Search clinical trials for: Metabolizing enzyme genotype

Total 49383 results

R-Pharm
Almedis

Completed

Efficacy and Safety of All-Oral Combination of Narlaprevir/Ritonavir and Daclatasvir in Treatment-Naїve Patients With Chronic Hepatitis C Genotype 1b

Chronic Hepatitis C Genotype 1b

Russian Federation
Takeda

Completed

Voglibose Tablets 0.2 / OD Tablets 0.2 Special Drug Use Surveillance "Long-term Use in Patients With Impaired Glucose Tolerance"

Impaired Glucose Tolerance

Japan
Nemours Children's Clinic

Completed

Implementation of PPI Medication PGX Testing (PGX)

Gastroesophageal Reflux

United States
Janssen R&D Ireland

Completed

A Study of Pharmacokinetics, Efficacy, Safety, Tolerability, of the Combination of Simeprevir (TMC435), Daclatasvir (BMS-790052), and Ribavirin (RBV) in Patients With Recurrent Chronic Hepatitis C Genotype 1b Infection After Orthotopic Liver Transplantation

Hepatitis C, Chronic

Spain, Germany, Poland
Baylor College of Medicine

Completed

Matched Unrelated or Non-Genotype Identical Related Donor Transplantation For Chronic Granulomatous Disease (MUNCHR)

Chronic Granulomatous Disease

United States
Meenakshi Ammal Dental College and Hospital

Completed

In-vitro Effect of Mangosteen Pericarp Extract on Cell Lines (invitro)

Apoptosis
Eli Lilly and Company

Completed

A Study to Evaluate the Effect of Genotype on LY2216684

Depressive Disorder, Major

United States
AbbVie

Completed

ABT-450/Ritonavir/ ABT-267 (ABT-450/r/ABT-267) and ABT-333 Co-Administered With Ribavirin (RBV) in Treatment Naïve and Treatment Experienced Asian Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection and Compensated Cirrhosis

Chronic Hepatitis C Virus (HCV)
USDA Beltsville Human Nutrition Research Center

Completed

Effect of Kale Consumption on Human Xenobiotic Metabolizing Enzymes

Healthy Volunteers

United States
Ain Shams University

Completed

Effect of Cyclosporine A Versus Tacrolimus on Response to Antiviral Therapy After Hepatitis C Genotype -4 Recurrence Post Liver Transplantation

Liver Transplantation
National Cerebral and Cardiovascular Center
Ministry of Health, Labor and Welfare (Japan)

Terminated

Assessment of an Alpha-glucosidase Inhibitor to Block Cardiac Events in Patients With MI and IGT

Myocardial Infarction | Impaired Glucose Tolerance

Japan
Hamid Sayar
Bayer; Merck Sharp & Dohme LLC; Millennium Pharmaceuticals, Inc.

Completed

Phase I/II Study of Combination of Sorafenib, Vorinostat, and Bortezomib for the Treatment of Acute Myeloid Leukemia With Complex- or Poor-risk (Monosomy 5/7) Cytogenetics or FLT3-ITD Positive Genotype

Acute Myeloid Leukemia

United States
Myeong Jun Song
Bristol-Myers Squibb; Korea University Guro Hospital; Severance Hospital; Eulji... and other collaborators

Completed

The Safety and Efficacy of Daclatasvir and Asunaprevir With Chronic HCV Genotype 1b Infection and Chronic Renal Failure

Hepatitis C

Korea, Republic of
AbbVie (prior sponsor, Abbott)

Completed

Study to Assess the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of ABT-267 in HCV Infected Subjects

Chronic Hepatitis C Infection

United States
VA Office of Research and Development

Completed

Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities (MTG)

PTSD

United States
AbbVie (prior sponsor, Abbott)

Completed

A Study to Evaluate the Safety and Effect of Treatment With Experimental Antiviral Drugs in Combination With Peginterferon Alpha-2a and Ribavirin in People With Hepatitis C Virus Who Did Not Respond to Treatment in a Previous AbbVie/Abbott Combination Study

Chronic Hepatitis C
AbbVie

Completed

Study to Evaluate the Efficacy and Safety of ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) in Japanese Adults With Subgenotype 1b Chronic Hepatitis C Virus (HCV) Infection (GIFT I)

