Search clinical trials for: single domain antibody

Total 14203 results

Mahidol University

Completed

3-year Follow-up After a Single Dose Acellular Pertussis Vaccination

Pertussis

Thailand
University of Cologne
Umm Al-Qura University

Completed

Effect of Acute Ethanol Consumption on The Activity of Major Cytochrome P450 Enzymes, NAT2 and P-glycoprotein

AOD Effects and Consequences

Germany
Ipsen

Completed

Study to Determine the Maximum Tolerated Dose, Safety and Tolerability of a Single Dose of Lanreotide Prolonged Release Formulation (PRF) in Subjects With Acromegaly

Acromegaly

France, Germany, Spain, Belgium, Russian Federation, United Kingdom, Italy, Lithuania, Czechia, Romania, Poland, Netherlands
Henry M. Jackson Foundation for the Advancement...
Uniformed Services University of the Health Sciences

Unknown

Study to Identify the Genetic Variations Associated With Phantom Limb Pain

Phantom Limb

United States
Elusys Therapeutics

Completed

Safety, Tolerability, and PK of a Single Intravenous Dose of ETI-204 in Adult Volunteers

Inhalational Anthrax

United States
Dragonboat Biopharmaceutical Company Limited
West China Hospital; Shanghai Public Health Clinical Center

Unknown

Clinical Trial to Evaluate Pharmacokinetics,Safety and Immunogenicity of Single Injection of CDP1 to Healthy Volunteers Compared to Erbitux

Healthy Volunteers

China
University of Arkansas

Withdrawn

2017-03: A Single-Arm, Open-label Study of Anti-Signaling Lymphocytic Activation Molecule F7 (Anti-SLAMF7) Monoclonal Antibody (mAb) Therapy After Autologous Stem Cell Transplant in Patients With Multiple Myeloma

Multiple Myeloma

United States
St George's, University of London

Unknown

Study of Single IV Administration of P2G12 (FuturePharma)

HIV Infection

United Kingdom
GlaxoSmithKline
PRA Health Sciences for clinical study conduct.

Completed

A Positron Emission Tomography (PET) Imaging Study to Investigate the Biodistribution and Clearance of an Albumin Binding Domain Antibody (AlbudAb) GSK3128349 in Healthy Male Subjects

Drug-Related Side Effects and Adverse Reactions

Netherlands
National Cancer Institute (NCI)

Terminated

SS1(dsFV)PE38 Plus Pemetrexed and Cisplatin to Treat Malignant Pleural Mesothelioma

Mesothelioma

United States
CytoDyn, Inc.
Amarex Clinical Research

No longer available

An Expanded Access Protocol for a Single Subject Who Has Completed 24-Weeks of Treatment in PR0140_CD02 Study (CD02_EA)

HIV

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Stage I-IIIB Non-Small Cell Lung Cancer After Completion of Radiation Therapy Alone or Combined Radiation Therapy and Chemotherapy

Lung Cancer

United States
Rockefeller University
University of Cologne

Completed

A Study of the Safety, Pharmacokinetics and Antiretroviral Activity of 10-1074

Healthy | HIV

Germany, United States
National Cancer Institute (NCI)

Completed

Phase II Randomized Trial of the Combination of Cetuximab and Sorafenib or Single Agent Cetuximab

Tongue Cancer | Recurrent Metastatic Squamous Neck Cancer With Occult Primary | Recurrent Salivary Gland Cancer | Recurrent Squamous Cell Carcinoma of the Hypopharynx | Recurrent Squamous Cell Carcinoma of the Larynx | Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity | Recurrent Squamous... and other conditions

United States
Menoufia University

Completed

Single Dose Omeprazole Versus High Dose in High-risk Critically Ill Patients.

Critical Illness
Shenyang Sunshine Pharmaceutical Co., LTD.

