Construction of Early Warning Model for the New Psychoactive Substances Using in Adolescents

Early Warning Model Construction on Cognition, Resistance and Using Risk of the New Psychoactive Substances in Adolescents Based on Behavioral Expression of Addiction Susceptibility Genes and Adverse Childhood Experience

Based on the biological-psychology-sociological medicine pattern, this study aims to construction an early warning model of the New Psychoactive Substances (NPS) using for adolescents aged 14-35 years old. This study intends to obtain the data related to the behavioral expression of addiction susceptibility genes, adverse childhood experience, cognition, resistance and the use of NPS in adolescents by questionnaire survey (sample size: 200), and then use logistic regression and machine learning to construct an early warning model.

Study Overview

• Status: Not yet recruiting
• Conditions: Drug Addiction
• Intervention / Treatment: Other: Questionnaires

Detailed Description

Based on the biological-psychology-sociological medicine pattern, this study aims to construction an early warning model on the use of the New Psychoactive Substances using for adolescents aged 14-35 years old. This study intends to conduct a questionnaire survey (sample size 200) to obtain data related to the behavioral expression of addiction susceptibility genes, childhood adversity experience, cognition, resistance and the use of NPS in adolescents from different regions and different populations. Through data analysis, this study aims to get the weight of different risk factors on NPS use, and then use logistic regression and machine learning to construct an early warning model, so as to screen out high-risk groups. At the same time, the expert group was consulted to establish a risk early warning system to provide a basis for intervention.

• Study Type: Observational
• Enrollment (Estimated): 200

Contacts and Locations

• Study Contact: Name: wei Xia, PhD; Phone Number: 18823359471; Email: xiaw23@mail.sysu.edu.cn

Study Locations

• China
  • Guangdong
    • Guangzhou, Guangdong, China, 510080
      • Sun Yat-sen University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

General adolescents between 14-35 years old

Description

Inclusion Criteria:

• Adolescents aged 14-35 (including 14,35 years old)
• Agree to participate in the studies

Exclusion Criteria:

• Be diagnosed with psychological or mental illness
• People that are unconscious, emotionally unstable, or unable to communicate normally
• Patients with severe diseases

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Investigation Team; Questionnaires assessed adolescents aged 14-35 years old (including 14,25 years old) who agreed to participate in the study	Other: Questionnaires; Participants will be asked to complete the questionnaire including general demographic information, the cognition, resistance and use of NPS as well as the behavioral expression of addiction susceptibility genes and adverse childhood experience.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
the cognition of NPS	knowledge questionnaire of drug types and risk awareness of drug use will be investigated to know the degree of cognition to NPS	Baseline
the resistance of NPS	the drug refusal self-efficacy scale and the drug use permissive attitude will be used to measure the the resistance of NPS	Baseline
the use of NPS	there will be some questions to investigate the drug use conditions	Baseline
Adverse Childhood Experience	the Chinese version of Adverse Childhood Experience Scale with 10 items will be used to measure the adverse childhood experience	Baseline
hedonic hunger	the Power of Food Scale with 15 items will be used to measure hedonic hunger	Baseline
sensation seeking personality	the Brief Sensation Seeking Scale for Chinese with 8 items will be used to measure sensation seeking personality	Baseline
prosocial behavior	the Prosocial Tendencies Measure with 26 items will be used to measure prosocial behavior	Baseline
externalizing behavior	17 items of aggressive behavior and 15 items of rule-breaking behavior from the Chinese Version of Achenbach Youth Self-Report-2001 Version will be used to measure adolescents' degree of externalizing behavior	Baseline
sleep quality	the Pittsburgh Sleep Quality Index with 9 items will be used to measure adolescents' sleep quality	Baseline

Collaborators and Investigators

• Sponsor: Wei XIA, PhD
• Investigators: Principal Investigator: Wei Xia, PhD, Sun Yat-sen University

Study record dates

Study Major Dates

• Study Start (Estimated): July 17, 2023
• Primary Completion (Estimated): October 31, 2023
• Study Completion (Estimated): November 30, 2023

Study Registration Dates

• First Submitted: July 16, 2023
• First Submitted That Met QC Criteria: July 21, 2023
• First Posted (Estimated): July 24, 2023

Study Record Updates

• Last Update Posted (Estimated): July 24, 2023
• Last Update Submitted That Met QC Criteria: July 21, 2023
• Last Verified: July 1, 2023

More Information

Terms related to this study

• Keywords: adolescents; NPS; risk prediction model; addiction susceptibility genes; adverse childhood experience
• Additional Relevant MeSH Terms: Mental Disorders; Chemically-Induced Disorders; Compulsive Behavior; Impulsive Behavior; Substance-Related Disorders; Behavior, Addictive
• Other Study ID Numbers: 202310893

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No