Chronic Hepatitis C Infection
AbbVie (prior sponsor, Abbott)

Completed

A Study to Evaluate ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Japanese Adults With Chronic Hepatitis C Virus Infection

Chronic Hepatitis C Infection
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France; Institut... and other collaborators

Completed

Hepatosplenic CANdidiasis : PETscan and Immune Response Analysis (CANHPARI)

Neutropenia | Hematopoietic Stem Cell Transplantation | Hematological Malignancies | Invasive Fungal Disease | Chronic Disseminated Candidiasis

France
Tainan Municipal Hospital

Withdrawn

Interferon-free Antiviral Treatment of HCV-Positive Genotype 1b Related Indolent Non-Hodgkin Lymphomas

Hepatitis c
Sony Tuteja
American College of Clinical Pharmacy

Completed

Pharmacogenetics to Predict Drug Interactions in Kidney Transplant Recipients

Kidney Transplantation

United States
Hannover Medical School

Terminated

Pharmacovigilance in Gerontopsychiatric Patients (GAP)

Depression | Schizophrenia | Anxiety Disorders | Dementia | Psychosomatic Disorders

Germany
AbbVie

Completed

A Study to Evaluate the Safety and Antiviral Effect of ABT-450/Ritonavir and ABT-530 Coadministered With and Without Ribavirin in Adults With Genotype 3 Hepatitis C (HCV) Infection

Chronic Hepatitis C | Hepatitis C Virus
H. Lundbeck A/S

Completed

Effects of Repeated Doses of Lu AF35700 on Drug Metabolizing Enzymes

Drug Reactions

United Kingdom
Emory University

Terminated

Comparison of Behavioral Activation and Antidepressant Medication in the Treatment of Adolescents With Depression

Major Depressive Disorder

United States
AbbVie

Terminated

A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/r With or Without Dasabuvir and With or Without Ribavirin in Chronic Hepatitis C Virus Genotype 1 or 4 Infected Adults With Successfully Treated Early Stage Hepatocellular Carcinoma (GEODE - I)

Chronic Hepatitis C Infection
AbbVie

Completed

Ombitasvir/Paritaprevir/Ritonavir With or Without Dasabuvir in Adults With Genotype 1a or Genotype 4 Chronic Hepatitis C Virus (HCV) Infection, With Severe Kidney Impairment or End Stage Kidney Disease

Hepatitis C Virus (HCV)
Yonsei University

Completed

Genotype-Driven Treatment of Advanced Non-small Cell Lung Cancer Based on mRNA Expression of ERCC1 & RRM1 as First-line Chemotherapy

Non-small Cell Lung Carcinoma

Korea, Republic of
AbbVie

Completed

Safety, Tolerability and PK Study of Single Doses of ABT-450 With and Without Ritonavir to Treat Hepatitis C Virus (HCV) Genotype 1

HCV Infection

United States
AbbVie

Completed

Ombitasvir/ABT-450/Ritonavir and Dasabuvir With or Without Ribavirin in HCV Genotype 1-Infected Adults With Chronic Kidney Disease

Chronic Hepatitis C | Hepatitis C Virus | Severe Renal Impairment | Compensated Cirrhosis | End-stage Renal Disease
AbbVie

Completed

A Study to Evaluate Chronic Hepatitis C Infection in Adult Transplant Recipients (CORAL-I)

Chronic Hepatitis C Infection
AbbVie

Completed

Ombitasvir/ABT-450/Ritonavir and Dasabuvir Therapy With Low Dose Ribavirin (RBV), Full Dose RBV or RBV Add-On in Treatment Naive Genotype 1a Hepatitis C Virus Infected Adults

Chronic Hepatitis C | Hepatitis C (HCV) | Hepatitis C Genotype 1a
University of Sao Paulo
Novartis; Fundação de Amparo à Pesquisa do Estado de São Paulo; Conselho Nacional...

