Search clinical trials for: Molecular Conformation

Total 97399 results

Institut de Recherches Internationales Servier
Servier Bio-Innovation LLC

Not yet recruiting

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation (PyramIDH)

Myelodysplastic Syndromes (MDS) | Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS)
David Ilan Sandberg

Not yet recruiting

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

Recurrent Ependymoma | Recurrent Medulloblastoma | CNS Malignancies

United States
Swiss GO Trial Group
Tumor Profiler Center Switzerland

Not yet recruiting

OV Precision: Study Examining the Benefit of a Tumor- and Patient-specific Cancer Therapy (OVPrecision)

Fallopian Tube Neoplasms | Ovarian Neoplasm Epithelial | High-grade Serous Ovarian Carcinoma (HGSOC) | Ovarian Endometrioid Carcinoma

Switzerland
Clinact
Association CRO - Tous unis pour la vision

Recruiting

Research Into Diagnostic and Prognostic Molecular and Imaging Biomarkers of Ocular Disorders Associated With Neurovascular Deregulation: Biocor Cohort (BIOCOR)

Ocular Rosacea | Pachychoroid Disease

France
M.D. Anderson Cancer Center

Not yet recruiting

A Phase I Study of Hyper-CVAD In Combination With Venetoclax In Pediatric Patients With Relapsed or Refractory Acute Leukemias That Are of the Lymphoid Lineage Including Bi-Phenotypic or Undifferentiated Leukemias

Refractory Acute Leukemia | Undifferentiated Leukemia | Relapsed Acute Leukemia | Bi-Phenotypic Leukemia

United States
Stefano Vicari
Italian Institute of Technology (IIT)

Recruiting

Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome

Down Syndrome

Italy
University of Chile
Centro FONDAP de Gerociencia, Salud mental y Metabolismo (GERO); Center for...

Recruiting

Nicotinamide Supplementation Improves Physical Performance in Older Adults at Risk of Falls (NICE-FIT)

Frailty | Fall | Frailty Syndrome | Falls

Chile
The First Affiliated Hospital of Xiamen University

Recruiting

ImmunoPET Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) in Thyroid Cancer

Solid Tumor | Thyroid Cancer | Tumor | Positron-Emission Tomography

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine (ANTAMIN)

Limb Injury

France
Gruppo Oncologico Italiano di Ricerca Clinica

Recruiting

AGNOSTIC THERAPY IN A PHASE II SINGLE-ARM STUDY IN FIRST-LINE TREATMENT OF DURVALUMAB IN ASSOCIATION WITH CARBOPLATIN OR CISPLATIN AND ETOPOSIDE IN PATIENTS AFFECTED BY EXTENSIVE STAGE - EXTRAPULMONARY SMALL CELL CARCINOMA (DURVASCC)

Extrapulmonary Small Cell Carcinoma

Italy
Hospital do Coracao
Brazilian Research in Intensive Care Network (BRICNet)

Not yet recruiting

Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis (NoVa)

Septic Shock

Brazil
Milton S. Hershey Medical Center
Aminex Therapeutics, Inc.

Not yet recruiting

Difluoromethylornithine (DFMO) and AMXT-1501 for Neuroblastoma, CNS Tumors, and Sarcomas

Ewing Sarcoma | Embryonal Tumor With Multilayered Rosettes | Osteosarcoma Recurrent | Atypical Teratoid/Rhabdoid Tumor | DIPG Brain Tumor | Neuroblastoma Recurrent
Yunpeng Liu
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Irinotecan Hydrochloride Liposome Combined With Capecitabine and Lenvatinib in Patients With Biliary Tract Carcinoma

Biliary Tract Carcinoma

China
Genelux Corporation
Newsoara Biopharma Co., Ltd.

