Search clinical trials for: Off label-use

Total 13158 results

Biohaven Therapeutics Ltd.

Recruiting

A Phase 1/2 Study of PBI-410 in Advanced Solid Tumors

Solid Tumor

United States
VA Office of Research and Development

Not yet recruiting

Personalized Approach Bias Modification in Heavy Drinking Veterans With Mild to Moderate Traumatic Brain Injury (TABM)

Alcohol Use Disorder | Mild-Moderate Traumatic Brain Injury

United States
Mayo Clinic
National Cancer Institute (NCI)

Not yet recruiting

Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advance or Metastatic Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma | Locally Advanced Pancreatic Adenocarcinoma | Unresectable Pancreatic Adenocarcinoma

United States
University of Roma La Sapienza

Recruiting

Relationship Between Acute Phase Markers and Post-operative Pain in Open Tension-free Inguinal Hernia Repair: An Observational Study

Inguinal Hernia | Post Operative Pain

Italy
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Pain and Muscle Biopsy (BIODOMU)

Neuromuscular Diseases
Mayo Clinic

Recruiting

Stereotactic Body Radiation Therapy Plus Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy for Treatment of Metastatic, Recurrent Hormone-Sensitive Prostate Cancer, DIVINE Trial (DIVINE)

Recurrent Prostate Cancer | Castration-resistant Prostate Cancer | Stage IVB Prostate Cancer AJCC v8 | Recurrent Castration-Sensitive Prostate Carcinoma

United States
Shanghai JMT-Bio Inc.

Not yet recruiting

JMT101 in Combination With Osimertinib, Versus Cisplatin-pemetrexed in Participants With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Characterized by Epithermal Growth Factor Receptor (EGFR) Exon 20ins Mutations

Local Advanced or Metastatic NSCLC
Mayo Clinic

Recruiting

Remote Cognitive Assessment Battery and Wearable Device Monitoring Platform While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy

Malignant Brain Neoplasm

United States
VA Office of Research and Development

Not yet recruiting

Smartphone App Enhanced Facilitation Among Veterans in a Mental Health Inpatient Setting (Project HOPE) (Project HOPE)

Suicidal Ideation | Suicide Attempt | Suicide Prevention

United States
Yale University
Office on Violence Against Women (OVW)

Not yet recruiting

Single Session Intervention to Promote Hope

Domestic Violence

United States
National Cancer Institute (NCI)

Recruiting

Natural History Study of Kaposi Sarcoma

HIV | Kaposi Sarcoma

United States
University of Connecticut
University of Malaya

Not yet recruiting

Integrated Online-to-offline (O2O) Model of Care for HIV Prevention and Treatment Among Transgender Women (CINTAI)

HIV Prevention Program

Malaysia
Nanfang Hospital, Southern Medical University

Recruiting

Prospective Cohort Study of Complications and Outcomes in Cirrhosis

Decompensated Cirrhosis | Overt Hepatic Encephalopathy | CMV Reactivation

China
University of Connecticut
University of Malaya

Not yet recruiting

Integrated Online-to-offline (O2O) Model of Care for HIV Prevention and Treatment Among Men Who Have Sex With Men (CINTAI)

HIV Prevention Program

Malaysia
Temple University

Not yet recruiting

Peer Facilitated Waitlist Controlled Transportation Study

Serious Mental Illness
Mayo Clinic

Recruiting

Risk Stratified De-escalated Hormone Therapy With Radiation Therapy for the Treatment Prostate Cancer

Prostate Adenocarcinoma | Oligometastatic Prostate Carcinoma

United States
Bielefeld University
Technical University of Munich; Muhimbili University of Health and Allied Sciences and other collaborators

Recruiting

Preventing Physical and Emotional Violence by Parents and Teachers in Public Schools in Tanzania (ICC-T/ICC-P_Tanz) (PreVio)

Violence

Tanzania
CT Glaucoma Associates

Recruiting

How Much Does Reduced Dosing of Latanoprost and Dorzolamide-timolol Affect Pressure?

