University of Science and Technology Union Shenzhen Hospital | Shenzhen, Shenzhen, 518052, China Recruiting Chunshui Cang 13809896581 [email protected]
West China Hospital Of Sichuan University | Chengdou, Sichuan, 610041, China Recruiting Li He 13808185446 [email protected]
Chengdu second Municipal People'sHospital | Chengdu, Sichuan, 610000, China Recruiting Bei Zhang 18908178068 [email protected]
The first Affiliated Hospital of Chengdu Medical College | Chengdu, Sichuan, 610500, China Recruiting Jie Yang 13678130516 [email protected]
dazhou Central Hospital | Dazhou, Sichuan, 635099, China Recruiting Hua Huang 15328245616 [email protected]
Tianjin Medical University General Hospital | Tianjin, Tianjin, 300052, China Recruiting Fudong Shi 15822011530 [email protected]
First Affiliated Hospital of Xinjiang Medical University | Guiyang, Xinjiang Autonomous Region, 8300054, China Recruiting Jianhua Ma 13109956336 [email protected]
People's Hospital Of Xinjiang Uygur Autonomous Region | Urumqi, Xinjiang Autonomous Region, 830001, China Recruiting Hongyan Li 13659942323 [email protected]
Friendship Hospital of Ili Kazak Autonomous Prefecture | Yining, Xinjiang Autonomous Region, 835000, China Recruiting Yuqing Liu 18935778685 [email protected]
First People's Hospital of Yunnan Province | Kunming, Yunnan, 650000, China Recruiting Qiang Meng 13888492028 [email protected]
Hangzhou first people's Hospital | Hangzhou, Zhejiang, 310006, China Recruiting Hao Zhang 13706513204 [email protected]
lishui municipal Central Hospital | Lishui, Zhejiang, 323000, China Recruiting Xueli Cai 13967059836 [email protected]
Zhejiang Wenzhou Medical College Third Affiliated Hospital | Ruian, Zhejiang, 325200, China Recruiting Xuerong Huang 13958860081 [email protected]
Taizhou First People's Hospital | Taizhou, Zhejiang, 318020, China Recruiting Zhimin Wang 15105867866 [email protected]
Location Countries

China

Verification Date

July 2020

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Beijing Tiantan Hospital

Investigator Full Name: Yongjun Wang

Investigator Title: Vice president of Beijing Tiantan Hospital

Keywords
Has Expanded Access No
Condition Browse
Number Of Arms 2
Arm Group

Label: Ticagrelor plus Aspirin Group

Type: Experimental

Description: Ticagrelor of loading dosing of 180mg followed by 90mg bid for 3 months plus aspirin of loading dose of 75-300mg followed by 75mg daily for 21 days

Label: Clopidogrel plus Aspirin Group

Type: Active Comparator

Description: Clopidogrel of loading dosing of 300mg followed by 75mg daily for 3 months plus aspirin loading dose of 75-300mg followed by 75mg daily for 21 days

Acronym CHANCE-2
Patient Data No
Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Primary Purpose: Prevention

Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Masking Description: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Source: ClinicalTrials.gov