Search clinical trials for: genes

Total 3153 results

Zhongmou Therapeutics

Recruiting

Safety and Efficacy Study of Novel Gene Therapy ZM-01 for X-linked Retinoschisis Patients

X-linked Retinoschisis

China
AviadoBio Ltd

Recruiting

A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) (ASPIRE-FTD)

Frontotemporal Dementia | FTD | FTD-GRN | Dementia, Frontotemporal

Netherlands, Spain, Poland, United States
Xijing Hospital of Digestive Diseases
Ankang Central Hospital; Xi'an International Medical Center Hospital; The First... and other collaborators

Recruiting

High-concentration Small-volume Versus Low-concentration Large-volume Iodine Solution for Esophageal Chromoendoscopy

Esophageal Squamous Cell Carcinoma

China
National Cancer Institute (NCI)

Recruiting

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Hormone Receptor-Positive Breast Carcinoma | HER2-Negative Breast Carcinoma

United States
A2 Biotherapeutics Inc.
Tempus AI

Recruiting

A Study to Evaluate the Safety and Efficacy of A2B694, a Logic-gated CAR T, in Subjects With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression (EVEREST-2)

Cancer | Colorectal Cancer | Ovarian Neoplasms | Ovarian Cancer | NSCLC | Lung Cancer | Rectal Cancer | Non Small Cell Lung Cancer | Mesothelioma | Mesothelioma, Malignant | Colon Cancer | Pancreas Cancer | Colorectal Adenocarcinoma | Solid Tumor, Adult | CRC | Pancreatic Neoplasm | Ovary Cancer | NSCLC, Recurrent | Non-Small Cell... and other conditions

United States
Pfizer

Recruiting

A Study to Learn How the Body Processes the Study Medicine Called PF-07923568 in People With Loss of Kidney Function

Renal Impairment

United States
Centre Hospitalier Sud Francilien

Not yet recruiting

Metagenomic Analysis of Bacterial Microbiota in Breast Milk (MIC-LAMA2)

Bacteria in Breast Milk

France
University Hospital, Clermont-Ferrand

Recruiting

Discordance in the Evaluation of Suicidal Intent Between Parents and Adolescents in Adolescence and Evolution of the Suicidal Crisis : a Mixed Study (discord-Ados)

Suicide, Attempted | Parent-Child Relations | Suicidal Intention

France
HuidaGene Therapeutics Co., Ltd.
Eye & ENT Hospital of Fudan University; Tianjin Medical University Eye Hospital

Recruiting

CRISPR/cas13-medIated RNA tarGeting tHerapy for the Treatment of Neovascular Age-related Macular Degeneration Investigator-initiated Trial (SIGHT-I)

Neovascular Age-related Macular Degeneration(nAMD)

China
Changchun GeneScience Pharmaceutical Co., Ltd.

Not yet recruiting

A Study to Investigate the Safety and Efficacy of Once-weekly PEG-somatropin (GenSci004) in Children With Growth Hormone Deficiency (ESCALATE)

GHD
Tianjin Medical University Second Hospital

Recruiting

Pemigatinib for FGF/FGFR Alterations Advanced Pan Solid Tumors

Solid Tumor | FGF Receptor Gene Mutation | FGF Amplification | FGF Receptor Gene Family Rearrangement | FGF Receptor Gene Translocation

China
OncoNano Medicine, Inc.

Recruiting

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas. (ON-5001)

Lymphoma, Non-Hodgkin | Follicular Lymphoma | Carcinoma in Situ | Mantle Cell Lymphoma | Metastatic Cancer | Bladder Cancer | Skin Cancer | Triple Negative Breast Cancer | Cervix Cancer | Diffuse Large B Cell Lymphoma | Head and Neck Squamous Cell Carcinoma | Tumor, Solid | Tumor Recurrence | Uveal Melanoma, Recurrent

United States
Regeneron Pharmaceuticals

Recruiting

A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations (ENSEMBLE)

Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF) | Biallelic Mutations in the Gap Junction Beta 2 (GJB2) Gene | Digenic Mutations in GJB2/Gap Junction Beta 6 (GJB6) Genes

United States
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Mutational Oncology in Clinical Practice (FPG-500)

Genetic Predisposition to Disease | Gene Rearrangement | Genome Instability

Italy
Chinese PLA General Hospital
Peking University; EdiGene Inc.