Not yet recruiting

Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's of Choice Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer (VIRO-25) ((VIRO-25))

Non-small Cell Lung Cancer Stage III | Non-small Cell Lung Cancer | Advanced Non-squamous Non-small-cell Lung Cancer | Non-small Cell Lung Cancer Stage IV | Metastatic Squamous Non-Small Cell Lung Carcinoma | Non-small Cell Lung Cancer Recurrent | Metastatic Non-squamous Non Small Cell Lung Cancer and other conditions
Wuhan University

Not yet recruiting

A Real-World Study of Neoadjuvant/Conversion Therapy for Locally Advanced or Metastatic Gastric Cancer

Gastric Cancer

China
Pfizer

Not yet recruiting

A Study to Learn About the Study Medicine PF-07220060 Together With Letrozole Compared to Letrozole Alone in Women Post Menopause

Breast Cancer
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.

Not yet recruiting

A Study of IMM01 in Combiniation With Tiselizumab Versus Physician's Choice Chemotherapy in PD-(L)1-refractory Classical Hodgkin Lymphoma

Classic Hodgkin Lymphoma
The First Affiliated Hospital of Henan University...

Not yet recruiting

Adebrelimab in Combination With Apatinib and Chemotherapy/Chemoradiotherapy in Immuno-experienced Second-line ESCC.

Esophageal Cancer

China
Francois Corbin

Not yet recruiting

Association Between Serum and Neuroimaging Measurements of the GABAergic System

GABAergic System
University of Sao Paulo
University of Campinas, Brazil; Faculdade de Medicina do ABC

Recruiting

Use of Botulinum Toxin A in Direct Eyebrow Lift Scar

Skin Scarring | Eyebrow Ptosis

Brazil
Aretaieion University Hospital

Recruiting

Opioid-based Versus Opioid-free Endotracheal Intubation

Anesthesia | Opioid Use | Fentanyl | Analgesic Non-narcotic | Anesthesia Intubation

Greece
Tianjin Medical University Cancer Institute and...

Not yet recruiting

Sonrotoclax, Zanubrutinib and CD20mab in Untreated MCL Patients

MCL
University Hospital, Strasbourg, France

Recruiting

Optimizing the Management of Sickle Cell Patients on Hydroxyurea: The Value of Therapeutic Pharmacological Monitoring (OPTIMDREP)

Sickle Cell Disease

France
Egymedicalpedia

Recruiting

Dexmedetomidine Versus Midazolam-Fentanyl for Analgesia and Sedation

Valvular Cardiac Surgeries

Egypt
Belfast Health and Social Care Trust

Recruiting

CMR Right Ventricular Contractile Reserve Following Lung Resection

Lung Cancer | Surgery | Anesthesia

United Kingdom
The Cooper Health System

Not yet recruiting

Localized Injection of Lidocaine and Glucocorticoid for Headache Treatment (LIGHT)

Refractory Migraine

United States
University of Florida

Not yet recruiting

Preoperative Nicotine Cessation for Women With Breast Cancer Recommended for Reconstruction

Breast Cancer
Faeth Therapeutics
GOG Foundation

Not yet recruiting

Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel, Serabelisib With Paclitaxel, and Paclitaxel Alone in Patients With Advanced/Recurrent Endometrial Cancer

Endometrial Cancer
Zhou Chengzhi
Guangdong Provincial Hospital of Traditional Chinese Medicine; Sun Yat-sen... and other collaborators

Not yet recruiting

Liposomal Irinotecan Combination Regimen for First-line Treatment of Small Cell Lung Cancer

Small Cell Lung Cancer
AbbVie

Not yet recruiting

A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis (Start Up)

Atopic Dermatitis
Guangzhou Medical University

Not yet recruiting

Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors

Leptomeningeal Metastasis

China
Central Hospital, Nancy, France

Not yet recruiting

Comparison of Changes in Tumor Burden in 68Ga-PSMA-11 PET/CT and 177Lu-PSMA SPECT/CT in Metastatic Castration-resistant Prostate Cancer (PROLUT)

Prostate Cancer Metastatic

France
National Institute of Mental Health (NIMH)