Glaucoma, Open-Angle | Glaucoma; Drugs

United States
AstraZeneca

Recruiting

Change in Patient-repOrted Outcomes in COPD Patients Newly Initiated on TRIXEO AEROSPHERE in Real worlD (COnCORD)

Chronic Obstructive Pulmonary Disease (COPD)

Romania
University of California, San Francisco

Not yet recruiting

Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis

Adolescent Idiopathic Scoliosis (AIS)

United States
Ibrahim Halil Sahin
GlaxoSmithKline

Not yet recruiting

Niraparib and Dostarlimab for Patients With MMR-D/MSI-H Colorectal Cancers

MMR-D/MSI-H Colorectal Cancers

United States
University Hospital, Basel, Switzerland
St. Clara Hospital, Basel, Switzerland; Klinikum Kempten, Kempten, Germany

Not yet recruiting

oPen Versus RobotIc retrOmuscular Repair in Medium to Large Ventral Hernias (PRIOR)

Ventral Hernia | Abdominal Wall Defect | Incisional Hernia
Mayo Clinic

Recruiting

Non-Invasive Identification of Endometrial Cancer/Endometrial Atypical Hyperplasia With an AI-Based Classifier Applied to Transvaginal Ultrasound in Patients With Post-Menopausal Bleeding

Endometrial Carcinoma

United States
National Cancer Institute (NCI)

Not yet recruiting

Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Chronic Lymphocytic Leukemia (CLL)

Leukemia, Lymphocytic, Chronic, B-Cell | B-Cell Chronic Lymphocytic Leukemia | B-Lymphocytic Leukemia, Chronic

United States
Medical College of Wisconsin

Not yet recruiting

Molecular Analyses to Identify Pathways of Endocrine Resistance Following Short Term Neoadjuvant Endocrine Treatment in Patients With Hormone Receptor-Positive HER2-negative Breast Cancer

Breast Cancer

United States
University of Sao Paulo General Hospital
Samsung Eletrônica da Amazônia Ltda; Academic Research Organization of Instituto...

Recruiting

Assessment of Smartwatch SAMSUNG to Monitor Sleep Quality: an Observational Prospective Study - SleepEx2 Protocol (SLEEP-EX2)

Insomnia | Sleep Initiation and Maintenance Disorders | Sleep | Health Status | Wearable Electronic Devices

Brazil
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Fertility Preservation and Pregnancy and Offspring Health Outcomes in Female Cancer

Cancer | Fertility Issues

China
University of British Columbia
Canadian Institutes of Health Research (CIHR); Fraser Health; Providence Health... and other collaborators

Not yet recruiting

Re-Purposing the Ordering of Routine Laboratory Tests in Hospitals in British Columbia (RePORT-BC)

Hospital Acquired Condition
Mayo Clinic

Recruiting

Oropharynx (OPX) Biomarker Trial

Oropharyngeal Squamous Cell Carcinoma | Recurrent Oropharyngeal Squamous Cell Carcinoma | Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Stage III Oropharyngeal (p16-Negative)... and other conditions

United States
Amref Health Africa

Recruiting

Impact of the Financial Inclusion Improves Sanitation and Health (FINISH)

Health Knowledge, Attitudes, Practice

Kenya
Damascus University

Recruiting

Re-infusion of Unwashed Shed Blood During Off-pump Surgery

Coronary Artery Disease | Cardiovascular Complication | Blood Transfusion Complication

Syrian Arab Republic
VistaGen Therapeutics, Inc.

Recruiting

Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder (PALISADE-3) (PALISADE-3)

Social Anxiety Disorder

United States
VA Office of Research and Development

Not yet recruiting

Overcontrol and Suicide in PTSD (OSP)

Compulsive Personality Disorder | Stress Disorders, Post-Traumatic

United States
Eli Lilly and Company

Recruiting

Effect of Retatrutide Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1)

Diabetes Type 2

United States, India, Mexico, Puerto Rico
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Efficacy of Intraoperative Use of 20% Albumin Combined With Ringer Lactate Versus Ringer Lactate During Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy (ALBUCHIP)

Postoperative Complications | Peritoneal Neoplasms | Fluid Therapy | Hyperthermic Intraperitoneal Chemotherapy | Intraoperative Care
Mayo Clinic
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Recruiting