Recruiting

TRAC and Power3 Genes Knock-out Allogeneic CD19-targeting CAR-T Cell Therapy in r/r B-NHL

Non Hodgkin's Lymphoma

China
Vanderbilt University
National Institute on Aging (NIA); Ohio State University

Recruiting

Telehealth-enhanced Patient-oriented Recovery Trajectory After Intensive Care (TelePORT)

Post-intensive Care Syndrome

United States
University of British Columbia
Providence Health & Services; Canadian Anesthesiologists' Society

Recruiting

Paravertebral Block for Improvement of Quality of Recovery Following Cardiac Surgery

Cardiac Disease | Post-operative Pain | Post-cardiac Surgery

Canada
Changchun GeneScience Pharmaceutical Co., Ltd.

Not yet recruiting

A Study to Investigate Efficacy and Safety of Weekly PEG-somatropin (GenSci004) in Treatment Naive Children With Growth Hormone Deficiency (ELEVATE)

GHD

United States
Solarea Bio, Inc

Recruiting

SBD121, a Synbiotic Medical Food for RA Management

Rheumatoid Arthritis

Australia, New Zealand
RenJi Hospital

Not yet recruiting

Multi-Dimensional MRI Spatial Heterogeneity Analysis for Predicting Key Genes and Prognosis of High-Grade Gliomas: A Multi-Center Study

High-grade Glioma

China
Muğla Sıtkı Koçman University

Not yet recruiting

Comparison of the Quality of Recovery After Cesarean Section Surgery

Abdominal Pain | Cesarean Section | Postoperative Recovery

Turkey
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors

Hodgkin Lymphoma | Non-Hodgkin Lymphoma

United States
Shenzhen Geno-Immune Medical Institute
The Second Affiliated Hospital of Hainan Medical University; Beijing Jingdu...

Recruiting

4SCAR19U T Cells Targeting B Cell Malignancies

B Cell Malignancies

China
Institute of Hematology & Blood Diseases Hospital

Recruiting

Growth and Development-related Outcomes in Children With Transfusion-dependent Beta-thalassemia After Gene Therapy

Gene Therapy | Transfusion-dependent Beta-Thalassemia

China
National Cancer Institute (NCI)

Recruiting

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder for Bladder Cancer Treatment, MODERN Study

Stage III Bladder Urothelial Carcinoma AJCC v6 and v7 | Stage IV Bladder Urothelial Carcinoma AJCC v7 | Stage II Bladder Urothelial Carcinoma AJCC v6 and v7 | Muscle Invasive Bladder Urothelial Carcinoma

United States
GeneScience Pharmaceuticals Co., Ltd.

Recruiting

Safety & Efficacy of Genakumab in Patients With Frequent Flares

Acute Gout

China
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

Mantle Cell Lymphoma

United States
Beijing Northland Biotech. Co., Ltd.

Recruiting

Angiogenesis and Blood Perfusion Effect of HGF Gene Therapy in PAD Patients

Peripheral Artery Disease

China
Taiho Oncology, Inc.

Recruiting

A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation. (REZILIENT2)

Advanced or Metastatic NSCLC Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations

United States, Japan, Spain, France, Australia, Italy, Korea, Republic of, United Kingdom, Canada, Germany, Turkey, Hong Kong
Fundacion de la Sociedad Chilena de Cardiologia...
Pontificia Universidad Catolica de Chile; Hospital Dipreca

Recruiting

Gender Specific Registry in Subjects Hospitalized With Heart Failure in Santiago (GENESIS)

Heart Failure

Chile
Wei XIA, PhD

Not yet recruiting

Construction of Early Warning Model for the New Psychoactive Substances Using in Adolescents

Drug Addiction

China
David Pérez Torres
Instituto de Investigación Biomédica de Salamanca; Hospital del Río Hortega; Sanidad... and other collaborators

Recruiting

Immune Dysfunction in Critical Illness: Utility of a Panel of Genes and Molecules Involved in the Immunological Synapse (EFIMERO)

Critical Illness

Spain
BeiGene

Recruiting

Study to Evaluate the Efficacy and Safety of BGB-11417 in Participants With Waldenström's Macroglobulinemia

Waldenstrom Macroglobulinemia | Waldenstrom's Macroglobulinemia Recurrent | Waldenstrom's Macroglobulinemia Refractory