Not yet recruiting

Natural History of Depression, Bipolar Disorder and Suicide Risk

Behavioral Symptoms | Suicide | Self-Injurious Behavior | Depressive Symptoms | Major Depressive Disorder | Treatment Resistant Depression | Ketamine | Molecular Mechanisms of Pharmacological Action | Depression, Unipolar | Depression, Bipolar | Physiological Effects of Drugs | Peripheral Nervous System Agents | Central Nervous System Depressants and other conditions

United States
University of Melbourne
Monash University; University of Adelaide; University of Sydney; The University... and other collaborators

Not yet recruiting

PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol] (PLATIPUS)

Preterm Birth
First Affiliated Hospital of Zhejiang University
The Second Hospital of Hebei Medical University; Shenzhen Second People's Hospital and other collaborators

Not yet recruiting

Dobutamine for Management of Surgical Patients With Septic Shock

General Anesthesia | Surgical Patients | Patients With Septic Shock
CytomX Therapeutics
Merck Sharp & Dohme LLC

Not yet recruiting

First In Human Study of CX-801 in Advanced Solid Tumors

Solid Tumor, Adult

United States
Fudan University

Recruiting

Short-course Radiotherapy Combined With CAPOX and PD-1 Antibody Versus Long-course Chemoradiotherapy Combined With CAPOX for Early Low-lying Rectal Cancer (TORCH-E2)

Early Low Rectal Cancer

China
Assiut University

Not yet recruiting

Extra-Corporeal Shock Wave Lithotripsy for Renal and Upper Ureteral Stones in Adults Under Locally Infiltrate d Anaesthetics ; a Clinical Randomized Controlled Study

Stone Ureter
Chen Xiaoping

Recruiting

Precision Treatment of Unresectable HCC Guided by Multi-omics Deep Learning Models

HCC | Precision Therapy

China
Anhui Provincial Hospital

Recruiting

Head-to-head Comparison of [18F]F-PSMA-N5 With [68Ga]Ga-PSMA-11 PET/CT in PCa Diagnosis, Recurrence, and Metastasis

Prostate Cancer | PET/CT

China
Zai Lab (Hong Kong), Ltd.

Recruiting

A Study to Compare the Effect of Omadacycline Versus Moxifloxacin in Healthy Adult Volunteers

Healthy Volunteer

China
University Hospital, Rouen

Recruiting

EFFECT OF A SUBSTANCE P ANTAGONIST ON THE SECRETION OF ALDOSTERONE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND ARTERIAL HYPERTENSION (APHOS 3)

Apnea, Obstructive

France
Guangzhou Medical University

Not yet recruiting

Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer

Leptomeningeal Metastases
Akamis Bio

Not yet recruiting

NG-350A Plus Chemoradiotherapy for Locally Advanced Rectal Cancer (FORTRESS)

Locally Advanced Rectal Cancer (LARC)
Vertex Pharmaceuticals Incorporated

Not yet recruiting

Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Participants 12 Months of Age and Older

Cystic Fibrosis
Merck Sharp & Dohme LLC
GOG Foundation; European Network of Gynaecological Oncological Trial Groups...

Not yet recruiting

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

Cervical Cancer
Istanbul University

Not yet recruiting

Intraosseous Local Anesthesia System in Children With Molar Incisor Hypomineralization

Molar Incisor Hypomineralization | Intraosseous Anesthesia

Turkey
Assiut University

Not yet recruiting

Serum Cystatin C for Early Detection of Acute Kidney Injury After Primary Percutaneous Coronary Intervention

Acute Kidney Injury
Xuanwu Hospital, Beijing
Merck Serono Co., Ltd., China; Institute of Zoology, Chinese Academy of Sciences and other collaborators

Not yet recruiting

Pilot Study on Evaluating the Geroprotective Effect of Metformin (AGE-M)

Aging | Metformin

China
ProDa BioTech, LLC
Emory University; Georgia State University

Not yet recruiting

ProAgio in Combination With Gemcitabine in Patients With Metastatic Triple Negative Breast Cancer

Triple Negative Breast Cancer

United States

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