Biomarkers to Predict Cancer Therapy-related Cardiotoxicity

Malignant Solid Neoplasm | Hematopoietic and Lymphatic System Neoplasm

United States
Alvernia University

Recruiting

The Effects of Open Chain Versus Closed Chain Strengthening on Dynamic Valgus During a Step Down Test

Dynamic Knee Valgus

United States
Mayo Clinic

Recruiting

Quality of Life After Treatment for Bladder Cancer: The Bladder Cancer Survivorship Study

Stage 0a Bladder Cancer AJCC v8 | Stage 0is Bladder Cancer AJCC v8 | Stage I Bladder Cancer AJCC v8 | Stage IIIA Bladder Cancer AJCC v8 | Stage II Bladder Cancer AJCC v8

United States
Mayo Clinic

Recruiting

Predicting Response to Immune Checkpoint Inhibitors Across Solid Tumors Using a Live Tumor Diagnostic Platform (CYBRID-04)

Metastatic Lung Non-Small Cell Carcinoma | Metastatic Clear Cell Renal Cell Carcinoma | Resectable Lung Non-Small Cell Carcinoma | Metastatic Malignant Solid Neoplasm | Metastatic Bladder Urothelial Carcinoma | Metastatic Colorectal Carcinoma | Metastatic Triple-Negative Breast Carcinoma | Locally... and other conditions

United States
Aya Ayman Ahmed

Not yet recruiting

Assessment of Serum Concentration of Interleukin-17 and Osteoprotegerin in Response to Surgical Trauma Induced by Management of Mandibular Fractures Via Intraoral Versus Extraoral Approaches: Prospective Cohort Study

Mandibular Fractures
Northwestern University
Ohio State University

Recruiting

Ureteroscopy With High-powered Holmium:Yag Laser Lithotripsy With and Moses On or Moses Off

Kidney Stone | Ureteral Stone

United States
Thammasat University

Not yet recruiting

Bronchodilator Effect of Oral Doxofylline and Procaterol in Chronic Obstructive Pulmonary Disease

COPD
China National Center for Cardiovascular Diseases

Recruiting

Cerebral Microembolization Associated With PFO Closure

Thrombosis Cardiac

China
National Cancer Institute (NCI)

Not yet recruiting

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Glioma | Astrocytoma | Recurrent Glioblastoma

United States
Casa Sollievo della Sofferenza IRCCS
Ministry of Health, Italy

Recruiting

Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis (STEMALS) (STEMALS)

Amyotrophic Lateral Sclerosis

Italy
ICE Intelligent Healthcare Co., Ltd

Not yet recruiting

Cardiac Interventional ICE Imaging Trial (INTELICE)

Atrial Fibrillation | Arrhythmias, Cardiac | Atrial Septal Defect | Patent Foramen Ovale | Valve Disease, Heart | Supraventricular Tachycardia | Structural Heart Diseases

China
Shanghai Ninth People's Hospital Affiliated to...

Not yet recruiting

Accuracy of Two Methods of Making Impressions for Complete-arch Implant Supported Fixed Prosthesis

Edentulous Jaw
Mayo Clinic

Recruiting

Identification of Novel High Quality Methylated DNA Markers in Renal Tumors: Whole Methylome Discovery, Tissue Validation, and Feasibility Testing In Blood and Urine, The INQUIRE Study

Clear Cell Renal Cell Carcinoma | Urothelial Carcinoma | Chromophobe Renal Cell Carcinoma | Papillary Renal Cell Carcinoma | Kidney Oncocytoma | Clear Cell Papillary Renal Tumor

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study

Lymphohistiocytosis, Hemophagocytic | Macrophage Activation Syndrome | Secondary Hemophagocytic Lymphohistiocytosis | Hyperinflammatory Syndromes

United States
Guangdong Ruishun Biotech Co., Ltd
Changhai Hospital; Peking University People's Hospital; RenJi Hospital; The Affiliated...

Not yet recruiting

A Study of RJMty19 in Refractory Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus

China

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