United States, Australia, France, China, Spain, United Kingdom
Universita degli Studi di Genova

Not yet recruiting

Toothbrush in the Genesis and Prevention of Dental Recessions (Recession)

Recession, Gingival

Italy
University of Colorado, Denver
University of Virginia

Recruiting

Genetic Regulators of Bone Health That Are Unique to Vertebral Bone

Age-Related Osteoporosis

United States
Incannex Healthcare Ltd

Recruiting

Safety and Effect on Pain and Function According to RAPID-3 of IHL-675A in Patients With Rheumatoid Arthritis (CHAPPII)

Rheumatoid Arthritis

Australia
Central Hospital, Nancy, France

Not yet recruiting

Sequencing of 14 Genes From Leptin Melanocortin Pathway in Severe Obesity in Childhood. (OBEGEN)

Obesity, Child
Yangzhou University

Not yet recruiting

Application of Transcutaneous Electrical Acupoint Stimulation in Laparoscopic Cholecystectomy

Postoperative Recovery | Pain Postoperative
GeneScience Pharmaceuticals Co., Ltd.
Huashan Hospital

Recruiting

Safety and Efficacy of Genakumab for Injection in Patients With Gout Flare (Gensci 048-203)

Gout Flare | Acute Gout

China
Ruijin Hospital
RenJi Hospital; West China Hospital; Shandong Provincial Hospital; Tianjin Medical... and other collaborators

Recruiting

Different Molecular Subtypes of Peripheral T-cell Lymphoma, a Real-world Registry Study. (TRUST)

Peripheral T Cell Lymphoma

China
GeneScience Pharmaceuticals Co., Ltd.
Huashan Hospital

Not yet recruiting

Safety and Efficacy of Genakumab for Injection in Patients With Gout Initiating Urico-lowering Therapy (Gensci 048-202)

Acute Gout | Gout Initiating Urico-lowering Therapy

China
St. Jude Children's Research Hospital

Not yet recruiting

Liver Biopsy Following Gene Therapy For Hemophilia

Hemophilia A | Hemophilia B

United States
Eli Lilly and Company

Recruiting

A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight (TRIUMPH-2)

Obesity | Overweight | Obstructive Sleep Apnea | Type 2 Diabetes

Australia, United States, Mexico, Spain, India, Brazil, Romania, Taiwan, Argentina
SWOG Cancer Research Network
National Cancer Institute (NCI)

Recruiting

Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC v8 | Early Stage Triple-Negative Breast Carcinoma

United States, Puerto Rico
ZIWIG
Monitoring Force Group

Recruiting

ALS Diagnosis From a Saliva Sample: a Non-coding RNA Analysis Approach (RNALS)

Amyotrophic Lateral Sclerosis | Amyotrophic Lateral Sclerosis, Sporadic

France
GeneScience Pharmaceuticals Co., Ltd.

Not yet recruiting

To Evaluate the Efficacy and Safety of Genalumab for Injection in the Treatment of Active Systemic Juvenile Idiopathic Arthritis.

Active Systemic Juvenile Idiopathic Arthritis

China
Affiliated Hospital of Guangdong Medical University

Recruiting

Safety and Efficacy Study of KL-7SHRNA Injection Solution in the Treatment of AIDS Patients With Lymphoma

HIV Infections | Lymphoma

China
Amgen

Recruiting

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Non-Small Cell Lung Cancer (NSCLC)

United States, Australia, Netherlands, Taiwan, Korea, Republic of, United Kingdom, Spain, Austria, Japan, Switzerland, Sweden, France, Czechia, Italy, Portugal, Hong Kong, Thailand, Singapore, Bulgaria, Turkey, Argentina, Belgium, G... and more
Hummingbird Bioscience

Recruiting

Study of an Anti-HER3 Antibody, HMBD-001, With or Without Chemotherapy in Patients With Solid Tumors Harboring an NRG1 Fusion or HER3 Mutation

Pancreatic Cancer | Non-Small Cell Lung Cancer | Metastatic Solid Tumor | Locally Advanced Solid Tumor

Australia
GeneScience Pharmaceuticals Co., Ltd.

Recruiting

Gentuximab Combined With Paclitaxel Compared With Placebo Combined With Paclitaxel for Gastric Adenocarcinoma.

Adenocarcinoma of Stomach

China

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