Search clinical trials for: PDE

Total 190 results

Tetra Discovery Partners

Completed

Study to Evaluate the Effects of BPN14770 on Scopolamine-induced Cognitive Impairment in Healthy Volunteers

Alzheimer Disease

United States
University of Florence

Completed

Vardenafil and Cognitive-behavioral Sex Therapy for the Treatment of Erectile Dysfunction (STEDOV) (STEDOV)

Erectile Dysfunction

Italy
The University of Texas Medical Branch, Galveston

Completed

The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue

Fatigue

United States
National Institute of Mental Health (NIMH)

Completed

Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients

Healthy | Major Depressive Disorder

United States
Dr. Robert Klempfner Heart Rehabilitation Institute

Completed

PDEI Following Mitral Valve Surgery in Patients With Pulmonary Hypertension

Pulmonary Hypertension | Mitral Valve Surgery

Israel
Eli Lilly and Company

Completed

A Study to Determine if There is a Possible Association Between NAION and Phosphodiesterase Type 5 (PDE5) Inhibitors

Nonarteritic Anterior Ischemic Optic Neuropathy

United States
IRCCS Policlinico S. Matteo

Completed

Pomalidomide and Dexamethasone (PDex) in AL Amyloidosis

Primary Amyloidosis of Light Chain Type

Italy
Hasselt University
Jessa Hospital

Completed

Study Assessing the Effectiveness of a Cardiac Web-based eLearning Platform (eEduHeart I)

Coronary Artery Disease

Belgium
Pfizer

Completed

Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Study Of PF-04447943, Co-Administered With And Without Hydroxyurea, In Subjects With Stable Sickle Cell Disease

Phase 1 Sickle Cell

United States, United Kingdom, Belgium, Netherlands, Italy
Tritech Biopharmaceuticals Co., Ltd.
A2 Healthcare Taiwan Corporation

Unknown

A Study to Assess the Safety and Tolerability Profile of TR399 in Healthy Volunteers and Erectile Dysfunction Patients

Erectile Dysfunction

Taiwan
Amsterdam UMC, location VUmc

Unknown

Goal Oriented Strategy to Preserve Ejection Fraction Trial (GOSPEL)

Pulmonary Arterial Hypertension

Netherlands
United Therapeutics

Completed

FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH)

Pulmonary Hypertension

United States, United Kingdom, Canada, Spain, Australia, Israel, Germany, Belgium, France, Austria, Italy, Poland, Ireland, Netherlands
Beth Israel Deaconess Medical Center

Completed

Coenzyme Q10 in Post-Cardiac Arrest Cerebral Resuscitation

Cardiac Arrest | Sudden Cardiac Arrest

United States
Mansoura University

Unknown

Phosphodiesterase 5 Inhibitors (PDE5i) (Sildenafil) as Medical Expulsive Therapy in Distal Ureteral Stones

Urolithiasis | Ureteral Stone
GlaxoSmithKline

Completed

Healthy Volunteer Positron Emission Tomography (PET) Brain Occupancy Study of a Phosphodiesterase 4 (PDE4) Inhibitor in Huntington's Disease

Huntington Disease

United Kingdom
GlaxoSmithKline

Completed

A Repeat Dose Study in Healthy Volunteers Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK356278

Huntington Disease

Netherlands
Vanderbilt University Medical Center

Completed

Effect of Prolonged PDE-5 Inhibition on Insulin Signaling in Skeletal Muscle.

Metabolic Syndrome

United States
Vanderbilt University

Terminated

Renin-Angiotensin and Fibrinolysis in Humans: Effect of Long-Term PDE5 Inhibition on Glucose Homeostasis

Impaired Glucose Tolerance

United States
Chiesi Farmaceutici S.p.A.

Completed

A Study to Evaluate the Efficacy After Allergen Challenge, Safety and Tolerability of Inhaled CHF6001 DPI in Asthmatics (CHF6001_POC2)

Asthma

United Kingdom
ProDigest
University Ghent; Maastricht University; Embria Health Sciences; Drug Research...

Completed

Clinical Evaluation of the Effects of EpiCor on Digestive Comfort

Constipation | Gastrointestinal Discomfort
Barretos Cancer Hospital

Unknown

Fluorescence Surgery for Sentinel Node Identification in Melanoma

Melanoma | Lymph Node Metastasis

Brazil
Vanderbilt University

Completed

Treatment of Orthostatic Hypotension in Autonomic Failure

Orthostatic Hypotension | Autonomic Failure

United States
Tetra Discovery Partners

Completed

A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects

Alzheimer's Disease

United States
Palobiofarma SL
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Terminated

Study to Assess the Safety, Tolerability and Pharmacokinetic Profile of PBF-999 "After Multiple Oral Doses" in Healthy Volunteers

Huntington Disease

Spain
Eco Fusion

Unknown

Stress Management Using an App to Improve Response With PDE5 Inhibitors in Men With Erectile Dysfunction.