Completed

Using Drug Augmentation to Treat Obsessive Compulsive Disorder Patients Who Did Not Respond to Previous Treatment (EPMTOC)

Obsessive Compulsive Disorder

Brazil
AbbVie

Completed

ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 in Treatment-Naïve and Treatment-Experienced, Non-Cirrhotic Asian Adults With Subgenotype 1b Chronic Hepatitis C Virus (HCV) Infection

Hepatitis C Virus (HCV)
AbbVie

Completed

A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir With or Without Ribavirin in US Veterans With Genotype 1 Chronic Hepatitis C Virus Infection

Cirrhosis | Chronic Hepatitis C | Hepatitis C Virus
Mayo Clinic

Withdrawn

CYP2C19 Genotype Predictor of Gastric Acid Suppression

Esophagitis

United States
Shanghai Mental Health Center
First Affiliated Hospital Xi'an Jiaotong University; Chinese Academy of Sciences and other collaborators

Unknown

Multi-Dimensional Diagnosis,Individualized Therapy,and Management Technique for Major Depressive Disorder:Based on Clinical and Pathological Characteristics (STEP-MDD)

Depressive Disorder

China
Washington University School of Medicine

Completed

Genotype-directed Neoadjuvant Chemoradiation for Rectal Carcinoma

Rectal Carcinoma

United States
AbbVie

Completed

Ombitasvir/ABT-450 (Paritaprevir)/Ritonavir With Dasabuvir and Ribavirin (RBV) in Treatment Naive and Treatment Experienced Genotype 1a Hepatitis C Virus Infected Adults

Chronic Hepatitis C | Hepatitis C (HCV) | Hepatitis C Genotype 1a
Capital Medical University

Completed

Comparison of Venlafaxine and Fluoxetine in the Treatment of Postmenopausal Women With Major Depression

Major Depression

China
Laboratorios Silanes S.A. de C.V.
INTEC Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología... and other collaborators

Suspended

Fixed Dose Combination of Fluoxetin and Metformin in the Management of Overweight and Obesity (Metfluo)

Overweight and Obesity

Mexico
AbbVie

Completed

A Randomized, Open-Label Study to Evaluate the Safety and Efficacy of Ombitasvir/ABT-450/Ritonavir Co-administered With Ribavirin (RBV) in Adults With Genotype 4 Chronic Hepatitis C Virus (HCV) Infection and Cirrhosis (AGATE-1) (AGATE-1)

Hepatitis C Virus
New York State Psychiatric Institute
National Institute of Mental Health (NIMH)

Completed

Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder

Suicide | Borderline Personality Disorder

United States
Gene PreDiT
Blueclinical, Ltd.

Terminated

Influence of Carboxypeptidase D (CPD) Gene on Body Weight and Fat Mass Reduction by Perindopril in Obese Subjects (GPD-01-01)

Obesity

Portugal
AbbVie

Completed

A Study to Evaluate the Efficacy and Safety of Three Experimental Drugs in Adults With Hepatitis C Virus Infection, Who Are Either Treatment-naive or Treatment-experienced in Brazil

Chronic Hepatitis C Infection
Federal University of São Paulo

Completed

Randomized Clinical Trial of Sofosbuvir in Combination With Daclatasvir or Simeprevir for 12 Weeks in Non-cirrhotic Subjects Infected With Chronic Hepatitis C Virus Genotype 1 (TNT)

Hepatitis C, Chronic

Brazil
AbbVie

Completed

A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir With Ribavirin in Adults With Genotype 1 and Ombitasvir/Paritaprevir/Ritonavir With Ribavirin in Adults With Genotype 4 Chronic Hepatitis C Virus Infection and Decompensated Cirrhosis (TURQUOISE-CPB)

Decompensated Cirrhosis | Chronic Hepatitis C | Hepatitis C Virus
Janssen R&D Ireland

Completed

A Study to Evaluate the Efficacy, Safety and Tolerability of TMC435 in Combination With PegIFN Alfa-2a (Pegasys) and Ribavirin (Copegus) in Treatment-Naïve or Treatment-Experienced, Chronic Hepatitis C Virus Genotype-4 Infected Patients (RESTORE)

Hepatitis C

France, Belgium
National Institutes of Health Clinical Center (CC)

Completed

Influence of the MDR1 Genotype on Blood Levels of Indinavir and Saquinavir in Healthy Volunteers

HIV Infections | Healthy

United States
University of Pennsylvania

Completed

Impact of GABA-Enhancing Agents on Cortical GABA Concentrations Across the Menstrual Cycle in Women

Healthy

United States

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