Completed

A Trial With Humanized TNFα Monoclonal Antibody Injection by Single Dose and Dose Escalation in Healthy Subjects

Rheumatoid Arthritis

China
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Immunoscintigraphy Using Radiolabeled Monoclonal Antibody in Finding Tumor Cells in Patients With Colorectal Cancer

Colorectal Cancer

United States
Bristol-Myers Squibb

Terminated

Single Ascending Dose and Multiple Ascending Dose Study in Healthy Participants and Proof of Mechanism Study in Patients With Ulcerative Colitis

Healthy Volunteers | Ulcerative Colitis

Australia, Georgia, Moldova, Republic of
GlaxoSmithKline

Completed

A Phase I Rheumatoid Arthritis Study in Healthy Volunteers

Arthritis, Rheumatoid

United States
C2N Diagnostics

Completed

Safety, Tolerability, and Pharmacokinetics of C2N-8E12 in Subjects With Progressive Supranuclear Palsy

Progressive Supranuclear Palsy

United States
GlaxoSmithKline

Completed

A Single Dose Pharmacokinetics (PK) Study of GSK2434735 in Healthy Male Volunteers

Asthma

United Kingdom
GlaxoSmithKline

Completed

Single Ascending Doses Study of Anti- Interleukin-7 Receptor α Monoclonal Antibody (GSK2618960) in Healthy Volunteers

Autoimmune Diseases

United Kingdom
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of a Single Dose of CNTO 136 (Sirukumab) on CYP450 Enzyme Activities After Subcutaneous Administration in Patients With Rheumatoid Arthritis

Arthritis, Rheumatoid

Germany, Korea, Republic of, South Africa, Moldova, Republic of
Novartis

Completed

An Exploratory Study of the Effects of a Single Dose of QAX576 (an Interleukin-13 Monoclonal Antibody) on Simulated Hayfever

Allergic Rhinitis

United Kingdom, Germany
Biogen

Completed

BIIB033 Single Ascending Dose Study in Healthy Volunteer Subjects

Healthy

Netherlands, United States
Göteborg University

Completed

Remicade in the Treatment of Patients With Active Ankylosing Spondylitis

Ankylosing Spondylitis

Sweden
OSE Immunotherapeutics

Completed

Safety, Tolerability, PK, PD, and Immunogenicity of Single and Multiple Ascending Intravenous Doses of FR104

Rheumatoid Arthritis | Complication of Transplant

Belgium
Mayo Clinic
National Cancer Institute (NCI)

Completed

Agatolimod Sodium, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Recurrent or Refractory Non-Hodgkin Lymphoma

Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Grade 3 Follicular Lymphoma | Recurrent Mantle Cell Lymphoma | Recurrent Marginal Zone Lymphoma | Splenic Marginal Zone Lymphoma | Waldenstrom Macroglobulinemia | Recurrent... and other conditions

United States
National Cancer Institute (NCI)

Terminated

RO4929097and Bevacizumab in Treating Patients With Progressive or Recurrent Malignant Glioma

Adult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Tumor

United States
UCB Celltech
Parexel

Completed

A First-In-Human Study With a Single Dose UCB7665 in Healthy Volunteers

Healthy

United Kingdom
Bristol-Myers Squibb

Completed

A Two-Part, Phase 1, Single-Dose Study of IL-31 mAb (Anti-Interleukin 31 Monoclonal Antibody); in Healthy Subjects and Adults With Atopic Dermatitis

Healthy Subjects and Atopic Dermatitis Subjects

United Kingdom
Sinocelltech Ltd.

Unknown

Safety, Tolerability and Pharmacokinetics of Recombinant Anti-epidermal Growth Factor Receptor(EGFR) Monoclonal Antibody in Patients With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer
Gilead Sciences

Completed

Study to Evaluate the Safety and Efficacy of a Single Tablet Regimen of Emtricitabine/Rilpivirine/Tenofovir Disoproxil Fumarate Compared With a Single Tablet Regimen of Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate in HIV-1 Infected, Antiretroviral Treatment-Naive Adults

HIV-1 Infection

Canada, United States, Puerto Rico, Spain, United Kingdom, France, Portugal, Netherlands, Belgium, Italy, Australia, Austria, Germany, Switzerland
Grifols Therapeutics LLC

Completed

An Open-label, Single-Arm Study to Evaluate the Safety and Rabies Virus Antibody Titers of Intramuscularly Administered Rabies Immune Globulin (Human)

Rabies

United States
Cancer Advances Inc.