Erectile Dysfunction

United States
Pfizer

Completed

A Study To Evaluate the Safety, Tolerability, And Pharmacokinetics Of PF-06266047 In Healthy Adult Subjects

Healthy Volunteers

Belgium
CHDI Foundation, Inc.

Completed

[PETDE10] Imaging of PDE10A Enzyme Levels in Huntington's Disease Gene Expansion Carriers and Healthy Controls With PET. (PEARL-HD)

Huntington's Disease

Sweden, Denmark, Netherlands, Norway
Fundació Institut de Recerca de l'Hospital de la...
Palo Biofarma, S.L

Completed

Study To Assess the Safety and Tolerability of Single Ascending Oral Doses of PBF-999 in Healthy Young Male Volunteers

Huntington's Disease

Spain
United Therapeutics

Completed

Study of Incidence of Respiratory Tract AEs in Patients Treated With Tyvaso® Compared to Other FDA Approved PAH Therapies (Aspire)

Pulmonary Arterial Hypertension

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell Disease

Sickle Cell Disease | Pulmonary Hypertension

United States, United Kingdom
Actelion

Completed

Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH) (Compass-2)

Pulmonary Arterial Hypertension

United States, Denmark, Sweden, Germany, Spain, Brazil, Saudi Arabia, Portugal, Greece, Slovakia, United Kingdom, Czech Republic
University of Copenhagen
Glostrup University Hospital, Copenhagen

Terminated

Phosphodiesterase (PDE) Inhibitors Effect on Cognitive Deficits Associated to Schizophrenia

Schizophrenia | Cognitive Deficits

Denmark
Mansoura University

Unknown

Role of Low-intensity Shock Wave Therapy in Penile Rehabilitation Post Nerve Sparing Radical Cysto-prostatectomy

Bladder Cancer

Egypt
Bayer
GlaxoSmithKline

Completed

FDA Phase IV - Commitment - Retinal Function Study

Safety
Herlev Hospital

Withdrawn

Effect of Tadalafil in Chronic Obstructive Lung Disease Patients Suffering From Secondary Pulmonary Hypertension

Chronic Obstructive Lung Disease

Denmark
VIVUS LLC

Completed

Safety Study Looking at the Effects of Stendra on Vision

Vision

United States
Bayer

Completed

A Randomised Study of Levitra to Treat Men With Erections Problems and Previously Untreated With Similar Therapy. (FINDER)

Erectile Dysfunction

Belgium, Finland, Germany, France, Denmark, United Kingdom, Spain
Bayer

Completed

BAY38-9456 - Supportive Trial for Spinal Injury

Sexual Dysfunction | Erectile Dysfunction | Spinal Cord Injury

Japan
Bayer

Completed

BAY38-9456 - Pivotal Trial for Diabetes Patient

Diabetes Mellitus | Erectile Dysfunction
Universitair Ziekenhuis Brussel
University of Adelaide; Cook Group Incorporated

Terminated

Influence of a Prematuration Culture With a Phosphodiesterase-3 Inhibitor (PDE3-I) on Embryonic Aneuploidy Rate and Developmental Potential

Infertility

Belgium
Universitair Ziekenhuis Brussel

Terminated

Influence of a Prematuration Culture With a Phosphodiesterase-3 Inhibitor (PDE3-I) on Embryonic Aneuploidy Rate and Developmental Potential

Infertility

Belgium
Pfizer

Completed

A Study To Evaluate The PDE10 Enzyme Occupancy Following A Single Dose Of PF-02545920 In Healthy Male Volunteers (PET)

Healthy

Sweden
Bayer

Completed

Clinical Proof-of-concept Study for the Combination BAY60-4552 / Vardenafil for the Treatment of Erectile Dysfunction Not Sufficiently Responsive to Standard Therapy With PDE5 Inhibitors

Erectile Dysfunction

Spain, Italy, Netherlands, Finland, Germany, France, Sweden
VIVUS LLC

Completed

Research Evaluating a PDE5 Inhibitor for Erectile Dysfunction

Erectile Dysfunction

United States
University Medical Centre Ljubljana

Completed

PDE-4 Inhibitor Roflumilast and GLP-1 Agonist Liraglutide in Polycystic Ovary Syndrome

Obesity | PCOS

Slovenia
Pfizer

Withdrawn

A Study Of The Safety, Tolerability, And Pharmacokinetics Of Multiple Doses Of PF-05180999 In Healthy Adults

Migraine
Pfizer

Terminated

A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of PF-05180999 In Healthy Adults

Migraine

United States
Samsung Medical Center

Unknown

Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image (UMPIRE)

Microvascular Angina

Korea, Republic of
Gilead Sciences

Terminated

Study of Cicletanine for Pulmonary Arterial Hypertension (PAH)

Pulmonary Arterial Hypertension

United States, Israel, Australia, Canada, Mexico, Spain, Belgium, Austria, Germany, United Kingdom
Cedars-Sinai Medical Center

Completed

PDE Inhibitors in DMD Study (Acute Dosing Study)

Duchenne Muscular Dystrophy

United States

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