Completed

An Open, Single-center Study to Determine the Antibody Repsonse to Gastrimmune and Its Safety and Tolerability in Patients With Advanced Pancreatic Carcinoma (PC1)

Pancreatic Cancer
Cancer Advances Inc.

Completed

Single Centre Study to Determine the Antibody Response to G17DT in Patients With Advanced Pancreatic Cancer.

Pancreatic Cancer | Jaundice
Nanfang Hospital of Southern Medical University

Unknown

a Single-center Registered Clinical Research of Chinese Patients With Moderate to Severe Crohn's Disease

Serological C Reactive Protein or Erythrocyte Sedimentation Rate
Eisai Co., Ltd.

Completed

A Phase 1 Single Dose Study of E6011 in Japanese Healthy Adult Male Subjects (Study E6011-J081-001)

Healthy Male Volunteers

Japan
National Institute of Diabetes and Digestive and...

Completed

Combination Drug Therapy Followed by Single Drug Steroid Free Therapy to Prevent Organ Rejection in Kidney Transplantation

Kidney Transplantation

United States
EBMT Solid Tumors Working Party
Lymphoma Trials Office

Completed

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation With or Without Rituximab in Treating Patients With Relapsed Non-Hodgkin's Lymphoma

Lymphoma

France, Spain, United Kingdom, Australia, Israel, Poland, Belgium, Switzerland, Canada, Germany, Denmark, New Zealand, Austria, Portugal, Turkey, Czech Republic, Sweden
Astellas Pharma Global Development, Inc.
Kyowa Kirin Co., Ltd.

Completed

Study of ASKP1240 After a Single Intravenous Dose at Escalating Dose Levels in Healthy Subjects

Healthy Volunteers | Pharmacokinetics of ASKP1240

United States
University of Surrey
European Commission

Completed

A Safety Study Of A Single Vaginal Administration Of P2G12 Antibody In Healthy Female Subjects

Human Immunodeficiency Virus

United Kingdom
Seoul National University Hospital
Seoul National University Boramae Hospital

Completed

The Change of the Tetanus Antibody Titer After Single Injection of Td and Simultaneous Injection of TIG With Td

Tetanus
PanGenetics UK Limited

Terminated

Single Dose PG102 in Patients With Active Psoriatic Arthritis

Arthritis, Psoriatic

Serbia
Nantes University Hospital

Completed

Comparison of Antisecretory Effect of a Single Dose of Rabeprazole 20 mg and Omeprazole 20 mg in Obese Subjects (Oberab)

Gastroesophageal Reflux

France
ESBATech AG

Completed

Study of Intra-articular DLX105 Applied to Patients With Severely Painful Osteoarthritis of the Knee

Osteoarthritis

Germany, Switzerland
Peking University People's Hospital

Unknown

Persistence of Rabies Antibody 1-5 Years After the Post-exposure Prophylaxis With Vero Cell Antirabies Vaccine and Antibody Response to a Single Booster Dose

Rabies

China
Pfizer

Completed

Single Dose Escalation Study of PF-04360365 In Subjects With Mild To Moderate Alzheimer's Disease

Alzheimer's Disease

United States
Renovo

Completed

Scar-Improvement Efficacy and Safety of a Single Intradermal Injection of Avotermin (Juvista) Administered Following Full-Thickness Skin Incisions

Cicatrix

United Kingdom
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Not yet recruiting

A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Unresectable Locally Advanced or Recurrent Metastatic Triple-negative Breast Cancer

Triple-negative Breast Cancer

China

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